May 2016 PMID 26856717

Role of Dietary Fructose and Hepatic De Novo Lipogenesis in Fatty Liver Disease.

Samir Softic, David E Cohen, C Ronald Kahn

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Mentions

33
Peak: 3 in Dec 2024
across 5 sources since Sep 2020

Extended reach

80,450
potential audience

Total likes

130

Video views

4,980

Mentions per month

Sep 2020 – Dec 2024

Where it's discussed

  • X / Twitter14 posts
  • Facebook9 posts
  • News6 articles
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

Discussions strongly align with the publication's emphasis on fructose's role in fatty liver disease, with posts referencing specific mechanisms like hepatic lipogenesis and linking to scientific studies, which shows deep interest and engagement. The tone varies from informative to casual, reflecting both academic curiosity and general concern about sugar intake.

AgreementStrong agreement

Most discussions support the article's findings that fructose significantly contributes to fatty liver disease.

InterestHigh interest

Participants show high curiosity, referencing multiple research papers and encouraging viewers to explore the mechanisms of fructose metabolism.

EngagementHigh engagement

Comments actively delve into detailed explanations, sharing related literature and personal insights, demonstrating deep engagement.

ImpactModerate impact

The discourse highlights a strong recognition of the research's importance for understanding metabolic diseases, though some responses are more casual.

Abstract in brief

  • NAFLD, or nonalcoholic fatty liver disease, is linked to metabolic syndrome and is mainly caused by excessive consumption of high-fat diets and sugary drinks, especially high fructose corn syrup.
  • The key abnormality in NAFLD is increased hepatic de novo lipogenesis (DNL), where the liver produces fat, and this process is strongly driven by dietary fructose, which promotes fat production more effectively than high-fat diets.
  • Fructose's unique metabolism in the liver enhances fat synthesis through various mechanisms, including enzyme upregulation, ATP depletion, and stress responses, suggesting that targeting fructose metabolism could be a promising approach to treat NAFLD.]

Top posts

Most liked on X and Bluesky
DiscoStew
@DiscoStew66 · X

How did saturated fat end up in the liver? Oh that’s right. De Novo Lipogenesis, the endogenous metabolic process in which the body turns excess carbs into saturated fat, specifically palmitic acid... https://t.co/WZfaBYXt8N https://t.co/6BPpavSf6U

Mar 31, 2021 · 4 likes · 10,792 followers View post →
Kirsty Woods
@MetabolicEP · X

For any else wondering the properties and mechanisms of fructose metabolism that make it particularly lipogenic, specifically in the liver. https://t.co/ZN9ATQDsvu #FattyLiver @RobertLustigMD @davidbeard122

Aug 23, 2021 · 4 likes · 2,043 followers View post →
FittrwithKJ | Kapil Jadhav
@Fittrwithkj · X

@Wegiveyouhealt1 Role of Dietary Fructose and Hepatic de novo Lipogenesis in Fatty Liver Disease by Softic, Cohen & Kahn is a brilliant 2016 paper which does a good job of explaining the current situation of fructose over consumption , probable role of fructose in NAFD & eventually NASH but …

Jun 10, 2023 · 2 likes · 7,746 followers View post →
Evelia Apolinar
@EveApolinar · X

@casarrubiasnt @SBarquera @RiveraDommarco @bmj_latest Este es un bonito artículo de revisión que explora las rutas metabólicas de la lipogénesis de novo a partir de alimentos altos en grasas y bebidas azucaradas, y cómo ello se asocia con hígado graso. https://t.co/o0EXwkq7G7

Sep 5, 2020 · 2 likes · 1 share · 1,934 followers View post →
Claus Carlsen
@ClausCarlsen1 · X

@Mqsley @mdredpillawake @mikeoniron ..goes on forever https://t.co/AP2EVKV8XI

May 12, 2024 · 1 like · 15,792 followers View post →
Greg Mushen
@gregmushen · X

@TarbuckSam @MiocanDanijel @MohammedAlo @ElieJarrougeMD Yes. I’ve described why fructose is unique a couple of times in this thread. It’s metabolized by the liver differently than glucose. Here are some papers that explain. https://t.co/ryNdLV9ILr https://t.co/RNmVxGsqMf https://t.co/wSSNnXyyCb https://t.co/tPfNkw99dS

Feb 17, 2024 · 30,350 followers View post →

All mentions

Steven Florek
@stevenflorek · X

RT @stevenflorek: @tylerblack32 Fructose, unlike other sugars, is metabolized by the liver directly into fat independent of insulin signali…

Dec 2, 2024 · 1 share · 45 followers View post →
Steven Florek
@stevenflorek · X

@tylerblack32 Fructose, unlike other sugars, is metabolized by the liver directly into fat independent of insulin signaling. It is also directly absorbed into the bloodstream, unlike sucrose. https://t.co/FnzfYaOgRT https://t.co/eKE7aqzRwp

Dec 2, 2024 · 1 share · 45 followers View post →
Mark Gossage
@bulkbiker · X

@withered_haze https://t.co/f8aXFdjArG

Aug 23, 2024 · 2,944 followers View post →
Janne Aikio
@janne_aikio · X

@HtsHelja @MRaulahti @M1guelSuna @PekkaPuska1 Softic, S., Cohen, D. E., & Kahn, C. R. (2016). Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease. Digestive Diseases and Sciences, 61(5), 1282-1293. Tutkimus käsittelee, miten fruktoosi edistää maksan rasvoittumista ja tulehdusta.

Aug 6, 2024 · 202 followers View post →
णणड्ठ - 周沫辰
@sitdh · X

ได้มาอ่านเพิ่มอีก 1 เปเปอร์ https://t.co/03AumueKWr https://t.co/8Dpz7EOxXh

Jun 24, 2024 · 1,865 followers View post →
Claus Carlsen
@ClausCarlsen1 · X

@Mqsley @mdredpillawake @mikeoniron ..goes on forever https://t.co/AP2EVKV8XI

May 12, 2024 · 1 like · 15,792 followers View post →
Greg Mushen
@gregmushen · X

@TarbuckSam @MiocanDanijel @MohammedAlo @ElieJarrougeMD Yes. I’ve described why fructose is unique a couple of times in this thread. It’s metabolized by the liver differently than glucose. Here are some papers that explain. https://t.co/ryNdLV9ILr https://t.co/RNmVxGsqMf https://t.co/wSSNnXyyCb https://t.co/tPfNkw99dS

Feb 17, 2024 · 30,350 followers View post →
FittrwithKJ | Kapil Jadhav
@Fittrwithkj · X

@Wegiveyouhealt1 Role of Dietary Fructose and Hepatic de novo Lipogenesis in Fatty Liver Disease by Softic, Cohen & Kahn is a brilliant 2016 paper which does a good job of explaining the current situation of fructose over consumption , probable role of fructose in NAFD & eventually NASH but …

Jun 10, 2023 · 2 likes · 7,746 followers View post →
Ketogenic European
@Ketogenic_EU · X

@T19R84 @DrYaelAdler https://t.co/bGXjKgbpki Ich kann dir empfehlen diese lecture zu schauen, der Herr hat sein Leben damit verbracht https://t.co/2VUuPLLm4z

Sep 15, 2022 · 1,023 followers View post →
Luca Nicora
@Lucanicora · X

5. Reduce sugar I want candyyyy Sugar (https://t.co/KeYEvO5prO) contains fructose, which is linked to many chronic diseases (https://t.co/CCykgUhhJJ) when consumed excessively. So not only bad for your belly (https://t.co/C31l9A3tyc)....

Jan 11, 2022 · 502 followers View post →
Kirsty Woods
@MetabolicEP · X

For any else wondering the properties and mechanisms of fructose metabolism that make it particularly lipogenic, specifically in the liver. https://t.co/ZN9ATQDsvu #FattyLiver @RobertLustigMD @davidbeard122

Aug 23, 2021 · 4 likes · 2,043 followers View post →
DiscoStew
@DiscoStew66 · X

How did saturated fat end up in the liver? Oh that’s right. De Novo Lipogenesis, the endogenous metabolic process in which the body turns excess carbs into saturated fat, specifically palmitic acid... https://t.co/WZfaBYXt8N https://t.co/6BPpavSf6U

Mar 31, 2021 · 4 likes · 10,792 followers View post →
Joel HM
@Zrockejhma · X

RT @EveApolinar: @casarrubiasnt @SBarquera @RiveraDommarco @bmj_latest Este es un bonito artículo de revisión que explora las rutas metaból…

Sep 11, 2020 · 1 share · 179 followers View post →
Evelia Apolinar
@EveApolinar · X

@casarrubiasnt @SBarquera @RiveraDommarco @bmj_latest Este es un bonito artículo de revisión que explora las rutas metabólicas de la lipogénesis de novo a partir de alimentos altos en grasas y bebidas azucaradas, y cómo ello se asocia con hígado graso. https://t.co/o0EXwkq7G7

Sep 5, 2020 · 2 likes · 1 share · 1,934 followers View post →