Nat Commun October 2016 PMID 27721479

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans.

Samuel A J Trammell, Mark S Schmidt, Benjamin J Weidemann, Philip Redpath, Frank Jaksch, Ryan W Dellinger, Zhonggang Li, E Dale Abel, Marie E Migaud, Charles Brenner

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Mentions

44
Peak: 2 in Feb 2021
across 5 sources since Jan 2019

Extended reach

142,072
potential audience

Total likes

2,124

Video views

68,078

Mentions per month

Jan 2019 – Aug 2025

Where it's discussed

  • News23 articles
  • YouTube6 videos
  • Blogs6 articles
  • X / Twitter5 posts
  • Facebook4 posts

AI synopsis

What people are saying

The group discusses the bioavailability of nicotinamide riboside, questioning its claimed uniqueness in humans and referencing other NAD precursors like NAM, which indicates moderate engagement and interest. The tone varies from curiosity to skepticism, exemplified by comments that challenge the study's conclusions and highlight potential conflicts of interest, reflecting a nuanced view of its impact.

AgreementNeither agree nor disagree

The discussions show skepticism and questioning about the study's claims, especially regarding its uniqueness and real-world relevance.

InterestModerate interest

Participants demonstrate curiosity about the research, raising questions and comparing it with other NAD precursors.

EngagementModerate engagement

Posts involve referencing the study, debating its validity, and considering its implications, indicating moderate engagement.

ImpactNeutral impact

The discourse suggests a cautious outlook on the significance of the findings, with some noting conflicts of interest and the need for further evidence.

Abstract in brief

  • Nicotinamide riboside (NR) is an effective and orally bioavailable supplement that can significantly increase NAD levels in both mice and humans, with human blood NAD levels rising up to 27 times after a single dose.
  • In human trials, doses of 100, 300, and 1000 mg of NR cause dose-dependent increases in blood NAD metabolites, and NR's pharmacokinetics in mice show it to be more efficient than other NAD precursors like nicotinic acid and nicotinamide.
  • The study also reveals that a previously unexpected metabolite, NAAD, is produced from NR and can serve as a sensitive biomarker to monitor successful NAD repletion in the body.]

Top posts

Most liked on X and Bluesky
Chris Masterjohn
@ChrisMasterjohn · X

I'm rereading this paper by @CharlesMBrenner titled "Nicotinamide riboside is uniquely and orally bioavailable in mice and humans." Can someone show me where they showed it "uniquely" does anything in humans? https://t.co/ttg5uMogJn

Feb 11, 2021 · 5 likes · 68,634 followers View post →
Andrés Suárez Glez.
@serdna975 · X

@ga_me88 @dani370z NAD+ (y ADPR): con niacina asquerosamente barata... ¿para qué gastar en derivados más eficientes si nos gusta el "subidón"? Yo tomo 0'5g/día (no quiero que me baje el colesterol). https://t.co/QsDOFxABG0 Descarté NAC. Especulativo respecto cáncer: frío. https://t.co/fgQFIP0yw3 https://t.co/YLKlKWktTr

Oct 22, 2019 · 1 like · 2,930 followers View post →
MartinK
@mdkO_o · X

Hi @PeterAttiaMD, loved your episode 216 about Metabolomics (https://t.co/dewY5Py2xI) in which the efficacy of oral administration of NR is strongly called into question. What do you think about this contrasting study https://t.co/WebswGJPxi - lots of conflicts of interest, n=1?

Oct 4, 2022 · 1 like · 61 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. https://t.co/J7BNUUiyWZ

Jan 31, 2019 · 2,242 followers View post →

All mentions

MartinK
@mdkO_o · X

Hi @PeterAttiaMD, loved your episode 216 about Metabolomics (https://t.co/dewY5Py2xI) in which the efficacy of oral administration of NR is strongly called into question. What do you think about this contrasting study https://t.co/WebswGJPxi - lots of conflicts of interest, n=1?

Oct 4, 2022 · 1 like · 61 followers View post →
MagChad
@magnesiumchad · X

@revhowardfurst @ENirenberg @ProfBootyPhD This one was done in mice. Even when NR is being hydrolized to NAM before uptake it has a clear advantage over plain NAM. https://t.co/EG1aNrZr0c

Nov 24, 2021 · 128 followers View post →
Chris Masterjohn
@ChrisMasterjohn · X

I'm rereading this paper by @CharlesMBrenner titled "Nicotinamide riboside is uniquely and orally bioavailable in mice and humans." Can someone show me where they showed it "uniquely" does anything in humans? https://t.co/ttg5uMogJn

Feb 11, 2021 · 5 likes · 68,634 followers View post →
Andrés Suárez Glez.
@serdna975 · X

@ga_me88 @dani370z NAD+ (y ADPR): con niacina asquerosamente barata... ¿para qué gastar en derivados más eficientes si nos gusta el "subidón"? Yo tomo 0'5g/día (no quiero que me baje el colesterol). https://t.co/QsDOFxABG0 Descarté NAC. Especulativo respecto cáncer: frío. https://t.co/fgQFIP0yw3 https://t.co/YLKlKWktTr

Oct 22, 2019 · 1 like · 2,930 followers View post →
Kelly A. Hogan Ph.D.
@Loose_Lab_Rat · X

Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. https://t.co/J7BNUUiyWZ

Jan 31, 2019 · 2,242 followers View post →