Br J Pharmacol July 2016 PMID 26472268

High-fat diet-induced metabolic disorders impairs 5-HT function and anxiety-like behavior in mice.

Juliane Zemdegs, Gaël Quesseveur, David Jarriault, Luc Pénicaud, Xavier Fioramonti, Bruno P Guiard

Mentions

15
Peak: 6 in Nov 2020
across 3 sources since Apr 2019

Extended reach

198,018
potential audience

Total likes

10,735

Video views

184,427

Mentions per month

Apr 2019 – Apr 2022

Where it's discussed

  • X / Twitter7 posts
  • News6 articles
  • YouTube2 videos

AI synopsis

What people are saying

The overall discussions show appreciation for the research’s relevance to common mental health issues, with examples like posts mentioning skipping meals, coffee addiction, and listening to moody music, which reflect personal reflection and interest. The tone is informal and relatable, emphasizing how diet and habits influence anxiety, but there's limited deep analysis or critique, contributing to the moderate scores.

AgreementModerate agreement

Most posts acknowledge the connection between diet, mental health, and anxiety, reflecting general support for the publication's implications.

InterestModerate interest

Discussions show moderate interest, with posts referencing everyday habits and mental health, indicating a focus on practical relevance.

EngagementModerate engagement

Posts include reflections on personal habits, mental health, and related behavioral factors, suggesting a moderate level of engagement.

ImpactNeutral impact

While some posts highlight important links between diet and mental health, many just touch on everyday concerns, resulting in a neutral impact score.

Abstract in brief

  • High-fat diet (HFD) causes metabolic issues like weight gain and high blood sugar in mice, which are linked to anxiety-like and depression-like behaviors, possibly due to decreased serotonin (5HT) levels in the brain.
  • The study found that treatments like the antidepressant escitalopram and stopping HFD can reverse some of these metabolic and behavioral problems, but escitalopram's effects are less effective in HFD-fed mice, suggesting diet influences drug efficacy.
  • Overall, the research suggests that metabolic disorders and mental health issues are closely connected through disruptions in serotonin signaling in the hippocampus, highlighting the need for tailored treatments for people with both conditions.]

Top posts

Most liked on X and Bluesky
Anna-Rose
@lopcute · X

https://t.co/AoZeEWeg3A

Nov 27, 2020 · 7,632 followers View post →
Dale Crites
@MadonnaLoveDale · X

RT @SpOlympicsMD: Do you ever feel anxious randomly throughout the day and are unsure why? Watch this video that clearly explains 8 everyda…

Dec 19, 2020 · 5,409 followers View post →
Hoodie
@TheHoodBox · X

(ꈍ ‸ ꈍ) feel attacked : skipping meals (sometimes), Coffee addiction, Not getting enough sleep (sometimes), Listening to moody music https://t.co/37EBFeerC8

Nov 26, 2020 · 153 followers View post →
Damien Luviano
@damienluviano · X

Fat intake linked to depression https://t.co/pRtNpxCevz

Apr 20, 2019 · 117 followers View post →
dxDivine
@divine_dx · X

And here’s 8 Everyday Habits That Are Making You #Anxious… via @Psych2go. https://t.co/iwAmTq0NH8 #Mentalhealth #MentalHealthMatters #MentalHealthAwareness #mentalillness #Anxiety

Nov 27, 2020 · 98 followers View post →
Alice laglissade
@abvect · X

https://t.co/kBMmTmCEQm

Nov 28, 2020 · 76 followers View post →

All mentions

Dale Crites
@MadonnaLoveDale · X

RT @SpOlympicsMD: Do you ever feel anxious randomly throughout the day and are unsure why? Watch this video that clearly explains 8 everyda…

Dec 19, 2020 · 5,409 followers View post →
Alice laglissade
@abvect · X

https://t.co/kBMmTmCEQm

Nov 28, 2020 · 76 followers View post →
Maria Shahid
@Maria_Rikuo · X

8 Everyday Habits That Are Making You Anxious https://t.co/pu2kTyLWAQ

Nov 27, 2020 · 47 followers View post →
Anna-Rose
@lopcute · X

https://t.co/AoZeEWeg3A

Nov 27, 2020 · 7,632 followers View post →
dxDivine
@divine_dx · X

And here’s 8 Everyday Habits That Are Making You #Anxious… via @Psych2go. https://t.co/iwAmTq0NH8 #Mentalhealth #MentalHealthMatters #MentalHealthAwareness #mentalillness #Anxiety

Nov 27, 2020 · 98 followers View post →
Hoodie
@TheHoodBox · X

(ꈍ ‸ ꈍ) feel attacked : skipping meals (sometimes), Coffee addiction, Not getting enough sleep (sometimes), Listening to moody music https://t.co/37EBFeerC8

Nov 26, 2020 · 153 followers View post →
Damien Luviano
@damienluviano · X

Fat intake linked to depression https://t.co/pRtNpxCevz

Apr 20, 2019 · 117 followers View post →
Handbook of Research On Student Engagement: Amy L. Reschly ...
News

Child Development, 91(5), Psychological Measurement, 69, 794–824. https://doi. 1800–1818. https://doi.org/10.1111/cdev.13343 org/10.1177/0013164409332214

Dec 12, 2025 View →
Depresi post partum dengan animal models | PDF
News

High-fat diet-induced metabolic disorders impairs 5-HT function and anxiety- like behavior in mice. Br. J. Pharm. 2095–2110. https://doi.org/10.1111/ bph.13343.

Dec 12, 2025 View →
1-s2.0-S0306453021004649-main_cópia | PDF | Major Depressive ...
News

https://doi.org/10.1111/bph.12640. 46, 123–134. https://doi.org/10.1016/j ... 13343. Schweizer-Schubert, S., Gordon, J.L., Eisenlohr-Moul, T.A. ...

Dec 12, 2025 View →
Kanser Hastalarının Sıkça Başvurduğu Geleneksel Ve Tamamlayıcı ...
News

Cancer pain relief: with a doi: 10.1111/bph.13887. Epub 2017 Jul 27. PMID ... 13343. Scherb. in Hungary and Romania: A case study. Genet. 5. Li X ...

Dec 12, 2025 View →
Machine Learning in Biological Sciences: Shyamasree Ghosh Rathi ...
News

... 10.1111/nph.15771. Valletta JJ, Torney C, Kings M, Thornton A, Madden J (2017) ... the prostate gland in the categories of BPH or Malignant) is another popular ...

Dec 12, 2025 View →
High-fat diet may cause changes in brain that lead to anxiety ...
News

British Journal of Pharmacology, 2015; DOI: 10.1111/bph.13343. Cite This Page: MLA; APA; Chicago. Wiley. "High-fat diet may cause changes in ...

Oct 19, 2015 View →