Cell Metab April 2016 PMID 26916363

Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology in Humans with Obesity.

Faidon Magkos, Gemma Fraterrigo, Jun Yoshino, Courtney Luecking, Kyleigh Kirbach, Shannon C Kelly, Lisa de las Fuentes, Songbing He, Adewole L Okunade, Bruce W Patterson, Samuel Klein

Mentions

38
Peak: 3 in Jan 2021
across 6 sources since Sep 2019

Extended reach

50,832
potential audience

Total likes

65

Video views

1,362

Mentions per month

Sep 2019 – Dec 2025

Where it's discussed

  • News14 articles
  • X / Twitter10 posts
  • Instagram8 posts
  • Facebook3 posts
  • YouTube2 videos
  • Blogs1 articles

AI synopsis

What people are saying

Most posts recognize the metabolic and health benefits highlighted in the article, with comments such as 'cardiometabolic benefits of weight loss' and references to previous research, which reflect engagement with the scientific implications. However, some posts, like 'Talking in circles', reveal a dismissive tone that detracts from full engagement, while mentions of 'fatphobic' comments show a diverse range of perspectives influencing the overall assessment of impact.

AgreementNeither agree nor disagree

The discussions show mixed reactions; some acknowledge the benefits of weight loss on metabolic health, while others are dismissive or skeptical, indicating balanced support and disagreement.

InterestModerate interest

Overall, there is a moderate level of curiosity, especially in references to interesting findings and related studies, but some posts seem dismissive or jaded.

EngagementModerate engagement

Several posts engage deeply by referencing specifics of the research and related studies, indicating an active discussion rather than superficial comments.

ImpactModerate impact

The conversations suggest that the research has a meaningful influence on ongoing discussions within health and science communities, but not uniformly transformative.

Abstract in brief

  • The study explored how moderate (around 5%) and further progressive weight loss affect metabolic health in people with obesity, finding that even modest weight loss improves insulin sensitivity and cell function in adipose tissue, liver, and muscle.
  • Additional weight loss led to further improvements in insulin sensitivity, muscle cell function, and changes in adipose tissue, including reductions in fat mass, liver triglycerides, and alterations in gene expression related to cholesterol, lipids, and stress.
  • Overall, the findings suggest that losing a moderate amount of weight provides significant metabolic benefits, and further weight loss causes additional beneficial changes in adipose tissue biology and metabolic function.]

Top posts

Most liked on X and Bluesky
Kevin C. Klatt, PhD, RD
@KCKlatt · X

@whsource @NutritionNerd @DrMikeStanton @MichelleCardel @CJMannMD @YoungRock_H @dominicklemas @UFPHHP @UFMedicine @HibaJebeile @UF @UFExplore Reminds of this study by Kleins group - really interesting to see the progressive metabolic (static & dynamic) shifts with WL. https://t.co/ZFm0EPzxHL https://t.co/yU4LWvULQl

Jan 27, 2021 · 8 likes · 2 shares · 21,182 followers View post →
SANCYD
@SANCYDnutricion · X

Efectos de la pérdida de peso moderada y progresiva sobre la función metabólica y la biología del tejido adiposo en personas con obesidad. Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology https://t.co/pFUp48473z https://t.co/Hd22AIJPTX

Sep 14, 2022 · 3 likes · 2 shares · 3,028 followers View post →
Kristin Hoddy PhD RD
@KristinHoddyPhD · X

@adipose_regina Yes, the cardiometabolic benefits of weight loss in obesity is well established. Typically 5% weight loss is a clinical goal, but some research suggests 15% may be important for type 2 diabetes remission. https://t.co/ObKwJXen3U

Apr 13, 2021 · 3 likes · 1,333 followers View post →
Gregg S Mallett, PhD(c), ATC
@mallett_gregg · X

@LiveUthing @DoctorTro Talking in circles. Weight loss/fat loss has significant implications on cardiometabolic markers. https://t.co/jFnxfIZhS2

Nov 6, 2020 · 1 like · 1 share · 5 followers View post →
Michelle Cardel, PhD, MS, RD
@MichelleCardel · X

RT @KCKlatt: @whsource @NutritionNerd @DrMikeStanton @MichelleCardel @CJMannMD @YoungRock_H @dominicklemas @UFPHHP @UFMedicine @HibaJebeile…

Jan 27, 2021 · 2 shares · 11,640 followers View post →
Tanya Halliday, PhD, RD
@NutritionNerd · X

RT @KCKlatt: @whsource @NutritionNerd @DrMikeStanton @MichelleCardel @CJMannMD @YoungRock_H @dominicklemas @UFPHHP @UFMedicine @HibaJebeile…

Jan 27, 2021 · 2 shares · 9,208 followers View post →

All mentions

nono gonzalez
@nonogonzalez71 · X

RT @SANCYDnutricion: Efectos de la pérdida de peso moderada y progresiva sobre la función metabólica y la biología del tejido adiposo en pe…

Sep 14, 2022 · 2 shares · 1,152 followers View post →
maria yolanda castillo garcia
@whicha64 · X

RT @SANCYDnutricion: Efectos de la pérdida de peso moderada y progresiva sobre la función metabólica y la biología del tejido adiposo en pe…

Sep 14, 2022 · 2 shares · 20 followers View post →
SANCYD
@SANCYDnutricion · X

Efectos de la pérdida de peso moderada y progresiva sobre la función metabólica y la biología del tejido adiposo en personas con obesidad. Effects of Moderate and Subsequent Progressive Weight Loss on Metabolic Function and Adipose Tissue Biology https://t.co/pFUp48473z https://t.co/Hd22AIJPTX

Sep 14, 2022 · 3 likes · 2 shares · 3,028 followers View post →
Neil Abate
@AbateNeil · X

@libsoftiktok SCIENCE IS FATPHOBIC!

May 6, 2022 · 218 followers View post →
Kristin Hoddy PhD RD
@KristinHoddyPhD · X

@adipose_regina Yes, the cardiometabolic benefits of weight loss in obesity is well established. Typically 5% weight loss is a clinical goal, but some research suggests 15% may be important for type 2 diabetes remission. https://t.co/ObKwJXen3U

Apr 13, 2021 · 3 likes · 1,333 followers View post →
Bhopender Thakur
@TheBhupiThakur · X

RT @mallett_gregg: @LiveUthing @DoctorTro Talking in circles. Weight loss/fat loss has significant implications on cardiometabolic markers.…

Apr 11, 2021 · 1 share · 1,397 followers View post →
Tanya Halliday, PhD, RD
@NutritionNerd · X

RT @KCKlatt: @whsource @NutritionNerd @DrMikeStanton @MichelleCardel @CJMannMD @YoungRock_H @dominicklemas @UFPHHP @UFMedicine @HibaJebeile…

Jan 27, 2021 · 2 shares · 9,208 followers View post →
Michelle Cardel, PhD, MS, RD
@MichelleCardel · X

RT @KCKlatt: @whsource @NutritionNerd @DrMikeStanton @MichelleCardel @CJMannMD @YoungRock_H @dominicklemas @UFPHHP @UFMedicine @HibaJebeile…

Jan 27, 2021 · 2 shares · 11,640 followers View post →
Kevin C. Klatt, PhD, RD
@KCKlatt · X

@whsource @NutritionNerd @DrMikeStanton @MichelleCardel @CJMannMD @YoungRock_H @dominicklemas @UFPHHP @UFMedicine @HibaJebeile @UF @UFExplore Reminds of this study by Kleins group - really interesting to see the progressive metabolic (static & dynamic) shifts with WL. https://t.co/ZFm0EPzxHL https://t.co/yU4LWvULQl

Jan 27, 2021 · 8 likes · 2 shares · 21,182 followers View post →
Gregg S Mallett, PhD(c), ATC
@mallett_gregg · X

@LiveUthing @DoctorTro Talking in circles. Weight loss/fat loss has significant implications on cardiometabolic markers. https://t.co/jFnxfIZhS2

Nov 6, 2020 · 1 like · 1 share · 5 followers View post →
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