PubHawk
Respirology February 2016 PMID 26638130

Randomized controlled trial of the effect of regular paracetamol on influenza infection.

Sarah Jefferies, Irene Braithwaite, Steven Walker, Mark Weatherall, Lance Jennings, Michelle Luck, Kevin Barrett, Robert Siebers, Timothy Blackmore, Richard Beasley, Kyle Perrin

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Mentions

76
Peak: 7 in Sep 2024
across 6 sources since Dec 2017

Extended reach

49,966
potential audience

Total likes

56

Video views

468

Mentions per month

Dec 2017 – Apr 2025

Where it's discussed

  • News34 articles
  • X / Twitter23 posts
  • Facebook12 posts
  • Blogs4 articles
  • YouTube2 videos
  • Bluesky1 posts

AI synopsis

What people are saying

Discussions frequently mention that the study found no effect of paracetamol on viral load or symptoms, with words like 'no effect' and 'no benefit' emphasizing skepticism. Some examples, such as posts questioning its clinical value or mentioning the lack of evidence, reflect a cautious tone, while a few posts express concern about potential effects like immune suppression, showing a varied but predominantly moderate impact of the publication.

AgreementLow agreement

Most discussions highlight that the study found no significant benefit of paracetamol on influenza outcomes, indicating some disagreement with positive view of the drug's efficacy.

InterestModerate interest

Participants show mild interest, as some posts express curiosity or skepticism, but overall there is limited enthusiasm or detailed analysis.

EngagementNeutral engagement

The engagement level appears neutral; some users share observations or ask questions, but few delve deeply into methodology or broader implications.

ImpactNeutral impact

The overall impact is moderate or negligible since the discussions do not suggest a major shift in practice or widespread influence, mostly confirming existing skepticism or raising awareness.

Abstract in brief

  • This study was a randomized controlled trial testing whether regular paracetamol affects viral load and symptoms in adults with influenza; it found no significant differences in viral shedding, symptom relief, or illness duration between those taking paracetamol and those taking a placebo.
  • The trial involved adults aged 18-65 with confirmed influenza, comparing 1 gram of paracetamol four times daily to a placebo over 5 days, with measurements of viral load, temperature, and symptom scores taken throughout the illness.
  • The results suggest that regular paracetamol does not influence the course of influenza infection, indicating that current use for symptom relief may not impact viral shedding or illness resolution, and highlighting a need for more research on its role in influenza treatment.
Read the full abstract

Top posts

Most liked on X and Bluesky
Fred Stalder
@sudokuvariante · X

https://t.co/KPMblPDU7N https://t.co/wkcNEoL5zy https://t.co/C2nsbi1JFG Aucun effet clinique positif, tendance à augmenter la durée de portage viral, diminution de la réponse immunitaire

Sep 16, 2024 · 41 likes · 5 shares · 4,729 followers View post →
Mats Jacob H:son Lin
@Medicinmanden · X

Jeg ligger hjemme med influenza-symptomer. Vil paracetamol hjælpe, eller måske, forlænge sygdommen? Der findes, utrolig nok, kun 1 klinisk forsøg. Jeg fortæller om det i tråden nedenfor. #dksund #dklæger https://t.co/D0NmprGAh1

Feb 14, 2023 · 6 likes · 1,302 followers View post →
Fred Stalder
@sudokuvariante · X

@fluidloading @LoLoWarn @WhiteL_o_t_u_s Là, je pars préparer le repas, mais en attendant mon thread, je vous laisse lire ça: https://t.co/wkcNEoL5zy https://t.co/KPMblPDU7N https://t.co/C2nsbi1JFG https://t.co/oc48Qm780Y https://t.co/UCpqxSkgrX https://t.co/fKO2aNavuC 1/2

Sep 16, 2024 · 5 likes · 4,729 followers View post →
Maryam Henein/ (aka BeeLady) / Non Psyop
@MaryamHenein · X

Read: A randomized controlled trial of the effect of regular paracetamol on influenza infection https://t.co/jfuzd4wNdV

Mar 18, 2020 · 1 like · 1 share · 25,844 followers View post →
Remedios infantiles
@sergioverd · X

In animal infection, antipyretic drugs increase mortality. In humans paracetamol prolongs infection in varicella zoster, malaria and rhinovirus, and impairs immune responses doi: 10.1111/resp.12685. Agrava el paracetamol la inflamación por el coronavirus?https://t.co/cK3zCo1z7E

Oct 28, 2020 · 1 like · 337 followers View post →
Michel de Toeuf
@ToeufDe · X

@silvano_trotta https://t.co/nx16obvY8Q

Feb 10, 2021 · 1 like · 41 followers View post →

All mentions

Éric Maeker
@dr.maeker.fr · Bluesky

A randomized controlled trial of the effect of supervised exercise on functional outcomes in older African American and non-Hispanic White breast cancer survivors: Are there racial differences in the effects of exercise on functional outcomes? Cancer 2022 2/5

Apr 9, 2025 · 1 share View post →
bob
@bob6429 · X

RT @sudokuvariante: https://t.co/KPMblPDU7N https://t.co/wkcNEoL5zy https://t.co/C2nsbi1JFG Aucun effet clinique positif, tendance à augme…

Sep 17, 2024 · 5 shares · 867 followers View post →
Labeyrie Hélène
@Conneriephobe56 · X

RT @sudokuvariante: https://t.co/KPMblPDU7N https://t.co/wkcNEoL5zy https://t.co/C2nsbi1JFG Aucun effet clinique positif, tendance à augme…

Sep 17, 2024 · 5 shares · 1,543 followers View post →
Floribus
@Floribus52 · X

RT @sudokuvariante: https://t.co/KPMblPDU7N https://t.co/wkcNEoL5zy https://t.co/C2nsbi1JFG Aucun effet clinique positif, tendance à augme…

Sep 16, 2024 · 5 shares · 241 followers View post →
BotAntiPass
@BotAntiPass · X

RT @sudokuvariante: https://t.co/KPMblPDU7N https://t.co/wkcNEoL5zy https://t.co/C2nsbi1JFG Aucun effet clinique positif, tendance à augme…

Sep 16, 2024 · 5 shares · 1,525 followers View post →
Frédéric Poncet
@fredericponcet · X

RT @sudokuvariante: https://t.co/KPMblPDU7N https://t.co/wkcNEoL5zy https://t.co/C2nsbi1JFG Aucun effet clinique positif, tendance à augme…

Sep 16, 2024 · 5 shares · 1,127 followers View post →
Fred Stalder
@sudokuvariante · X

https://t.co/KPMblPDU7N https://t.co/wkcNEoL5zy https://t.co/C2nsbi1JFG Aucun effet clinique positif, tendance à augmenter la durée de portage viral, diminution de la réponse immunitaire

Sep 16, 2024 · 41 likes · 5 shares · 4,729 followers View post →
Fred Stalder
@sudokuvariante · X

@fluidloading @LoLoWarn @WhiteL_o_t_u_s Là, je pars préparer le repas, mais en attendant mon thread, je vous laisse lire ça: https://t.co/wkcNEoL5zy https://t.co/KPMblPDU7N https://t.co/C2nsbi1JFG https://t.co/oc48Qm780Y https://t.co/UCpqxSkgrX https://t.co/fKO2aNavuC 1/2

Sep 16, 2024 · 5 likes · 4,729 followers View post →
Suphil Philipose
@Suphee33 · X

@drkohilathas And it's not an accident that not a single randomized placebo controlled study was done on paracetamol for COVID. https://t.co/na76VC1GGB

Jun 13, 2023 · 458 followers View post →
Alzheimer's Prevention
@AlzheimersPrev2 · X

Despite recommendations to administer paracetamol for symptom relief in influenza and influenza-like illnesses, this study has found that regular administration of paracetamol has no effect on viral or clinical outcomes in this setting. https://t.co/S7z9OPwMhx

Jun 10, 2023 · 395 followers View post →
Mats Jacob H:son Lin
@Medicinmanden · X

Jeg ligger hjemme med influenza-symptomer. Vil paracetamol hjælpe, eller måske, forlænge sygdommen? Der findes, utrolig nok, kun 1 klinisk forsøg. Jeg fortæller om det i tråden nedenfor. #dksund #dklæger https://t.co/D0NmprGAh1

Feb 14, 2023 · 6 likes · 1,302 followers View post →
Il Duca
@DOCTORWHO71 · X

@GuidoMattioni partiamo dalle evidenze, studio sull'influenza dove il paracetamolo non ha assolutamente peggiorato la situazione. https://t.co/IfWh3dSSCm

Aug 25, 2021 · 806 followers View post →
Roshan
@Roshan_Karia · X

@doc_santanu @mkarthik3090 @Neurophysik @drabbyphilips Well crocin doesn't work in influenza... https://t.co/yaI5VpIcKr And maybe doctors with their practice assume that Glutathione depletion that happens with crocin won't affect the inflammation in lungs in later stages of covid..

Mar 22, 2021 · 306 followers View post →
S P
@toutvaencore · X

@moreau1_quentin @OSS117_IHU @FabienneCASSAGN Deja fait mais j'ai trouve que ca.. https://t.co/wKDKMw8M6O

Mar 17, 2021 · 86 followers View post →
Michel de Toeuf
@ToeufDe · X

@silvano_trotta https://t.co/nx16obvY8Q

Feb 10, 2021 · 1 like · 41 followers View post →
EkiVox
@JeanT_Angry · X

@JolieEmile @LuquetSabine @DIVIZIO1 Une étude pour confirmer l'efficacité du Doliprane sur les symptômes du C19 ? Parce que sur la grippe cela n'a aucun effet ! ⬇️ https://t.co/QRNCK2wpA1

Nov 21, 2020 · 119 followers View post →
Remedios infantiles
@sergioverd · X

In animal infection, antipyretic drugs increase mortality. In humans paracetamol prolongs infection in varicella zoster, malaria and rhinovirus, and impairs immune responses doi: 10.1111/resp.12685. Agrava el paracetamol la inflamación por el coronavirus?https://t.co/cK3zCo1z7E

Oct 28, 2020 · 1 like · 337 followers View post →
Jack Atall
@Jacobin_11 · X

https://t.co/MWbjuVr9Xk Le #paracetamol (utilisé massivement dans les hopitaux pour traiter le #COVID19 ) n'a aucun effet sur la charge virale grippale d'après une étude faite en 2003 https://t.co/8THH2BbQ13 https://t.co/v2yhHxgZLh

May 30, 2020 · 250 followers View post →
Dick
@concierge24_24 · X

@Tsarorius @Amellal1490 Par exemple pour influenza https://t.co/m9x1DWhoib

Apr 6, 2020 · 2 followers View post →
Samantha Owen
@samanthaowen008 · X

RT @MaryamHenein: Read: A randomized controlled trial of the effect of regular paracetamol on influenza infection https://t.co/jfuzd4wNdV

Mar 18, 2020 · 1 share · 2,082 followers View post →
Maryam Henein/ (aka BeeLady) / Non Psyop
@MaryamHenein · X

Read: A randomized controlled trial of the effect of regular paracetamol on influenza infection https://t.co/jfuzd4wNdV

Mar 18, 2020 · 1 like · 1 share · 25,844 followers View post →
Remedios infantiles
@sergioverd · X

Good time to avoid antipyretics. In animal models, treatment with antipyretics for influenza infection increases the risk of mortality.https://t.co/FI9XhcRrIg In humans, there remains insufficient evidence for #paracetamol use in influenza infection 10.1111/resp.12685

Mar 15, 2020 · 337 followers View post →
Sparrow Science
@sparrow_science · X

@StartupMinistry At this stage, we believe that a hint of an answer may lie within the press releases of or announcements by @WHO or any of the regional bodies like @NHSuk & @CDCgov. But here are two early stage research papers about viruses https://t.co/nK4vDjQfEP & https://t.co/yJm57AbM8y

Mar 5, 2020 · 2,281 followers View post →
MDSENT
@Badbloodfounder · X

Recently researchers published a study in the journal Respirology that examined the same drug: The study, “Randomized controlled trial of the effect of regular paracetamol on influenza infection,” was a... https://t.co/XHhlXlO9rE

Apr 18, 2019 · 25 followers View post →