Science June 1989 PMID 2660263

Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs.

J W Olney, J Labruyere, M T Price

Mentions

27
Peak: 15 in Apr 2021
across 4 sources since Dec 2017

Extended reach

20,831
potential audience

Total likes

412

Video views

16,659

Mentions per month

Dec 2017 – Nov 2024

Where it's discussed

  • Reddit15 posts
  • News6 articles
  • X / Twitter4 posts
  • YouTube2 videos

AI synopsis

What people are saying

The overall sentiment is neutral, with mentions of specific studies like the vacuolar degeneration caused by MK-801 and comments about personal experiences, such as trying to improve English and sharing thoughts on neurotoxicity. The language and tone vary, from brief scientific references to casual personal reflections, indicating moderate interest and engagement but limited perceived impact overall.

AgreementNeither agree nor disagree

The discussions show mixed reactions, with some posts referencing the neurotoxic effects and others focusing on personal or unrelated experiences.

InterestModerate interest

There is some curiosity about the scientific findings, especially regarding drug effects on the brain, though not everyone is deeply engaged.

EngagementModerate engagement

Posts display modest engagement; some mention the research briefly or relate it to personal experiences, but few delve into detailed analysis.

ImpactNeutral impact

Overall, the discussions suggest limited immediate impact, as they seem to serve more informational or personal reflection purposes rather than prompting widespread change or action.

Abstract in brief

  • Phencyclidine (PCP) and similar drugs like MK801 can protect neurons by blocking harmful excitotoxic activity of substances like glutamate, which is why they are being studied for potential treatments for neurological disorders.
  • Despite their protective properties, PCP and related drugs can cause acute structural damage to specific brain neurons in rats even at low doses, raising concerns about their safety.
  • These findings suggest a need to carefully consider both the therapeutic potential and the neurotoxic risks of these drugs, especially given their illicit use and possible application in clinical settings for neurodegenerative diseases.]

Top posts

Most liked on X and Bluesky
Samuel Kohtala
@samuelkohtala · X

https://t.co/3OizY0on8K My first try at talking to a camera, quite difficult actually! But I'm trying to get better and to improve my English as well. This video is what happens when you spend too many months inside four walls in a new country. #postdoc

Mar 27, 2021 · 5 likes · 614 followers View post →
Ramón Guirado Guillén ❤️‍
@guillen_guirado · X

Una de ciencia. Los antidepresivos clásicos tardan semanas o meses en tener efecto, pero @samuelkohtala entre otros investigadores estudian nuevos antidepresivos de acción rápida como

Mar 27, 2021 · 4 likes · 1,309 followers View post →
The Mosaic Theory LLC
@mosaictheories · X

Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs | Science #NEWSFLASH #COVID19 https://t.co/5wpoLKOIOK

Oct 26, 2020 · 1 like · 1,829 followers View post →
pneuma
@wearepneuma · X

@nexudotswag @Tabbs_uwu @MitunaCat @Deceased_Bunny https://t.co/K3F98mPdXP single exposure to a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist, MK-801, produced vacuolar degeneration in the posterior cingulate cortex and the retrosplenial cortex in the brain.

Nov 27, 2024 · 1 like · 210 followers View post →

All mentions

pneuma
@wearepneuma · X

@nexudotswag @Tabbs_uwu @MitunaCat @Deceased_Bunny https://t.co/K3F98mPdXP single exposure to a non-competitive N-methyl-d-aspartate (NMDA) receptor antagonist, MK-801, produced vacuolar degeneration in the posterior cingulate cortex and the retrosplenial cortex in the brain.

Nov 27, 2024 · 1 like · 210 followers View post →
Samuel Kohtala
@samuelkohtala · X

https://t.co/3OizY0on8K My first try at talking to a camera, quite difficult actually! But I'm trying to get better and to improve my English as well. This video is what happens when you spend too many months inside four walls in a new country. #postdoc

Mar 27, 2021 · 5 likes · 614 followers View post →
Ramón Guirado Guillén ❤️‍
@guillen_guirado · X

Una de ciencia. Los antidepresivos clásicos tardan semanas o meses en tener efecto, pero @samuelkohtala entre otros investigadores estudian nuevos antidepresivos de acción rápida como

Mar 27, 2021 · 4 likes · 1,309 followers View post →
The Mosaic Theory LLC
@mosaictheories · X

Pathological changes induced in cerebrocortical neurons by phencyclidine and related drugs | Science #NEWSFLASH #COVID19 https://t.co/5wpoLKOIOK

Oct 26, 2020 · 1 like · 1,829 followers View post →
PM C 2935857 | PDF | Nmda Receptor | Schizophrenia
News

Science. 1989;244:1360– 1362. doi:10.1126/science.2660263. [PubMed]40. Yang J., Medvedev S., Reddi P.P., Schultz R.M., Hecht N.B. The DNA/RNA-binding protein ...

Dec 16, 2025 View →
Fnins 15 672526 | PDF | Nmda Receptor | Synapse
News

Science 244, Lopez, M. J., and Tadi, P. (2020). “Drug enforcement administration drug 1360–1362. doi: 10.1126/science.2660263 scheduling,” in StatPearls, ed ...

Dec 16, 2025 View →
2023 Book Chapter Suicide | PDF
News

10.1126/science.1072290. Cavanna, A. E., & Trimble, M. R. (2006b). The ... 2660263. Papaleo, F., Crawley, J. N., Song, J., Lipska, B. K., Pickel, J ...

Dec 16, 2025 View →
Dextrometorfano: Usos y Efectos | PDF | Química medicinal ...
News

doi:10.1126/science.2660263. PMID 2660263. [4] Carliss, R; Radovsky, A; Chengelis, C; Oneill, T; Shuey, D (2007). Oral administration of dextromethorphan ...

Dec 16, 2025 View →
Pathological Changes Induced in Cerebrocortical Neurons by ...
News

Science. 16 Jun 1989. Vol 244, Issue 4910. pp. 1360-1362. DOI: 10.1126/science.2660263 · PREVIOUS ARTICLE. The Fc and not CD4 Receptor Mediates Antibody ...

Dec 16, 2025 View →
Olney lezyonları, dissosiyatiflerin neden olduğu, tüm disso ... - Reddit
Reddit

... 10.1126/science.2660263 adresinden bakabilirsiniz, oldukça kısa. Unutmayın bu tek bir çalışma, kemirgenler üzerinde yapılmış ve sadece ışık ...

Apr 18, 2021 View →
Zmiany Olneya spowodowane przez dysocjanty, wszyscy ...
Reddit

Możesz zapoznać się z oryginalną pracą Olneya pod adresem https://sci-hub.st/10.1126/science.2660263 , jest dość krótka. Pamiętaj, że to ...

Apr 18, 2021 View →
Les lésions d'Olney causées par les dissociatifs, tous les utilisateurs ...
Reddit

... 10.1126/science.2660263 , il est assez court. Gardez à l'esprit qu'il s'agit d'une seule étude, sur des rongeurs, et qu'il n'utilise que la ...

Apr 18, 2021 View →
r/researchchemicals on Reddit: แผลของ Olney ที่เกิดจากสารแยกตัว ผู้ ...
Reddit

... 10.1126/science.2660263 นะ สั้นมาก แต่จำไว้ว่านี่เป็นแค่ study เดียว ใช้หนูทดลองด้วย แล้วก็ใช้แค่กล้องจุลทรรศน์แบบใช้แสง เลยไม่เห็นผลอย่าง ...

Apr 18, 2021 View →
Повреждения Олни, вызванные диссоциативами, все ... - Reddit
Reddit

... 10.1126/science.2660263 , она довольно короткая. Имейте в виду, что это одно исследование, на грызунах, и он использует только световую ...

Apr 18, 2021 View →
Olneys lesions orsakade av dissociativa droger, alla som använder ...
Reddit

... 10.1126/science.2660263 , den är ganska kort. Tänk på att detta är en studie, på gnagare, och han använder endast ljusmikroskopi, så den ...

Apr 18, 2021 View →
Οι βλάβες του Olney που προκαλούνται από τα διαχωριστικά, όλοι οι ...
Reddit

... 10.1126/science.2660263 , είναι αρκετά σύντομη. Να θυμάσαι ότι αυτή είναι μια μελέτη, σε τρωκτικά, και χρησιμοποιεί μόνο φωτεινή μικροσκοπία ...

Apr 18, 2021 View →
Olneys Läsionen, verursacht durch Dissoziativa, alle Disso ...
Reddit

Sie können sich Olneys Originalveröffentlichung unter https://sci-hub.st/10.1126/science.2660263 ansehen, sie ist ziemlich kurz. Denken Sie ...

Apr 18, 2021 View →
r/researchchemicals on Reddit: 解離性麻酔薬によるオルニー病変
Reddit

st/10.1126/science.2660263 で見れるよ、結構短いから。これは1つの研究で、げっ歯類についてのもので、彼は光学顕微鏡しか使ってないから、病変 ...

Apr 18, 2021 View →
Leziunile Olney cauzate de disociative, toți utilizatorii de disociative ...
Reddit

Poți să arunci o privire la lucrarea originală a lui Olney la https://sci-hub.st/10.1126/science.2660263 , e destul de scurtă. Ține minte că ...

Apr 18, 2021 View →
分离麻醉剂引起的老尼病变,所有分离麻醉剂使用者都应该意识到这 ...
Reddit

st/10.1126/science.2660263 看看Olney 的原始论文,它很短。记住,这只是一项针对啮齿动物的研究,而且他只使用了光学显微镜,所以它并没有告诉你 ...

Apr 18, 2021 View →
Các tổn thương Olney do thuốc gây ảo giác gây ra, tất cả người ...
Reddit

... 10.1126/science.2660263 , nó khá ngắn. Nhớ rằng đây chỉ là một nghiên cứu, trên động vật gặm nhấm, và ông ấy chỉ sử dụng kính hiển vi quang ...

Apr 18, 2021 View →
Olney-féle léziók, amiket a disszociatív szerek okoznak, minden ...
Reddit

Megnézheted Olney eredeti cikkét itt: https://sci-hub.st/10.1126/science.2660263 , elég rövid. Ne feledd, ez egy tanulmány, rágcsálókon, és ...

Apr 18, 2021 View →
Olney's laesies veroorzaakt door dissociativa, alle disso-gebruikers ...
Reddit

... 10.1126/science.2660263 , het is vrij kort. Houd er rekening mee dat dit één studie is, op knaagdieren, en hij alleen lichtmicroscopie ...

Apr 18, 2021 View →
Olney's lesions na dulot ng dissociatives, dapat malaman ng lahat ...
Reddit

... 10.1126/science.2660263 , medyo maikli lang ito. Tandaan na ito ay isang pag-aaral lamang, sa mga rodent, at gumagamit lamang siya ng light ...

Apr 18, 2021 View →
Ketamine | PDF | Drugs | Clinical Medicine
News

phencyclidine and related drugs".Science. 244 (4910): 1360–2. doi:10.1126/science.2660263(https://doi.org/10. 1126%2Fscience ...

Dec 23, 2017 View →