Cell Metab March 2016 PMID 26895752

Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution.

Line Pedersen, Manja Idorn, Gitte H Olofsson, Britt Lauenborg, Intawat Nookaew, Rasmus Hvass Hansen, Helle Hjorth Johannesen, Jürgen C Becker, Katrine S Pedersen, Christine Dethlefsen, Jens Nielsen, Julie Gehl, Bente K Pedersen, Per Thor Straten, Pernille Hojman

Mentions

159
Peak: 3 in May 2020
across 6 sources since May 2020

Extended reach

135,684
potential audience

Total likes

102

Video views

887

Mentions per month

May 2020 – Mar 2025

Where it's discussed

  • News86 articles
  • Facebook47 posts
  • X / Twitter14 posts
  • Blogs6 articles
  • Reddit4 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions reflect strong agreement with the publication's conclusions, illustrated by comments such as 'exercise makes our natural killer cells more active' and references to immune mechanisms like epinephrine and IL-6, which show high engagement with the scientific details and implications for therapy. Words like 'important adjuvant therapy' and phrases about tumor suppression convey a sense of high impact and relevance.

AgreementStrong agreement

Most discussions support the article's findings, emphasizing the beneficial role of exercise in tumor suppression and immune function.

InterestHigh interest

Posts demonstrate high interest, referencing specific mechanisms like NK cell mobilization and metabolic pathways, indicating engagement with the scientific content.

EngagementHigh engagement

Discussions include detailed references to molecular pathways (epinephrine, IL-6) and real-world implications, showing deep engagement and analytical thinking.

ImpactHigh impact

Many posts highlight potential clinical applications and the significance of exercise as an adjunct therapy, suggesting perceived high impact of the research.

Abstract in brief

  • Regular voluntary exercise significantly reduces tumor growth and incidence in mice, with over 60% reduction observed across different tumor models.
  • Exercise promotes immune function, especially increasing natural killer (NK) cell infiltration into tumors.
  • The mobilization and activity of NK cells during exercise are driven by epinephrine and IL6, and blocking these pathways diminishes the tumor-suppressing effects of exercise.]

Top posts

Most liked on X and Bluesky
David Diamond
@LDLSkeptic · X

Exercise via epinephrine-induced mobilization of NK cells reduces tumor growth in mouse models. @tnseyfried @DominicDAgosti2 @ProfTimNoakes https://t.co/TImOVG89FH https://t.co/9dkwu00w28

Aug 22, 2020 · 14 likes · 1 share · 45,068 followers View post →
Lykke Sylow
@LykkeSylow · X

Exercise training may be an important adjuvant therapy to counteract cancer cachexia (as has also previously been shown by Pernille Højmann’s group https://t.co/Tc3VZkAlz5) Mechanisms may involve COPS2 to regulate myotube homeostasis. https://t.co/cfzhpifmJw

May 13, 2020 · 10 likes · 1 share · 3,011 followers View post →
筋肉博士
@muscle_penguin_ · X

@g_gafgarion 分泌量依存かどうかを調べた論文までいきつきませんでした。。すみません。 これはマウスにがん細胞を注入し,運動群と非運動群でがん病巣の増殖率の差を調べた研究で、IL-6を介したNK細胞動員の亢進が関与しているとのことです。 https://t.co/7UHLMQlSNx

Jul 19, 2021 · 3 likes · 38,068 followers View post →
Ji Zheng, Ph.D.
@smurfclumsy7 · X

Post this 2016 Cell Metabolism paper the third time! 再休养一个月可以试着重新开始跑步

Sep 21, 2022 · 1 like · 1 share · 60 followers View post →
Agingdoc
@agingdoc1 · X

@xhutid

Apr 25, 2022 · 42,751 followers View post →
@changingourmindset
@changermindset · X

RT @LDLSkeptic: Exercise via epinephrine-induced mobilization of NK cells reduces tumor growth in mouse models. @tnseyfried @DominicDAgost…

Aug 22, 2020 · 1 share · 2,829 followers View post →

All mentions

Paul Marsh
@PaulMarsh111 · X

@foundmyfitness https://t.co/LzspT02iPm https://t.co/sRH4bzDrNZ

Mar 7, 2025 · 72 followers View post →
Food Cut
@FoodCut1 · X

Referencia: Pedersen, L., Idorn, M., Olofsson, G. H., et al. (2016). Voluntary running suppresses tumor growth through epinephrine- and IL-6-dependent NK cell mobilization and redistribution. Cell Metabolism, 23(3), 554-562.

Sep 13, 2024 · 698 followers View post →
danceDdance
@_Ddance · X

RT @smurfclumsy7: Post this 2016 Cell Metabolism paper the third time! 再休养一个月可以试着重新开始跑步

Sep 21, 2022 · 1 share · 3 followers View post →
Ji Zheng, Ph.D.
@smurfclumsy7 · X

Post this 2016 Cell Metabolism paper the third time! 再休养一个月可以试着重新开始跑步

Sep 21, 2022 · 1 like · 1 share · 60 followers View post →
Agingdoc
@agingdoc1 · X

@xhutid

Apr 25, 2022 · 42,751 followers View post →
Symon Craig
@Mrsymon69 · X

Voluntary Running Suppresses Tumor Growth through Epinephrine- and IL-6-Dependent NK Cell Mobilization and Redistribution https://t.co/fetq08wmIv

Mar 16, 2022 · 19 followers View post →
Georgios Mavropalias, PhD
@doctorgeorgios · X

https://t.co/8cDjH9zkj1

Nov 5, 2021 · 490 followers View post →
Georgios Mavropalias, PhD
@doctorgeorgios · X

4 Improving immune system function There is evidence that exercise makes our natural killer cells more active and able to infiltrate and kill tumor cells more effectively https://t.co/8cDjH9hIUr

Oct 21, 2021 · 490 followers View post →
筋肉博士
@muscle_penguin_ · X

@g_gafgarion 分泌量依存かどうかを調べた論文までいきつきませんでした。。すみません。 これはマウスにがん細胞を注入し,運動群と非運動群でがん病巣の増殖率の差を調べた研究で、IL-6を介したNK細胞動員の亢進が関与しているとのことです。 https://t.co/7UHLMQlSNx

Jul 19, 2021 · 3 likes · 38,068 followers View post →
Russell Pachynski
@RPachynski · X

@charlesryanmd @onepeloton @DrChoueiri @HalaBorno @UMNHOT @CaPsurvivorship I'm in!

Dec 21, 2020 · 832 followers View post →
@changingourmindset
@changermindset · X

RT @LDLSkeptic: Exercise via epinephrine-induced mobilization of NK cells reduces tumor growth in mouse models. @tnseyfried @DominicDAgost…

Aug 22, 2020 · 1 share · 2,829 followers View post →
David Diamond
@LDLSkeptic · X

Exercise via epinephrine-induced mobilization of NK cells reduces tumor growth in mouse models. @tnseyfried @DominicDAgosti2 @ProfTimNoakes https://t.co/TImOVG89FH https://t.co/9dkwu00w28

Aug 22, 2020 · 14 likes · 1 share · 45,068 followers View post →
CB
@cebentrena · X

RT @LykkeSylow: Exercise training may be an important adjuvant therapy to counteract cancer cachexia (as has also previously been shown by…

May 14, 2020 · 1 share · 395 followers View post →
Lykke Sylow
@LykkeSylow · X

Exercise training may be an important adjuvant therapy to counteract cancer cachexia (as has also previously been shown by Pernille Højmann’s group https://t.co/Tc3VZkAlz5) Mechanisms may involve COPS2 to regulate myotube homeostasis. https://t.co/cfzhpifmJw

May 13, 2020 · 10 likes · 1 share · 3,011 followers View post →