How did saturated fat end up in the liver? Oh that’s right. De Novo Lipogenesis, the endogenous metabolic process in which the body turns excess carbs into saturated fat, specifically palmitic acid... https://t.co/WZfaBYXt8N https://t.co/6BPpavSf6U
Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease.
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Sep 2020 – Dec 2024Where it's discussed
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Discussions strongly align with the publication's emphasis on fructose's role in fatty liver disease, with posts referencing specific mechanisms like hepatic lipogenesis and linking to scientific studies, which shows deep interest and engagement. The tone varies from informative to casual, reflecting both academic curiosity and general concern about sugar intake.
Most discussions support the article's findings that fructose significantly contributes to fatty liver disease.
Participants show high curiosity, referencing multiple research papers and encouraging viewers to explore the mechanisms of fructose metabolism.
Comments actively delve into detailed explanations, sharing related literature and personal insights, demonstrating deep engagement.
The discourse highlights a strong recognition of the research's importance for understanding metabolic diseases, though some responses are more casual.
Abstract in brief
- NAFLD, or nonalcoholic fatty liver disease, is linked to metabolic syndrome and is mainly caused by excessive consumption of high-fat diets and sugary drinks, especially high fructose corn syrup.
- The key abnormality in NAFLD is increased hepatic de novo lipogenesis (DNL), where the liver produces fat, and this process is strongly driven by dietary fructose, which promotes fat production more effectively than high-fat diets.
- Fructose's unique metabolism in the liver enhances fat synthesis through various mechanisms, including enzyme upregulation, ATP depletion, and stress responses, suggesting that targeting fructose metabolism could be a promising approach to treat NAFLD.]
Top posts
Most liked on X and BlueskyFor any else wondering the properties and mechanisms of fructose metabolism that make it particularly lipogenic, specifically in the liver. https://t.co/ZN9ATQDsvu #FattyLiver @RobertLustigMD @davidbeard122
@Wegiveyouhealt1 Role of Dietary Fructose and Hepatic de novo Lipogenesis in Fatty Liver Disease by Softic, Cohen & Kahn is a brilliant 2016 paper which does a good job of explaining the current situation of fructose over consumption , probable role of fructose in NAFD & eventually NASH but …
@casarrubiasnt @SBarquera @RiveraDommarco @bmj_latest Este es un bonito artículo de revisión que explora las rutas metabólicas de la lipogénesis de novo a partir de alimentos altos en grasas y bebidas azucaradas, y cómo ello se asocia con hígado graso. https://t.co/o0EXwkq7G7
@Mqsley @mdredpillawake @mikeoniron ..goes on forever https://t.co/AP2EVKV8XI
@TarbuckSam @MiocanDanijel @MohammedAlo @ElieJarrougeMD Yes. I’ve described why fructose is unique a couple of times in this thread. It’s metabolized by the liver differently than glucose. Here are some papers that explain. https://t.co/ryNdLV9ILr https://t.co/RNmVxGsqMf https://t.co/wSSNnXyyCb https://t.co/tPfNkw99dS
All mentions
The Impact of Fructose from Juices and Sweets on Liver Health
This video discusses how fructose from fruit juice and sugar-sweetened beverages is linked to increased liver fat, especially in people with type 2 diabetes. Understanding these effects can help in making healthier…
Impact of Refined Fructose on Metabolic Health and Liver Fat
Refined fructose can cause health issues like increased hunger, cravings, and fat buildup in the liver, especially when consumed in excess over time, while fructose from fruit is generally safe when eaten with whole…
RT @stevenflorek: @tylerblack32 Fructose, unlike other sugars, is metabolized by the liver directly into fat independent of insulin signali…
@tylerblack32 Fructose, unlike other sugars, is metabolized by the liver directly into fat independent of insulin signaling. It is also directly absorbed into the bloodstream, unlike sucrose. https://t.co/FnzfYaOgRT https://t.co/eKE7aqzRwp
@withered_haze https://t.co/f8aXFdjArG
@HtsHelja @MRaulahti @M1guelSuna @PekkaPuska1 Softic, S., Cohen, D. E., & Kahn, C. R. (2016). Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease. Digestive Diseases and Sciences, 61(5), 1282-1293. Tutkimus käsittelee, miten fruktoosi edistää maksan rasvoittumista ja tulehdusta.
ได้มาอ่านเพิ่มอีก 1 เปเปอร์ https://t.co/03AumueKWr https://t.co/8Dpz7EOxXh
@Mqsley @mdredpillawake @mikeoniron ..goes on forever https://t.co/AP2EVKV8XI
@TarbuckSam @MiocanDanijel @MohammedAlo @ElieJarrougeMD Yes. I’ve described why fructose is unique a couple of times in this thread. It’s metabolized by the liver differently than glucose. Here are some papers that explain. https://t.co/ryNdLV9ILr https://t.co/RNmVxGsqMf https://t.co/wSSNnXyyCb https://t.co/tPfNkw99dS
@Wegiveyouhealt1 Role of Dietary Fructose and Hepatic de novo Lipogenesis in Fatty Liver Disease by Softic, Cohen & Kahn is a brilliant 2016 paper which does a good job of explaining the current situation of fructose over consumption , probable role of fructose in NAFD & eventually NASH but …
@T19R84 @DrYaelAdler https://t.co/bGXjKgbpki Ich kann dir empfehlen diese lecture zu schauen, der Herr hat sein Leben damit verbracht https://t.co/2VUuPLLm4z
5. Reduce sugar I want candyyyy Sugar (https://t.co/KeYEvO5prO) contains fructose, which is linked to many chronic diseases (https://t.co/CCykgUhhJJ) when consumed excessively. So not only bad for your belly (https://t.co/C31l9A3tyc)....
For any else wondering the properties and mechanisms of fructose metabolism that make it particularly lipogenic, specifically in the liver. https://t.co/ZN9ATQDsvu #FattyLiver @RobertLustigMD @davidbeard122
How did saturated fat end up in the liver? Oh that’s right. De Novo Lipogenesis, the endogenous metabolic process in which the body turns excess carbs into saturated fat, specifically palmitic acid... https://t.co/WZfaBYXt8N https://t.co/6BPpavSf6U
RT @EveApolinar: @casarrubiasnt @SBarquera @RiveraDommarco @bmj_latest Este es un bonito artículo de revisión que explora las rutas metaból…
@casarrubiasnt @SBarquera @RiveraDommarco @bmj_latest Este es un bonito artículo de revisión que explora las rutas metabólicas de la lipogénesis de novo a partir de alimentos altos en grasas y bebidas azucaradas, y cómo ello se asocia con hígado graso. https://t.co/o0EXwkq7G7
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