Other answers: Elephants & bowhead whales are both exceptionally long-lived and highly cancer resistant. The elephant (lifespan up to 70 years) has 19 additional copies of the p53 tumor suppressor, which makes it highly cancer resistant. https://t.co/04CBgjmDOq 13/ https://t.co/6Pz04kgk2n
Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans.
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Jan 2016 – Aug 2025Where it's discussed
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What people are saying
The discussions reflect curiosity about the mechanisms behind elephant cancer resistance, exemplified by mentions of the 'p53 tumor suppressor' and 'gene duplication,' which indicate both interest and a desire to understand practical implications. The tone is generally respectful and focused, emphasizing research significance and potential for medical advances, which supports a moderate level of engagement and impact.
Most discussions acknowledge the significance of the research, with some explicitly supporting findings about elephants' cancer resistance mechanisms.
Participants show moderate curiosity, often connecting the research to broader topics like long lifespan and genetic defense mechanisms.
Comments demonstrate some depth, referencing specific aspects such as the p53 gene copies and gene duplication, indicating thoughtful consideration.
The discussions highlight the potential implications of understanding elephant genetics for human cancer prevention, suggesting a moderate perceived influence.
Abstract in brief
- The study investigates how elephants are naturally resistant to cancer despite their large size and long lifespan, analyzing their genomes for cancer-related gene adaptations.
- Researchers compared cellular responses to DNA damage in elephants, healthy humans, and patients with Li-Fraumeni syndrome (LFS), finding elephants have enhanced mechanisms like multiple copies of the TP53 gene, which may protect against cancer.
- The findings suggest that strategies found in elephants, such as gene duplication involved in DNA repair and apoptosis, could provide insights for developing new cancer prevention and treatment approaches in humans.
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Most liked on X and BlueskyPotential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans
@GruppSteve https://t.co/rchXnEmVFc
Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans. JAMA. 2015;314(17):1850–1860. doi:10.1001/jama.2015.13134.
Potential mechanisms for cancer resistance in elephants and comparative cellular response to DNA damage in humans. https://t.co/YbXMzMsIc4
It's not the main topic but it is mentioned at around 23-26 minutes. @cmaley.bsky.social, who contributes to the video, was a senior author of the "Potential Mechanisms for Cancer Resistance in Elephants" paper published in JAMA in 2015 (jamanetwork.com/journals/jam...)
All mentions
Understanding Elephant Cancer Resistance: Insights from Research
Hola amigos, today we explore why elephants rarely develop cancer, a fascinating topic that extends beyond humans. We analyze how factors like mass and gestation time influence cancer prevalence in various species…
Understanding Cancer Resistance in Large Animals: The Petos Paradox
How do healthy cells transform into cancerous ones? This video explores the remarkable phenomenon of why large animals like elephants experience cancer less frequently despite having more cells at risk. We delve into…
Genetic Adaptations in Elephants for Cancer Resistance
The study investigates how elephants are naturally resistant to cancer despite their large size and long lifespan, analyzing their genomes for cancer-related gene adaptations.
المرجع
RT @HotPaperTweet: 【動物学】【医学】体が大きく細胞数が多いのに、ゾウはガンになりにくい。これは「ゲノムの守護者」p53遺伝子がゾウゲノムに20コピーあり、ゾウは損傷した細胞がすぐアポトーシスするためと分かった。ゾウの血液から得た細胞で検証。OA https:…
It's not the main topic but it is mentioned at around 23-26 minutes. @cmaley.bsky.social, who contributes to the video, was a senior author of the "Potential Mechanisms for Cancer Resistance in Elephants" paper published in JAMA in 2015 (jamanetwork.com/journals/jam...)
Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans
2015. Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans ... https://t.co/K2BqKcgJOT
Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans. JAMA. 2015;314(17):1850–1860. doi:10.1001/jama.2015.13134.
RT @nickmmark: Other answers: Elephants & bowhead whales are both exceptionally long-lived and highly cancer resistant. The elephant (lif…
RT @nickmmark: Other answers: Elephants & bowhead whales are both exceptionally long-lived and highly cancer resistant. The elephant (lif…
RT @drsam: @GruppSteve https://t.co/rchXnEmVFc
RT @drsam: @GruppSteve https://t.co/rchXnEmVFc
@GruppSteve https://t.co/rchXnEmVFc
RT @nickmmark: Other answers: Elephants & bowhead whales are both exceptionally long-lived and highly cancer resistant. The elephant (lif…
RT @nickmmark: Other answers: Elephants & bowhead whales are both exceptionally long-lived and highly cancer resistant. The elephant (lif…
Other answers: Elephants & bowhead whales are both exceptionally long-lived and highly cancer resistant. The elephant (lifespan up to 70 years) has 19 additional copies of the p53 tumor suppressor, which makes it highly cancer resistant. https://t.co/04CBgjmDOq 13/ https://t.co/6Pz04kgk2n
It's #WorldElephantDay: 'Potential Mechanisms for #Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans.' a @JAMANetwork article found on #ScienceOpen: https://t.co/pwwdwlxbxg
RT @oncologiavet: Potential mechanisms for cancer resistance in elephants and comparative cellular response to DNA damage in humans. https…
Potential mechanisms for cancer resistance in elephants and comparative cellular response to DNA damage in humans. https://t.co/YbXMzMsIc4
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