February 2017 PMID 26615402

A high-fat, high-saturated fat diet decreases insulin sensitivity without changing intra-abdominal fat in weight-stable overweight and obese adults.

Anize D von Frankenberg, Anna Marina, Xiaoling Song, Holly S Callahan, Mario Kratz, Kristina M Utzschneider

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Mentions

68
Peak: 5 in Jan 2023
across 5 sources since Apr 2020

Extended reach

165,140
potential audience

Total likes

289

Video views

5,819

Mentions per month

Apr 2020 – Dec 2025

Where it's discussed

  • X / Twitter55 posts
  • Facebook4 posts
  • News4 articles
  • Reddit3 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions demonstrate strong agreement with the research, with many posts citing studies like 'high saturated fat causes insulin resistance' and sharing personal experiences with low-carb and vegan diets. The tone is analytical and assertive, reflecting concern about dietary fats' role in metabolic health and emphasizing the importance of scientifically backed information.

AgreementStrong agreement

Most discussions strongly support the article's findings, emphasizing that high-fat diets impair insulin sensitivity.

InterestHigh interest

Participants actively engage with the research, referencing multiple studies and personal insights, indicating high interest.

EngagementHigh engagement

Posts involve detailed interpretations, such as noting the relationship between saturated fats and insulin resistance, showing deep involvement.

ImpactHigh impact

The widespread consensus and emphasis on practical consequences suggest these discussions have significant influence on dietary perceptions.

Abstract in brief

  • A high-fat diet, especially one high in saturated fat, reduces the body's insulin sensitivity, which can increase the risk of developing type 2 diabetes, even if body fat distribution doesn't change much.
  • The study found that a low-fat diet helped keep insulin sensitivity stable, while a high-fat diet decreased it, and these changes weren't linked to shifts in abdominal fat but were associated with changes in lipoprotein fatty acid composition.
  • Specifically, alterations in certain fatty acids in VLDL particles, like n6 docosapentaenoic acid, were strongly connected to changes in insulin sensitivity across both diets, suggesting diet impacts fatty acid profiles that influence insulin function.

Top posts

Most liked on X and Bluesky
Dr. Philip Eckardt, MD
@MedEckardt · X

@bigfatsurprise Blood sugar spikes are not the cause of diabetes, insulin resistance is. Fat causes insulin resistance. Leaving out the carbs will help in a high fat diet. Leaving out the fat will also help. We call it the sugar-fat-trap. The combo is bad. https://t.co/hIEPOFKZMg

Aug 14, 2024 · 11 likes · 1,167 followers View post →
Nassim Taleb's Gunt
@Bobsdplissken · X

@hansen61028 @BioLayne Low carb high fat diets induce insulin resistance. Any amount of weight loss will improve IR for reasons I hope would seem obvious, but a diet high in saturated fats makes IR worse. https://t.co/BNpvy26N9z

Jan 2, 2024 · 6 likes · 21 followers View post →
CoffeeBlackMD
@CoffeeBlackMD · X

@AbudBakri High fat diets are a hack. There is good data they are associated with worsening insulin resistance. https://t.co/FmvWZscVxk

May 30, 2025 · 5 likes · 16,340 followers View post →
Emily Woods
@emilywoo56 · X

@fifthtimecharm @FecesEater @afrodietee_ @caffeineaddicte @eye_am_sprout @olivia_vault PCOS has mainly hormonal etiology, so it’s not what we would call a metabolic condition; I’m mainly talking about the IR specifically. there’s a lot of literature on this! here’s just two: https://t.co/Vnt3lHUe6Q https://t.co/fpnNEtpqWP

Apr 3, 2020 · 5 likes · 263 followers View post →
Will Brink
@WillBrink · X

@BioLayne And a high sat fat intake will often decrease insulin sensitivity: https://t.co/83RAiDtd4l

Jul 6, 2023 · 3 likes · 1 share · 3,597 followers View post →
ZKForTre
@ZKForTre · X

@BenBikmanPhD @AKoutnik https://t.co/QifLGuyCV8 https://t.co/C8hucqnf5F https://t.co/Qd8TWRBnZM https://t.co/3p3vPls0mQ https://t.co/n8mXYsv6ep For starters

Feb 16, 2024 · 3 likes · 1 share · 2,866 followers View post →

All mentions

CoffeeBlackMD
@CoffeeBlackMD · X

@AbudBakri High fat diets are a hack. There is good data they are associated with worsening insulin resistance. https://t.co/FmvWZscVxk

May 30, 2025 · 5 likes · 16,340 followers View post →
Seek the truth
@babadsb · X

@mitch1752972 @ElieJarrougeMD @SBakerMD Here is a paper and there are many. Please don’t respond with what worked for you unless it back up by professionals whose business it is to study science https://t.co/cQgpGptBHg

Mar 16, 2025 · 93 followers View post →
Natka
@r3viv3you · X

@meatyfitness @naturalguy @bulkbiker @Botanical2383 @DrEenfeldt https://t.co/8VbtbArvc6

Jan 10, 2025 · 47 followers View post →
Eric Schwartz
@naturalguy · X

@BobMaso55089289 @ElieJarrougeMD Yup https://t.co/tVrPUuvrc4 https://t.co/i7B6tewwLb

Dec 15, 2024 · 2 likes · 3,671 followers View post →
Eric Schwartz
@naturalguy · X

@jpwkeeper @ElieJarrougeMD High saturated fat causes insulin resistance https://t.co/i7B6tex4AJ https://t.co/tVrPUuvZ1C

Dec 15, 2024 · 2 likes · 3,671 followers View post →
Teval
@Tevalbtc · X

@carniyogi @SamaHoole A high-fat, high-saturated fat diet decreases insulin sensitivity without changing intra-abdominal fat in weight-stable overweight and obese adults - PubMed (https://t.co/SvsvvbZlpV)

Oct 1, 2024 · 167 followers View post →
Eric Schwartz
@naturalguy · X

@gmohan64 @shashiiyengar Another https://t.co/i7B6tewwLb

Sep 15, 2024 · 3,671 followers View post →
Eric Schwartz
@naturalguy · X

@whitley_rick @DrNadolsky I think you need to get up to date https://t.co/i7B6tex4AJ

Aug 26, 2024 · 1 like · 3,671 followers View post →
Dr. Philip Eckardt, MD
@MedEckardt · X

@bigfatsurprise Blood sugar spikes are not the cause of diabetes, insulin resistance is. Fat causes insulin resistance. Leaving out the carbs will help in a high fat diet. Leaving out the fat will also help. We call it the sugar-fat-trap. The combo is bad. https://t.co/hIEPOFKZMg

Aug 14, 2024 · 11 likes · 1,167 followers View post →
Eric Schwartz
@naturalguy · X

@Wojtek7919 @DoctorTro @Bart_WT_Kay Here’s more if you didn’t like that one Conclusions: A diet very high in fat and saturated fat adversely affects insulin sensitivity and thereby might contribute to the development of type 2 diabetes. https://t.co/i7B6tex4AJ

Jul 11, 2024 · 3,671 followers View post →
Eric Schwartz
@naturalguy · X

@sammmmaureen @5MinuteBody It causes cognitive decline: https://t.co/gLXECEEFXV It’s metabolically unhealthy and causes non alcoholic fatty liver disease: https://t.co/0j8xm0JXuX It causes insulin resistance; https://t.co/i7B6tewwLb Higher risk of mortality: https://t.co/uL1sUiEJ5x.

Jul 10, 2024 · 1 like · 3,671 followers View post →
Andrew Waltamath
@WALTamath · X

@gordon_fox76654 @ValerieAnne1970 You may want to revisit the research. Research shouldn’t be biased. What do we see clinically? High fat diets increase insulin resistance and diabetic. When we look at insulin, high fat diets gums up the lock of the cell causing insulin’s resistance. https://t.co/ATqyP7kWNF

Jul 8, 2024 · 84 followers View post →
Diana
@PharmphoodTM · X

@lynne_drummond https://t.co/wkUsENBwr9

May 23, 2024 · 555 followers View post →
scorp_ Make 1984 Fiction Again
@scorpiotiger · X

@robertlufkinmd My blood sugar kept rising on low carb. when I converted to wfpb - my blood sugar came down - as long as I kept the fat down. I tried a 2 week potato diet - just potatoes - my blood sugar dropped to 85. One of many studies on this https://t.co/v8WE8ixtGY

Mar 28, 2024 · 3 likes · 2,759 followers View post →
Earthling
@_earthling74 · X

@VeganLinked @KenDBerryMD So eat less saturated fat then right Ken? https://t.co/ymFoiGhCbg https://t.co/26yI9nGTRk And make sure if eating a high carb diet it's also high fiber right (and low in saturated fat) right Ken? https://t.co/L1nJDMKyVS

Mar 8, 2024 · 1 like · 428 followers View post →
Earthling
@_earthling74 · X

So eat less saturated fat then right Ken? https://t.co/51eKVRqem1 https://t.co/F6a7Ub3eci And make sure if eating a high carb diet it's also high fiber right (and low in saturated fat) right Ken? https://t.co/9hP9kCkZRd https://t.co/9FnUgq3VWu

Mar 6, 2024 · 1 like · 428 followers View post →
Earthling
@_earthling74 · X

@KenDBerryMD Make sure you remind people to avoid saturated fat then Ken. https://t.co/F6a7Ub3eci

Mar 6, 2024 · 428 followers View post →
Andrew Koutnik, Ph.D.
@AKoutnik · X

RT @ZKForTre: @BenBikmanPhD @AKoutnik https://t.co/QifLGuyCV8 https://t.co/C8hucqnf5F https://t.co/Qd8TWRBnZM https://t.co/3p3vPls0mQ h…

Feb 16, 2024 · 1 share · 7,609 followers View post →
ZKForTre
@ZKForTre · X

@BenBikmanPhD @AKoutnik https://t.co/QifLGuyCV8 https://t.co/C8hucqnf5F https://t.co/Qd8TWRBnZM https://t.co/3p3vPls0mQ https://t.co/n8mXYsv6ep For starters

Feb 16, 2024 · 3 likes · 1 share · 2,866 followers View post →
Paul K Barnett
@paulb3rd · X

Does a diet high in saturated fats make you insulin-resistant and less anabolic? Studies have shown that a diet high in saturated fat can lead to increased insulin resistance. https://t.co/i2i8EqyG0R #bodybuilding #contestprep #mensphysique #classicphysique #saturatedfat https://t.co/jqjaqcmV8R

Jan 16, 2024 · 1 like · 1,620 followers View post →
John Galt
@John_Galt_ZA · X

@ewlamy @ted_ryce https://t.co/WTWaMLSEv1 Saturated fat causes a negligible spike in insulin, unlike carbs and has been showing to reverse insulin resistance when carbs are removed

Jan 5, 2024 · 985 followers View post →
Nassim Taleb's Gunt
@Bobsdplissken · X

@hansen61028 @BioLayne Low carb high fat diets induce insulin resistance. Any amount of weight loss will improve IR for reasons I hope would seem obvious, but a diet high in saturated fats makes IR worse. https://t.co/BNpvy26N9z

Jan 2, 2024 · 6 likes · 21 followers View post →
Mindful Livet
@MindfulLivet · X

@the1researcher1 I understand that and duly noted. The point can also be made for high fat. https://t.co/zQfKzf5AaI

Dec 14, 2023 · 2 followers View post →
Kristie Leong M.D.
@DrKristieLeong · X

@PaulGradenwitz @KenDBerryMD Refined carbohydrates and ultra-processed foods are horrible for fatty liver b/c they contribute to insulin resistance. A diet very high in saturated fat does too. https://t.co/N4xwK90lQl If it worked for you great. That doesn't make it the right choice for everyone.

Sep 17, 2023 · 60,175 followers View post →
Rx Readmore Livemore
@SopitaSirirata1 · X

RT @renatodumbra: 4-week low-fat diet (20 % fat/8 % sat fat/62 % carb) or high-fat diet (55 % fat/25 % sat fat/27 % carb). All foods and t…

Sep 2, 2023 · 1 share · 178 followers View post →
SAE SAE
@SAESAE86361193 · X

@ChrisPalmerMD Dietary fat seems to cause rise in insulin resistance -maybe keto works at first because all-time high insulin has no chance to go down ever in high fat high sugar combo diet-but later fatty diet makes IR worse? https://t.co/jn4sz2Dwqk

Aug 30, 2023 · 106 followers View post →
Jordi Paleo
@blogpaleodieta · X

@JuanJ2830 Existen estudios que relacionan el alto consumo de grasa saturada con problemas en la insulina. Desconozco de donde proceden esas grasas. Dudo que sean de mantequilla, coco o sesos. También es cierto que los animales salvajes son muy magros. https://t.co/1nzxCHsck0

Aug 25, 2023 · 1 like · 9,409 followers View post →
Renato Dumbra
@renatodumbra · X

4-week low-fat diet (20 % fat/8 % sat fat/62 % carb) or high-fat diet (55 % fat/25 % sat fat/27 % carb). All foods and their eucaloric energy content were provided. A diet very high in fat and saturated fat adversely affects insulin sensitivity. https://t.co/KmY81c3ItE

Aug 18, 2023 · 1 like · 1 share · 120 followers View post →
Michael02
@Michael02 · X

@robertlufkinmd @REV_Insulin_Res Lipids cause insulin resistance in humans - sat fat especially so. Billions have eaten unlimited carbs without issue for millennia, and then we see diabetes epidemic w/spread of Western habits (

Jul 23, 2023 · 42 followers View post →
LogicalⓋegan
@logical__vegan · X

@KryptoCain @SamaHoole You’re just claiming keto has benefits for blood sugar? Those changes aren’t significant after 12 months and long-term keto is detrimental. Your first claim: https://t.co/BWq0l4SkVl Your second claim: https://t.co/FruC0yG61C

Jul 17, 2023 · 62 followers View post →
Biomass Bob
@SentientBlobBob · X

RT @WillBrink: @BioLayne And a high sat fat intake will often decrease insulin sensitivity: https://t.co/83RAiDtd4l

Jul 6, 2023 · 1 share · 824 followers View post →
Will Brink
@WillBrink · X

@BioLayne And a high sat fat intake will often decrease insulin sensitivity: https://t.co/83RAiDtd4l

Jul 6, 2023 · 3 likes · 1 share · 3,597 followers View post →
Diana
@PharmphoodTM · X

@nicknorwitz https://t.co/wkUsENBwr9

Apr 30, 2023 · 555 followers View post →
Earthling
@_earthling74 · X

@bnorry @Drlipid @theproof Brendan- please be sure to clarify the massive distinction between whole food carbs and refined carbs, as well as the potential role excess fat intake esp saturated can play in carbohydrate metabolism. Example https://t.co/F6a7Ub3eci

Apr 22, 2023 · 428 followers View post →
RaceRealist
@Race__Realist · X

@SteveDa39872898 @skydog576 @sairaph @CarnivorousMe1 @SBakerMD https://t.co/8qoMXYvgYO https://t.co/6NWSz2FKo4

Feb 6, 2023 · 4,247 followers View post →
skydog
@skydog576 · X

@bretatwood @charly_knaller @SBakerMD https://t.co/Y9QWcRjoXj

Feb 4, 2023 · 3 followers View post →
Harmless Frog
@FrogHarmless · X

@AlejandroTN7 @dylanarmbruste3 @lipo_fan @drscottyk @AlexJLeaf @gonzaeperez @_earthling74 @shivadas29 @betholand @Echoraljpangio @VietHeartPA @SABOURETCardio @ScepticalDoctor We're discussing this study, and what we can and/or cannot infer from its results, due to its design. You're dropping in with a tangent, not having read the discussion, or even understood the tweet you're replying to. It's tiresome. https://t.co/ZjUqCTc27c

Jan 22, 2023 · 501 followers View post →
Alejandro Tello
@AlejandroTN7 · X

@FrogHarmless @lipo_fan @drscottyk @AlexJLeaf @dylanarmbruste3 @gonzaeperez @_earthling74 @shivadas29 @betholand @Echoraljpangio @VietHeartPA @SABOURETCardio @ScepticalDoctor https://t.co/cbi3fC4WQG https://t.co/1PjjKZ78mh https://t.co/gAoozK7lPd https://t.co/WXLw0G9CUK https://t.co/sxpFe175yW https://t.co/gcFvtq4Wzx https://t.co/JTn9ki94jz https://t.co/HjQZ3MntoU

Jan 21, 2023 · 2 likes · 81 followers View post →
Crownet
@Crownet829 · X

@KetoCounselor I wouldn't say it is the most effective treatment. High fat diets have been shown to increase insulin resistance in humans. https://t.co/gAq9ACVqBw I would say a high carb low fat vegan diet would be the all around best.

Jan 16, 2023 · 2 followers View post →
Destini Moody, RD, CSSD, LD
@TheAthletesRD · X

@ThelastStyleb16 @penneyworth1 @lowcarbGP Does it? https://t.co/p5GwXZQNCP https://t.co/xCXFYHQxnU https://t.co/NAiW0zwqKQ https://t.co/nZg8NzYmcP

Jan 15, 2023 · 1,136 followers View post →
Hip Hop & Rap Music videos
@AJ4Tay · X

@MichaelLNeely @nutrition_facts You clearly have no idea how metabolism works. Here’s some real research, if you would like to actually know what you are talking about. https://t.co/qFbcXmcP14 https://t.co/tGbyeiPBTS https://t.co/zp46rwm9Pw https://t.co/o3Q8qhWKcB

Nov 13, 2022 · 1 like · 125 followers View post →
kungry
@kungry123 · X

@squeeshymeeshy @ERNutrition @arunkumar3112 https://t.co/x9jIOZkkjc

Nov 4, 2022 · 14 followers View post →
Earthling
@_earthling74 · X

@ScepticalDoctor I just think important distinctions should be made then when discussing this topic bc at least a subset who doesn’t lose weight and chooses wrong fats on a low carb diet may end up worsening their situation right? https://t.co/F6a7Ub2GmK https://t.co/vtYkgw3ETk

Apr 19, 2022 · 428 followers View post →
Rethink
@EscapeLow · X

@John_G_Willis https://t.co/gkjE364rdQ

Mar 2, 2022 · 631 followers View post →
OlivePUFA
@OlivePufa · X

@ascentovalhalla @MacroFour https://t.co/qeAkDT1Ujy

Nov 24, 2021 · 49 followers View post →
Fusion Prog Guy @ fusionprogguy.bsky.social
@FusionProgGuy · X

@MacroFour @Alundra @rodedc1 @DoctorTro @DBelardoMD There’s plenty of evidence to show it’s possible to gain weight and become insulin resistant on low carb, high fat diets. Why deny it when it’s completely plausible and consistent with our understanding of T2D? https://t.co/Jt65cEjWXE https://t.co/FGyiXEQViB

Jul 10, 2021 · 1 like · 1,590 followers View post →
Chef Ty, RDN, CNSC
@FoodFirst_Ty · X

@danpincus @garytaubes @MarikaSboros @TamarHaspel @TheAlanAragon @whsource https://t.co/KZDzt5DwH4 https://t.co/kzxpj8i9UK https://t.co/MBuiWbgnGS https://t.co/DYvM6yrSus https://t.co/Y516FhnfCh https://t.co/JQVSdm5GK7 https://t.co/qHF5GohebE https://t.co/vuSrWi1jpF

Jan 22, 2021 · 2 likes · 2,126 followers View post →
Chef Ty, RDN, CNSC
@FoodFirst_Ty · X

@ExPhysAdjunct @BioPhysChemMark @MariaPNutrition @eatright “Peddling carbs to diabetics”. LC and diabetes: https://t.co/Y516Fh5EdH https://t.co/JQVSdlO5lx https://t.co/qHF5GnZCN4 https://t.co/vuSrWiiUhd

Sep 20, 2020 · 3 likes · 1 share · 2,126 followers View post →
Chef Ty, RDN, CNSC
@FoodFirst_Ty · X

@practicalbob @KenDBerryMD Show me the evidence otherwise. https://t.co/Y516Fh5EdH https://t.co/JQVSdlO5lx https://t.co/qHF5GnZCN4 https://t.co/vuSrWiiUhd https://t.co/r8aH6izyTp

Sep 9, 2020 · 3 likes · 2,126 followers View post →
Chef Ty, RDN, CNSC
@FoodFirst_Ty · X

@ElieJarrougeMD @PatrickJCook @ChristianTams https://t.co/Y516Fh5EdH https://t.co/JQVSdlO5lx https://t.co/qHF5GnZCN4 https://t.co/vuSrWiiUhd

Sep 5, 2020 · 2 likes · 2,126 followers View post →
Chef Ty, RDN, CNSC
@FoodFirst_Ty · X

@PatrickJCook @ElieJarrougeMD @ChristianTams https://t.co/Y516Fh5EdH https://t.co/JQVSdlO5lx https://t.co/qHF5GnZCN4 https://t.co/vuSrWiiUhd

Sep 5, 2020 · 1 like · 2,126 followers View post →
Chef Ty, RDN, CNSC
@FoodFirst_Ty · X

@DirkJFvdW @PissedOff_PT @MarikaSboros @zoeharcombe @Introvertmark20 @ProfTimNoakes “The true science is settled”. Um nope. https://t.co/SbX6koqIJL https://t.co/Yi4xxxyRJG https://t.co/bGuSbeObub https://t.co/Y516FhnfCh https://t.co/JQVSdm5GK7 https://t.co/qHF5GohebE https://t.co/vuSrWi1jpF

Jul 6, 2020 · 2,126 followers View post →
Chef Ty, RDN, CNSC
@FoodFirst_Ty · X

@aga_pallavi @rebelhealth1 @tednaiman 1. You just tagged a bunch of low-carb diet zealots. 2. You are incorrect. https://t.co/Yi4xxxQsBe https://t.co/SbX6koIjBj https://t.co/Y516Fh5EdH https://t.co/JQVSdlO5lx https://t.co/qHF5GnZCN4 https://t.co/vuSrWiiUhd

Jul 2, 2020 · 2,126 followers View post →
Chef Ty, RDN, CNSC
@FoodFirst_Ty · X

@PeterFaberSP https://t.co/Y516Fh5EdH https://t.co/JQVSdlO5lx https://t.co/qHF5GnZCN4 https://t.co/vuSrWiiUhd

Jun 26, 2020 · 2,126 followers View post →
Emily Woods
@emilywoo56 · X

@fifthtimecharm @FecesEater @afrodietee_ @caffeineaddicte @eye_am_sprout @olivia_vault PCOS has mainly hormonal etiology, so it’s not what we would call a metabolic condition; I’m mainly talking about the IR specifically. there’s a lot of literature on this! here’s just two: https://t.co/Vnt3lHUe6Q https://t.co/fpnNEtpqWP

Apr 3, 2020 · 5 likes · 263 followers View post →
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