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Curr Biol April 2016 PMID 27085214

Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution.

Enzo Tagliazucchi, Leor Roseman, Mendel Kaelen, Csaba Orban, Suresh D Muthukumaraswamy, Kevin Murphy, Helmut Laufs, Robert Leech, John McGonigle, Nicolas Crossley, Edward Bullmore, Tim Williams, Mark Bolstridge, Amanda Feilding, David J Nutt

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Mentions

18
Peak: 5 in Apr 2016
across 4 sources since Apr 2016

Extended reach

177,145
potential audience

Total likes

6,221

Video views

96,782

Mentions per month

Apr 2016 – Dec 2025

Where it's discussed

  • X / Twitter7 posts
  • News7 articles
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

The overall discussion reflects a keen interest in how LSD affects brain connectivity and ego states, exemplified by descriptive language such as 'el viaje del cerebro' and mentions of network dysregulation, which suggest deep engagement. The tone varies from scientific support to curiosity about the psychedelic effects, indicating recognition of the study’s potential importance but also a focus on understanding the phenomena.

AgreementModerate agreement

Most discussions acknowledge and support the findings that LSD increases brain connectivity and relates to ego dissolution.

InterestHigh interest

The discussions show high interest, with phrases like 'el viaje del cerebro' and references to neural elevation and boundary dissolution.

EngagementHigh engagement

Posts are detailed, referencing specific neural networks and mechanisms, indicating substantial engagement.

ImpactModerate impact

While some posts emphasize the significance of the findings, others seem to focus more on scientific curiosity than practical implications, resulting in a moderate impact score.

Abstract in brief

  • LSD, a powerful psychedelic, affects the brain by increasing global connectivity, especially in areas involved with consciousness, perception, and self-awareness.
  • The study found that this increased brain connectivity under LSD correlates with experiences of ego dissolution, where the sense of self and boundaries with the environment become blurred.
  • These effects are linked to LSD's action on serotonin 2A receptors and cause the brain's usual organized networks to become more integrated and less modular.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Chris Timmermann
@neurodelia · X

These findings support previous findings of TOP networks being more prominently dysregulated (https://t.co/Dx2b5jsdRP) rather than sensory ones (https://t.co/1LFufNM3tz) during psychedelics 8/n

Mar 20, 2023 · 19 likes · 1 share · 11,894 followers View post →
Alejandro Piscitelli
@piscitelli · X

Así es el viaje del cerebro a bordo del LSD El 'ácido' eleva las conexiones neuronales y disuelve los límites entre las áreas cerebrales https://t.co/fQ36CEf6q8 @marbasch Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution https://t.co/oLIxKVn2xM https://t.co/5WwSP8R0zv

Mar 23, 2021 · 8 likes · 3 shares · 30,447 followers View post →
Mariano Amartino
@amartino · X

RT @piscitelli: Así es el viaje del cerebro a bordo del LSD El 'ácido' eleva las conexiones neuronales y disuelve los límites entre las áre…

Mar 24, 2021 · 3 shares · 29,204 followers View post →
Bruce Waynejrv
@Bob_Stinson1234 · X

Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution - ScienceDirect https://t.co/YQQqCnBQGj

Sep 14, 2022 · 5,119 followers View post →
fotis saltaferis HIV+ U=U
@Fsalt · X

RT @neurodelia: These findings support previous findings of TOP networks being more prominently dysregulated (https://t.co/Dx2b5jsdRP) rath…

Mar 26, 2023 · 1 share · 2,663 followers View post →
Ga Santamaria
@gaspliacob · X

RT @piscitelli: Así es el viaje del cerebro a bordo del LSD El 'ácido' eleva las conexiones neuronales y disuelve los límites entre las áre…

Mar 23, 2021 · 3 shares · 795 followers View post →

All mentions

fotis saltaferis HIV+ U=U
@Fsalt · X

RT @neurodelia: These findings support previous findings of TOP networks being more prominently dysregulated (https://t.co/Dx2b5jsdRP) rath…

Mar 26, 2023 · 1 share · 2,663 followers View post →
Chris Timmermann
@neurodelia · X

These findings support previous findings of TOP networks being more prominently dysregulated (https://t.co/Dx2b5jsdRP) rather than sensory ones (https://t.co/1LFufNM3tz) during psychedelics 8/n

Mar 20, 2023 · 19 likes · 1 share · 11,894 followers View post →
Bruce Waynejrv
@Bob_Stinson1234 · X

Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution - ScienceDirect https://t.co/YQQqCnBQGj

Sep 14, 2022 · 5,119 followers View post →
Maximiliano
@M_SG93 · X

RT @piscitelli: Así es el viaje del cerebro a bordo del LSD El 'ácido' eleva las conexiones neuronales y disuelve los límites entre las áre…

Mar 24, 2021 · 3 shares · 124 followers View post →
Mariano Amartino
@amartino · X

RT @piscitelli: Así es el viaje del cerebro a bordo del LSD El 'ácido' eleva las conexiones neuronales y disuelve los límites entre las áre…

Mar 24, 2021 · 3 shares · 29,204 followers View post →
Ga Santamaria
@gaspliacob · X

RT @piscitelli: Así es el viaje del cerebro a bordo del LSD El 'ácido' eleva las conexiones neuronales y disuelve los límites entre las áre…

Mar 23, 2021 · 3 shares · 795 followers View post →
Alejandro Piscitelli
@piscitelli · X

Así es el viaje del cerebro a bordo del LSD El 'ácido' eleva las conexiones neuronales y disuelve los límites entre las áreas cerebrales https://t.co/fQ36CEf6q8 @marbasch Increased Global Functional Connectivity Correlates with LSD-Induced Ego Dissolution https://t.co/oLIxKVn2xM https://t.co/5WwSP8R0zv

Mar 23, 2021 · 8 likes · 3 shares · 30,447 followers View post →
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