Nat Commun October 2016 PMID 27725675

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells.

Joanna Ratajczak, Magali Joffraud, Samuel A J Trammell, Rosa Ras, Núria Canela, Marie Boutant, Sameer S Kulkarni, Marcelo Rodrigues, Philip Redpath, Marie E Migaud, Johan Auwerx, Oscar Yanes, Charles Brenner, Carles Cantó

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Peak: 2 in Jul 2021

across 4 sources since Jul 2021

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177,620

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2,241

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Jul 2021 – Jan 2024

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The group expresses strong agreement with the article, citing previous studies and emphasizing that NMN's cellular uptake depends on extracellular conversion by NRK1, using language like 'confirmed' and 'shows.' The tone reflects a technical and professional interest, with references to specific pathways and researchers, highlighting both understanding and discussion of its significance in NAD metabolism.

AgreementModerate agreement

Most discussions support the findings, emphasizing the role of NRK1 in NAD metabolism, with comments referencing prior research and confirming the conclusions.

InterestHigh interest

Posts demonstrate high interest, mentioning specific studies, pathways, and implications for NAD biosynthesis.

EngagementModerate engagement

Participants actively discuss mechanisms, cite literature, and respond to each other's points, indicating moderate engagement.

ImpactModerate impact

The discussions suggest that the research influences ongoing debates and confirms existing theories, indicating a moderate impact.

Abstract in brief

NRK1 is essential for converting external nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN) into NAD, which is crucial for cellular functions.
NMN is first broken down outside the cell into NR, which is then absorbed and used to produce NAD inside the cell, highlighting the importance of extracellular conversion.
The study shows that NAD biosynthesis from other precursors like nicotinamide or nicotinic acid does not rely on NRK1, emphasizing its specific role in processing NR and NMN.

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Comparing NMN and NR: Best NAD+ Boosters for Longevity

This video analyzes NMN and NR as NAD+ boosters and their potential anti-aging benefits based on the latest studies. It explores their effects on longevity, insulin sensitivity, and overall health, highlighting the…

Solensis · Jan 6, 2022 1,710 views

Natural Methods to Boost NAD+ Levels for Healthy Aging

NADplus is a vital molecule supporting energy, cellular health, and DNA repair. As we age, NADplus levels decline, leading to signs of aging and health issues. This video offers five natural strategies to increase…

Vital Aging Lab · Nov 17, 2023 531 views

Evan K

@ewkerr · X

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells - PubMed https://t.co/xCJ60ic3Qg

Jan 8, 2024 · 2 likes · 51 followers View post →

Rene Sugar

@renesugar · X

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells https://t.co/wiutWXbeEi

Jan 5, 2024 · 3 likes · 3,952 followers View post →

Filip Čabart

@FilipCabart · X

@CharlesMBrenner @ScienceMagazine it also pointed me to your 2016 paper on extracelular metabolization of NMN to NR (https://t.co/JfeVBjZg9o) to enable cellular uptake. I understand this is not controversial and even Kim et al in 2020 also claims exogenous NMNs effect on NAD+ is via an indirect pathway?

Apr 6, 2023 · 147 followers View post →

Charles Brenner, PhD

@CharlesMBrenner · X

@TommyJones9901 known for a long long time.... it acts as NR https://t.co/FP6wDNAAMj

Apr 2, 2023 · 2 likes · 57,025 followers View post →

HairyBiologist

@BiologistHairy · X

@Dimon_Lers @CharlesMBrenner FYI https://t.co/C1JhlodV4a, https://t.co/7HG5hfAzKl

Jun 21, 2022 · 1 like · 127 followers View post →

Charles Brenner, PhD

@CharlesMBrenner · X

Feb 2, 2022 · 14 likes · 57,025 followers View post →

Superoxide Dismutase

@SDismutase · X

RT @CharlesMBrenner: Precisely because NMN won't go into cells intact (shown by @carlescanto, myself & others) https://t.co/mYFIZTIP7F, /42

Jul 6, 2021 · 1 share · 23 followers View post →

Charles Brenner, PhD

@CharlesMBrenner · X

Precisely because NMN won't go into cells intact (shown by @carlescanto, myself & others) https://t.co/mYFIZTIP7F, /42

Jul 4, 2021 · 17 likes · 1 share · 57,025 followers View post →

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells.

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Where it's discussed

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Abstract in brief

Top posts

All mentions

Comparing NMN and NR: Best NAD+ Boosters for Longevity

Natural Methods to Boost NAD+ Levels for Healthy Aging