Endocr Rev December 2015 PMID 26544531

EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals.

A C Gore, V A Chappell, S E Fenton, J A Flaws, A Nadal, G S Prins, J Toppari, R T Zoeller

Mentions

120
Peak: 5 in Apr 2019
across 6 sources since Jan 2019

Extended reach

357,698
potential audience

Total likes

1,367

Video views

29,036

Mentions per month

Jan 2019 – Sep 2025

Where it's discussed

  • News48 articles
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AI synopsis

What people are saying

Many discussions highlight the importance of understanding endocrine disruptors' effects, with posts referencing the broad scope of research, such as mentioning 'gene-environment interactions' and the effects on reproductive health. The tone varies from scientific and analytical to urgent and advocacy-oriented, emphasizing the perceived significance of the publication in shaping future health measures and awareness.

AgreementModerate agreement

Most discussions recognize the significance of the publication, with many emphasizing the established links between endocrine disruptors and health issues. Phrases like 'most supporting the importance' and references to multiple scientific references indi

InterestHigh interest

The discussions demonstrate high curiosity, with multiple mentions of specific chemicals, health effects, and calls for further research. The tone shows participants are eager to understand and explore the topic deeply.

EngagementModerate engagement

Posts often go beyond surface-level mention, referencing specific molecular mechanisms, sex differences, and critiques of regulatory gaps, indicating a meaningful level of involvement with the topic.

ImpactHigh impact

Numerous comments highlight the potential for these findings to influence health policies, public awareness, and personal health choices—suggesting that users perceive this publication as having a substantial impact on science and society.

Abstract in brief

  • The second scientific statement from The Endocrine Society updates and expands on the 2009 findings, emphasizing that exposure to endocrine-disrupting chemicals (EDCs) during development can lead to lasting health effects, including in future generations, through gene-environment interactions and epigenetic changes.
  • The statement reviews recent high-quality research, mainly from the past five years, on how EDCs are linked to diseases such as obesity, diabetes, reproductive issues, hormone-sensitive cancers, and neurodevelopmental disorders, using both animal and human epidemiological studies.
  • Although strong evidence supports these causal links, the authors highlight the need for cautious interpretation due to variability in experimental methods, emphasizing the importance of continued research to better understand EDCs’ impacts on human health.

Top posts

Most liked on X and Bluesky
Lawrence James
@LawrenceJJames · X

Also known as 'Hormone Disruptors' Exposure to these potent chemicals can cause problems with: - obesity, diabetes and metabolism - reproductive system - prostate - thyroid - impaired brain development Some of which only show up years later! https://t.co/RKs7VCZML1

May 18, 2022 · 13 likes · 1,391 followers View post →
Endocrine Society
@TheEndoSociety · X

Our scientific statement explains how #EDCs impact #womenshealth leading to reproductive disorders: early puberty, endometriosis, fibroids, infertility, premature ovarian failure/menopause, adverse cyclicity and pregnancy outcomes: https://t.co/KSmJwFtKhB #NWHW #EndocrineReviews

May 15, 2020 · 7 likes · 5 shares · 32,210 followers View post →
Leo Trasande, MD, MPP
@leotrasande · X

The issue is about synthetic chemicals that mess with hormones on our bodies. And in this regard there are huge gaps in @US_FDA oversight, as explained by @TheEndoSociety. They include phthalates, some of which antagonize testosterone & promote obesity. 2/ https://t.co/kkXDtmLpeJ

Jan 9, 2019 · 7 likes · 1 share · 3,140 followers View post →
Zeptej se vědce
@Zeptej_se_vedce · X

[10] https://t.co/obU9HyCwzp [11] https://t.co/uQzwnvtFCU [12] https://t.co/oQcjVD2qEQ [13] https://t.co/lnFHo5Kh5W [14] https://t.co/qkJVOcvyMW [15] https://t.co/s04lCLfCL7 [16] https://t.co/NldJ9nBWFX [17] https://t.co/EGue6IVZJ3 [18] https://t.co/2iuRWPhOGf

Feb 20, 2024 · 5 likes · 16,645 followers View post →
Alex Leaf
@AlexJLeaf · X

The Endocrine Society published a position stand in 2015 that makes these same arguments — that various persistent organic pollutants and synthetic pesticides have low-dose effects that could be especially problematic for vulnerable populations. 14/n https://t.co/YoPgMz5MI4

Aug 22, 2020 · 5 likes · 3,941 followers View post →
Fibroid Network UK
@fibroidsupport · X

So often, women blame themselves, for #Endometriosis & #Fibroids & are often told by Drs that "no one knows what causes it" & theres No Research. But in some types of Iatrogenic (treatment caused) or Pharma Industry caused disease, Its Not true #Exposome https://t.co/I1X2eyGYzr https://t.co/GkLkMVgtqD https://t.co/L23r1KJQQB

Feb 24, 2021 · 4 likes · 2 shares · 3,450 followers View post →

All mentions

yz1707
@yz1707 · X

@tapassito @chaskrrr @deadzach44 @ZEVENTFR Gore, A. C. et al. (2015) Titre : EDC-2: The Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals Publication : Endocrine Reviews, vol. 36(6), pp. E1–E150 Résumé : Montre l’impact des perturbateurs endocriniens (ex. : bisphénol A, phtalates, DDT)

Aug 1, 2025 · 180 followers View post →
Philippe Hurlaux
@PHurlaux · X

Santé des enfants et environnement: Les perturbateurs endocriniens, avec Ana Soto. https://t.co/6S6voXgHOL

Jul 22, 2024 · 404 followers View post →
Guillaume SEE
@GuillaumeSEE · X

Aujourd'hui j’échange avec Ana Soto (!). #bisphenola #perturbateursendocriniens #zeroplastique https://t.co/GtGkGCEAkM

Jul 22, 2024 · 1 like · 108 followers View post →
sara.art
@saraart4 · X

@davidperrotin @mathildemathieu Society's Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocr Rev. 2015 Dec;36(6):E1-E150. doi: 10.1210/er.2015-1010. 11. Garcia-Falgueras A, Swaab DF. A sex difference in the hypothalamic uncinate nucleus: relationship to gender identity. Brain. 2008 Dec;131

May 6, 2024 · 8,469 followers View post →
sara.art
@saraart4 · X

@davidperrotin @mathildemathieu 2. Gore AC, Chappell VA, Fenton SE, et al. EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals. Endocr Rev. 2015 Dec;36(6):E1-E150. doi: 10.1210/er.2015-1010.

May 6, 2024 · 8,469 followers View post →
Zeptej se vědce
@Zeptej_se_vedce · X

[10] https://t.co/obU9HyCwzp [11] https://t.co/uQzwnvtFCU [12] https://t.co/oQcjVD2qEQ [13] https://t.co/lnFHo5Kh5W [14] https://t.co/qkJVOcvyMW [15] https://t.co/s04lCLfCL7 [16] https://t.co/NldJ9nBWFX [17] https://t.co/EGue6IVZJ3 [18] https://t.co/2iuRWPhOGf

Feb 20, 2024 · 5 likes · 16,645 followers View post →
SUlam
@SUlam00731161 · X

@CNN Not implausible https://t.co/kgK239MO2h

Jul 13, 2023 · 347 followers View post →
Emily A. The Spirit of Jezebel
@emzorbit · X

Physicians and scientists issued a wake-up call in 2009, followed by another in 2015. The EPA has proposed a rule governing PFAS (which will still be very difficult) but opposition says it will cost billions. https://t.co/wYhILxJDCu

Jul 6, 2023 · 1 like · 17,757 followers View post →
Denouncer of Everything
@searchingthru · X

"Future research needs to focus on sex differences in endocrine disruption of the brain and to consider both age of exposure and age at assessment in interpreting results." https://t.co/xunnDMPybS

Mar 17, 2023 · 393 followers View post →
Lawrence James
@LawrenceJJames · X

Also known as 'Hormone Disruptors' Exposure to these potent chemicals can cause problems with: - obesity, diabetes and metabolism - reproductive system - prostate - thyroid - impaired brain development Some of which only show up years later! https://t.co/RKs7VCZML1

May 18, 2022 · 13 likes · 1,391 followers View post →
Increado
@Incognoscible_ · X

@Dictatriz @elyiyitu @dinamo1234 @INavarrorum https://t.co/IfDpzMwbQn https://t.co/dgRwj62mWX

Oct 22, 2021 · 4,022 followers View post →
Leo Trasande, MD, MPP
@leotrasande · X

But “correlation is not causation” misses the main point. You don’t perform observational or randomized studies in isolation. @TheEndoSociety Scientific Statement contextualizes the rapidly accumulating evidence to date in animals, tissues & humans. https://t.co/kkXDtmtOnb 3/

Oct 21, 2021 · 2 likes · 3,140 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @NeilFlochMD: EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals - PubMed #obesity #EDC https:…

May 3, 2021 · 3 shares · 1,368 followers View post →
Interexposome
@interexposome · X

RT @fibroidsupport: So often, women blame themselves, for #Endometriosis & #Fibroids & are often told by Drs that "no one knows what causes…

Feb 24, 2021 · 2 shares · 898 followers View post →
Emma Murphy (INFACT) ☘️
@Emma4facs · X

RT @fibroidsupport: So often, women blame themselves, for #Endometriosis & #Fibroids & are often told by Drs that "no one knows what causes…

Feb 24, 2021 · 2 shares · 3,829 followers View post →
Fibroid Network UK
@fibroidsupport · X

So often, women blame themselves, for #Endometriosis & #Fibroids & are often told by Drs that "no one knows what causes it" & theres No Research. But in some types of Iatrogenic (treatment caused) or Pharma Industry caused disease, Its Not true #Exposome https://t.co/I1X2eyGYzr https://t.co/GkLkMVgtqD https://t.co/L23r1KJQQB

Feb 24, 2021 · 4 likes · 2 shares · 3,450 followers View post →
DrDeaRoberts
@DrDeaRoberts · X

RT @NeilFlochMD: EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals - PubMed #obesity #EDC https:…

Sep 17, 2020 · 3 shares · 2,040 followers View post →
Neil Floch MD
@NeilFlochMD · X

EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals - PubMed #obesity #EDC https://t.co/eTKiAszy3B

Sep 17, 2020 · 3 likes · 3 shares · 130,110 followers View post →
Alex Leaf
@AlexJLeaf · X

The Endocrine Society published a position stand in 2015 that makes these same arguments — that various persistent organic pollutants and synthetic pesticides have low-dose effects that could be especially problematic for vulnerable populations. 14/n https://t.co/YoPgMz5MI4

Aug 22, 2020 · 5 likes · 3,941 followers View post →
Prof.Reem Abdullah Al Khalifah
@dr_ralkhalifah · X

RT @TheEndoSociety: Our scientific statement explains how #EDCs impact #womenshealth leading to reproductive disorders: early puberty, endo…

May 15, 2020 · 5 shares · 3,339 followers View post →
MedPage Endocrinology
@MedPageEndo · X

RT @TheEndoSociety: Our scientific statement explains how #EDCs impact #womenshealth leading to reproductive disorders: early puberty, endo…

May 15, 2020 · 5 shares · 1,332 followers View post →
Miriam Sánchez
@MRM_sg · X

RT @TheEndoSociety: Our scientific statement explains how #EDCs impact #womenshealth leading to reproductive disorders: early puberty, endo…

May 15, 2020 · 5 shares · 220 followers View post →
Endocrine Society
@TheEndoSociety · X

Our scientific statement explains how #EDCs impact #womenshealth leading to reproductive disorders: early puberty, endometriosis, fibroids, infertility, premature ovarian failure/menopause, adverse cyclicity and pregnancy outcomes: https://t.co/KSmJwFtKhB #NWHW #EndocrineReviews

May 15, 2020 · 7 likes · 5 shares · 32,210 followers View post →
Herodote63 (Rémy Malgouyres)
@herodote63 · X

https://t.co/Rk3KYxPw0R

Feb 4, 2020 · 26 followers View post →
Stefanie Winston
@StefanieWinston · X

RT @SMahalingaiahMD: @clue This is a great summary by @TheEndoSociety on endocrine disrupting chemicals and effects on reproductive organs…

Nov 5, 2019 · 2 shares · 422 followers View post →
Endocrine Society
@TheEndoSociety · X

RT @SMahalingaiahMD: @clue This is a great summary by @TheEndoSociety on endocrine disrupting chemicals and effects on reproductive organs…

Nov 5, 2019 · 2 shares · 32,210 followers View post →
Shruthi Mahalingaiah
@SMahalingaiahMD · X

@clue This is a great summary by @TheEndoSociety on endocrine disrupting chemicals and effects on reproductive organs and tissues: https://t.co/77uHIAgWYu

Nov 5, 2019 · 1 like · 2 shares · 1,142 followers View post →
Ferran Campillo i López, MD
@doktorkampi · X

RT @leotrasande: Por ejemplo lee las reportajes de la @TheEndoSociety con sus 1.331 referencias https://t.co/kkXDtmtOnb 2/

Jun 8, 2019 · 1 share · 1,912 followers View post →
Leo Trasande, MD, MPP
@leotrasande · X

Por ejemplo lee las reportajes de la @TheEndoSociety con sus 1.331 referencias https://t.co/kkXDtmtOnb 2/

Jun 8, 2019 · 1 like · 1 share · 3,140 followers View post →
Eugenia Koreneva
@Lastochkaplus · X

RT @EndoSocJournals: “… we have much stronger knowledge about how #EDCs alter gene-environment interactions via physiological, cellular, mo…

May 21, 2019 · 1 share · 11 followers View post →
Endocrine Society Journals
@EndoSocJournals · X

“… we have much stronger knowledge about how #EDCs alter gene-environment interactions via physiological, cellular, molecular, and epigenetic changes, thereby producing effects in exposed individuals...” https://t.co/NVKvnlh708 #endocrinereviews @UTexasPharmacy https://t.co/GM36f4ujK9

May 17, 2019 · 3 likes · 1 share · 9,888 followers View post →
PalSon
@umm_elshawf · X

EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals https://t.co/2fzXEVdvzk

May 11, 2019 · 1,012 followers View post →
FromPinktoPrevention
@pink_prevention · X

RT @leotrasande: @breastcancernow @BPAinReceipts Thank you - I study endocrine disruption for a living, & am familiar with latest literatur…

Apr 5, 2019 · 4 shares · 255 followers View post →
TippingPointFilmFund
@_tpff · X

RT @leotrasande: @breastcancernow @BPAinReceipts Thank you - I study endocrine disruption for a living, & am familiar with latest literatur…

Apr 4, 2019 · 4 shares · 771 followers View post →
CHEM Trust
@CHEMTrust · X

RT @leotrasande: @breastcancernow @BPAinReceipts Thank you - I study endocrine disruption for a living, & am familiar with latest literatur…

Apr 4, 2019 · 4 shares · 5,332 followers View post →
Michael Warhurst mwarhurst.bsky.social
@mwarhurst · X

RT @leotrasande: @breastcancernow @BPAinReceipts Thank you - I study endocrine disruption for a living, & am familiar with latest literatur…

Apr 4, 2019 · 4 shares · 2,657 followers View post →
Leo Trasande, MD, MPP
@leotrasande · X

@breastcancernow @BPAinReceipts Thank you - I study endocrine disruption for a living, & am familiar with latest literature showing DDT, BPA among environmental contributors. I suggest catching up by reading @TheEndoSociety scientific statement on endocrine disrupting chemicals. https://t.co/kkXDtmtOnb

Apr 3, 2019 · 4 likes · 4 shares · 3,140 followers View post →
Liza Gross
@lizabio · X

RT @leotrasande: The issue is about synthetic chemicals that mess with hormones on our bodies. And in this regard there are huge gaps in @U…

Mar 19, 2019 · 1 share · 5,825 followers View post →
Leo Trasande, MD, MPP
@leotrasande · X

@DILIprof @joesph_wiencek @SOToxicology @acmt A gentle suggestion would be to read the work others outside toxicology have published. We don’t stay in the toxicology silo, or spread chemophobia. https://t.co/kkXDtmtOnb

Jan 31, 2019 · 3,140 followers View post →
Leo Trasande, MD, MPP
@leotrasande · X

The issue is about synthetic chemicals that mess with hormones on our bodies. And in this regard there are huge gaps in @US_FDA oversight, as explained by @TheEndoSociety. They include phthalates, some of which antagonize testosterone & promote obesity. 2/ https://t.co/kkXDtmLpeJ

Jan 9, 2019 · 7 likes · 1 share · 3,140 followers View post →
Elena Haskins, Authentic American
@ElenaHaskins · X

RT @MariahCBlake: Here's the link: https://t.co/P0mKwJshb6 You can also find additional @TheEndoSociety statements on the topic here: https…

Jan 7, 2019 · 1 share · 3,427 followers View post →
Mariah Blake
@MariahCBlake · X

Here's the link: https://t.co/P0mKwJshb6 You can also find additional @TheEndoSociety statements on the topic here: https://t.co/8zeZuQOmUc

Jan 5, 2019 · 2 likes · 1 share · 7,013 followers View post →