Int J Oncol August 2016 PMID 27279602

Naltrexone at low doses upregulates a unique gene expression not seen with normal doses: Implications for its use in cancer therapy.

Wai M Liu, Katherine A Scott, Jayne L Dennis, Elwira Kaminska, Alan J Levett, Angus G Dalgleish

Mentions

55
Peak: 19 in Sep 2022
across 4 sources since Oct 2018

Extended reach

97,249
potential audience

Total likes

61

Video views

3,351

Mentions per month

Oct 2018 – Feb 2025

Where it's discussed

  • X / Twitter47 posts
  • News4 articles
  • YouTube3 videos
  • Facebook1 posts

AI synopsis

What people are saying

The community shows curiosity about low doses of naltrexone and shares personal stories about managing health conditions like Crohn's and Takayasus, with phrases like 'asking my dr about starting LDN' and 'thinking about trying experimental medication.' The tone is casual and personal, emphasizing individual experiences over technical analysis, which reflects moderate interest and engagement but limited perceived broader impact.

AgreementNeither agree nor disagree

Most discussions around the article are neutral or exploratory, with some expressing curiosity and others showing skepticism.

InterestModerate interest

Participants show moderate interest, focusing on personal health experiences and potential treatments rather than deep scientific analysis.

EngagementModerate engagement

Posts frequently share personal health stories and ask questions, indicating a moderate level of engagement, but lack detailed scientific discussion.

ImpactNeutral impact

The discussions have limited perceived broad impact, mostly centered on individual cases and treatment considerations.

Abstract in brief

  • Low doses of naltrexone (LDN) uniquely alter gene expression related to cell cycle control and immune response, which is not seen with regular doses.
  • LDN can increase the expression of proapoptotic genes like BAD and BIK1 and, when used in specific treatment schedules, enhances the effectiveness of chemotherapy drugs by making cancer cells more sensitive.
  • Modifying treatment schedules, such as including a drug-free period after initial LDN treatment, can significantly boost the drug's ability to kill cancer cells, suggesting potential for improved cancer therapies with LDN.

Top posts

Most liked on X and Bluesky
Artie
@artiecarden_ · X

talking about my LDN research https://t.co/kdfFvHGl2I #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohns #adhd #autistic #chronicillness #chronicillnessvlogger #chronicallyillyoutuber #disabledyoutuber #disabledvlogger #healthupdate #mercaptopurine #adalimumab https://t.co/mt2a7CSguS

Sep 2, 2022 · 1 like · 3 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

chronically sick vlog https://t.co/kdfFvHoKba #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohns #adhd #autistic #chronicillness #chronicillnessvlogger #chronicallyillyoutuber #disabledyoutuber #disabledvlogger #healthupdate #mercaptopurine #adalimumab https://t.co/nGoo1DxbCF

Sep 1, 2022 · 1 like · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

talking about my health and medication https://t.co/kdfFvHGl2I #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohns #adhd #autistic #chronicillness #chronicillnessvlogger #chronicallyillyoutuber #disabledyoutuber #disabledvlogger #mercaptopurine #adalimumab https://t.co/QYaGLQXjNN

Aug 29, 2022 · 1 like · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: thinking about trying experimental medication https://t.co/kdfFvHoKba #disabilitytwitter #medication #takayasus #lowdosen…

Sep 1, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: chronically sick vlog https://t.co/kdfFvHoKba #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohns #adhd…

Sep 2, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

back on the chronically sick vlogs https://t.co/kdfFvHGl2I #disabilitytwitter #medication #takayasus #lowdosenaltrexone #adhd #autistic #chronicillness #chronicillnessvlogger #chronicallyillyoutuber #disabledyoutuber #disabledvlogger #healthupdate #mercaptopurine #adalimumab https://t.co/3R7HywysVB

Sep 1, 2022 · 2 shares · 2,073 followers View post →

All mentions

Artie
@artiecarden_ · X

RT @artiecarden_: talking about my LDN research https://t.co/kdfFvHGl2I #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohn…

Feb 14, 2025 · 3 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: talking about my LDN research https://t.co/kdfFvHGl2I #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohn…

Nov 25, 2022 · 3 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: back on the chronically sick vlogs https://t.co/kdfFvHGl2I #disabilitytwitter #medication #takayasus #lowdosenaltrexone…

Nov 22, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: don't forget to watch my video from this week: https://t.co/kdfFvHoKba I'm talking about how my health is doing and how m…

Nov 6, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: chronically sick vlog https://t.co/kdfFvHoKba #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohns #adhd…

Nov 6, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: thinking about trying experimental medication https://t.co/kdfFvHoKba #disabilitytwitter #medication #takayasus #lowdosen…

Nov 5, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: Steroids Suck & I'm Looking into Experimental Treatment | https://t.co/zKBVL0e4MQ New video letting you know how my heal…

Nov 5, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: talking about my health and medication https://t.co/kdfFvHGl2I #disabilitytwitter #medication #takayasus #lowdosenaltrexo…

Nov 4, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: getting tired of steroids https://t.co/kdfFvHoKba #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohns #a…

Nov 3, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: I totally forgot my video went live earlier today! Steroids Suck & I'm Looking into Experimental Treatment | https://t.c…

Nov 3, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: a health update: https://t.co/kdfFvHGl2I #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohns #adhd #auti…

Nov 2, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: talking about my health and medication https://t.co/kdfFvHGl2I #disabilitytwitter #medication #takayasus #lowdosenaltrexo…

Nov 1, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: don't forget to watch my video from this week: https://t.co/kdfFvHoKba I'm talking about how my health is doing and how m…

Oct 27, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: is LDN worth a shot? https://t.co/kdfFvHoKba #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohns #adhd #…

Oct 24, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: back on the chronically sick vlogs https://t.co/kdfFvHGl2I #disabilitytwitter #medication #takayasus #lowdosenaltrexone…

Sep 21, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: don't forget to watch my video from this week: https://t.co/kdfFvHoKba I'm talking about how my health is doing and how m…

Sep 13, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: talking about my health and medication https://t.co/kdfFvHGl2I #disabilitytwitter #medication #takayasus #lowdosenaltrexo…

Sep 8, 2022 · 1 share · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: crossingn my fingers something will work out https://t.co/kdfFvHGl2I #disabilitytwitter #medication #takayasus #lowdosena…

Sep 8, 2022 · 1 share · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: talking about my health and medication https://t.co/kdfFvHGl2I #disabilitytwitter #medication #takayasus #lowdosenaltrexo…

Sep 6, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

crossingn my fingers something will work out https://t.co/kdfFvHGl2I #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohns #adhd #autistic #chronicillness #chronicillnessvlogger #chronicallyillyoutuber #disabledyoutuber #disabledvlogger #healthupdate https://t.co/yV9MU6siaL

Sep 4, 2022 · 1 share · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: a health update: https://t.co/kdfFvHGl2I #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohns #adhd #auti…

Sep 4, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: is LDN worth a shot? https://t.co/kdfFvHoKba #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohns #adhd #…

Sep 4, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

is LDN worth a shot? https://t.co/kdfFvHoKba #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohns #adhd #autistic #chronicillness #chronicillnessvlogger #chronicallyillyoutuber #disabledyoutuber #disabledvlogger #healthupdate #mercaptopurine #adalimumab https://t.co/YzJbzHk5vd

Sep 3, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: getting tired of steroids https://t.co/kdfFvHoKba #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohns #a…

Sep 3, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: asking my dr about starting LDN https://t.co/kdfFvHoKba #disabilitytwitter #medication #takayasus #lowdosenaltrexone #cro…

Sep 3, 2022 · 1 share · 2,073 followers View post →
Artie
@artiecarden_ · X

asking my dr about starting LDN https://t.co/kdfFvHoKba #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohns #adhd #autistic #chronicillness #chronicillnessvlogger #chronicallyillyoutuber #disabledyoutuber #disabledvlogger #healthupdate #mercaptopurine #adalimumab https://t.co/wHyzdeIBxB

Sep 3, 2022 · 1 share · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: I totally forgot my video went live earlier today! Steroids Suck & I'm Looking into Experimental Treatment | https://t.c…

Sep 3, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: talking about my LDN research https://t.co/kdfFvHGl2I #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohn…

Sep 3, 2022 · 3 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

talking about my LDN research https://t.co/kdfFvHGl2I #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohns #adhd #autistic #chronicillness #chronicillnessvlogger #chronicallyillyoutuber #disabledyoutuber #disabledvlogger #healthupdate #mercaptopurine #adalimumab https://t.co/mt2a7CSguS

Sep 2, 2022 · 1 like · 3 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: chronically sick vlog https://t.co/kdfFvHoKba #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohns #adhd…

Sep 2, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

back on the chronically sick vlogs https://t.co/kdfFvHGl2I #disabilitytwitter #medication #takayasus #lowdosenaltrexone #adhd #autistic #chronicillness #chronicillnessvlogger #chronicallyillyoutuber #disabledyoutuber #disabledvlogger #healthupdate #mercaptopurine #adalimumab https://t.co/3R7HywysVB

Sep 1, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: thinking about trying experimental medication https://t.co/kdfFvHoKba #disabilitytwitter #medication #takayasus #lowdosen…

Sep 1, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

chronically sick vlog https://t.co/kdfFvHoKba #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohns #adhd #autistic #chronicillness #chronicillnessvlogger #chronicallyillyoutuber #disabledyoutuber #disabledvlogger #healthupdate #mercaptopurine #adalimumab https://t.co/nGoo1DxbCF

Sep 1, 2022 · 1 like · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

thinking about trying experimental medication https://t.co/kdfFvHoKba #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohns #adhd #autistic #chronicillness #chronicillnessvlogger #chronicallyillyoutuber #disabledyoutuber #disabledvlogger #healthupdate https://t.co/y3kmylBCtC

Aug 31, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

getting tired of steroids https://t.co/kdfFvHoKba #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohns #adhd #autistic #chronicillness #chronicillnessvlogger #chronicallyillyoutuber #disabledyoutuber #disabledvlogger #healthupdate #mercaptopurine #adalimumab https://t.co/DPFkNLwTw3

Aug 31, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

a health update: https://t.co/kdfFvHGl2I #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohns #adhd #autistic #chronicillness #chronicillnessvlogger #chronicallyillyoutuber #disabledyoutuber #disabledvlogger #healthupdate #mercaptopurine #adalimumab https://t.co/mC4NIGRUe1

Aug 30, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: talking about my health and medication https://t.co/kdfFvHGl2I #disabilitytwitter #medication #takayasus #lowdosenaltrexo…

Aug 30, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

talking about my health and medication https://t.co/kdfFvHGl2I #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohns #adhd #autistic #chronicillness #chronicillnessvlogger #chronicallyillyoutuber #disabledyoutuber #disabledvlogger #healthupdate #adalimumab https://t.co/8gt3GKzV8z

Aug 30, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

talking about my health and medication https://t.co/kdfFvHGl2I #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohns #adhd #autistic #chronicillness #chronicillnessvlogger #chronicallyillyoutuber #disabledyoutuber #disabledvlogger #mercaptopurine #adalimumab https://t.co/QYaGLQXjNN

Aug 29, 2022 · 1 like · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: don't forget to watch my video from this week: https://t.co/kdfFvHoKba I'm talking about how my health is doing and how m…

Aug 29, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

don't forget to watch my video from this week: https://t.co/kdfFvHoKba I'm talking about how my health is doing and how my meds are. RTs appreciated #DisabilityTwitter #Takayasus #TakayasusArteritis #Mercaptoputine #Adalimumab #LowDoseNaltrexone #cosybloggersclub https://t.co/m1AS9sV8rh

Aug 29, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

talking about my health and medication https://t.co/kdfFvHGl2I #disabilitytwitter #medication #takayasus #lowdosenaltrexone #crohns #adhd #autistic #chronicillness #chronicillnessvlogger #chronicallyillyoutuber #disabledyoutuber #disabledvlogger #healthupdate #mercaptopurine https://t.co/UNTPnfCS3a

Aug 28, 2022 · 1 share · 2,073 followers View post →
Artie
@artiecarden_ · X

don't forget to watch my video from this week: https://t.co/kdfFvHoKba I'm talking about how my health is doing and how my meds are. RTs appreciated #DisabilityTwitter #Takayasus #TakayasusArteritis #Mercaptoputine #Adalimumab #LowDoseNaltrexone #cosybloggersclub https://t.co/VRWsP65rud

Aug 28, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

RT @artiecarden_: Steroids Suck & I'm Looking into Experimental Treatment | https://t.co/zKBVL0e4MQ New video letting you know how my heal…

Aug 26, 2022 · 2 shares · 2,073 followers View post →
Artie
@artiecarden_ · X

Steroids Suck & I'm Looking into Experimental Treatment | https://t.co/zKBVL0e4MQ New video letting you know how my health and medical care plan are going

Aug 26, 2022 · 2 shares · 2,073 followers View post →
BEL W
@BelindzW · X

@LeahBracknell @DailyMirror @LeahBracknell Please research Low Dose Naltrexone and give it a try. It helped shrink my tumours in two months. I was Stage 3 https://t.co/ldcTyB24KL

Aug 24, 2019 · 35 followers View post →
QuestBest
@QuestBest · X

Naltrexone at low doses upregulates a unique gene expression not seen with normal doses: Implications for its use in cancer therapy https://t.co/4huoTLqIUv

Mar 22, 2019 · 353 followers View post →
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