J Physiol September 2016 PMID 26638792

Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training?

Troy L Merry, Michael Ristow

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Mentions

69
Peak: 9 in Sep 2025
across 8 sources since Nov 2017

Extended reach

441,518
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Total likes

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Video views

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Mentions per month

Nov 2017 – Dec 2025

Where it's discussed

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AI synopsis

What people are saying

The discussions reveal a strong consensus that antioxidant supplements may impair muscle adaptation, supported by examples like references to compounds blocking signaling pathways such as mTOR. The tone is serious and analytical, involving detailed references to studies and biological mechanisms, which underscores high engagement and perceived impact on athletic practices.

AgreementModerate agreement

Most discussions agree that antioxidant supplements can interfere with muscle adaptation based on research findings, supporting the publication's conclusions.

InterestHigh interest

Posts reflect high interest with detailed insights and mentions of specific studies and compounds like resveratrol and vitamin E, showing engagement with the topic.

EngagementHigh engagement

Many comments analyze mechanisms such as ROS signaling, cite research, and discuss practical implications, indicating deep engagement.

ImpactHigh impact

The discussions highlight significant concerns about supplementation's effects on training outcomes and recovery, emphasizing notable impact.

Abstract in brief

  • Antioxidant supplements are often taken by active individuals trying to reduce muscle damage and fatigue, but they may interfere with the body's natural muscle adaptation process by blocking important signaling molecules called ROS and RNS.
  • Research shows that taking antioxidants can sometimes reduce the benefits of endurance training, like improving mitochondrial function and insulin sensitivity, but these effects are not always consistent, possibly because the body has multiple ways to adapt to exercise.
  • There is little evidence to suggest antioxidants actually help with exercise gains, and high doses might be harmful, as ROS and RNS play a beneficial role in muscle remodeling, especially in high-intensity or resistance training where their signaling is crucial.

Top posts

Most liked on X and Bluesky
Layne Norton, PhD
@BioLayne · X

(9/n): Anti-oxidants do NOT increase muscle mass in healthy people. In fact, they actually impede adaptations to resistance training: https://t.co/LdBddXcKf7 https://t.co/6q37Jd7R66 https://t.co/MLMCWj4PF6

Feb 5, 2021 · 19 likes · 1 share · 226,450 followers View post →
Saúl Sánchez
@SaulNutri · X

La suplementación con antioxidantes en el contexto del ejercicio puede interferir en las vías de señalización, obstaculizando las adaptaciones musculares a los estímulos ofrecidos. https://t.co/u1CiCi01fS

Nov 15, 2020 · 16 likes · 2 shares · 108,077 followers View post →
OJSN
@iamojsn · X

@three_lifting https://t.co/bt8IBRVHBc https://t.co/5oeLAH90ra https://t.co/8QQeOlMcki ※マイナス無かった、みたいなのも結構あります 有名サイトだと… https://t.co/3yaT2f08gp

Aug 12, 2020 · 2 likes · 15,007 followers View post →
Jesús Olivares-Jabalera
@JesusyOlivares · X

It could be an option to recover after key periods of congested matches, but its supplementation may interfere with training adaptations...

Apr 1, 2020 · 2 likes · 1 share · 1,010 followers View post →
南部 博昭(Hiroaki Nanbu)
@Hiroaki_Nanbu · X

参考までにもういっちょ。 細胞が適応するには炎症反応そのものが必要だったりするんです。 https://t.co/1yBGHGBUJS

Apr 2, 2021 · 1 like · 1,693 followers View post →
Kristie Leong M.D.
@DrKristieLeong · X

@rckiser @CMichaelGibson @Gurdur Here’s an article on antioxidant supplements: https://t.co/9teJY4j8Rr

Jun 26, 2019 · 60,050 followers View post →

All mentions

taka_hirai
@stac_hirai_sub · X

Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training? https://t.co/7aJcCAIs0Q

Sep 3, 2024 · 7,891 followers View post →
Jon Chung
@drjonathanchung · X

Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training? https://t.co/CtbQv4anla

May 10, 2024 · 2,070 followers View post →
Carlo Cantu
@carlocantuuu · X

Varios estudios han encontrado que los suplementos antioxidantes como la vitamina E y C, así como los medicamentos antiinflamatorios

Feb 20, 2024 · 9 followers View post →
Johan Neve
@jfneve · X

@ClevelandClinic Chocolate and exercise https://t.co/0maylHoYQw

Apr 17, 2022 · 148 followers View post →
R Need
@ThaRobfather · X

Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training? https://t.co/C5CK1tCLzq

Mar 17, 2022 · 124 followers View post →
Laurence Hunt
@LaurenceRHunt · X

There is another line of research that antioxidant supplements, notably resveratrol, vitamin E, sulforaphane and others, which block mTOR, also reduce exercise benefits if taken while exercising or soon after. https://t.co/dIG7sTEep7

Sep 13, 2021 · 5,804 followers View post →
南部 博昭(Hiroaki Nanbu)
@Hiroaki_Nanbu · X

参考までにもういっちょ。 細胞が適応するには炎症反応そのものが必要だったりするんです。 https://t.co/1yBGHGBUJS

Apr 2, 2021 · 1 like · 1,693 followers View post →
Layne Norton, PhD
@BioLayne · X

(9/n): Anti-oxidants do NOT increase muscle mass in healthy people. In fact, they actually impede adaptations to resistance training: https://t.co/LdBddXcKf7 https://t.co/6q37Jd7R66 https://t.co/MLMCWj4PF6

Feb 5, 2021 · 19 likes · 1 share · 226,450 followers View post →
Ignacio Hernando Valle
@nachoafysalud · X

RT @SaulNutri: La suplementación con antioxidantes en el contexto del ejercicio puede interferir en las vías de señalización, obstaculizand…

Nov 15, 2020 · 2 shares · 5,821 followers View post →
Carlos Colmenero
@colme99 · X

RT @SaulNutri: La suplementación con antioxidantes en el contexto del ejercicio puede interferir en las vías de señalización, obstaculizand…

Nov 15, 2020 · 2 shares · 76 followers View post →
Saúl Sánchez
@SaulNutri · X

La suplementación con antioxidantes en el contexto del ejercicio puede interferir en las vías de señalización, obstaculizando las adaptaciones musculares a los estímulos ofrecidos. https://t.co/u1CiCi01fS

Nov 15, 2020 · 16 likes · 2 shares · 108,077 followers View post →
OJSN
@iamojsn · X

@three_lifting https://t.co/bt8IBRVHBc https://t.co/5oeLAH90ra https://t.co/8QQeOlMcki ※マイナス無かった、みたいなのも結構あります 有名サイトだと… https://t.co/3yaT2f08gp

Aug 12, 2020 · 2 likes · 15,007 followers View post →
OptimOZ.com.au
@OptimOZ · X

antioxidants blunt exercise gainz, bro https://t.co/qyLOI4U5bu https://t.co/AK5RGiS8Ni https://t.co/i2Qy3eIEmU https://t.co/yDFHi1pEwF https://t.co/733ADrK7iR

Apr 5, 2020 · 472 followers View post →
Alberto Fílter PhD
@AlbertoFilter · X

RT @jesusyolivares: It could be an option to recover after key periods of congested matches, but its supplementation may interfere with tra…

Apr 1, 2020 · 1 share · 2,124 followers View post →
Jesús Olivares-Jabalera
@JesusyOlivares · X

It could be an option to recover after key periods of congested matches, but its supplementation may interfere with training adaptations...

Apr 1, 2020 · 2 likes · 1 share · 1,010 followers View post →
Lisa Bailey
@LBaileyHealth · X

“several studies have reported a detrimental effect of antioxidant supplementation on high‐intensity exercise performance. This may suggest that ROS are more pivotal in regulating adaptations to high‐intensity exercise”. https://t.co/zTRGp8SgGO

Dec 17, 2019 · 980 followers View post →
Kristie Leong M.D.
@DrKristieLeong · X

@rckiser @CMichaelGibson @Gurdur Here’s an article on antioxidant supplements: https://t.co/9teJY4j8Rr

Jun 26, 2019 · 60,050 followers View post →
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First published online, doi: 10.1113/JP270654. Do antioxidant supplements interfere with skeletal muscle adaptation to exercise training? By ...

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