PubHawk
J Cell Sci January 2016 PMID 26659665

Fast and precise targeting of single tumor cells in vivo by multimodal correlative microscopy.

Matthia A Karreman, Luc Mercier, Nicole L Schieber, Gergely Solecki, Guillaume Allio, Frank Winkler, Bernhard Ruthensteiner, Jacky G Goetz, Yannick Schwab

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Mentions

9
Peak: 3 in Mar 2022
across 4 sources since May 2016

Extended reach

8,925
potential audience

Total likes

28

Video views

5,552

Mentions per month

May 2016 – Mar 2022

Where it's discussed

  • X / Twitter3 posts
  • YouTube2 videos
  • Facebook2 posts
  • Blogs2 articles

AI synopsis

What people are saying

The discussions highlight the technical aspects of the microscopy method, with phrases like 'correlate FIB-SEM micrographs' indicating technical interest and engagement. Words like 'microscopic' and 'advanced imaging' reflect curiosity, while the mention of broad applications hints at perceived high impact in biomedical research.

AgreementModerate agreement

Most discussions acknowledge or support the significance of the multimodal microscopy approach.

InterestHigh interest

Posts demonstrate high curiosity, especially about the advanced imaging techniques and their applications.

EngagementModerate engagement

Participants refer to specific methods like X-ray computed tomography and electron microscopy, indicating meaningful engagement.

ImpactModerate impact

Conversations suggest the research could influence future cancer studies and imaging protocols, though some see it as a developing approach.

Abstract in brief

  • This study introduces a multimodal correlative microscopy method that combines intravital microscopy, X-ray computed tomography, and 3D electron microscopy to rapidly (about 2 weeks) and precisely (within 5 micrometers) analyze the ultrastructure of single tumor cells in vivo, allowing researchers to better understand metastatic processes.
  • The approach enables detailed observation of rare and transient cellular events, such as tumor cells traveling in blood vessels, by linking functional imaging with ultrastructural data, which was difficult with previous techniques due to resolution limitations.
  • Thanks to its improved throughput and versatility, this workflow supports multiple samples and has broad applications in biological research fields like cancer and developmental biology, enhancing our ability to study cell behavior in realistic, living conditions.
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Top posts

Most liked on X and Bluesky
Daniel Thomson
@djthomson · X

RT @focalplane_jcs: It’s #EMmonday! In this image, microscopic X-ray computed tomography was used to correlate FIB-SEM micrographs with int…

Mar 28, 2022 · 3 shares · 2,089 followers View post →
@MetaphysicalCells
@M_T_A1976 · X

RT @focalplane_jcs: It’s #EMmonday! In this image, microscopic X-ray computed tomography was used to correlate FIB-SEM micrographs with int…

Mar 28, 2022 · 3 shares · 935 followers View post →

All mentions

Sharon Ahmad
@DrSharonAhmad · X

RT @focalplane_jcs: It’s #EMmonday! In this image, microscopic X-ray computed tomography was used to correlate FIB-SEM micrographs with int…

Mar 29, 2022 · 3 shares · 332 followers View post →
@MetaphysicalCells
@M_T_A1976 · X

RT @focalplane_jcs: It’s #EMmonday! In this image, microscopic X-ray computed tomography was used to correlate FIB-SEM micrographs with int…

Mar 28, 2022 · 3 shares · 935 followers View post →
Daniel Thomson
@djthomson · X

RT @focalplane_jcs: It’s #EMmonday! In this image, microscopic X-ray computed tomography was used to correlate FIB-SEM micrographs with int…

Mar 28, 2022 · 3 shares · 2,089 followers View post →