Eur Neuropsychopharmacol August 2016 PMID 27216487

Receptor interaction profiles of novel psychoactive tryptamines compared with classic hallucinogens.

Anna Rickli, Olivier D Moning, Marius C Hoener, Matthias E Liechti

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Abstract in brief

The study examined how novel psychoactive tryptamines (DiPT, 4OHDiPT, 4OHMET, 5MeOAMT, 5MeOMiPT) interact with monoamine receptors and transporters, comparing their effects to classic hallucinogens like LSD, psilocin, DMT, and mescaline.
All the tryptamines interacted with the 5HT2A receptor as partial or full agonists, but their binding affinity was generally lower than LSD, correlating with typical psychoactive doses. Some tryptamines also affected serotonin and norepinephrine transporters, similar to MDMA, but unlike LSD and mescaline, they did not strongly interact with adrenergic or dopaminergic receptors.
Overall, these findings suggest that the novel tryptamines may produce hallucinations similar to traditional serotonergic hallucinogens and could also have psychoactive effects resembling MDMA, based on their receptor interaction profiles.

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layomi

@_layomi_ · X

@chidustarr i can be bothered to explain it but this video helped me understand https://t.co/EQrdiFbgeL

May 21, 2023 · 1 like · 1,898 followers View post →

Awaken The “I AM” | r/microdosing | Mush Love

@LiveInMushLove · X

ELI5: 2-Minute #Neuroscience: #LSD | Neuroscientifically Challenged [Apr 2020] @neurochallenged https://t.co/fF4MHfKo26

Feb 21, 2022 · 739 followers View post →

:•:permagrin:•:

@ryebur · X

Receptor interaction profiles of novel psychoactive #tryptamines compared with classic #hallucinogens

Jun 10, 2020 · 534 followers View post →

PAN

@twitteerdePan · X

2-Minute Neuroscience: LSD or Lysergic acid diethylamide https://t.co/tveNQWUpvs

Apr 12, 2020 · 100 followers View post →