PubHawk
January 2016 PMID 26574953

Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man.

Jonathan M Hazlehurst, Andrei I Oprescu, Nikolaos Nikolaou, Riccardo Di Guida, Annabel E K Grinbergs, Nigel P Davies, Robert B Flintham, Matthew J Armstrong, Angela E Taylor, Beverly A Hughes, Jinglei Yu, Leanne Hodson, Warwick B Dunn, Jeremy W Tomlinson

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Mentions

30
Peak: 21 in Apr 2024
across 4 sources since Oct 2022

Extended reach

36,973
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Total likes

812

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36,696

Mentions per month

Oct 2022 – Aug 2025

Where it's discussed

  • Reddit26 posts
  • YouTube2 videos
  • X / Twitter1 posts
  • Instagram1 posts

AI synopsis

What people are saying

The overall tone suggests a cautious recognition of the study's relevance, with remarks like 'the article investigates liver fat and enzyme changes,' indicating awareness of the metabolic effects. The discussion's language remains relatively neutral, focusing on implications for men over 66 and hormonal changes, reflecting moderate engagement and interest.

AgreementModerate agreement

Moderate support exists for the article's findings, with some posts recognizing the metabolic side effects as significant.

InterestModerate interest

Discussions show curiosity about the effects on liver fat and hormonal impacts, but not overly enthusiastic.

EngagementNeutral engagement

Posts briefly mention the study's implications without deep analysis or detailed discussion.

ImpactModerate impact

The topic appears relevant, especially regarding health implications of medications, but not regarded as profoundly transformative.

Abstract in brief

  • The study investigated how inhibiting the enzymes SRD5A1 and SRD5A2, especially through drugs like dutasteride and finasteride, impacts liver fat and metabolism in healthy men.
  • Results showed that dutasteride, which blocks both enzymes, increases liver fat, causes insulin resistance in the liver, and reduces fat breakdown in fat tissue, whereas finasteride did not have these effects.
  • Overall, dual inhibition of SRD5A enzymes, particularly with dutasteride, can lead to increased liver fat accumulation and altered lipid metabolism, highlighting potential metabolic side effects of these medications.]
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Most liked on X and Bluesky
langitradum
@aaaajjw223 · X

@_Padomay_ @gsyi_siken_ @INTEGRAL1907 @CypriotUrban Cinsel etkileri üzerine: https://t.co/DGPKuOVwiN 66yaş üzeri erkeklerdeki psikolojik etki: https://t.co/riXVxZsRL0 Karaciğer yağlanması ve enzimlerdeki değişiklikleri inceleyen makale https://t.co/u0OklVckid

Jun 20, 2025 · 8 followers View post →

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langitradum
@aaaajjw223 · X

@_Padomay_ @gsyi_siken_ @INTEGRAL1907 @CypriotUrban Cinsel etkileri üzerine: https://t.co/DGPKuOVwiN 66yaş üzeri erkeklerdeki psikolojik etki: https://t.co/riXVxZsRL0 Karaciğer yağlanması ve enzimlerdeki değişiklikleri inceleyen makale https://t.co/u0OklVckid

Jun 20, 2025 · 8 followers View post →
ถ้าอายุ 15-20 ปี แล้วมี AGA (ผมร่วงจากพันธุกรรม) นี่มีแค่ dutasteride เป็น ...
Reddit

... 10.1210/jc.2015-2928. [DOI] [PMC free article]. Livingstone DE, Barat P, Di Rollo EM, Rees GA, Weldin BA, Rog-Zielinska EA, et al. การขาดหรือ ...

Aug 15, 2025 View →
Is dutastride the only option if you have AGA at the age of 15-20 : r ...
Reddit

... 10.1210/jc.2015-2928. [DOI] [PMC free article]. Livingstone DE, Barat P, Di Rollo EM, Rees GA, Weldin BA, Rog-Zielinska EA, et al. 5α ...

Aug 15, 2025 View →
La dutasteride è l'unica opzione se hai l'AGA tra i 15 e i 20 anni? : r ...
Reddit

... 10.1210/jc.2015-2928. [DOI] [PMC articolo gratuito]. Livingstone DE, Barat P, Di Rollo EM, Rees GA, Weldin BA, Rog-Zielinska EA, et al. La ...

Aug 15, 2025 View →
क्या 15-20 की उम्र में AGA होने पर ड्यूटैस्टराइड ही एकमात्र विकल्प है ...
Reddit

... 10.1210/jc.2015-2928. [DOI] [PMC मुक्त लेख]. लिविंगस्टोन डीई, बरट पी, डि रोलो ईएम, रीस जीए ...

Aug 15, 2025 View →
¿Dutasterida es la única opción si tienes AGA entre los 15 y los 20 ...
Reddit

... 10.1210/jc.2015-2928. [DOI] [Artículo gratuito de PMC]. Livingstone DE, Barat P, Di Rollo EM, Rees GA, Weldin BA, Rog-Zielinska EA, et al. La ...

Aug 15, 2025 View →
VOCÊ TOMA ALGO PRA CABELO? ENTÃO LÊ ISSO. Em 2015, a ...
Instagram

... 10.1210/jc.2015-2928 Esse conteúdo é informativo, baseado em artigo científico real, e não substitui avaliação médica. #Finasterida ...

Jun 24, 2025 View →
Qual seria a inibição da DHT no couro cabeludo com uma dose alta ...
Reddit

Do DOI 10.1210/jc.2015-2928: Dutasterida, não finasterida, aumentou a resistência à insulina hepática. A gordura intra-hepática aumentou na ...

Apr 18, 2024 View →
Quel serait le degré d'inhibition de la DHT du cuir chevelu par ...
Reddit

D'après le DOI 10.1210/jc.2015-2928 : La dutastéride, et non la finastéride, a augmenté la résistance à l'insuline hépatique. Les lipides ...

Apr 18, 2024 View →
高劑量的dutasteride 頭皮DHT 抑制會是多少？ : r/tressless - Reddit
Reddit

可以請你提供完整的DOI 嗎？ 來自DOI 10.1210/jc.2015-2928：. 達特他雄胺（Dutasteride），而不是非那雄胺（finasteride），增加了肝臟胰島素抵抗。在 ...

Apr 18, 2024 View →
高用量のデュタステリドは、頭皮のDHTをどれくらい阻害するんだ ...
Reddit

DOI全文教えてくんない？ DOI 10.1210/jc.2015-2928 から：. デュタステリドは、フィナステリドではなく、肝臓のインスリン抵抗性を増加させた ...

Apr 18, 2024 View →
Quanto costerebbe un'alta dose di dutasteride per l'inibizione del ...
Reddit

Da DOI 10.1210/jc.2015-2928: Dutasteride, non finasteride, ha aumentato la resistenza all'insulina epatica. I lipidi intraepatici sono ...

Apr 18, 2024 View →
การยับยั้ง DHT บนหนังศีรษะด้วย dutasteride ขนาดสูง จะได้ผลมากแค่ไหน ...
Reddit

จาก DOI 10.1210/jc.2015-2928: Dutasteride ไม่ใช่ finasteride ทำให้ความต้านทานอินซูลินในตับเพิ่มขึ้น ไขมันในตับเพิ่มขึ้นหลังการรักษาด้วย ...

Apr 18, 2024 View →
Mennyi lenne a nagy dózisú dutaszterid fejbőr DHT-gátlása? : r ...
Reddit

A DOI 10.1210/jc.2015-2928-ból: A dutaszterid, nem a finaszterid, növelte a máj inzulinrezisztenciáját. A májon belüli lipid növekedett MRS ...

Apr 18, 2024 View →
Wie hoch wäre die DHT-Hemmung auf der Kopfhaut bei einer ...
Reddit

und doi: 10.1210 zeigen keinen Leberschaden bis zu 40 mg an. ... Aus DOI 10.1210/jc.2015-2928: Dutasterid, nicht Finasterid, erhöhte ...

Apr 18, 2024 View →
고용량 두타스테리드 두피 DHT 억제는 얼마나 될까? : r/tressless
Reddit

전체 DOI를 제공해 주시겠어요? DOI 10.1210/jc.2015-2928에서: Dutasteride는 finasteride가 아닌 간 인슐린 저항성을 증가시켰습니다. Dutasteride ...

Apr 18, 2024 View →
Πόσο θα ήταν η αναστολή DHT στο τριχωτό της κεφαλής με μια ...
Reddit

Μπορείς να δώσεις το πλήρες DOI;. Από το DOI 10.1210/jc.2015-2928: Η Dutasteride, όχι η finasteride, αύξησε την ηπατική αντίσταση στην ...

Apr 18, 2024 View →
Cât de mare ar fi inhibarea DHT-ului de pe scalp cu o doză mare de ...
Reddit

Din DOI 10.1210/jc.2015-2928: Dutasterida, nu finasterida, a crescut rezistența hepatică la insulină. Lipidele intrahepatice au crescut pe ...

Apr 18, 2024 View →
Ile wynosiłoby zahamowanie DHT na skórze głowy przy wysokiej ...
Reddit

Z DOI 10.1210/jc.2015-2928: Dutasteryd, a nie finasteryd, zwiększał insulinooporność wątroby. Zawartość lipidów wewnątrz wątroby wzrosła po ...

Apr 18, 2024 View →
Berapa banyak penghalang DHT kat kulit kepala kalau ambil ...
Reddit

Daripada DOI 10.1210/jc.2015-2928: Dutasteride, bukan finasteride, tingkatkan rintangan insulin hati. Lipid intrahepatik meningkat pada MRS ...

Apr 18, 2024 View →
Yüksek doz dutasterid'in kafa derisindeki DHT inhibisyonu ne kadar ...
Reddit

Lütfen tam DOI'yi verebilir misin? DOI 10.1210/jc.2015-2928'den: Dutasterid, finasterid değil, hepatik insülin direncini artırdı. Dutasterid ...

Apr 18, 2024 View →
Kuinka paljon iso annos dutasteridia päänahan DHT:n estossa ...
Reddit

DOI 10.1210/jc.2015-2928:sta: Dutasteridi, ei finasteridi, lisäsi maksan insuliiniresistenssiä. Intrahepaattinen lipidi lisääntyi MRS:ssä ...

Apr 18, 2024 View →
Hvor mye ville en høy dose dutasterid i hodebunnen for dht ... - Reddit
Reddit

Ja, transkjønnet terapi er mer effektiv, men vi vil være menn med hår. Kan du gi hele DOI-en? Fra DOI 10.1210/jc.2015-2928: Dutasterid, ikke ...

Apr 18, 2024 View →
Насколько сильным будет подавление ДГТ в коже головы при ...
Reddit

Из DOI 10.1210/jc.2015-2928: Дутастерид, а не финастерид, увеличивал резистентность печени к инсулину. Внутрипеченочный липид увеличился на ...

Apr 18, 2024 View →
हाई डोज़ ड्यूटैस्टराइड से स्कैल्प DHT इनहिबिशन कितना होगा? : r/tressless
Reddit

DOI 10.1210/jc.2015-2928 से: ड्यूटैस्टराइड, फिनास्टराइड नहीं, ने हेपेटिक इंसुलिन ...

Apr 18, 2024 View →
高剂量度他雄胺对头皮DHT的抑制效果会怎样？ : r/tressless
Reddit

是的，跨性别治疗更有效，但我们想成为有头发的男人。 你能提供完整的DOI 吗？ 来自DOI 10.1210/jc.2015-2928：. 达特他雄胺（而非非那雄胺）增加了 ...

Apr 18, 2024 View →
Quanto custaria uma inibição de DHT no couro cabeludo com alta ...
Reddit

Do DOI 10.1210/jc.2015-2928: Dutasterida, não finasterida, aumentou a resistência à insulina hepática. O lipídio intra-hepático aumentou na ...

Apr 18, 2024 View →
How much would a high dose dutasteride scalp dht inhibition be? : r ...
Reddit

From DOI 10.1210/jc.2015-2928: Dutasteride, not finasteride, increased hepatic insulin resistance. Intrahepatic lipid increased on MRS after ...

Apr 18, 2024 View →