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Am J Psychiatry November 2016 PMID 27609244

Using Neuroscience to Help Understand Fear and Anxiety: A Two-System Framework.

Joseph E LeDoux, Daniel S Pine

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Mentions

116
Peak: 23 in Jul 2021
across 5 sources since Nov 2020

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Total likes

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Nov 2020 – Oct 2025

Where it's discussed

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AI synopsis

What people are saying

The discussions highlight strong interest in the neuroscience aspects, with participants referencing specific brain regions like the amygdala and PFC, and noting how drugs and therapy align with the two-system model. The tone suggests an appreciation for the scientific depth and potential implications, using words like 'supports,' 'meshes well,' and 'new study' to convey both respect and curiosity about the article's ideas.

AgreementModerate agreement

Most discussions acknowledge the significance of the two-system framework, with some explicit references to LeDoux & Pine's work and recent studies supporting the idea.

InterestHigh interest

Posts show high curiosity, as evidenced by comments about wanting in-depth neuroscience explanations and referencing new research findings.

EngagementModerate engagement

Several comments delve into detailed mechanisms, such as the amygdala's role and therapy methods, indicating thoughtful engagement.

ImpactModerate impact

While some posts suggest the framework could influence understanding or treatments, most view the publication as an insightful but not yet transformative piece.

Abstract in brief

  • Recent neuroscience research has revealed how the brain detects and reacts to threats across various mammals, including humans, but this knowledge hasn't yet improved treatments for fear and anxiety disorders.
  • The authors argue that a key reason for this is the failure to distinguish between two types of responses to threats: the automatic behavioral and physiological reactions, and the conscious feelings of fear and anxiety that people report.
  • Recognizing these as two separate systems—a "two-system" framework—could help improve our understanding and treatment of fear and anxiety by focusing on different aspects of the threat response.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Joseph E. LeDoux "The Four Realms of Existence"
@theamygdaloid · X

New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and Pine 2016 Two Systems paper DOI: 10.1176/appi.ajp.2016.16030353 in AJP https://t.co/jbScpnLrpi

Jul 21, 2021 · 74 likes · 22 shares · 13,224 followers View post →
くらしげ
@t_kurashige0314 · X

脅威や不安に対する主観的な感情体験と行動および身体反応は核となる脳部位が異なることを神経心理学的知見から考察した論文です 扁桃体および周辺領域を基盤とする、不安に対する身体反応に作用する治療介入として注意バイアス修正がとりあげられています https://t.co/Okq15U6H6q

Aug 22, 2021 · 2 likes · 178 followers View post →
ℙ
@Reharmonization · X

@OfJaggedEdges You want that thick neuroscience talk, don't you? I've been reading this: https://t.co/2fdQtPKpyv 》

Dec 11, 2020 · 1 like · 133 followers View post →
Neuropsychology
@neuropsychblog · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 21, 2021 · 22 shares · 65,735 followers View post →
CLaE
@leafs_s · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 30, 2021 · 22 shares · 28,250 followers View post →
Gregg Caruso
@GreggDCaruso · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 21, 2021 · 22 shares · 24,049 followers View post →

All mentions

HealingHand
@HandHealin91784 · X

You CAN'T Die Before You Read This One Book (Exit Life Cycle) - NO BS Guide https://t.co/SQrGAlflBI via @YouTube

Oct 19, 2025 · 1,611 followers View post →
HealingHand
@HandHealin91784 · X

You CAN'T Die Before You Read This One Book (Exit Life Cycle) - NO BS Guide https://t.co/iUF1qllYtM via @YouTube

Oct 19, 2025 · 1,611 followers View post →
Danny Flinker
@FlinkerDanny · X

https://t.co/QAweeBZRT4

Oct 19, 2025 · 141 followers View post →
Rodney Leonard
@leonard5691 · X

https://t.co/kqo62qLIQi Perpetual fear and anxiety in PTSD and "loop therapy" at the unconscious level (psychodynamic): fracturing the loop to circumvent suicidal ideation through contemporary coping mechanisims and rationalism

Sep 19, 2024 · 81 followers View post →
くらしげ
@t_kurashige0314 · X

脅威や不安に対する主観的な感情体験と行動および身体反応は核となる脳部位が異なることを神経心理学的知見から考察した論文です 扁桃体および周辺領域を基盤とする、不安に対する身体反応に作用する治療介入として注意バイアス修正がとりあげられています https://t.co/Okq15U6H6q

Aug 22, 2021 · 2 likes · 178 followers View post →
Jungjoon Park
@kafkapple · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 30, 2021 · 22 shares · 42 followers View post →
CLaE
@leafs_s · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 30, 2021 · 22 shares · 28,250 followers View post →
Nick Frye
@NickFryeCox · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 22, 2021 · 22 shares · 232 followers View post →
Alan Lee @alanlee.bsky.social
@alanlflee · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 22, 2021 · 22 shares · 187 followers View post →
Matthias Michel
@MatthiasMichel_ · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 22, 2021 · 22 shares · 4,386 followers View post →
Hsing-Hao Lee
@hsinghaolee · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 22, 2021 · 22 shares · 283 followers View post →
Gregg Caruso
@GreggDCaruso · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 21, 2021 · 22 shares · 24,049 followers View post →
Hasan Ali, MSc
@serotoninkid · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 21, 2021 · 22 shares · 508 followers View post →
FND Portal - is no longer on X
@FndPortal · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 21, 2021 · 22 shares · 6,937 followers View post →
hakwan lau
@hakwanlau · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 21, 2021 · 22 shares · 7,409 followers View post →
Vincent Taschereau-Dumouchel
@Vincent_T_D · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 21, 2021 · 22 shares · 623 followers View post →
Miss Leesa
@drceowave · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 21, 2021 · 22 shares · 412 followers View post →
nicola sambuco
@NicolaSambuco · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 21, 2021 · 22 shares · 885 followers View post →
Fabie
@usernamefabie · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 21, 2021 · 22 shares · 133 followers View post →
Sanja
@Jevremovic · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 21, 2021 · 22 shares · 1,465 followers View post →
RJ Brassfield
@rjber15 · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 21, 2021 · 22 shares · 3,760 followers View post →
Neuropsychology
@neuropsychblog · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 21, 2021 · 22 shares · 65,735 followers View post →
Jordan Marrocco
@jordanmarrocco · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 21, 2021 · 22 shares · 1,300 followers View post →
Anton Pashkov
@anton_pashkov03 · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 21, 2021 · 22 shares · 1,675 followers View post →
George Kalarritis
@gkalarritis · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 21, 2021 · 22 shares · 919 followers View post →
ししまる
@shishimaru1970 · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 21, 2021 · 22 shares · 3,275 followers View post →
Yuki Kamitani
@ykamit · X

RT @theamygdaloid: New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and P…

Jul 21, 2021 · 22 shares · 16,018 followers View post →
Joseph E. LeDoux "The Four Realms of Existence"
@theamygdaloid · X

New study shows drugs tweak amygdala, while psychotherapy tweaks PFC. This meshes well with the message of LeDoux and Pine 2016 Two Systems paper DOI: 10.1176/appi.ajp.2016.16030353 in AJP https://t.co/jbScpnLrpi

Jul 21, 2021 · 74 likes · 22 shares · 13,224 followers View post →
Dr. Indrit Bègue
@indrit_begue · X

Using Neuroscience to Help Understand Fear and Anxiety: A Two-System Framework | American Journal of Psychiatry https://t.co/sCPNdwZ7dy

Jun 17, 2021 · 994 followers View post →
ℙ
@Reharmonization · X

@OfJaggedEdges You want that thick neuroscience talk, don't you? I've been reading this: https://t.co/2fdQtPKpyv 》

Dec 11, 2020 · 1 like · 133 followers View post →
valentinaglueck
@GluckValentina · X

@criticalneuro The two-system framework proposed by LeDoux & Pine may also account for this type of experience, I guess -> https://t.co/2OBf6i1aji

Nov 2, 2020 · 99 followers View post →