Med Hypotheses February 2016 PMID 26826644

Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle.

László G Boros, Dominic P D'Agostino, Howard E Katz, Justine P Roth, Emmanuelle J Meuillet, Gábor Somlyai

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Mentions

54
Peak: 14 in Sep 2021
across 4 sources since Mar 2014

Extended reach

669,775
potential audience

Total likes

290

Video views

45,900

Mentions per month

Mar 2014 – Oct 2025

Where it's discussed

  • X / Twitter43 posts
  • YouTube5 videos
  • Facebook5 posts
  • Bluesky1 posts

AI synopsis

What people are saying

Throughout the discussions, several posts affirm the importance of deuterium's biological roles, highlighting the therapeutic potential of deuterium-depleted water and connecting it to dietary and environmental factors, which shows genuine interest. The tone varies from scientific references to enthusiastic mentions of future applications, reflecting a balanced view of credible research and curiosity about its broader impact.

AgreementModerate agreement

Most discussions support the idea that deuterium depletion and its role in cell transformation are significant, with some posts emphasizing the therapeutic potential.

InterestHigh interest

The ongoing conversations about complex biochemical processes and potential health benefits demonstrate high curiosity.

EngagementModerate engagement

Participants reference multiple articles, courses, and implications, indicating moderate to deep involvement.

ImpactModerate impact

While some recognize potential impacts on cancer treatment and diet, the overall consensus suggests moderate influence on existing practices.

Abstract in brief

  • Deuterium (2H), a natural isotope of hydrogen, may play a significant role in biology by affecting cell growth and tumor progression, with deuterium-depleted water (DDW) shown to delay cancer development across multiple species.
  • Hydratase enzymes in the TCA cycle help regulate cell growth by removing deuterium from key molecules, influencing processes like gluconeogenesis and fatty acid oxidation, which are linked to cancer prevention and treatment.
  • The study suggests that DDW could be a natural, submolecular way to combat cancer, potentially connecting dietary factors (like processed carbs and fats) to increased deuterium levels in western diets, and offering a mechanism for targeted therapies using natural or diet-based approaches.]

Top posts

Most liked on X and Bluesky
Mg2+ Papi, the BowTied Mg2+
@Grimhood · X

Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle https://t.co/HXylCHXwQb The primary benefit of the ketogenic diet is deuterium depletion. https://t.co/I1DNpzXXsv

Jan 29, 2022 · 56 likes · 18 shares · 133,696 followers View post →
Mg2+ Papi, the BowTied Mg2+
@Grimhood · X

Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle https://t.co/btm9gV91fk https://t.co/oKoKniHKOe

Nov 29, 2021 · 8 likes · 1 share · 133,696 followers View post →
Raphael Sirtoli
@raphaels7 · X

@wiseoldguy @TuckerGoodrich @Ken__Strain deuterium depletion is a hypothesized anti-cancer mechanism https://t.co/627Vofd2Ju cc @DominicDAgosti2

May 12, 2022 · 4 likes · 8,592 followers View post →
Esther Boros
@mseszti · X

@bigfatsurprise Here are some interesting papers, what we recommend to read: deuterium depletion, termed “deupletion”: https://t.co/aTFme5mgEl https://t.co/Q1aj5yucOf and there is a graduate course, too, https://t.co/JOsHIgzztv

Sep 13, 2021 · 4 likes · 209 followers View post →
htw
@heniek-htw.bsky.social · Bluesky

Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle www.sciencedirect.com/science/arti...

Nov 25, 2024 · 4 likes · 4 shares View post →
Esther Boros
@mseszti · X

@ifixhearts Here are some interesting papers, what we recommend to read: https://t.co/aTFme5mgEl https://t.co/Q1aj5yucOf https://t.co/pv85nrEuwz

Sep 13, 2021 · 3 likes · 209 followers View post →

All mentions

Richard
@PGC1a_RB · X

RT @Grimhood: Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid subs…

Oct 25, 2025 · 18 shares · 14,745 followers View post →
Cankay Koryak
@CankayKoryak · X

Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle (2016) ​The biological impact of deuterium and therapeutic potential of deuterium-depleted water (2024)

Oct 5, 2025 · 3,660 followers View post →
László Géza Boros MD
@laszlogboros · X

based on the following three articles and previous lectures I gave at UCLA and Madeira. These are shown below in chronological order: https://t.co/ta3engVfuM https://t.co/dCnTL8wlRS https://t.co/mpOUNs1hzy https://t.co/XqjZwHwJEA https://t.co/BwCBJiOFrp

Jun 6, 2025 · 1 like · 77 followers View post →
htw
@heniek-htw.bsky.social · Bluesky

Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle www.sciencedirect.com/science/arti...

Nov 25, 2024 · 4 likes · 4 shares View post →
Nick Smart
@nick96smart · X

RT @Grimhood: Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid subs…

Apr 14, 2024 · 18 shares · 1,374 followers View post →
Richard
@PGC1a_RB · X

RT @Grimhood: Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid subs…

Apr 14, 2024 · 18 shares · 14,745 followers View post →
Ægean
@Aegean_E · X

RT @Grimhood: Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid subs…

Mar 19, 2024 · 18 shares · 28,657 followers View post →
Esther Boros
@mseszti · X

@DrJackKruse Please read the original contribution to the field in the peer reviewed medical literature. https://t.co/Q1aj5yucOf

Dec 22, 2023 · 209 followers View post →
László Géza Boros MD
@laszlogboros · X

@MaxGulhaneMD @JohnSpeakman4 @AllyTransforms @bruno_crocco @TuckerGoodrich @Peter_InNorfolk @KetoCarnivore @stephanieseneff Deuterium also has significant roles in the regulation of the Szent-Györgyi-Krebs cycle and structural proteins like bone collagen under challenging living conditions: https://t.co/ta3engVfuM

Dec 20, 2023 · 1 like · 77 followers View post →
INGENEZ SOLUTIONS
@Ingenezkc · X

RT @Grimhood: Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid subs…

Nov 13, 2023 · 18 shares · 100 followers View post →
SalvajeDesterrado
@frelu96 · X

RT @Grimhood: Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid subs…

Nov 13, 2023 · 18 shares · 191 followers View post →
OxLodi
@AsayaAthletics · X

RT @Grimhood: Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid subs…

Nov 13, 2023 · 18 shares · 32 followers View post →
Carlos Esguerra
@CarlosEsguerra4 · X

¡mantener los niveles de deuterio bajos! La insulina y el mecanismo del azúcar tiene una utilidad, pero la naturaleza hace todo su esfuerzo para eliminar el deuterio ¿Es pseudociencia? https://t.co/KqPJnKZ8gx https://t.co/BgwuofnVx9 https://t.co/1lQMvDYH1q

Aug 31, 2023 · 1 like · 208 followers View post →
Esther Boros
@mseszti · X

11. References: 1. https://t.co/V0SKkPIOZI 2. https://t.co/hqxHoG7ALl 3. https://t.co/Q1aj5yucOf 4. https://t.co/td3akZLI2F

Aug 14, 2023 · 209 followers View post →
Silvia de Dios
@SilviadeDios12 · X

RT @Grimhood: Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid subs…

Jun 23, 2023 · 18 shares · 225 followers View post →
Maitreya
@Mithreu · X

RT @Grimhood: Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid subs…

Jun 23, 2023 · 18 shares · 1,261 followers View post →
Mg2+ Papi, the BowTied Mg2+
@Grimhood · X

RT @Grimhood: Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid subs…

Jun 22, 2023 · 18 shares · 133,696 followers View post →
Raphael Sirtoli
@raphaels7 · X

@wiseoldguy @TuckerGoodrich @Ken__Strain deuterium depletion is a hypothesized anti-cancer mechanism https://t.co/627Vofd2Ju cc @DominicDAgosti2

May 12, 2022 · 4 likes · 8,592 followers View post →
Maitreya
@Mithreu · X

RT @Grimhood: Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid subs…

Mar 13, 2022 · 18 shares · 1,261 followers View post →
4Love&Money
@ExilioForzoso · X

RT @Grimhood: Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid subs…

Mar 10, 2022 · 18 shares · 1,383 followers View post →
富士369
@FujiTom4 · X

RT @Grimhood: Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid subs…

Mar 10, 2022 · 18 shares · 1,037 followers View post →
Mg2+ Papi, the BowTied Mg2+
@Grimhood · X

RT @Grimhood: Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid subs…

Mar 10, 2022 · 18 shares · 133,696 followers View post →
3 6 9
@nikkileele92 · X

RT @Grimhood: Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid subs…

Feb 2, 2022 · 18 shares · 74 followers View post →
ENDALA klinika zdraví
@endalaclinic · X

RT @Grimhood: Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid subs…

Jan 30, 2022 · 18 shares · 252 followers View post →
izzatt
@izzattzuhair · X

RT @Grimhood: Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid subs…

Jan 29, 2022 · 18 shares · 155 followers View post →
Mg2+ Papi, the BowTied Mg2+
@Grimhood · X

Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle https://t.co/HXylCHXwQb The primary benefit of the ketogenic diet is deuterium depletion. https://t.co/I1DNpzXXsv

Jan 29, 2022 · 56 likes · 18 shares · 133,696 followers View post →
Don Tidwell
@tidwell_don · X

RT @Grimhood: Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid subs…

Nov 29, 2021 · 1 share · 2,801 followers View post →
Mg2+ Papi, the BowTied Mg2+
@Grimhood · X

Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle https://t.co/btm9gV91fk https://t.co/oKoKniHKOe

Nov 29, 2021 · 8 likes · 1 share · 133,696 followers View post →
Esther Boros
@mseszti · X

@EileenWhitePhD @KivancBirsoy @WeillCornell @ChristofkLab @RJDLab @lydfinley @JeffRathmell @RuggeroDavide @WellenLab Here are some interesting papers, what I recommend to read, before the conference: https://t.co/aTFme5mgEl https://t.co/Q1aj5yucOf and there is a graduate course, too, https://t.co/JOsHIgzztv

Oct 27, 2021 · 209 followers View post →
Esther Boros
@mseszti · X

@DoctorTro @DrAseemMalhotra And here are some interesting papers, not only obesity is the problem, but the high deuterium content of food: https://t.co/aTFme5mgEl https://t.co/Q1aj5yucOf

Sep 13, 2021 · 209 followers View post →
Esther Boros
@mseszti · X

@ifixhearts Here are some interesting papers, what we recommend to read: https://t.co/aTFme5mgEl https://t.co/Q1aj5yucOf https://t.co/pv85nrEuwz

Sep 13, 2021 · 3 likes · 209 followers View post →
Esther Boros
@mseszti · X

@bschermd We hope, one day your favorite word will be deupletion: deuterium depletion :) Here are some interesting papers, what we recommend to read: https://t.co/aTFme5mgEl https://t.co/Q1aj5yucOf

Sep 13, 2021 · 1 like · 209 followers View post →
Esther Boros
@mseszti · X

@DrEenfeldt Here are some interesting papers, what we recommend to read: https://t.co/aTFme5mgEl https://t.co/Q1aj5yucOf https://t.co/vSgy0mWQIj

Sep 13, 2021 · 209 followers View post →
Esther Boros
@mseszti · X

@DaveKeto @davidludwigmd @garytaubes @nicknorwitz Here are some interesting papers, what we recommend to read: deuterium depletion, termed “deupletion”: https://t.co/aTFme5mgEl https://t.co/Q1aj5yucOf and there is a graduate course, too, https://t.co/JOsHIgzztv

Sep 13, 2021 · 209 followers View post →
Esther Boros
@mseszti · X

@bigfatsurprise Here are some interesting papers, what we recommend to read: deuterium depletion, termed “deupletion”: https://t.co/aTFme5mgEl https://t.co/Q1aj5yucOf and there is a graduate course, too, https://t.co/JOsHIgzztv

Sep 13, 2021 · 4 likes · 209 followers View post →
Esther Boros
@mseszti · X

@lowcarbGP @HarrisonSea @ProfTimNoakes @DietDoctor @DrAseemMalhotra @tednaiman Here are some interesting papers, what we recommend to read: deuterium depletion, termed “deupletion”: https://t.co/aTFme5mgEl https://t.co/Q1aj5yucOf And there is a graduate course, too: https://t.co/JOsHIgzztv

Sep 13, 2021 · 1 like · 209 followers View post →
Esther Boros
@mseszti · X

@nicknorwitz @ChrisPalmerMD @bigfatsurprise @KenDBerryMD @TuitNutrition @DougieReynolds @lowcarbGP @ahhite @jen_unwin @BrianLenzkes @davidludwigmd Interesting readings: glyphosate exposure and deuterium depletion, termed “deupletion”: https://t.co/aTFme5mgEl https://t.co/Q1aj5yucOf a graduate

Sep 11, 2021 · 209 followers View post →
Esther Boros
@mseszti · X

@davidludwigmd glyphosate exposure and deuterium depletion, termed “deupletion”: https://t.co/aTFme5mgEl https://t.co/Q1aj5yucOf a graduate

Sep 11, 2021 · 209 followers View post →
Esther Boros
@mseszti · X

@nicknorwitz And Dr. Seneff’s readings to link glyphosate exposure and deuterium depletion, termed “deupletion”: https://t.co/aTFme5mgEl https://t.co/Q1aj5yucOf a graduate

Sep 6, 2021 · 209 followers View post →
Esther Boros
@mseszti · X

@gerdosi Gábor, if you’re interested: Dr. Seneff’s readings to link glyphosate exposure and deuterium depletion, termed “deupletion”: https://t.co/aTFme5mgEl https://t.co/Q1aj5yucOf a graduate

Sep 4, 2021 · 209 followers View post →
Esther Boros
@mseszti · X

@Consumer_GD @LoriShemek @picardonhealth @YoniFreedhoff @DietitianOnline @MicheleRSimon @joybauer @LizWeiss @KellyOlexa @theresaboyle @AmanGill_89 If you’re interested, please contact us. Here you will find Dr. Seneff’s readings to link glyphosate exposure and deuterium depletion, termed “deupletion”: https://t.co/aTFme5mgEl https://t.co/Q1aj5yucOf a graduate

Sep 4, 2021 · 1 like · 209 followers View post →
Esther Boros
@mseszti · X

@Kevin_McKernan Dr. Seneff’s readings to link glyphosate exposure and deuterium depletion, termed “deupletion”: https://t.co/aTFme5mgEl https://t.co/Q1aj5yucOf a graduate

Sep 4, 2021 · 1 like · 209 followers View post →
Esther Boros
@mseszti · X

@ProfTimNoakes Dr. Seneff’s readings to link glyphosate exposure and deuterium depletion, termed “deupletion”: https://t.co/aTFme5mgEl https://t.co/Q1aj5yucOf a graduate

Sep 4, 2021 · 209 followers View post →
Rene Sugar
@renesugar · X

Submolecular regulation of cell transformation by deuterium depleting water exchange reactions in the tricarboxylic acid substrate cycle https://t.co/uzhRRtkOgx

Feb 9, 2019 · 3,973 followers View post →