June 2017 PMID 27572683

Cross-sex hormone therapy in transgender persons affects total body weight, body fat and lean body mass: a meta-analysis.

M Klaver, M J H J Dekker, R de Mutsert, J W R Twisk, M den Heijer

Mentions

23
Peak: 4 in Apr 2023
across 4 sources since Feb 2020

Extended reach

238,791
potential audience

Total likes

85

Video views

4,746

Mentions per month

Feb 2020 – Apr 2025

Where it's discussed

  • X / Twitter17 posts
  • YouTube3 videos
  • News2 articles
  • Bluesky1 posts

AI synopsis

What people are saying

The discussions reflect a nuanced interest with some posts emphasizing the physiological details, such as the loss of muscle mass in trans women and its implications, using precise figures like 'trans women lose around 2.4 kg lean body mass.' The tone varies from scientific analysis to societal questions, showing moderate impact, but the focus remains on understanding health and performance effects of hormone therapy.

AgreementModerate agreement

Most discussions acknowledge the research findings, especially around body composition changes, indicating general agreement.

InterestHigh interest

The mention of specific physiological effects and the implications for health and athletic performance demonstrates a high level of engagement and curiosity.

EngagementModerate engagement

Posts reference detailed results from the meta-analysis, such as lean body mass changes and implications for cardiometabolic risks, showing thoughtful engagement.

ImpactModerate impact

The discussions highlight concerns about health, athletic performance, and societal impacts, suggesting moderate recognition of the study's significance.

Abstract in brief

  • Cross-sex hormone therapy in transgender individuals causes changes in body weight, body fat, and lean body mass, with men to women gaining weight and fat but losing lean muscle, and women to men gaining weight and muscle but losing fat.
  • The meta-analysis found that male-to-female transgender people experience an average weight increase of about 1.8 kg, with an increase in body fat and a decrease in lean muscle, whereas female-to-male transgender people have similar weight gains with different body composition changes.
  • These changes in body composition may elevate the risk of cardiometabolic diseases, especially for male-to-female individuals who gain fat and lose muscle during hormone therapy.]

Top posts

Most liked on X and Bluesky
Greg
@BrowngaGreg · X

@StateOfSwimming @mara_yamauchi @FondOfBeetles @Scienceofsport @TLexercise 2) This meta analysis of several studies on changes in lean body mass in transgender individuals indicates that after 1 year GAHT the transwomen still have ~5kg more lean body mass than the 90th %ile of comparably aged women https://t.co/ohHEzP25Wm

Apr 26, 2023 · 8 likes · 2 shares · 2,184 followers View post →
Bugman Hegel
@FedPoasting · X

https://t.co/flyek6wSmu

Jun 10, 2023 · 7 likes · 2 shares · 86,782 followers View post →
Greg
@BrowngaGreg · X

2) These authors don’t make direct comparisons between transwomen and women, but they observed that transwomen lost an average of 2.4 kg lean body mass. Adult men typically have 12 kg more muscle mass than women... https://t.co/ohHEzP25Wm

Feb 4, 2023 · 7 likes · 1 share · 2,184 followers View post →
Bugman Hegel
@FedPoasting · X

@drewhjones @blessed2finesse @_LadyBadger_ https://t.co/flyek6wSmu

Jun 10, 2023 · 1 like · 86,782 followers View post →
annikusrex
@annikusrex · X

@BrowngaGreg @KimJonesICONS @cathydevine56 @jaketeater @FondOfBeetles @jayneair79 @icons_women @ekreps @JimBUWDawg @boysvswomen @runthinkwrite i'm not disputing the evidence re sex differences in childhood. i wonder tho if blockers (which can cause weight gain & osteopenia) followed by estrogen (also weight gain, https://t.co/gnPLyo7Tcr) might be a significant drag on performance even assuming prepuberty differences.

Jan 9, 2023 · 1 like · 305 followers View post →
TESG (Journal of Economic and Human Geography)
@tesg-journal.bsky.social · Bluesky

How do past infrastructures shape a green future? This study shows how Thailand repurposes Cold War sites as green assets, linking finance, power, and sustainability. Read the full open-access article: https://onlinelibrary.wiley.com/doi/10.1111/tesg.12660

Feb 24, 2025 · 1 like View post →

All mentions

leah leacwm! ^•^
@leacwm · X

@DeStijl8 @canoozie @ashleysbored You ask AI, I will do real research, whatever https://t.co/lxaVscltQH

Apr 22, 2025 · 113 followers View post →
TESG (Journal of Economic and Human Geography)
@tesg-journal.bsky.social · Bluesky

How do past infrastructures shape a green future? This study shows how Thailand repurposes Cold War sites as green assets, linking finance, power, and sustainability. Read the full open-access article: https://onlinelibrary.wiley.com/doi/10.1111/tesg.12660

Feb 24, 2025 · 1 like View post →
NishikiYotsuba
@NishikiYotsuba · X

@etcher10 @RepNancyMace Here's a host of reviews of medical care. https://t.co/7SVDcjaGum https://t.co/yu6HfntO3i https://t.co/uJHR9eIDD5 https://t.co/m5xD5gEWYX https://t.co/VxWxQpNBZh https://t.co/FZo7gXKpVb https://t.co/sYAEe4eSHG https://t.co/39KKtu1ykV https://t.co/3ruoiZrKAA

Nov 21, 2024 · 514 followers View post →
AcheJ
@AcheJ6 · X

RT @xxclusionary: https://t.co/flyek6wSmu

Jun 10, 2023 · 2 shares · 2,511 followers View post →
Kevin McGuire
@AmericanBear76 · X

RT @xxclusionary: https://t.co/flyek6wSmu

Jun 10, 2023 · 2 shares · 3,633 followers View post →
Bugman Hegel
@FedPoasting · X

@drewhjones @blessed2finesse @_LadyBadger_ https://t.co/flyek6wSmu

Jun 10, 2023 · 1 like · 86,782 followers View post →
Bugman Hegel
@FedPoasting · X

https://t.co/flyek6wSmu

Jun 10, 2023 · 7 likes · 2 shares · 86,782 followers View post →
StateOfSwimming.com
@StateOfSwimming · X

@MegaSexFalcon @catmatmc @Martina ‘My only objection’… ?

Apr 26, 2023 · 16,159 followers View post →
Sean Clark
@DrClarkIPresume · X

RT @BrowngaGreg: @StateOfSwimming @mara_yamauchi @FondOfBeetles @Scienceofsport @TLexercise 2) This meta analysis of several studies on cha…

Apr 26, 2023 · 2 shares · 472 followers View post →
Mara Yamauchi
@mara_yamauchi · X

RT @BrowngaGreg: @StateOfSwimming @mara_yamauchi @FondOfBeetles @Scienceofsport @TLexercise 2) This meta analysis of several studies on cha…

Apr 26, 2023 · 2 shares · 28,857 followers View post →
Greg
@BrowngaGreg · X

@StateOfSwimming @mara_yamauchi @FondOfBeetles @Scienceofsport @TLexercise 2) This meta analysis of several studies on changes in lean body mass in transgender individuals indicates that after 1 year GAHT the transwomen still have ~5kg more lean body mass than the 90th %ile of comparably aged women https://t.co/ohHEzP25Wm

Apr 26, 2023 · 8 likes · 2 shares · 2,184 followers View post →
Wendy
@me2intheuk · X

RT @BrowngaGreg: 2) These authors don’t make direct comparisons between transwomen and women, but they observed that transwomen lost an ave…

Feb 6, 2023 · 1 share · 2,312 followers View post →
Greg
@BrowngaGreg · X

2) These authors don’t make direct comparisons between transwomen and women, but they observed that transwomen lost an average of 2.4 kg lean body mass. Adult men typically have 12 kg more muscle mass than women... https://t.co/ohHEzP25Wm

Feb 4, 2023 · 7 likes · 1 share · 2,184 followers View post →
annikusrex
@annikusrex · X

@BrowngaGreg @KimJonesICONS @cathydevine56 @jaketeater @FondOfBeetles @jayneair79 @icons_women @ekreps @JimBUWDawg @boysvswomen @runthinkwrite i'm not disputing the evidence re sex differences in childhood. i wonder tho if blockers (which can cause weight gain & osteopenia) followed by estrogen (also weight gain, https://t.co/gnPLyo7Tcr) might be a significant drag on performance even assuming prepuberty differences.

Jan 9, 2023 · 1 like · 305 followers View post →
Bobby Labamba
@Beezer2000 · X

@cjonesaudio @Josie_26521 @MattZee0 @tonallycollette @BuckAngel cardiometabolic changes (which are what we see on the way to CVd and stroke). https://t.co/A0nEkEj3vO

Dec 5, 2022 · 384 followers View post →
ShieldCaptainGreenMage(Parody of a Parody Account)
@mage_you · X

@IAmDeathRay Okay fine, allow me to back it up with the research of some of the referenced scientists. https://t.co/BbYzHR1Cdq https://t.co/MCga1hLe4M https://t.co/N0toAFTs6v https://t.co/0QJnDgX4VJ https://t.co/9DbJ3JvnqL https://t.co/1ifj59dI7Z https://t.co/iXkLjnbpbE

Sep 20, 2021 · 338 followers View post →
Aoirann
@aoirann · X

@Phildidgee @GraceTveit @Scienceofsport @spikesandspokes Well I found your study. And it says nothing about athletic performance. At all. https://t.co/mPBirS8Bgy

Aug 27, 2020 · 276 followers View post →
Malcolm of the Marsh (He/Zir)
@MarshCommrade · X

@mr_croconuts @bluetrader660 @EvelynLouise8 @chasestrangio Because inhave a life and finding sources takes time. https://t.co/3ay7IWENRw The above article shows that trans men gain mucle mass on hrt and trans women lose muscle mass on hrt. It also shows that trans women gain fat mass and trans men lose fat mass.

Feb 18, 2020 · 212 followers View post →