ACS Synth Biol April 2016 PMID 26814170

A Tunable Protein Piston That Breaks Membranes to Release Encapsulated Cargo.

Jessica K Polka, Pamela A Silver

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Mentions

Peak: 2 in Feb 2016

across 6 sources since Feb 2016

Extended reach

4,884

potential audience

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Video views

210

Mentions per month

Feb 2016 – Nov 2024

Where it's discussed

X / Twitter3 posts
YouTube2 videos
News2 articles
Bluesky1 posts
Facebook1 posts
Blogs1 articles

AI synopsis

What people are saying

The discussions highlight the innovative nature of programmable protein pistons, with examples like mentions of 'tuning microscale needles' and 'membrane-breaking proteins,' illustrating curiosity about the methods and future applications, conveyed through a tone of technical intrigue and potential impact.

AgreementModerate agreement

Most discussions acknowledge the significance of the research, though some show playful skepticism or enthusiasm, reflecting general support.

InterestModerate interest

Participants seem curious about the novelty, mentioning terms like 'tuning' and 'membrane-breaking,' indicating moderate interest.

EngagementModerate engagement

Posts include references to specific aspects like 'R-bodies' and 'micro-scale needles,' suggesting deeper engagement with the methods and applications.

ImpactModerate impact

The emphasis on potential uses—such as cellular programming—implies the discussions see this work as having a notable influence in bioengineering and cellular biology.

Abstract in brief

This study introduces a protein-based piston derived from bacterial R bodies that can puncture cell membranes in response to specific pH changes, allowing controlled release of internal cargo.
The researchers developed methods to modify and select mutants with different pH sensitivities, enabling precise tuning of the piston’s extension and retraction behavior.
These programmable protein pistons could serve as innovative tools for selectively rupturing cellular compartments, advancing the field of cellular programming and compartmentalization control.

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All mentions

Protein-Based Piston for Controlled Membrane Rupture in Cells

This video explores a protein-based piston derived from bacterial R bodies that can puncture cell membranes in response to pH changes, enabling controlled cargo release. The study highlights methods to tune the piston’s…

Jessica Polka · Feb 1, 2016 125 views

Reversible Bacterial R Body Kinetics for Controlled Membrane Disruption

This study introduces a protein-based piston derived from bacterial R bodies that can puncture cell membranes in response to specific pH changes, allowing controlled release of internal cargo.

Jessica Polka · Feb 1, 2016 86 views

STCmicrobeblog

@stcmicrobeblog.bsky.social · Bluesky

yes, asbestos is truly bad for macrophages (but a good target for electron microscopists

Nov 28, 2024 · 1 share View post →

Lars Dietrich

@laahrs · X

RT @biorxiv_pubd: Tuning microscale, retractable, membrane-breaking protein needles published as: https://t.co/yYznyvWaB0 @acssynbio #biorx…

Jan 6, 2020 · 1 share · 1,068 followers View post →

bioRxiv Published

@biorxiv_pubd · X

Tuning microscale, retractable, membrane-breaking protein needles published as: https://t.co/yYznyvWaB0 @acssynbio #biorxiv

Jan 6, 2020 · 1 like · 1 share · 2,909 followers View post →

james wagstaff

@jamesmwag · X

@CellfOrganized R-bodies! Eg https://t.co/A08UVfMHA0

Aug 27, 2019 · 652 followers View post →

R Bodies: Membrane-Rupturing Microscopic Tools

Blogs

A Tunable Protein Piston That Breaks Membranes to Release Encapsulated Cargo. ACS Synth. Biol. (2016). doi:10.1021/acssynbio.5b00237. PubMed ...

Apr 14, 2016 View →

A Tunable Protein Piston That Breaks Membranes to Release ...

Facebook

... 10.1021/acssynbio. 5b00237. A Tunable Protein Piston That Breaks Membranes to Release Encapsulated Cargo - ACS Synthetic.. PUBS.ACS.ORG. A ...

Apr 14, 2016 View →

Punchy proteins could help advance drug delivery | ScienceDaily

News

ACS Synthetic Biology, 2016; DOI: 10.1021/acssynbio.5b00237. Cite This Page: MLA; APA; Chicago. American Chemical Society. "Punchy proteins ...

Feb 20, 2016 View →

Breaking cell barriers with retractable protein nanoneedles ...