The discussions demonstrate strong agreement with the research, with many posts citing studies like 'high saturated fat causes insulin resistance' and sharing personal experiences with low-carb and vegan diets. The tone is analytical and assertive, reflecting concern about dietary fats' role in metabolic health and emphasizing the importance of scientifically backed information.
AgreementStrong agreement
Most discussions strongly support the article's findings, emphasizing that high-fat diets impair insulin sensitivity.
InterestHigh interest
Participants actively engage with the research, referencing multiple studies and personal insights, indicating high interest.
EngagementHigh engagement
Posts involve detailed interpretations, such as noting the relationship between saturated fats and insulin resistance, showing deep involvement.
ImpactHigh impact
The widespread consensus and emphasis on practical consequences suggest these discussions have significant influence on dietary perceptions.
Abstract in brief
A high-fat diet, especially one high in saturated fat, reduces the body's insulin sensitivity, which can increase the risk of developing type 2 diabetes, even if body fat distribution doesn't change much.
The study found that a low-fat diet helped keep insulin sensitivity stable, while a high-fat diet decreased it, and these changes weren't linked to shifts in abdominal fat but were associated with changes in lipoprotein fatty acid composition.
Specifically, alterations in certain fatty acids in VLDL particles, like n6 docosapentaenoic acid, were strongly connected to changes in insulin sensitivity across both diets, suggesting diet impacts fatty acid profiles that influence insulin function.
@bigfatsurprise Blood sugar spikes are not the cause of diabetes, insulin resistance is. Fat causes insulin resistance. Leaving out the carbs will help in a high fat diet. Leaving out the fat will also help. We call it the sugar-fat-trap. The combo is bad.
https://t.co/hIEPOFKZMg
Aug 14, 2024 · 11 likes · 1,167 followersView post →
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Nassim Taleb's Gunt
@Bobsdplissken · X
@hansen61028 @BioLayne Low carb high fat diets induce insulin resistance. Any amount of weight loss will improve IR for reasons I hope would seem obvious, but a diet high in saturated fats makes IR worse. https://t.co/BNpvy26N9z
@AbudBakri High fat diets are a hack. There is good data they are associated with worsening insulin resistance.
https://t.co/FmvWZscVxk
May 30, 2025 · 5 likes · 16,340 followersView post →
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Emily Woods
@emilywoo56 · X
@fifthtimecharm @FecesEater @afrodietee_ @caffeineaddicte @eye_am_sprout @olivia_vault PCOS has mainly hormonal etiology, so it’s not what we would call a metabolic condition; I’m mainly talking about the IR specifically. there’s a lot of literature on this! here’s just two: https://t.co/Vnt3lHUe6Q
https://t.co/fpnNEtpqWP
A high-fat, especially saturated fat, diet decreases insulin sensitivity without changing intra-abdominal fat. This study highlights how diet influences fatty acid profiles affecting insulin function and potential…
This video explains the primary reason for difficulty in burning belly fat, focusing on the impact of high-fat diets on insulin sensitivity, which can increase diabetes risk even if body fat doesn't change much.
This video explores how low carb diets influence fasting blood glucose levels, discussing initial improvements and subsequent effects such as increased gluconeogenesis and insulin sensitivity changes. It highlights the…
@AbudBakri High fat diets are a hack. There is good data they are associated with worsening insulin resistance.
https://t.co/FmvWZscVxk
May 30, 2025 · 5 likes · 16,340 followersView post →
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Seek the truth
@babadsb · X
@mitch1752972 @ElieJarrougeMD @SBakerMD Here is a paper and there are many.
Please don’t respond with what worked for you unless it back up by professionals whose business it is to study science
https://t.co/cQgpGptBHg
@whitley_rick @DrNadolsky I think you need to get up to date https://t.co/i7B6tex4AJ
Aug 26, 2024 · 1 like · 3,671 followersView post →
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Dr. Philip Eckardt, MD
@MedEckardt · X
@bigfatsurprise Blood sugar spikes are not the cause of diabetes, insulin resistance is. Fat causes insulin resistance. Leaving out the carbs will help in a high fat diet. Leaving out the fat will also help. We call it the sugar-fat-trap. The combo is bad.
https://t.co/hIEPOFKZMg
Aug 14, 2024 · 11 likes · 1,167 followersView post →
ES
Eric Schwartz
@naturalguy · X
@Wojtek7919 @DoctorTro @Bart_WT_Kay Here’s more if you didn’t like that one
Conclusions: A diet very high in fat and saturated fat adversely affects insulin sensitivity and thereby might contribute to the development of type 2 diabetes.
https://t.co/i7B6tex4AJ
@sammmmaureen @5MinuteBody It causes cognitive decline:
https://t.co/gLXECEEFXV
It’s metabolically unhealthy and causes non alcoholic fatty liver disease:
https://t.co/0j8xm0JXuX
It causes insulin resistance;
https://t.co/i7B6tewwLb
Higher risk of mortality:
https://t.co/uL1sUiEJ5x.
Jul 10, 2024 · 1 like · 3,671 followersView post →
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Andrew Waltamath
@WALTamath · X
@gordon_fox76654 @ValerieAnne1970 You may want to revisit the research. Research shouldn’t be biased. What do we see clinically? High fat diets increase insulin resistance and diabetic. When we look at insulin, high fat diets gums up the lock of the cell causing insulin’s resistance. https://t.co/ATqyP7kWNF
@robertlufkinmd My blood sugar kept rising on low carb. when I converted to wfpb - my blood sugar came down - as long as I kept the fat down. I tried a 2 week potato diet - just potatoes - my blood sugar dropped to 85.
One of many studies on this
https://t.co/v8WE8ixtGY
Mar 28, 2024 · 3 likes · 2,759 followersView post →
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Earthling
@_earthling74 · X
@VeganLinked @KenDBerryMD So eat less saturated fat then right Ken?
https://t.co/ymFoiGhCbg
https://t.co/26yI9nGTRk
And make sure if eating a high carb diet it's also high fiber right (and low in saturated fat) right Ken?
https://t.co/L1nJDMKyVS
So eat less saturated fat then right Ken?
https://t.co/51eKVRqem1
https://t.co/F6a7Ub3eci
And make sure if eating a high carb diet it's also high fiber right (and low in saturated fat) right Ken?
https://t.co/9hP9kCkZRd https://t.co/9FnUgq3VWu
Feb 16, 2024 · 1 share · 7,609 followersView post →
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ZKForTre
@ZKForTre · X
@BenBikmanPhD @AKoutnik https://t.co/QifLGuyCV8
https://t.co/C8hucqnf5F
https://t.co/Qd8TWRBnZM
https://t.co/3p3vPls0mQ
https://t.co/n8mXYsv6ep
For starters
Feb 16, 2024 · 3 likes · 1 share · 2,866 followersView post →
PB
Paul K Barnett
@paulb3rd · X
Does a diet high in saturated fats make you insulin-resistant and less anabolic?
Studies have shown that a diet high in saturated fat can lead to increased insulin resistance.
https://t.co/i2i8EqyG0R
#bodybuilding #contestprep #mensphysique #classicphysique #saturatedfat https://t.co/jqjaqcmV8R
Jan 16, 2024 · 1 like · 1,620 followersView post →
JG
John Galt
@John_Galt_ZA · X
@ewlamy @ted_ryce https://t.co/WTWaMLSEv1
Saturated fat causes a negligible spike in insulin, unlike carbs and has been showing to reverse insulin resistance when carbs are removed
@hansen61028 @BioLayne Low carb high fat diets induce insulin resistance. Any amount of weight loss will improve IR for reasons I hope would seem obvious, but a diet high in saturated fats makes IR worse. https://t.co/BNpvy26N9z
@PaulGradenwitz @KenDBerryMD Refined carbohydrates and ultra-processed foods are horrible for fatty liver b/c they contribute to insulin resistance. A diet very high in saturated fat does too. https://t.co/N4xwK90lQl If it worked for you great. That doesn't make it the right choice for everyone.
@ChrisPalmerMD Dietary fat seems to cause rise in insulin resistance -maybe keto works at first because all-time high insulin has no chance to go down ever in high fat high sugar combo diet-but later fatty diet makes IR worse?
https://t.co/jn4sz2Dwqk
@JuanJ2830 Existen estudios que relacionan el alto consumo de grasa saturada con problemas en la insulina. Desconozco de donde proceden esas grasas. Dudo que sean de mantequilla, coco o sesos.
También es cierto que los animales salvajes son muy magros.
https://t.co/1nzxCHsck0
Aug 25, 2023 · 1 like · 9,409 followersView post →
RD
Renato Dumbra
@renatodumbra · X
4-week low-fat diet (20 % fat/8 % sat fat/62 % carb) or high-fat diet (55 % fat/25 % sat fat/27 % carb).
All foods and their eucaloric energy content were provided.
A diet very high in fat and saturated fat adversely affects insulin sensitivity.
https://t.co/KmY81c3ItE
Aug 18, 2023 · 1 like · 1 share · 120 followersView post →
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Michael02
@Michael02 · X
@robertlufkinmd @REV_Insulin_Res Lipids cause insulin resistance in humans - sat fat especially so. Billions have eaten unlimited carbs without issue for millennia, and then we see diabetes epidemic w/spread of Western habits (
@KryptoCain @SamaHoole You’re just claiming keto has benefits for blood sugar? Those changes aren’t significant after 12 months and long-term keto is detrimental.
Your first claim: https://t.co/BWq0l4SkVl
Your second claim: https://t.co/FruC0yG61C
@bnorry @Drlipid @theproof Brendan- please be sure to clarify the massive distinction between whole food carbs and refined carbs, as well as the potential role excess fat intake esp saturated can play in carbohydrate metabolism. Example https://t.co/F6a7Ub3eci
@AlejandroTN7 @dylanarmbruste3 @lipo_fan @drscottyk @AlexJLeaf @gonzaeperez @_earthling74 @shivadas29 @betholand @Echoraljpangio @VietHeartPA @SABOURETCardio @ScepticalDoctor We're discussing this study, and what we can and/or cannot infer from its results, due to its design. You're dropping in with a tangent, not having read the discussion, or even understood the tweet you're replying to. It's tiresome.
https://t.co/ZjUqCTc27c
@KetoCounselor I wouldn't say it is the most effective treatment. High fat diets have been shown to increase insulin resistance in humans. https://t.co/gAq9ACVqBw
I would say a high carb low fat vegan diet would be the all around best.
@MichaelLNeely @nutrition_facts You clearly have no idea how metabolism works. Here’s some real research, if you would like to actually know what you are talking about.
https://t.co/qFbcXmcP14
https://t.co/tGbyeiPBTS
https://t.co/zp46rwm9Pw https://t.co/o3Q8qhWKcB
@ScepticalDoctor I just think important distinctions should be made then when discussing this topic bc at least a subset who doesn’t lose weight and chooses wrong fats on a low carb diet may end up worsening their situation right?
https://t.co/F6a7Ub2GmK
https://t.co/vtYkgw3ETk
@MacroFour @Alundra @rodedc1 @DoctorTro @DBelardoMD There’s plenty of evidence to show it’s possible to gain weight and become insulin resistant on low carb, high fat diets. Why deny it when it’s completely plausible and consistent with our understanding of T2D? https://t.co/Jt65cEjWXE https://t.co/FGyiXEQViB
Jul 10, 2021 · 1 like · 1,590 followersView post →
@practicalbob @KenDBerryMD Show me the evidence otherwise.
https://t.co/Y516Fh5EdH
https://t.co/JQVSdlO5lx
https://t.co/qHF5GnZCN4
https://t.co/vuSrWiiUhd https://t.co/r8aH6izyTp
@aga_pallavi @rebelhealth1 @tednaiman 1. You just tagged a bunch of low-carb diet zealots.
2. You are incorrect.
https://t.co/Yi4xxxQsBe
https://t.co/SbX6koIjBj
https://t.co/Y516Fh5EdH
https://t.co/JQVSdlO5lx
https://t.co/qHF5GnZCN4
https://t.co/vuSrWiiUhd
@fifthtimecharm @FecesEater @afrodietee_ @caffeineaddicte @eye_am_sprout @olivia_vault PCOS has mainly hormonal etiology, so it’s not what we would call a metabolic condition; I’m mainly talking about the IR specifically. there’s a lot of literature on this! here’s just two: https://t.co/Vnt3lHUe6Q
https://t.co/fpnNEtpqWP
doi:10.1007/s00394-015-1108-6. American Heart Association. Saturated Fat. American Heart Association. How Much Sodium Should I Eat Per Day?. Kim JM, Kim TH ...