Sulforaphane-rich broccoli sprout extract improves hepatic abnormalities in male subjects.

Abstract in brief

• The study found that dietary supplementation with broccoli sprout extract containing sulforaphane precursor glucoraphanin improved liver function markers (ALT, GTP, and alkaline phosphatase) and reduced oxidative stress (urinary 8OHdG levels) in Japanese men with fatty liver.
• In an animal model of chronic liver failure induced in rats by NDMA, the same broccoli sprout extract decreased serum liver enzymes, reduced oxidative damage in the liver, and increased antioxidant enzyme activity, indicating a protective effect.
• The results suggest that sulforaphane-rich broccoli sprout extract could be a beneficial dietary supplement for improving liver health and reducing oxidative stress in liver disease contexts.]