@WallaceUcsf Necessary or just a correlation? Maybe differentiation & cell division just "finish" at same time. Epigenetic marks & chromatin must survive cell division in determination, and must be reversible in transdeterm & transdiff. Interesting article here: https://t.co/kkYazJ4M89
Why Cortical Neurons Cannot Divide, and Why Do They Usually Die in the Attempt?
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Jul 2021 – Feb 2023Where it's discussed
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Participants interpret the publication as highlighting the complex interplay between differentiation and cell division, with comments referencing epigenetic stability, chromatin, and the reversibility of cellular states. The tone suggests curiosity and recognition of the article's significance for fields like cellular biology and neuroscience, with phrases like 'interesting article' and questions about whether cell differentiation and division are simply correlated or causally connected.
The discussion indicates a general agreement with the article's insights about the relationship between differentiation, cell division, and epigenetic factors.
Participants show high curiosity, especially regarding the implications of neurons' inability to divide and epigenetic mechanisms.
Comments involve thoughtful considerations about the connection between cell differentiation and division, suggesting moderate to deep engagement.
The discussion hints at the broader importance of these findings for understanding cellular processes and potential implications in neuroscience and regenerative medicine.
Abstract in brief
- Cortical neurons are postmitotic cells, meaning they are specialized to not divide, but under certain conditions, they can reenter the cell cycle and replicate DNA.
- Their inability to divide is due to the high stability of their nuclear structure, which creates an energy barrier that prevents physical processes like mitosis.
- If cortical neurons attempt to replicate DNA without dividing, they typically die through apoptosis, mainly because their nuclear structure cannot support successful cell division.
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@WallaceUcsf Necessary or just a correlation? Maybe differentiation & cell division just "finish" at same time. Epigenetic marks & chromatin must survive cell division in determination, and must be reversible in transdeterm & transdiff. Interesting article here: https://t.co/kkYazJ4M89
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