J Neurosci Res April 2017 PMID 27402311

Why Cortical Neurons Cannot Divide, and Why Do They Usually Die in the Attempt?

Armando Aranda-Anzaldo, Myrna A R Dent

Mentions

6
Peak: 3 in Jul 2021
across 3 sources since Jul 2021

Extended reach

3,043
potential audience

Total likes

83

Video views

2,648

Mentions per month

Jul 2021 – Feb 2023

Where it's discussed

  • YouTube3 videos
  • Facebook2 posts
  • X / Twitter1 posts

AI synopsis

What people are saying

Participants interpret the publication as highlighting the complex interplay between differentiation and cell division, with comments referencing epigenetic stability, chromatin, and the reversibility of cellular states. The tone suggests curiosity and recognition of the article's significance for fields like cellular biology and neuroscience, with phrases like 'interesting article' and questions about whether cell differentiation and division are simply correlated or causally connected.

AgreementModerate agreement

The discussion indicates a general agreement with the article's insights about the relationship between differentiation, cell division, and epigenetic factors.

InterestHigh interest

Participants show high curiosity, especially regarding the implications of neurons' inability to divide and epigenetic mechanisms.

EngagementModerate engagement

Comments involve thoughtful considerations about the connection between cell differentiation and division, suggesting moderate to deep engagement.

ImpactModerate impact

The discussion hints at the broader importance of these findings for understanding cellular processes and potential implications in neuroscience and regenerative medicine.

Abstract in brief

  • Cortical neurons are postmitotic cells, meaning they are specialized to not divide, but under certain conditions, they can reenter the cell cycle and replicate DNA.
  • Their inability to divide is due to the high stability of their nuclear structure, which creates an energy barrier that prevents physical processes like mitosis.
  • If cortical neurons attempt to replicate DNA without dividing, they typically die through apoptosis, mainly because their nuclear structure cannot support successful cell division.

Top posts

Most liked on X and Bluesky
Michael A. Goldman
@MAG46XY · X

@WallaceUcsf Necessary or just a correlation? Maybe differentiation & cell division just "finish" at same time. Epigenetic marks & chromatin must survive cell division in determination, and must be reversible in transdeterm & transdiff. Interesting article here: https://t.co/kkYazJ4M89

Feb 26, 2023 · 1 like · 396 followers View post →

All mentions

Michael A. Goldman
@MAG46XY · X

@WallaceUcsf Necessary or just a correlation? Maybe differentiation & cell division just "finish" at same time. Epigenetic marks & chromatin must survive cell division in determination, and must be reversible in transdeterm & transdiff. Interesting article here: https://t.co/kkYazJ4M89

Feb 26, 2023 · 1 like · 396 followers View post →