Cytokines, and the neuroinflammation they create, activate circuits that regulate #anxiety and fear responses regions such as the amygdala, hippocampus, dorsal anterior cingulate cortex (dACC), and insula. https://t.co/S6LHEezIDy Wouldn't it be great if we offered ketogenic
The role of inflammation in depression: from evolutionary imperative to modern treatment target.
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Aug 2019 – Dec 2025Where it's discussed
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What people are saying
Discussions center around detailed immune mechanisms like cytokines activating brain circuits related to anxiety and fear, with examples such as the mention of the amygdala and hippocampus, showcasing a thorough understanding of neuroinflammation's role. The tone is analytical and supportive, highlighting the research’s potential to redefine depression treatment strategies.
Most discussions acknowledge the significance of inflammation in depression, reflecting support for the publication's ideas, especially with references to foundational work by Miller and Raison.
The posts show high engagement with the topic, with many participants referencing neuroinflammation, cytokines, and treatment implications, indicating strong interest.
Participants engage deeply, mentioning specific immune components, brain regions, dietary interventions, and citing studies, which demonstrates thoughtful discussion.
The exchange indicates recognition that this research influences how depression could be understood and treated, hinting at a moderate to high impact on ongoing scientific conversation.
Abstract in brief
- Inflammation in the brain historically helped early humans defend against pathogens and predators by triggering behaviors like avoidance and alarm, which were advantageous for survival.
- Nowadays, this same inflammatory response may contribute to the development of depression and can make some patients less responsive to traditional antidepressant treatments.
- Recent research has uncovered how immune system interactions with neurotransmitters and brain circuits influence depression risk, suggesting that targeting inflammation could be a promising new approach for treatment.]
Top posts
Most liked on X and BlueskyPro-inflammatory cytokines such as type I and type II interferons (IFNs), interleukin-1 beta (IL-1β), and tumor necrosis factor (TNF) may decrease serotonin (5-HT) availability. https://t.co/S6LHEezIDy In aged mice, even just a cyclic ketogenic diet significantly decreased
OPINION | Miller, A.H. & Raison, C.L., 2016. The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nature Reviews Immunology, 16: 22-34. (1/2) #Health #Fitness #MindBody https://t.co/FyKmzUwwJq
@sanilrege @psycheureka I think that the 2016 article by Miller and Raison on neuroinflammation is quite fundamental (I cited it in my Msc project). https://t.co/dmUqekGbyz . Interestingly, I did not notice the excellent figure you presented. Instead, I came across this one: https://t.co/2tz4wnoUFe
@hansellinas @gibranrr El link de sci-hub! A ver si jala https://t.co/o9xRAjwTNz
引用されていた重要な論文。見落としてたなぁ。 The role of inflammation in depression: from evolutionary imperative to modern treatment target Andrew H Miller 1, Charles L Raison 2 https://t.co/VuBW2aI0Yx
All mentions
Neuroinflammation: The Link Between Depression and Anxiety
Neuroinflammation is a process where inflammation in the nervous system impacts brain function, linked to disorders like depression and anxiety. Chronic stress, poor diet, and intestinal dysbiosis may trigger this…
Dietary Factors and Nutritional Strategies for Depression Management
This video discusses how certain foods and dietary patterns influence depression. Healthy foods like fish, fruits, and vegetables may reduce symptoms, while processed and sugary foods might increase risk. Nutritional…
Inflammation and Mental Health: Investigating Depression Links
Inflammation and mental health are interconnected. This content provides an educational overview of chronic inflammation's role in depression, highlighting a systematic review that found 27% of depressed individuals…
Low-Grade Chronic Inflammation and Depression: An Inflammatory Link
This video discusses low-grade inflammation's role in depression, based on recent epidemiological studies. About 27% of depressed individuals show elevated CRP levels, indicating inflammation's potential as a treatment…
Inflammation and Mental Health: Exploring the Link in Depression
Inflammation and mental health are interconnected. The systematic review shows about 27% of those with depression have low-grade inflammation, with many showing elevated CRP levels, indicating inflammation could be…
Chronic Low-Grade Inflammation and its Link to Depression
Based on recent epidemiological studies and scientific reviews, this content explains how low-grade inflammation, as indicated by CRP levels, affects a significant portion of people with depression and explores its…
RT @KetoCounselor: Cytokines, and the neuroinflammation they create, activate circuits that regulate #anxiety and fear responses regions su…
RT @KetoCounselor: Pro-inflammatory cytokines such as type I and type II interferons (IFNs), interleukin-1 beta (IL-1β), and tumor necrosis…
RT @KetoCounselor: Pro-inflammatory cytokines such as type I and type II interferons (IFNs), interleukin-1 beta (IL-1β), and tumor necrosis…
RT @KetoCounselor: Cytokines, and the neuroinflammation they create, activate circuits that regulate #anxiety and fear responses regions su…
RT @KetoCounselor: Pro-inflammatory cytokines such as type I and type II interferons (IFNs), interleukin-1 beta (IL-1β), and tumor necrosis…
RT @KetoCounselor: Cytokines, and the neuroinflammation they create, activate circuits that regulate #anxiety and fear responses regions su…
RT @KetoCounselor: Cytokines, and the neuroinflammation they create, activate circuits that regulate #anxiety and fear responses regions su…
RT @KetoCounselor: Cytokines, and the neuroinflammation they create, activate circuits that regulate #anxiety and fear responses regions su…
RT @KetoCounselor: Pro-inflammatory cytokines such as type I and type II interferons (IFNs), interleukin-1 beta (IL-1β), and tumor necrosis…
Pro-inflammatory cytokines such as type I and type II interferons (IFNs), interleukin-1 beta (IL-1β), and tumor necrosis factor (TNF) may decrease serotonin (5-HT) availability. https://t.co/S6LHEezIDy In aged mice, even just a cyclic ketogenic diet significantly decreased
RT @KetoCounselor: Cytokines, and the neuroinflammation they create, activate circuits that regulate #anxiety and fear responses regions su…
Cytokines, and the neuroinflammation they create, activate circuits that regulate #anxiety and fear responses regions such as the amygdala, hippocampus, dorsal anterior cingulate cortex (dACC), and insula. https://t.co/S6LHEezIDy Wouldn't it be great if we offered ketogenic
@sanilrege @psycheureka I think that the 2016 article by Miller and Raison on neuroinflammation is quite fundamental (I cited it in my Msc project). https://t.co/dmUqekGbyz . Interestingly, I did not notice the excellent figure you presented. Instead, I came across this one: https://t.co/2tz4wnoUFe
@FatEmperor The work of Raison and Miller might be of interest https://t.co/IWMANndQdK
Depression is a devastating disorder afflicting 10% of the adult population in the US (doi: 10.1038/nri.2015.5). Let us add spice to help us feel better. . You’re not just adding color you are adding antioxidants and anti-inflammatory properties to improve mental health condition https://t.co/R2IBQLbTJE
引用されていた重要な論文。見落としてたなぁ。 The role of inflammation in depression: from evolutionary imperative to modern treatment target Andrew H Miller 1, Charles L Raison 2 https://t.co/VuBW2aI0Yx
@nevnho https://t.co/PNegbQweYB
OPINION | Miller, A.H. & Raison, C.L., 2016. The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nature Reviews Immunology, 16: 22-34. (1/2) #Health #Fitness #MindBody https://t.co/FyKmzUwwJq
@hansellinas @gibranrr El link de sci-hub! A ver si jala https://t.co/o9xRAjwTNz
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