Mol Psychiatry February 2018 PMID 27752075

Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial.

R E Frye, J Slattery, L Delhey, B Furgerson, T Strickland, M Tippett, A Sailey, R Wynne, S Rose, S Melnyk, S Jill James, J M Sequeira, E V Quadros

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Mentions

358
Peak: 37 in Oct 2025
across 6 sources since Jan 2019

Extended reach

213,702
potential audience

Total likes

9,734

Video views

78,035

Mentions per month

Jan 2019 – Nov 2025

Where it's discussed

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AI synopsis

What people are saying

The overall tone reflects strong agreement and enthusiasm, with posts citing specific research studies like Frye et al.'s clinical trial and mentioning biological explanations such as folate receptor autoantibodies. The detailed references and discussion of potential treatment implications reveal active engagement and recognition of the research's importance for future therapies.

AgreementModerate agreement

Most discussions strongly support the findings, using affirming phrases like 'really interesting,' 'promising,' and references to multiple studies, indicating widespread acceptance.

InterestHigh interest

Posts show high interest, with many users mentioning the potential benefits, linking to studies, and discussing biological mechanisms, displaying active curiosity.

EngagementHigh engagement

Several users cite detailed research, such as Frye et al.'s 2016 trial and mention of autoantibodies, demonstrating deep engagement and specific knowledge integration.

ImpactHigh impact

Multiple posts emphasize the significance of the research for treatment options, policy implications, and parental considerations, suggesting a high perceived impact.

Abstract in brief

  • The study found that high-dose folinic acid significantly improved verbal communication in children with autism and language impairment, especially in those with FRAA positivity, indicating a potentially more effective response in this subgroup.
  • Improvements were also observed in other behavioral measures, such as adaptive behavior and autism symptoms, with no increase in adverse effects, suggesting that folinic acid is generally safe and beneficial.
  • The results support the idea that folinic acid could be a promising treatment to enhance communication in children with ASD, particularly for those with specific autoantibody profiles, though larger studies are needed for confirmation.]

Top posts

Most liked on X and Bluesky
Meesh
@MeeshFL · X

@realdefender45 Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/xR2njEzhfk Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment in

Sep 22, 2025 · 19 likes · 6 shares · 2,543 followers View post →
Marcus Fidelicus
@MarcusFidelicus · X

@dr_andrealove If only you were a real doctor https://t.co/77CrIGQOri https://t.co/77CrIGQOri

Sep 23, 2025 · 9 likes · 304 followers View post →
Meesh
@MeeshFL · X

@Kozmocostello @zerohedge Here’s a few studies for you look through. Let me know when you’re done and I’ll send over some more. This is wonderful news for children and adults with autism. Who gets upset about this??! Jesus Folinic acid improves verbal communication in children with autism and language

Sep 22, 2025 · 8 likes · 2,543 followers View post →
Paul Whiteley
@PaulWhiteleyPhD · X

Parents say son with autism was nonverbal until trying an off-label drug that treats chemo side effects https://t.co/aQP1QMqzzA Folinic acid front-and-centre. Here's some science: https://t.co/D8SogVyhad & some more: https://t.co/u7QDQ6KZlr There's your autism research targets.

Feb 18, 2025 · 7 likes · 4,983 followers View post →
IntegralAnswers
@IntegralAnswers · X

14/ Frye RE, et al. Mol Psychiatry 2018. RCT: folinic acid improved language in FRAA-positive autistic children. https://t.co/GAuzN9T46O

Sep 5, 2025 · 5 likes · 1 share · 8,435 followers View post →
Meesh
@MeeshFL · X

@Juliesnark1731 Leucovorin is B9 folinic acid. Read up

Sep 22, 2025 · 4 likes · 2,543 followers View post →

All mentions

@KORIAutismFoundation
@KORIAutism · X

https://t.co/pCO3KiK6fy

Nov 4, 2025 · 111 followers View post →
Meesh
@MeeshFL · X

@RealDrJaneRuby @US_FDA Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/xR2njEzhfk Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies

Oct 5, 2025 · 2,543 followers View post →
Jincy Lindsey
@LindseyJin214 · X

RT @MeeshFL: @thegarybrecka Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with auti…

Oct 3, 2025 · 1 share · 235 followers View post →
BrainHeal(th)
@BrainHealth919 · X

@zbingeldac @Inversionism https://t.co/OWrWuLanJh

Oct 2, 2025 · 547 followers View post →
Camilo santos
@CamiloS72891790 · X

RT @MeeshFL: @stopvaccinating Vitamin B9 folinic acid (Leucovorin) Folinic acid improves verbal communication in children with autism and…

Oct 2, 2025 · 1 share · 144 followers View post →
BrainHeal(th)
@BrainHealth919 · X

@IzabelTheodora @Inversionism Dr. Richard Frye is a good resource on this. Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial: https://t.co/i8Ynu3bHHN

Oct 1, 2025 · 547 followers View post →
MinimalistCapitalist
@MinCapitalist · X

@howelcb @Rightanglenews They have, and it’s very promising. 71% of people with ASD symptoms have a problem where antibodies prevent folate from getting to the brain. This active forms of folate bypasses that and is able to pass the blood brain barrier. https://t.co/J8wIxsSkMV https://t.co/qexPNK4fpl

Oct 1, 2025 · 55 followers View post →
MAGADADX
@MAGADADX · X

@LTrain5407 @disillusioned0x @Rightanglenews Just in case grok doesn't get to it: Frye et al. (2016, USA) RCT: https://t.co/hZJeRfk0b1 Ramaekers et al. (2020, France) EFFET Trial: https://t.co/bvI2ROcxqE Ghaleiha et al. (2020, Iran): https://t.co/xXr3gzJEiM Panda et al. (2024, India): https://t.co/Bmvu45gmvY Wang et

Oct 1, 2025 · 441 followers View post →
MAGADADX
@MAGADADX · X

@disillusioned0x @Rightanglenews Frye et al. (2016, USA) RCT: https://t.co/hZJeRfk0b1 Ramaekers et al. (2020, France) EFFET Trial: https://t.co/bvI2ROcxqE Ghaleiha et al. (2020, Iran): https://t.co/xXr3gzJEiM Panda et al. (2024, India): https://t.co/Bmvu45gmvY Wang et al. (2025, China):

Oct 1, 2025 · 441 followers View post →
ftxclone
@ftxclone · X

@SwiftKardia @RepMTG @SecKennedy Orange man bad!!!! Meanwhile in science world: Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial

Oct 1, 2025 · 530 followers View post →
ftxclone
@ftxclone · X

@tajhokenf @RepMTG @SecKennedy Orange man bad!!!! Meanwhile in science world: Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial

Oct 1, 2025 · 530 followers View post →
ftxclone
@ftxclone · X

@Patti78746960 @RepMTG @SecKennedy Orange man bad!!!! Meanwhile in science world: Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial

Oct 1, 2025 · 530 followers View post →
ftxclone
@ftxclone · X

@ICONemily1999 @RepMTG @SecKennedy Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/J97ERp1RLr Cerebral Folate Deficiency, Folate

Oct 1, 2025 · 530 followers View post →
ftxclone
@ftxclone · X

@UniverseCommon @RepMTG @SecKennedy Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/J97ERp1RLr Cerebral Folate Deficiency, Folate

Oct 1, 2025 · 530 followers View post →
ftxclone
@ftxclone · X

@soughtgod @RepMTG @SecKennedy Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/J97ERp2pAZ Cerebral Folate Deficiency, Folate

Oct 1, 2025 · 530 followers View post →
ftxclone
@ftxclone · X

@gypsyluc @RepMTG @SecKennedy Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/J97ERp1RLr Cerebral Folate Deficiency, Folate

Oct 1, 2025 · 530 followers View post →
ftxclone
@ftxclone · X

@GatorNature @RepMTG @SecKennedy Trust the science bro: Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/J97ERp2pAZ Cerebral

Oct 1, 2025 · 530 followers View post →
ftxclone
@ftxclone · X

@Terrytoo69 @RepMTG @SecKennedy Trust the science bro: Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/J97ERp1RLr Cerebral

Oct 1, 2025 · 530 followers View post →
ftxclone
@ftxclone · X

@The38Super @RepMTG @SecKennedy It did for many. Not all but many. Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/J97ERp1RLr

Oct 1, 2025 · 530 followers View post →
ftxclone
@ftxclone · X

@AmandaE73788354 @RepMTG @SecKennedy Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/J97ERp1RLr Cerebral Folate Deficiency, Folate

Oct 1, 2025 · 530 followers View post →
ftxclone
@ftxclone · X

@wiguy45 @RepMTG @SecKennedy Ok: Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/J97ERp1RLr Cerebral Folate Deficiency,

Oct 1, 2025 · 530 followers View post →
Kristen
@Kris28456 · X

RT @ftxclone: @AllahJesusXenu @RepMTG @SecKennedy Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid…

Oct 1, 2025 · 1 share · 383 followers View post →
ftxclone
@ftxclone · X

@LindaCo13916874 @RepMTG @SecKennedy Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/J97ERp1RLr Cerebral Folate Deficiency, Folate

Oct 1, 2025 · 530 followers View post →
ftxclone
@ftxclone · X

@dayquiljones2 @RepMTG @SecKennedy Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/J97ERp1RLr Cerebral Folate Deficiency, Folate

Oct 1, 2025 · 530 followers View post →
ftxclone
@ftxclone · X

@NickK51654981 @RepMTG @SecKennedy Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/J97ERp1RLr Cerebral Folate Deficiency, Folate

Oct 1, 2025 · 530 followers View post →
ftxclone
@ftxclone · X

@BurtMaclin_FBI @RepMTG @mtgreenee @SecKennedy Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/J97ERp1RLr Cerebral Folate Deficiency, Folate

Oct 1, 2025 · 530 followers View post →
ftxclone
@ftxclone · X

@1776x_com @RepMTG @SecKennedy Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/J97ERp1RLr Cerebral Folate Deficiency, Folate

Oct 1, 2025 · 530 followers View post →
ftxclone
@ftxclone · X

@AllahJesusXenu @RepMTG @SecKennedy Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/J97ERp1RLr Cerebral Folate Deficiency, Folate

Oct 1, 2025 · 2 likes · 1 share · 530 followers View post →
ftxclone
@ftxclone · X

@JosephMothers2 @RepMTG @SecKennedy Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/J97ERp1RLr Cerebral Folate Deficiency, Folate

Oct 1, 2025 · 530 followers View post →
ftxclone
@ftxclone · X

@MikeRunsMiles @RepMTG @SecKennedy Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/J97ERp1RLr Cerebral Folate Deficiency, Folate

Oct 1, 2025 · 530 followers View post →
ftxclone
@ftxclone · X

@jimstewartson @RepMTG @SecKennedy Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/J97ERp1RLr Cerebral Folate Deficiency, Folate

Oct 1, 2025 · 1 like · 530 followers View post →
UltimApe
@ultimape · X

RT @ultimape: "Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placeb…

Oct 1, 2025 · 1 share · 6,694 followers View post →
ftxclone
@ftxclone · X

@tazer_blazer @RepMTG @SecKennedy You an autism researcher? Or you just assuming it doesn’t make sense? Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind

Oct 1, 2025 · 530 followers View post →
ftxclone
@ftxclone · X

@ChilloutVille @RepMTG @SecKennedy MTG is whacky but so are you. Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/J97ERp1RLr

Oct 1, 2025 · 1 like · 530 followers View post →
ftxclone
@ftxclone · X

@MargaretSusanM6 @KupoPewPew @RepMTG @SecKennedy You are playing politics with your child’s wellbeing. Sad. Studies about folinic acid: Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial

Oct 1, 2025 · 530 followers View post →
ftxclone
@ftxclone · X

@DwanePorter @RepMTG @SecKennedy How about there are studies!

Oct 1, 2025 · 530 followers View post →
Meesh
@MeeshFL · X

@thegarybrecka Vitamin B9 folinic acid (Leucovorin) studies Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/xR2njEzhfk Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies

Oct 1, 2025 · 3 likes · 1 share · 2,543 followers View post →
ITGeekMonkeys™
@SEODESIGNTECH · X

#AutismAwareness Leucovorin Calcium. Folinic acid improves verbal communication in children with autism and language impairment. https://t.co/Gns0tkAVXq https://t.co/AZGQI2NOZV

Sep 30, 2025 · 501 followers View post →
LizW
@cave-malum.bsky.social · Bluesky

More concerns: 2018 paper: 48 subjects, positive results pubmed.ncbi.nlm.nih.gov/27752075 Clinical trial: 0 subjects, terminated by FDA and sponsor for PI non-compliance. www.clinicaltrials.gov/study/NCT016... Yes, this is the same trial. Scroll down to Publications to confirm.

Sep 29, 2025 · 3 likes View post →
Meesh
@MeeshFL · X

@stopvaccinating Vitamin B9 folinic acid (Leucovorin) Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/xR2njEzhfk Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and

Sep 28, 2025 · 2 likes · 1 share · 2,543 followers View post →
Meesh
@MeeshFL · X

@MAHA_Action Folinic acid Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/xR2njEzhfk Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid)

Sep 26, 2025 · 2,543 followers View post →
Meesh
@MeeshFL · X

@Dtownfanman @TheChiefNerd @MartyMakary Folinic acid Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/xR2njEzhfk Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid)

Sep 26, 2025 · 2,543 followers View post →
mmkay15
@mmkay822 · X

@NYPoliticalMom https://t.co/STVs2PABJg Here’s the link if you’re interested. I think they’re jumping the gun but I hope this will stop desperate parents from ordering it online because their peds won’t prescribe it or give any kind of guidance.

Sep 23, 2025 · 163 followers View post →
Meesh
@MeeshFL · X

@HHSGov @DrOzCMS @US_FDA @NIH Folinic acid Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/xR2njEzhfk Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid)

Sep 23, 2025 · 2,543 followers View post →
Bobby Labamba
@Beezer2000 · X

@maideninthewood @C2665Michelle @Denver4VA https://t.co/d6m0GUD7UK

Sep 23, 2025 · 379 followers View post →
Kasia Zbróg
@rubi1605 · X

RT @MeeshFL: @realdefender45 Folinic acid improves verbal communication in children with autism and language impairment: a randomized doubl…

Sep 23, 2025 · 6 shares · 1,214 followers View post →
ಠ_ಠ
@SkylabTermite · X

RT @MeeshFL: @realdefender45 Folinic acid improves verbal communication in children with autism and language impairment: a randomized doubl…

Sep 23, 2025 · 6 shares · 272 followers View post →
The Duck Of Essex
@EssexAristocrat · X

@Mollyploofkins Study from 2016 Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/lUIPwLAyMv

Sep 23, 2025 · 347 followers View post →
Yellie
@YellieB4 · X

RT @MeeshFL: @realdefender45 Folinic acid improves verbal communication in children with autism and language impairment: a randomized doubl…

Sep 23, 2025 · 6 shares · 1,524 followers View post →
Qué pasa calabaza
@argehoqm · X

RT @MeeshFL: @realdefender45 Folinic acid improves verbal communication in children with autism and language impairment: a randomized doubl…

Sep 23, 2025 · 6 shares · 7 followers View post →
Meesh
@MeeshFL · X

@stopvaccinating I just read that study. It’s really interesting. I don’t think I saved it but I’ll look. Here’s some other information Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial

Sep 23, 2025 · 1 like · 2,543 followers View post →
Marcus Fidelicus
@MarcusFidelicus · X

@dr_andrealove If only you were a real doctor https://t.co/77CrIGQOri https://t.co/77CrIGQOri

Sep 23, 2025 · 9 likes · 304 followers View post →
Meesh
@MeeshFL · X

@Craig_A_Spencer Yes folinic acid (leucovorin) can help improve autism. I bet they would find 75% of these children have MTHFR. Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial.

Sep 22, 2025 · 2,543 followers View post →
JJ Hernandez
@JJ_Foxxx · X

RT @MeeshFL: @realdefender45 Folinic acid improves verbal communication in children with autism and language impairment: a randomized doubl…

Sep 22, 2025 · 6 shares · 943 followers View post →
Meesh
@MeeshFL · X

@Juliesnark1731 Leucovorin is B9 folinic acid. Read up

Sep 22, 2025 · 4 likes · 2,543 followers View post →
Meesh
@MeeshFL · X

@realdefender45 Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/xR2njEzhfk Cerebral Folate Deficiency, Folate Receptor Alpha Autoantibodies and Leucovorin (Folinic Acid) Treatment in

Sep 22, 2025 · 19 likes · 6 shares · 2,543 followers View post →
Meesh
@MeeshFL · X

@politicalFF @realdefender45 Here’s some studies and other reading material ♥️ best of luck to your little boy! I have two boys, 5 & 8 ☺️ Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/xR2njEzhfk

Sep 22, 2025 · 2 likes · 2,543 followers View post →
Meesh
@MeeshFL · X

@Kozmocostello @zerohedge Here’s a few studies for you look through. Let me know when you’re done and I’ll send over some more. This is wonderful news for children and adults with autism. Who gets upset about this??! Jesus Folinic acid improves verbal communication in children with autism and language

Sep 22, 2025 · 8 likes · 2,543 followers View post →
Bella LaLuna
@GratefulHuman17 · X

@tokintroll @EricLDaugh Here you go https://t.co/eTrxDCuvqF https://t.co/YyfA81Qk8z https://t.co/E0iNb1vLsd https://t.co/w5gyCRQoBY

Sep 22, 2025 · 1,125 followers View post →
Clint
@zenzibot · X

@A86Spez @zerohedge @RobertKennedyJr https://t.co/NP3tKmyluZ https://t.co/cU96NML8zc https://t.co/pWjoUhMFT0 https://t.co/C9kyLd66mR https://t.co/ftDZP8xLlw I put the links into grok and have it and have it summarize it for me. These are just a few of many particles on PubMed

Sep 22, 2025 · 1 like · 205 followers View post →
RL22
@RLtwenty2 · X

@cuntycatlady @simonmaechling This one has an additional 38 https://t.co/6rmbODGoP1

Sep 22, 2025 · 105 followers View post →
KB
@kinziefur · X

RT @kinziefur: @EricLDaugh For 9 yrs they've known that folinic acid can help autistic kids. This is the first time I've heard of it. Fol…

Sep 7, 2025 · 1 share · 1,122 followers View post →
KB
@kinziefur · X

@EricLDaugh For 9 yrs they've known that folinic acid can help autistic kids. This is the first time I've heard of it. Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/eSWQo8MnOB

Sep 7, 2025 · 1 share · 1,122 followers View post →
Maegan Laporte unacceptable independent
@maegan_laporte · X

RT @IntegralAnswers: 14/ Frye RE, et al. Mol Psychiatry 2018. RCT: folinic acid improved language in FRAA-positive autistic children. htt…

Sep 5, 2025 · 1 share · 5,683 followers View post →
IntegralAnswers
@IntegralAnswers · X

14/ Frye RE, et al. Mol Psychiatry 2018. RCT: folinic acid improved language in FRAA-positive autistic children. https://t.co/GAuzN9T46O

Sep 5, 2025 · 5 likes · 1 share · 8,435 followers View post →
Kumar
@IndiaAviator · X

@theliverdr What about this https://t.co/Jd05MX6AYs

May 26, 2025 · 25 followers View post →
S
@S1m681155011 · X

@Autism @MailOnline https://t.co/AfMEwnS8tA

Feb 19, 2025 · 152 followers View post →
Szyzygy
@Szyzygy2 · X

Parents say son with autism was nonverbal until trying an off-label drug that treats chemo side effects https://t.co/I0eb1OCy9P… Folinic acid front-and-centre. Here's some science: https://t.co/xi5h1JqiBU & some more: https://t.co/EGf0PDrUKl https://t.co/zN5zSlwGPJ

Feb 18, 2025 · 2 likes · 1,174 followers View post →
Paul Whiteley
@PaulWhiteleyPhD · X

Parents say son with autism was nonverbal until trying an off-label drug that treats chemo side effects https://t.co/aQP1QMqzzA Folinic acid front-and-centre. Here's some science: https://t.co/D8SogVyhad & some more: https://t.co/u7QDQ6KZlr There's your autism research targets.

Feb 18, 2025 · 7 likes · 4,983 followers View post →
Paul Whiteley
@PaulWhiteleyPhD · X

@BeAVoice4Autism Another tough question. I'd like to believe there was some common mechanism, something that 'all roads lead to', but the sheer complexity of the brain, central nervous system and other biology makes this look unlikely. There's clues: https://t.co/u7QDQ6LxaZ however...

Jan 22, 2025 · 1 like · 4,983 followers View post →
AoA
@AshesWillKill · X

https://t.co/c0E3p0w4Aq

Feb 19, 2024 · 230 followers View post →
TW
@TeeeeDubya · X

@drdenwalker Yes thankfully I did this a decade ago. Also “enriched flour” has folic acid in it which I avoid. Also very important for those with autism and consider folinic acid instead: https://t.co/JoktL5kDL1 https://t.co/2Z0nc5Gemw

Feb 18, 2024 · 3 likes · 222 followers View post →
Paul Whiteley
@PaulWhiteleyPhD · X

@SethUnderwood56 Possibly. The trials on folinic acid in the context of autism have tended to include this group e.g. https://t.co/HiK1Zuq8SV

Jan 22, 2024 · 2 likes · 4,983 followers View post →
Valerie
@BroskyValerie · X

Folinic acid improves verbal communication in children with autism and language impairment: https://t.co/4C9HZBc9ri

Jun 15, 2023 · 3 likes · 1,860 followers View post →
UltimApe
@ultimape · X

"Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial" https://t.co/s7jUPiqQ9p Citation 69? about mTOR. https://t.co/yjzhdfWijD Nice. https://t.co/gPfBFAe9r7

May 29, 2023 · 2 likes · 1 share · 6,694 followers View post →
maximumeffortminimized
@_dempster_ · X

@faustosette @Sean_Great_C137 @Babygravy9 no… folonic acid. https://t.co/OdyOiFCvON

Feb 17, 2023 · 239 followers View post →
LizzyMiln
@MilnLizzy · X

Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/TGoBPadsNn

Aug 20, 2022 · 73 followers View post →
Paul Whiteley
@PaulWhiteleyPhD · X

Speech Development Across Subgroups of Autistic Children: A Longitudinal Study https://t.co/EC2QF9C2Y2 Various trajectories. Possible biological intervention for some e.g. https://t.co/HiK1Zuq8SV

Apr 20, 2022 · 3 likes · 4,983 followers View post →
Paul Whiteley
@PaulWhiteleyPhD · X

@MxOolong Indeed. But where there is an identified biological issue (e.g. folate autoantibodies & use of folinic acid), denial of medical action is akin to acceptance of health inequality. And if it affects presentation e.g. https://t.co/HiK1Zuq8SV

Apr 19, 2022 · 4,983 followers View post →
Thinking Autism
@TweetingAutism · X

RT @PaulWhiteleyPhD: New U.S. autism guidelines call for early treatment https://t.co/YOjEuCm8Lg Further to last tweet. Note that 'treatmen…

Dec 16, 2019 · 1 share · 14,359 followers View post →
Paul Whiteley
@PaulWhiteleyPhD · X

New U.S. autism guidelines call for early treatment https://t.co/YOjEuCm8Lg Further to last tweet. Note that 'treatment' does not just solely include psychological/behavioural. For example: https://t.co/7A3jiKyfYK

Dec 16, 2019 · 2 likes · 1 share · 4,983 followers View post →
The Natural Health Blogger
@naturalhealthbl · X

Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/rBKkY6p8oK #Autism #Science #Health #FolicAcid #Methylation #MTHFR #Supplements #Diet #Nutrition

Mar 30, 2019 · 2,288 followers View post →
Wellness Pharmacy
@wellnesspharm · X

Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial https://t.co/iIjfwrE1Ev

Feb 11, 2019 · 1,194 followers View post →
Nathan Holladay
@nbholladay · X

Helped most with folate receptor antibody positive patients: Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial. - PubMed - NCBI https://t.co/PzbIT6sOVa

Jan 23, 2019 · 116 followers View post →
FRATtest™
@IliadFRATtest · X

RT @IliadFRATtest: Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind pl…

Jan 13, 2019 · 5 shares · 219 followers View post →