June 2016 PMID 27127236

NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice.

Hongbo Zhang, Dongryeol Ryu, Yibo Wu, Karim Gariani, Xu Wang, Peiling Luan, Davide D'Amico, Eduardo R Ropelle, Matthias P Lutolf, Ruedi Aebersold, Kristina Schoonjans, Keir J Menzies, Johan Auwerx

Mentions

115
Peak: 4 in Jul 2021
across 6 sources since Apr 2020

Extended reach

208,624
potential audience

Total likes

632

Video views

15,789

Mentions per month

Apr 2020 – Oct 2025

Where it's discussed

  • News42 articles
  • X / Twitter29 posts
  • Facebook22 posts
  • Blogs17 articles
  • YouTube3 videos
  • Reddit2 posts

AI synopsis

What people are saying

Several discussions highlight research findings, such as NAD+ supplementation improving mitochondrial function and extending lifespan in mice, demonstrating an interest in the biological mechanisms and future possibilities. The tone varies from supportive to cautious, reflecting a curiosity about the translational impact on human health.

AgreementModerate agreement

The discussions generally show support or interest in the potential of NAD+ boosting and its effects on longevity, with many referencing the positive outcomes observed in mice.

InterestModerate interest

Overall curiosity and attention are moderate, as many posts express optimism about aging and mitochondrial function but also acknowledge limitations of current evidence.

EngagementModerate engagement

The posts engage with scientific concepts and cite specific research, indications of a nuanced conversation around mechanisms and future potential.

ImpactModerate impact

There's recognition that this research could influence future studies and health approaches, suggesting moderate perceived significance.

Top posts

Most liked on X and Bluesky
Mikhail V. Blagosklonny, MD PhD Professor Oncology
@Blagosklonny · X

Nicotinamide riboside (NR), a NAD+ booster, extends lifespan in mice by a modest 4.7% and marginally statistically significant p = 0.034). Only in one study, despite all efforts. Not reproduced yet. https://t.co/fNO0tI7Awm

Jul 6, 2021 · 46 likes · 6 shares · 22,282 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice https://t.co/Q7mz5ee1eZ

Feb 28, 2023 · 19 likes · 1 share · 9,735 followers View post →
Agingdoc
@agingdoc1 · X

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice (2016) https://t.co/4hratITg92 https://t.co/i5bIsTOv1V

Jul 4, 2023 · 13 likes · 1 share · 42,693 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice (2016) https://t.co/Q7mz5eez4x

Feb 15, 2023 · 9 likes · 9,735 followers View post →
IntegralAnswers
@IntegralAnswers · X

3C/ Zhang et al., 2016 Claimed citation: NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice PMID: 27127236

Jul 18, 2025 · 8 likes · 8,486 followers View post →
ぽん
@yasu0804 · X

高齢マウスに投与したところ、筋肉の再生がみられ、寿命が延びたとする報告。 脳神経細胞、皮膚細胞に投与した実験でも、同様の効果が得られたという。 Science, 2016 DOI:10.1126/science.aaf2693 投与したのはナイアシンアミドリポシド https://t.co/1SnE7rcDmr

Apr 19, 2020 · 3 likes · 2 shares · 4,574 followers View post →

All mentions

Aubrai
@Aubrai_ · X

@Elizabe87759412 @BioProtocol

Sep 11, 2025 · 10,535 followers View post →
爱吃饭的超人强
@zxyyydshhh · X

@Isluckyethan 微笑哥,目前是这样的,我给你查询了相关文献研究,对于NMN30000目的是通过提升NAD+来改善身体机能,NAD+是细胞能量代谢的关键辅酶,随着年龄增长其含量会下降。 这个结果是在2016年Science发现的,文章叫《NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in

Aug 4, 2025 · 1 like · 357 followers View post →
IntegralAnswers
@IntegralAnswers · X

3C/ Zhang et al., 2016 Claimed citation: NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice PMID: 27127236

Jul 18, 2025 · 8 likes · 8,486 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/Rherwpcolk

May 14, 2025 · 3,163 followers View post →
Lyceum.
@0DevilsAdv0cate · X

How so? — متخصص في الbiotech قلي هذا promising: https://t.co/XPJh1bY1nc https://t.co/UGuxxJ24SM

Feb 14, 2024 · 335 followers View post →
Ichor Grad Student
@IchorGrad · X

1) https://t.co/Q7sZZwwZLw 2) https://t.co/Kxloyqa5z8 3) https://t.co/K7QrO22jFa

Dec 18, 2023 · 1 like · 2,732 followers View post →
ぱんでミク
@Mamo26218715 · X

RT @yasu0804: 高齢マウスに投与したところ、筋肉の再生がみられ、寿命が延びたとする報告。 脳神経細胞、皮膚細胞に投与した実験でも、同様の効果が得られたという。 Science, 2016 DOI:10.1126/science.aaf2693 投与したのはナイアシ…

Nov 14, 2023 · 2 shares · 207 followers View post →
Nuala Woulfe
@Nuala_Woulfe · X

Multiple studies in mice have shown that NAD+ supplementation , lengthens life span by improving mitochondrial function and activating specific sirtuin proteins. #NAD+ #health #mitochondria #energy #longevity https://t.co/zYS11bBtfR

Jul 31, 2023 · 1,792 followers View post →
Agingdoc
@agingdoc1 · X

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice (2016) https://t.co/4hratITg92 https://t.co/i5bIsTOv1V

Jul 4, 2023 · 13 likes · 1 share · 42,693 followers View post →
Protein with PE strategy
@cadospharma · X

RT @mike_lustgarten: NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice https://t.co/Q7mz5ee1eZ

Mar 1, 2023 · 1 share · 420 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice https://t.co/Q7mz5ee1eZ

Feb 28, 2023 · 19 likes · 1 share · 9,735 followers View post →
Mike Lustgarten, PhD
@mike_lustgarten · X

NAD⁺ repletion improves mitochondrial and stem cell function and enhances life span in mice (2016) https://t.co/Q7mz5eez4x

Feb 15, 2023 · 9 likes · 9,735 followers View post →
luis hernan graffe
@hernangraffe · X

RT @hernangraffe: https://t.co/fAcgz4RCf7

Aug 5, 2022 · 1 share · 3,163 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/fAcgz4RCf7

Aug 5, 2022 · 1 share · 3,163 followers View post →
tokatti
@tokatti_ · X

機能が上昇 加齢にともなう筋肉の減少がストップし寿命が伸びた https://t.co/jHbiVuu45H NMNそのものは食品にもふくまれる 特にブロッコリーが最高とのこと 加熱による安定性はまだ不明らしい #自分用メモ

Jul 17, 2022 · 1 like · 189 followers View post →
tokatti
@tokatti_ · X

機能が上昇 加齢にともなう筋肉の減少がストップし寿命が伸びた https://t.co/jHbiVutwg9 NMNそのものは食品にもふくまれる 特にブロッコリーが最高とのこと 加熱による安定性はまだ不明らしい #自分用メモ

Jul 17, 2022 · 189 followers View post →
Juhana Harju
@JuhanaHarju · X

@Yung_Blyat @HealthyFellow @_atanas_ @_INPST @ScienceCommuni2 @DHPSP @foodbeforepills @johnlapuma @fitmslax @maxlugavere @Dr_R_Kreaz @NitinGa35829582 @aydinnalper I am familiar with flush response and I don't like it. Have you been reading any research on nicotinamide riboside? https://t.co/JpoFCz0xcV

May 18, 2022 · 1 like · 1,691 followers View post →
L.A. Ajayi (Author)
@84LanreA · X

RT @lholmesFX: NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice https://t.co/iP5nPOkFC1

Nov 11, 2021 · 1 share · 49 followers View post →
Lee Holmes
@lholmesFX · X

NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice https://t.co/iP5nPOkFC1

Nov 9, 2021 · 1 share · 63 followers View post →
Ricky
@ricky89449195 · X

RT @Blagosklonny: Nicotinamide riboside (NR), a NAD+ booster, extends lifespan in mice by a modest 4.7% and marginally statistically signif…

Sep 18, 2021 · 6 shares · 314 followers View post →
Rapamycin Press
@RapamycinPress · X

RT @Blagosklonny: Nicotinamide riboside (NR), a NAD+ booster, extends lifespan in mice by a modest 4.7% and marginally statistically signif…

Jul 10, 2021 · 6 shares · 3,434 followers View post →
Computer_coinsBrazy
@WALLA_MAJIC · X

RT @Blagosklonny: Nicotinamide riboside (NR), a NAD+ booster, extends lifespan in mice by a modest 4.7% and marginally statistically signif…

Jul 7, 2021 · 6 shares · 1,286 followers View post →
Deric Cadora
@HighDefHealth · X

RT @Blagosklonny: Nicotinamide riboside (NR), a NAD+ booster, extends lifespan in mice by a modest 4.7% and marginally statistically signif…

Jul 6, 2021 · 6 shares · 867 followers View post →
Mikhail V. Blagosklonny, MD PhD Professor Oncology
@Blagosklonny · X

Nicotinamide riboside (NR), a NAD+ booster, extends lifespan in mice by a modest 4.7% and marginally statistically significant p = 0.034). Only in one study, despite all efforts. Not reproduced yet. https://t.co/fNO0tI7Awm

Jul 6, 2021 · 46 likes · 6 shares · 22,282 followers View post →
Dr Brad Stanfield
@BradStanfieldMD · X

@CharlesMBrenner @CharlesMBrenner NR extends yeast lifespan as per your research: https://t.co/VeVEGEaUT3 NR slightly increased lifespan in mice: https://t.co/yQcrU2ZqL9 From that data, NR may have the POTENTIAL to increase human lifespan. Why does that irritate you & what am I missing?

Mar 28, 2021 · 1 like · 29,650 followers View post →
Dr Brad Stanfield
@BradStanfieldMD · X

@CharlesMBrenner I'm not saying we have proof that NR, NRH, etc extends longevity in humans. I'm talking about the potential it has, and what the future may hold. Example: "NR delays senescence of neural SCs and melanocyte SCs and increases mouse life span" https://t.co/yQcrU2ZqL9

Mar 28, 2021 · 2 likes · 29,650 followers View post →
Mashun ONISHI
@Mashun_Onishi · X

NAD repletion improves mitochondrial and stem cell function and enhances life span in mice https://t.co/rJkTGeM9lU

Aug 12, 2020 · 1 like · 1,539 followers View post →
い〇ままん
@strawbemoonmam · X

RT @yasu0804: 高齢マウスに投与したところ、筋肉の再生がみられ、寿命が延びたとする報告。 脳神経細胞、皮膚細胞に投与した実験でも、同様の効果が得られたという。 Science, 2016 DOI:10.1126/science.aaf2693 投与したのはナイアシ…

Apr 20, 2020 · 2 shares · 457 followers View post →
ぽん
@yasu0804 · X

高齢マウスに投与したところ、筋肉の再生がみられ、寿命が延びたとする報告。 脳神経細胞、皮膚細胞に投与した実験でも、同様の効果が得られたという。 Science, 2016 DOI:10.1126/science.aaf2693 投与したのはナイアシンアミドリポシド https://t.co/1SnE7rcDmr

Apr 19, 2020 · 3 likes · 2 shares · 4,574 followers View post →