I'm rereading this paper by @CharlesMBrenner titled "Nicotinamide riboside is uniquely and orally bioavailable in mice and humans." Can someone show me where they showed it "uniquely" does anything in humans? https://t.co/ttg5uMogJn
Nicotinamide riboside is uniquely and orally bioavailable in mice and humans.
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Jan 2019 – Aug 2025Where it's discussed
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What people are saying
The group discusses the bioavailability of nicotinamide riboside, questioning its claimed uniqueness in humans and referencing other NAD precursors like NAM, which indicates moderate engagement and interest. The tone varies from curiosity to skepticism, exemplified by comments that challenge the study's conclusions and highlight potential conflicts of interest, reflecting a nuanced view of its impact.
The discussions show skepticism and questioning about the study's claims, especially regarding its uniqueness and real-world relevance.
Participants demonstrate curiosity about the research, raising questions and comparing it with other NAD precursors.
Posts involve referencing the study, debating its validity, and considering its implications, indicating moderate engagement.
The discourse suggests a cautious outlook on the significance of the findings, with some noting conflicts of interest and the need for further evidence.
Abstract in brief
- Nicotinamide riboside (NR) is an effective and orally bioavailable supplement that can significantly increase NAD levels in both mice and humans, with human blood NAD levels rising up to 27 times after a single dose.
- In human trials, doses of 100, 300, and 1000 mg of NR cause dose-dependent increases in blood NAD metabolites, and NR's pharmacokinetics in mice show it to be more efficient than other NAD precursors like nicotinic acid and nicotinamide.
- The study also reveals that a previously unexpected metabolite, NAAD, is produced from NR and can serve as a sensitive biomarker to monitor successful NAD repletion in the body.]
Top posts
Most liked on X and Bluesky@ga_me88 @dani370z NAD+ (y ADPR): con niacina asquerosamente barata... ¿para qué gastar en derivados más eficientes si nos gusta el "subidón"? Yo tomo 0'5g/día (no quiero que me baje el colesterol). https://t.co/QsDOFxABG0 Descarté NAC. Especulativo respecto cáncer: frío. https://t.co/fgQFIP0yw3 https://t.co/YLKlKWktTr
Hi @PeterAttiaMD, loved your episode 216 about Metabolomics (https://t.co/dewY5Py2xI) in which the efficacy of oral administration of NR is strongly called into question. What do you think about this contrasting study https://t.co/WebswGJPxi - lots of conflicts of interest, n=1?
Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. https://t.co/J7BNUUiyWZ
All mentions
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Hi @PeterAttiaMD, loved your episode 216 about Metabolomics (https://t.co/dewY5Py2xI) in which the efficacy of oral administration of NR is strongly called into question. What do you think about this contrasting study https://t.co/WebswGJPxi - lots of conflicts of interest, n=1?
@revhowardfurst @ENirenberg @ProfBootyPhD This one was done in mice. Even when NR is being hydrolized to NAM before uptake it has a clear advantage over plain NAM. https://t.co/EG1aNrZr0c
I'm rereading this paper by @CharlesMBrenner titled "Nicotinamide riboside is uniquely and orally bioavailable in mice and humans." Can someone show me where they showed it "uniquely" does anything in humans? https://t.co/ttg5uMogJn
@ga_me88 @dani370z NAD+ (y ADPR): con niacina asquerosamente barata... ¿para qué gastar en derivados más eficientes si nos gusta el "subidón"? Yo tomo 0'5g/día (no quiero que me baje el colesterol). https://t.co/QsDOFxABG0 Descarté NAC. Especulativo respecto cáncer: frío. https://t.co/fgQFIP0yw3 https://t.co/YLKlKWktTr
Nicotinamide riboside is uniquely and orally bioavailable in mice and humans. https://t.co/J7BNUUiyWZ