Stem Cells February 2016 PMID 26580686

Maternal dietary imbalance between omega-6 and omega-3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites.

Nobuyuki Sakayori, Takako Kikkawa, Hisanori Tokuda, Emiko Kiryu, Kaichi Yoshizaki, Hiroshi Kawashima, Tetsuya Yamada, Hiroyuki Arai, Jing X Kang, Hideki Katagiri, Hiroshi Shibata, Sheila M Innis, Makoto Arita, Noriko Osumi

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Mentions

71
Peak: 1 in Apr 2016
across 5 sources since Apr 2016

Extended reach

346,786
potential audience

Total likes

4,662

Video views

330,599

Mentions per month

Apr 2016 – Oct 2024

Where it's discussed

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AI synopsis

What people are saying

Across the discussions, participants highlight the importance of balanced fatty acid intake during pregnancy, referring to the research as 'eye-opening' and emphasizing its potential to influence dietary recommendations. The tone varies from supportive to contemplative, reflecting moderate engagement and interest, with some users contemplating the policy implications or personal choices based on the findings.

AgreementModerate agreement

Most discussions acknowledge and support the significance of the research findings on maternal diet and brain development.

InterestModerate interest

Participants show general curiosity about neurodevelopment and dietary impacts but do not delve deeply into technical details.

EngagementNeutral engagement

Responses are somewhat passive, mainly expressing opinions rather than actively analyzing methodologies or implications.

ImpactModerate impact

There is recognition that the study has meaningful implications for maternal nutrition and public health policies.

Abstract in brief

  • A diet high in omega-6 and low in omega-3 fatty acids during pregnancy impairs brain development in mouse offspring by disrupting neural stem cell fate, leading to reduced neurogenesis in the neocortex.
  • The impairment is linked to epoxy metabolites produced from these fatty acids, which influence neural cell differentiation, as demonstrated through lipidomics and neurosphere tests.
  • Even when offspring are later fed a balanced diet, they still show increased anxiety in adulthood, indicating that maternal dietary imbalance can have lasting effects on mental health.]

Top posts

Most liked on X and Bluesky
大隅典子
@sendaitribune · X

@KentaSendai 魚食は2007年くらいから減少の一途を辿っています。ちなみに母乳には脂質が移行するので、子どもの成長に関しても肉食偏重はよろしくないです。妊娠期の影響に関しては、動物モデルで研究しました。そのまま人間に当て嵌める量ではありませんが、ご参考まで。https://t.co/amexRvFr4Z

Oct 22, 2023 · 1 like · 16,037 followers View post →
JUAN ARIEL JARA GUER
@Tigerariel40 · X

Maternal dietary imbalance between omega‐6 and omega‐3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites https://t.co/1GUtMTytUR

Sep 8, 2020 · 151 followers View post →

All mentions

大隅典子
@sendaitribune · X

@KentaSendai 魚食は2007年くらいから減少の一途を辿っています。ちなみに母乳には脂質が移行するので、子どもの成長に関しても肉食偏重はよろしくないです。妊娠期の影響に関しては、動物モデルで研究しました。そのまま人間に当て嵌める量ではありませんが、ご参考まで。https://t.co/amexRvFr4Z

Oct 22, 2023 · 1 like · 16,037 followers View post →
JUAN ARIEL JARA GUER
@Tigerariel40 · X

Maternal dietary imbalance between omega‐6 and omega‐3 polyunsaturated fatty acids impairs neocortical development via epoxy metabolites https://t.co/1GUtMTytUR

Sep 8, 2020 · 151 followers View post →