January 2016 PMID 26711676

The role of inflammation in depression: from evolutionary imperative to modern treatment target.

Andrew H Miller, Charles L Raison

Mentions

168
Peak: 12 in Jun 2025
across 5 sources since Aug 2019

Extended reach

174,701
potential audience

Total likes

2,685

Video views

124,340

Mentions per month

Aug 2019 – Dec 2025

Where it's discussed

  • News82 articles
  • Facebook44 posts
  • Blogs21 articles
  • X / Twitter19 posts
  • YouTube2 videos

AI synopsis

What people are saying

Discussions center around detailed immune mechanisms like cytokines activating brain circuits related to anxiety and fear, with examples such as the mention of the amygdala and hippocampus, showcasing a thorough understanding of neuroinflammation's role. The tone is analytical and supportive, highlighting the research’s potential to redefine depression treatment strategies.

AgreementModerate agreement

Most discussions acknowledge the significance of inflammation in depression, reflecting support for the publication's ideas, especially with references to foundational work by Miller and Raison.

InterestHigh interest

The posts show high engagement with the topic, with many participants referencing neuroinflammation, cytokines, and treatment implications, indicating strong interest.

EngagementModerate engagement

Participants engage deeply, mentioning specific immune components, brain regions, dietary interventions, and citing studies, which demonstrates thoughtful discussion.

ImpactModerate impact

The exchange indicates recognition that this research influences how depression could be understood and treated, hinting at a moderate to high impact on ongoing scientific conversation.

Abstract in brief

  • Inflammation in the brain historically helped early humans defend against pathogens and predators by triggering behaviors like avoidance and alarm, which were advantageous for survival.
  • Nowadays, this same inflammatory response may contribute to the development of depression and can make some patients less responsive to traditional antidepressant treatments.
  • Recent research has uncovered how immune system interactions with neurotransmitters and brain circuits influence depression risk, suggesting that targeting inflammation could be a promising new approach for treatment.]

Top posts

Most liked on X and Bluesky
Nicole Laurent, LMHC
@KetoCounselor · X

Cytokines, and the neuroinflammation they create, activate circuits that regulate #anxiety and fear responses regions such as the amygdala, hippocampus, dorsal anterior cingulate cortex (dACC), and insula. https://t.co/S6LHEezIDy Wouldn't it be great if we offered ketogenic

Jun 27, 2025 · 37 likes · 6 shares · 9,106 followers View post →
Nicole Laurent, LMHC
@KetoCounselor · X

Pro-inflammatory cytokines such as type I and type II interferons (IFNs), interleukin-1 beta (IL-1β), and tumor necrosis factor (TNF) may decrease serotonin (5-HT) availability. https://t.co/S6LHEezIDy In aged mice, even just a cyclic ketogenic diet significantly decreased

Jun 28, 2025 · 21 likes · 4 shares · 9,106 followers View post →
Aquela UK
@AquelaUK · X

OPINION | Miller, A.H. & Raison, C.L., 2016. The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nature Reviews Immunology, 16: 22-34. (1/2) #Health #Fitness #MindBody https://t.co/FyKmzUwwJq

Nov 19, 2019 · 2 likes · 275 followers View post →
Angelos Antonatos
@A_Antonatos · X

@sanilrege @psycheureka I think that the 2016 article by Miller and Raison on neuroinflammation is quite fundamental (I cited it in my Msc project). https://t.co/dmUqekGbyz . Interestingly, I did not notice the excellent figure you presented. Instead, I came across this one: https://t.co/2tz4wnoUFe

Jan 19, 2025 · 2 likes · 242 followers View post →
παμκι
@pamki · X

@hansellinas @gibranrr El link de sci-hub! A ver si jala https://t.co/o9xRAjwTNz

Aug 20, 2019 · 1 like · 14,464 followers View post →
さいこどくたーK
@psydrk · X

引用されていた重要な論文。見落としてたなぁ。 The role of inflammation in depression: from evolutionary imperative to modern treatment target Andrew H Miller 1, Charles L Raison 2 https://t.co/VuBW2aI0Yx

Feb 14, 2021 · 10,775 followers View post →

All mentions

Odie D
@defabstar1 · X

RT @KetoCounselor: Cytokines, and the neuroinflammation they create, activate circuits that regulate #anxiety and fear responses regions su…

Jun 29, 2025 · 6 shares · 271 followers View post →
Ben
@bwcoetzer · X

RT @KetoCounselor: Pro-inflammatory cytokines such as type I and type II interferons (IFNs), interleukin-1 beta (IL-1β), and tumor necrosis…

Jun 29, 2025 · 4 shares · 161 followers View post →
Marta Noya (Martouta)
@MartoutaTech · X

RT @KetoCounselor: Pro-inflammatory cytokines such as type I and type II interferons (IFNs), interleukin-1 beta (IL-1β), and tumor necrosis…

Jun 28, 2025 · 4 shares · 1,181 followers View post →
April EK
@Icutitup67 · X

RT @KetoCounselor: Cytokines, and the neuroinflammation they create, activate circuits that regulate #anxiety and fear responses regions su…

Jun 28, 2025 · 6 shares · 270 followers View post →
Benjiman Boyd
@BenjiBoyd4 · X

RT @KetoCounselor: Pro-inflammatory cytokines such as type I and type II interferons (IFNs), interleukin-1 beta (IL-1β), and tumor necrosis…

Jun 28, 2025 · 4 shares · 97 followers View post →
June
@June52352847 · X

RT @KetoCounselor: Cytokines, and the neuroinflammation they create, activate circuits that regulate #anxiety and fear responses regions su…

Jun 28, 2025 · 6 shares · 125 followers View post →
AF K
@HemlockDiegesis · X

RT @KetoCounselor: Cytokines, and the neuroinflammation they create, activate circuits that regulate #anxiety and fear responses regions su…

Jun 28, 2025 · 6 shares · 276 followers View post →
Penelope Figtree
@PenelopeFigtree · X

RT @KetoCounselor: Cytokines, and the neuroinflammation they create, activate circuits that regulate #anxiety and fear responses regions su…

Jun 28, 2025 · 6 shares · 2,248 followers View post →
LikeLifeMore.com
@nathanleary82 · X

RT @KetoCounselor: Pro-inflammatory cytokines such as type I and type II interferons (IFNs), interleukin-1 beta (IL-1β), and tumor necrosis…

Jun 28, 2025 · 4 shares · 96 followers View post →
Nicole Laurent, LMHC
@KetoCounselor · X

Pro-inflammatory cytokines such as type I and type II interferons (IFNs), interleukin-1 beta (IL-1β), and tumor necrosis factor (TNF) may decrease serotonin (5-HT) availability. https://t.co/S6LHEezIDy In aged mice, even just a cyclic ketogenic diet significantly decreased

Jun 28, 2025 · 21 likes · 4 shares · 9,106 followers View post →
Marta Noya (Martouta)
@MartoutaTech · X

RT @KetoCounselor: Cytokines, and the neuroinflammation they create, activate circuits that regulate #anxiety and fear responses regions su…

Jun 28, 2025 · 6 shares · 1,181 followers View post →
Nicole Laurent, LMHC
@KetoCounselor · X

Cytokines, and the neuroinflammation they create, activate circuits that regulate #anxiety and fear responses regions such as the amygdala, hippocampus, dorsal anterior cingulate cortex (dACC), and insula. https://t.co/S6LHEezIDy Wouldn't it be great if we offered ketogenic

Jun 27, 2025 · 37 likes · 6 shares · 9,106 followers View post →
Angelos Antonatos
@A_Antonatos · X

@sanilrege @psycheureka I think that the 2016 article by Miller and Raison on neuroinflammation is quite fundamental (I cited it in my Msc project). https://t.co/dmUqekGbyz . Interestingly, I did not notice the excellent figure you presented. Instead, I came across this one: https://t.co/2tz4wnoUFe

Jan 19, 2025 · 2 likes · 242 followers View post →
Owen Raybould
@Owen_333 · X

@FatEmperor The work of Raison and Miller might be of interest https://t.co/IWMANndQdK

Dec 17, 2024 · 246 followers View post →
StoicBeard
@stoicbeardguy · X

Depression is a devastating disorder afflicting 10% of the adult population in the US (doi: 10.1038/nri.2015.5). Let us add spice to help us feel better. . You’re not just adding color you are adding antioxidants and anti-inflammatory properties to improve mental health condition https://t.co/R2IBQLbTJE

Feb 19, 2021 · 17 followers View post →
さいこどくたーK
@psydrk · X

引用されていた重要な論文。見落としてたなぁ。 The role of inflammation in depression: from evolutionary imperative to modern treatment target Andrew H Miller 1, Charles L Raison 2 https://t.co/VuBW2aI0Yx

Feb 14, 2021 · 10,775 followers View post →
Erik 67kg
@Erik140000g · X

@nevnho https://t.co/PNegbQweYB

Aug 12, 2020 · 102 followers View post →
Aquela UK
@AquelaUK · X

OPINION | Miller, A.H. & Raison, C.L., 2016. The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nature Reviews Immunology, 16: 22-34. (1/2) #Health #Fitness #MindBody https://t.co/FyKmzUwwJq

Nov 19, 2019 · 2 likes · 275 followers View post →
παμκι
@pamki · X

@hansellinas @gibranrr El link de sci-hub! A ver si jala https://t.co/o9xRAjwTNz

Aug 20, 2019 · 1 like · 14,464 followers View post →