Genome Med April 2016 PMID 27102666

An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis.

Jun Chen, Kerry Wright, John M Davis, Patricio Jeraldo, Eric V Marietta, Joseph Murray, Heidi Nelson, Eric L Matteson, Veena Taneja

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Mentions

73
Peak: 2 in Nov 2020
across 5 sources since Jan 2020

Extended reach

51,699
potential audience

Total likes

2,133

Video views

45,704

Mentions per month

Jan 2020 – Jan 2025

Where it's discussed

  • News54 articles
  • Facebook8 posts
  • YouTube4 videos
  • Blogs4 articles
  • X / Twitter3 posts

AI synopsis

What people are saying

The discussions reflect a general acknowledgment of the article's findings, with mentions of how intestinal microbes relate to inflammation and disease, exemplified by statements like microbes increasing gut permeability. The tone is curious but not deeply analytical, indicating moderate engagement but recognition of the research's importance.

AgreementModerate agreement

Most discussions acknowledge the findings about gut microbes and their connection to rheumatoid arthritis, indicating general support.

InterestModerate interest

The topics of microbiome and autoimmune diseases seem moderately engaging to the audience, with some curiosity about the mechanisms involved.

EngagementNeutral engagement

The discussions are relatively surface-level, with some reference to specific concepts like intestinal permeability but little in-depth analysis.

ImpactModerate impact

The publication appears to hold some significance, especially in advancing understanding of RA, but the discussions don't reflect immediate or widespread influence.

Abstract in brief

  • The study found that rheumatoid arthritis (RA) patients have reduced gut microbial diversity, with specific expansion of rare microbes like Actinobacteria, and identified three genera (Collinsella, Eggerthella, Faecalibacterium) associated with the disease.
  • There is a strong link between Collinsella abundance and increased levels of inflammatory markers (like IL17A), as well as changes in metabolites that may promote inflammation and gut permeability, contributing to RA severity.
  • Experiments using human cell lines and a humanized mouse model confirmed that Collinsella can influence gut barrier function and worsen arthritis, highlighting its potential role in RA development and as a biomarker for the disease.

Top posts

Most liked on X and Bluesky
Julianne Taylor, Nutritionist
@juliannejtaylor · X

An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis. These appear to increase intestinal permeability and gut inflammation. https://t.co/7uBWvzuUa8

Jan 27, 2022 · 5,315 followers View post →
Dennis Ulrich
@D3NNIZZZ · X

RT @VeenaTaneja: An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis https://t.co/be71bpc0nk… #midweekmicro

Jan 5, 2020 · 1 share · 679 followers View post →

All mentions

Julianne Taylor, Nutritionist
@juliannejtaylor · X

An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis. These appear to increase intestinal permeability and gut inflammation. https://t.co/7uBWvzuUa8

Jan 27, 2022 · 5,315 followers View post →
Andreas Fürstenau
@AndreasFrstena2 · X

Dlaczego usuwanie toksyn pomaga w chorobach autoimmunologicznych https://t.co/7Ge73XWqmY via @YouTube

Nov 26, 2020 View post →
Dennis Ulrich
@D3NNIZZZ · X

RT @VeenaTaneja: An expansion of rare lineage intestinal microbes characterizes rheumatoid arthritis https://t.co/be71bpc0nk… #midweekmicro

Jan 5, 2020 · 1 share · 679 followers View post →