MRI Findings of Disc Degeneration are More Prevalent in Adults with Low Back Pain than in Asymptomatic Controls: A Systematic Review and Meta-Analysis.
Overall, the discussions exhibit a high level of interest, with many references to prior related studies like Brinjikji et al., and participants analyze how MRI findings correlate with symptoms. The tone varies from supportive to cautious, reflecting engagement with both methodology and clinical applications, which suggests the research has a meaningful but nuanced impact on clinical practice.
AgreementModerate agreement
Most discussions support the main findings, referencing prior research such as Brinjikji et al. 2015 and acknowledging the association between MRI findings and low back pain.
InterestHigh interest
The discussions indicate high interest, with many analyzing study details, referencing multiple studies, and debating clinical relevance.
EngagementModerate engagement
Participants show moderate engagement by referencing secondary studies, discussing implications, and noting the importance of contextual clinical reasoning.
ImpactModerate impact
The conversations highlight that the research influences clinical understanding, emphasizing the significance of MRI findings in diagnosis, but also recognize complexities and limitations.
Abstract in brief
MRI features of disc degeneration, such as disc bulges, degeneration, extrusion, protrusions, and Modic 1 changes, are more common in adults aged 50 or younger who experience low back pain compared to those without symptoms.
The study's meta-analysis of 14 research studies involving over 3,000 individuals showed that these degenerative findings have higher odds ratios in symptomatic people, indicating a stronger association with low back pain.
Some imaging findings, like Modic changes and disc protrusions, are significantly linked to low back pain, while others like central canal stenosis and high-intensity zones are not, suggesting that certain MRI features are more closely related to symptoms than others.]
20歳で29%
40歳で33%
80歳で43%
腰痛の症状がなくMRIでヘルニアが見つかった割合。
また37％がヘルニアがあっても20年以上腰痛を発症しなかった
MRI Findings of Disc Degeneration are More Prevalent in Adults with Low Back Pain than in Asymptomatic Controls: A … https://t.co/RwZE2kRD97
Nov 20, 2024 · 79 likes · 9 shares · 13,287 followersView post →
ɹP
ɹǝʇlnoԀ pıʌɐᗡ
@Retlouping · X
We really are a biased bunch as we rarely see Brinjikji et al second study talked about much.
https://t.co/mgQsyiqZXZ
MRI Findings of Disc Degeneration are More Prevalent in
Adults with Low Back Pain than in Asymptomatic Controls: A
ABSTRACT
Systematic Review and Meta-Analysis https://t.co/a8FitrKYgB
Dec 18, 2023 · 46 likes · 9 shares · 26,409 followersView post →
ɹP
ɹǝʇlnoԀ pıʌɐᗡ
@Retlouping · X
MRI Findings of Disc Degeneration are More Prevalent in
Adults with Low Back Pain than in Asymptomatic Controls: Systematic Review and Meta-Analysis https://t.co/HKsA3bfchX https://t.co/uNBVOuuabY
Feb 26, 2024 · 36 likes · 7 shares · 26,409 followersView post →
AD
Adam Dobson
@adamdobson123 · X
Bias challenge alert
Reviewing some well cited papers on lumbar MRI.
Here is the evil sister paper on MRI findings and LBP.
https://t.co/Dt3tEEZs2i
e.g disc proutsion:
20% asymptomatic group
40% in symptomatic group
1/2
Dec 3, 2022 · 26 likes · 2 shares · 5,379 followersView post →
ɹP
ɹǝʇlnoԀ pıʌɐᗡ
@Retlouping · X
@camtudor Plus for balance one needs to look at Brinjikji’s second paper, which is less quoted and reference
MRI Findings of Disc Degeneration are More Prevalent in
Adults with Low Back Pain than in Asymptomatic Controls: A
ABSTRACT
Systematic Review and Meta-Analysis https://t.co/UX40o2jx7i
In this tutorial, we consider the evidence to determine the clinical benefit in requesting MRI scans for diagnosing shoulder pathology. The study evaluates MRI findings in individuals with unilateral shoulder pain…
Are hernias always symptomless or can they present with symptoms? This video explores the controversy, presenting two real cases illustrating different realities of lumbar hernias and discussing current research on…
RT @Retlouping: MRI Findings of Disc Degeneration are More Prevalent in
Adults with Low Back Pain than in Asymptomatic Controls: Systematic…
May 22, 2025 · 7 shares · 26,409 followersView post →
B
Billy
@Bhayn15 · X
@marklaslett_NZ I agree mark, Brinjikji et al 2015. MRI Findings of Disc Degeneration are More Prevalent in Adults with Low Back Pain than in Asymptomatic Controls
May 22, 2025 · 2 likes · 1 share · 30 followersView post →
@arindam___paul You can find many research papers. Here’s a good one : https://t.co/aGvr4rKPiR
Pain is highly complex - read bio psychosocial model of pain.
There are many factors affecting pain perception. E.g. Just sleeping fewer hours than usual can increase pain perception. https://t.co/ou4GcRrsgX
Nov 20, 2024 · 9 shares · 1,917 followersView post →
毒
毒多TKO
@Chirosamurai · X
20歳で29%
40歳で33%
80歳で43%
腰痛の症状がなくMRIでヘルニアが見つかった割合。
また37％がヘルニアがあっても20年以上腰痛を発症しなかった
MRI Findings of Disc Degeneration are More Prevalent in Adults with Low Back Pain than in Asymptomatic Controls: A … https://t.co/RwZE2kRD97
Nov 20, 2024 · 79 likes · 9 shares · 13,287 followersView post →
VL
Victor Lima
@personalvictor · X
MRI Findings of Disc Degeneration are More Prevalent in Adults with Low Back Pain than in Asymptomatic Controls: A … https://t.co/zoeH5HCGDy
MRI Findings of Disc Degeneration are More Prevalent in Adults with Low Back Pain than in Asymptomatic Controls: A Systematic Review and Meta-Analysis https://t.co/BFjGlqrPbS
RT @Retlouping: MRI Findings of Disc Degeneration are More Prevalent in
Adults with Low Back Pain than in Asymptomatic Controls: Systematic…
Feb 27, 2024 · 7 shares · 632 followersView post →
KI
Kinetic Impact
@KineticImpactRP · X
RT @Retlouping: MRI Findings of Disc Degeneration are More Prevalent in
Adults with Low Back Pain than in Asymptomatic Controls: Systematic…
Feb 26, 2024 · 7 shares · 156 followersView post →
ɹP
ɹǝʇlnoԀ pıʌɐᗡ
@Retlouping · X
MRI Findings of Disc Degeneration are More Prevalent in
Adults with Low Back Pain than in Asymptomatic Controls: Systematic Review and Meta-Analysis https://t.co/HKsA3bfchX https://t.co/uNBVOuuabY
Feb 26, 2024 · 36 likes · 7 shares · 26,409 followersView post →
ɹP
ɹǝʇlnoԀ pıʌɐᗡ
@Retlouping · X
RT @Retlouping: @AshisArmyPhysio @rajkannanpt @marklaslett_NZ @deepakcapri @kunalkulkarni10 And to be balanced with the evidence
https://t…
Feb 26, 2024 · 3 shares · 26,409 followersView post →
A
Alex
@AlexandruBS11 · X
RT @Retlouping: We really are a biased bunch as we rarely see Brinjikji et al second study talked about much.
https://t.co/mgQsyiqZXZ
MRI…
RT @Retlouping: We really are a biased bunch as we rarely see Brinjikji et al second study talked about much.
https://t.co/mgQsyiqZXZ
MRI…
Dec 18, 2023 · 9 shares · 123 followersView post →
ɹP
ɹǝʇlnoԀ pıʌɐᗡ
@Retlouping · X
We really are a biased bunch as we rarely see Brinjikji et al second study talked about much.
https://t.co/mgQsyiqZXZ
MRI Findings of Disc Degeneration are More Prevalent in
Adults with Low Back Pain than in Asymptomatic Controls: A
ABSTRACT
Systematic Review and Meta-Analysis https://t.co/a8FitrKYgB
Dec 18, 2023 · 46 likes · 9 shares · 26,409 followersView post →
MF
mk-fé
@BhengHeng · X
@AudeMykinenzie @Agence_EBP https://t.co/R2K8YINngZ
On retrouve plus de "signes radiologiques" chez les jeunes (-de 50 ans) qui ont eu au moins UN épisode de douleurs lombaires dans leur vie que chez ceux qui n'en n'ont jamais eu.
Dec 18, 2023 · 1 like · 1,333 followersView post →
S
spaghettinoodles
@MattR22933259 · X
@Retlouping I’m guessing you’ve seen this study, it I thought it was interesting as a mild pushback to the commonly quoted chart in the bottom right. Not saying it would change my clinical practice. Just interesting.
https://t.co/3liVIdWI8G
@DrJeanLefebvre À la différence du tibia déboîté, le spondylolisthesis est un signe d'imagerie si courant qu'on en trouve pas plus chez les gens qui ont des douleurs que chez ceux qui n'en ont pas.
https://t.co/WXqzm9pYrg
@Physio1Sr @adrian_traeger @Chris_Han12 @eClinicalMed @SweekritiSharma @link_physio @CGMMaher @doctordoubter @msk_health @syd_health @MarkHancockPT Yes to a certain degree and to certain aberrations. This review by Brinjikiji exmplifies that
https://t.co/SSuEUbEAdA
Apr 13, 2023 · 1 like · 3,223 followersView post →
AP
Andreas Persson
@andreas7812 · X
@AgnesWold Ganska stora skillnader i denna metaanalys https://t.co/CRCxQ7gz7L
2/2
Brinjikji et al 2015 second paper found an association with discal degeneration attributes and those with LBP in those under 50.
https://t.co/iITcmb01EM
Mar 25, 2023 · 6 likes · 12,820 followersView post →
DB
Dr. Amy Bullock
@dramybullockpt · X
RT @Retlouping: This new study on MRI findings and correlation with LBP is making quite a stir, but it really reflects similar things to th…
Mar 11, 2023 · 2 shares · 402 followersView post →
AP
Andrew Pontin
@PontinAndrew · X
RT @Retlouping: This new study on MRI findings and correlation with LBP is making quite a stir, but it really reflects similar things to th…
Mar 11, 2023 · 2 shares · 292 followersView post →
ɹP
ɹǝʇlnoԀ pıʌɐᗡ
@Retlouping · X
This new study on MRI findings and correlation with LBP is making quite a stir, but it really reflects similar things to this older study https://t.co/HKsA3bfchX
MRI Findings of Disc Degeneration are More Prevalent in
Adults with Low Back Pain than in Asymptomatic Controls: A https://t.co/Vf4UBo4eNR https://t.co/Z2aVmxG2GB
Mar 10, 2023 · 16 likes · 2 shares · 26,409 followersView post →
JD
Jono Deer
@novicephysio · X
@GregLehman @miss_massimino @abbykcosplays And those with pathology are more likely to have pain
https://t.co/zBxOT9VG18
(Brinjikji et al., 2015)*** sorry for massacring your name @WBrinjikji
https://t.co/2fXytPVF2M
Jan 29, 2023 · 1 like · 3,537 followersView post →
BH
BOGAERTS Hugo
@BogaertsHugo · X
"MR imaging evidence of disc bulge, degeneration, extrusion, protrusion, Modic 1 changes and spondylolysis are more prevalent in adults 50 years of age or younger with back pain compared with asymptomatic individuals." @WBrinjikji https://t.co/Phu0qPA14f
@willcoles92 @Irish_Physio I don’t understand how everyone cites this paper on asymptomatics but # then ignores the second paper by the same authors on those with back pain. Important to be balanced https://t.co/Q1GLkfILEZ
Nov 2, 2022 · 5 likes · 2 shares · 395 followersView post →
AD
Adam Dobson
@adamdobson123 · X
5/10
In this large study of asymptomatic MRIs 68% of the 40-50 group had disc height loss and 18% had facet hypertrophy
https://t.co/mRCyK35SJc
Despite this, preliminary evidence suggests ‘some’ association of degeneration with pain in select groups
https://t.co/Dt3tEEZs2i
Aug 9, 2022 · 5 likes · 1 share · 12,820 followersView post →
PP
Paul Plant
@paulplant76 · X
RT @Retlouping: @camtudor Plus for balance one needs to look at Brinjikji’s second paper, which is less quoted and reference
MRI Findings…
@camtudor Plus for balance one needs to look at Brinjikji’s second paper, which is less quoted and reference
MRI Findings of Disc Degeneration are More Prevalent in
Adults with Low Back Pain than in Asymptomatic Controls: A
ABSTRACT
Systematic Review and Meta-Analysis https://t.co/UX40o2jx7i
RT @belavyprof: Individual meta-analyses + factors associated with back pain
➡️ pain processing https://t.co/gbNXTw62ra
➡️ disc degeneratio…
May 26, 2022 · 1 share · 1,614 followersView post →
DB
Daniel Belavy
@belavyprof · X
Bekannte Faktoren für Rückenschmerzen aus Metanalyse:
➡️ Schmerzverarbeitung https://t.co/gbNXTw62ra
➡️ Bandscheibendegeneration https://t.co/DyySkLhZuH
➡️ Muskelatrophie https://t.co/Xgi4ZzO01E
➡️ Depressionen/Angst https://t.co/tvfSwgOGhV
Aber ist ein Faktor wichtiger?
May 23, 2022 · 2 likes · 1,956 followersView post →
DB
Daniel Belavy
@belavyprof · X
Individual meta-analyses + factors associated with back pain
➡️ pain processing https://t.co/gbNXTw62ra
➡️ disc degeneration https://t.co/DyySkLhZuH
➡️ muscle atrophy https://t.co/Xgi4ZzO01E
➡️ depression / distress https://t.co/tvfSwgOGhV
But is one more important than other?
May 13, 2022 · 7 likes · 1 share · 1,956 followersView post →
AP
Alvaro Pinteño
@alvaropint · X
Sin embargo, solemos olvidar este otro estudio del mismo autor en el que se demuestra que los hallazgos en RMN de la degeneración del disco son más frecuentes en adultos con dolor lumbar que en personas asintomáticas.
https://t.co/6V52JRpJB5 https://t.co/ehfG6xMuta
May 9, 2022 · 6 likes · 5,990 followersView post →
RQ
Ricardo Quintero.
@rquinteromd · X
RT @adamdobson123: Bias challenge alert
Reviewing some well cited papers on lumbar MRI.
Here is the evil sister paper on MRI findings and…
Bias challenge alert
Reviewing some well cited papers on lumbar MRI.
Here is the evil sister paper on MRI findings and LBP.
https://t.co/Dt3tEEZs2i
e.g disc proutsion:
20% asymptomatic group
40% in symptomatic group
1/2
@coasthealthhub @marklaslett_NZ And yes I’m aware of Brijiki’s other study on symptomatic v asymptomatic individuals
MRI Findings of Disc Degeneration are More Prevalent in Adults with Low Back Pain than in Asymptomatic Controls: A Systematic Review and Meta-Analysis https://t.co/iU7brBHtbI
@JAMANetworkOpen On the other hand, this study found correlation between degenerative changes on MRI and increased LBP in the under 50 age group.
https://t.co/fMOCHCeKG4
RT @Retlouping: @AshisArmyPhysio @rajkannanpt @marklaslett_NZ @deepakcapri @kunalkulkarni10 And to be balanced with the evidence
https://t…
May 20, 2021 · 3 shares · 5,379 followersView post →
M
MarkCroucher2
@MarkCroucher2 · X
MR imaging evidence of disc bulge, degeneration, extrusion, protrusion, Modic 1 changes, and spondylolysis are more prevalent in adults 50 years of age or younger with back pain compared with asymptomatic individuals.
https://t.co/LEhcHYDrNP
@VermaN21 @MacWeningerMD @jeubanksMD @DrKirstinWeider @BarbellMedicine @PmrScholars @physiatrynow @drpaulwinston Yes, but most forget about their other article denoting relationship to findings and symptoms. The question becomes how much do these findings matter for individual management. https://t.co/54qgJyvV9Y
@JHeerey @BJSM_BMJ @JoanneLKemp @kaymcrossley @AndreaBMosler @DrTaniaPizzari @richsouza_ucsf Resembles Brinjikji et al’s work on the lumbar spine; symptomatic population had a higher prevalence of disc degeneration
https://t.co/zBxOT9DwN0
@MRWPhysio Contextualising indeed is the key. Not the scan itself. This should always be based on good clinical reasoning. People always discuss this paper from Brinjikji but always seem to forget about his other paper released the same year
https://t.co/mQHnKtzCSV
@FlippinPain https://t.co/ckPlQxQ6va
People always seem to miss or forget Brinjikji’s second paper released the same year.
In my opinion it’s about good clinical reasoning for choice of scan and contextualising the results in relation to this.
"These findings do not prove that disc and endplate related imaging and spondylosis are pain generators, they do suggest that...these findings could be explored as candidates for biomarkers of LBP"
Link to text:
https://t.co/99MVGUMt5j
@AshisArmyPhysio @rajkannanpt @marklaslett_NZ @deepakcapri @kunalkulkarni10 And to be balanced with the evidence
https://t.co/3v29jhlQjN
MRI Findings of Disc Degeneration are More Prevalent in
Adults with Low Back Pain than in Asymptomatic Controls: A
Systematic Review and Meta-Analysis
W. Brinjikji, X F.E. Diehn, J.G. Jarvik, https://t.co/1jocrR3frp
doi: 10.3174/ajnr.A4498. Epub 2015 Sep 10. PMID: 26359154; PMCID: PMC7964277. 2. Culvenor AG et al, Prevalence of knee osteoarthritis features on magnetic ...
” AJNR. American journal of neuroradiology vol. 36,12 (2015): 2394-9. doi: 10.3174/ajnr.A4498 - Jamaludin, A., et al. "ISSLS PRIZE in Clinical Science 2023 ...
Evidence Based Massage Therapy | PDF | Evidence Based ...
News
doi:10.3174/ajnr.A4173. Colloca, L., & Barsky, A. J. (2020). Placebo and ... ajnr.A4498. Brinjikji, W., Luetmer, P. H., Comstock, B., Bresnahan, B. W. ...
10.3174/ajnr.A4498. Brodsky BB, Persikov AV (2005) Molecular structure of the collagen triple helix. Advances in Protein Chemistry 70(4):301–339. doi ...
Hospital Guide to Low Back Pain | PDF | Back Pain | Causes Of Death
News
AJNR Am J Neuroradiol. 2015;36(12):2394–2399. https://doi.org/10.3174/ajnr.A4498 Chiverton N. Examination of the adult spine. In: Harris N, Ali F (eds) ...
毒
ɹP
AD
MF
ML
P
B
לע
N
三
森O
白
ぼの
矢野
VL
MN
RH
M
KI
A
ID
AG
NP
PE
A
HP
BM
GG
MF
S
け肩
TM
M
O
A
I
R
MY
AW
AP
DB
AP
JD
N
BH
JN
M
TD
DG
J
PP
LS
R
CT
JP
ES
RH
DB
AP
RQ
CC
PE
P
S
K
DE
MR
J
P
AM
MB