PubHawk
January 2017 PMID 27799272

Wide Variation in Reported Rates of Stroke Across Cohorts of Patients With Atrial Fibrillation.

Gene R Quinn, Olivia N Severdija, Yuchiao Chang, Daniel E Singer

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Mentions

44
Peak: 11 in Nov 2025
across 5 sources since Apr 2019

Extended reach

600,658
potential audience

Total likes

165

Video views

1,124

Mentions per month

Apr 2019 – Nov 2025

Where it's discussed

  • X / Twitter32 posts
  • Facebook5 posts
  • News3 articles
  • YouTube2 videos
  • Blogs2 articles

AI synopsis

What people are saying

Overall, the discussions reflect a strong consensus that the study exposes significant flaws in current stroke risk prediction methods, with phrases like 'crushes the notion' and calls to 'rethink' risk assessments. The tone is urgent and critical, emphasizing the need for personalized approaches and highlighting the broad implications for clinical practice, which underscores the high impact and deep engagement from the community.

AgreementStrong agreement

Most discussions highlight strong support for the paper’s findings, emphasizing that current risk assessment tools like CHADSVASC are unreliable, which reflects a consensus on the importance of reevaluating stroke risk estimation.

InterestHigh interest

The posts demonstrate high curiosity and concern about stroke risk variability, with repeated references to the paper's revelations about the limitations of existing scoring systems, indicating deep interest.

EngagementHigh engagement

Discussions include detailed references, such as mentions of specific studies, critiques of risk assessment methods, and calls to consider personalized approaches, showing active and in-depth engagement.

ImpactHigh impact

Many posts describe the paper as potentially transformative, arguing that it challenges established practices and could lead to changes in how clinical decisions are made for patients with atrial fibrillation, indicating a high level of perceived influenc

Abstract in brief

  • The study found that the reported annual stroke rates in patients with atrial fibrillation (AF) vary widely across different studies, with rates ranging from 0.45 to 9.28 per year, and these differences are not fully explained by factors like region or study design.
  • There is a significant discrepancy between the predicted stroke risks based on the CHADS2-VASc scoring system and the actual stroke rates observed in different populations, especially at lower risk scores. For example, many cohorts with a CHADS2-VASc score of 1 or 2 still reported low stroke rates, suggesting that the risk scores may not uniformly apply across different patient groups.
  • Overall, the findings indicate that stroke risk in AF patients is highly variable, which could impact how we use these risk scores to guide anticoagulant therapy and underscores the need for more personalized risk assessment approaches.
Read the full abstract

Top posts

Most liked on X and Bluesky
John Mandrola, MD
@drjohnm · X

Please look at Gene Quinn et al paper. The problem and this is warning. You can’t unsee the massive variance in stroke risk at a set CHADSVASC score. https://t.co/n2JKHLifnx Read paper. Save it. CHADSVASC calculator = folly https://t.co/WWpxS39KXk

Nov 11, 2025 · 65 likes · 11 shares · 69,013 followers View post →
John Mandrola, MD
@drjohnm · X

This paper crushes the notion of using CHADSVASC score. https://t.co/cBpug3K7rE We hardly know the untreated risk! https://t.co/pfysDYJARg

Mar 9, 2021 · 31 likes · 3 shares · 69,013 followers View post →
John Mandrola, MD
@drjohnm · X

@venkmurthy @sonodoc99 @VPrasadMDMPH @AndrewFoy82 This is a super important paper. Quinn et al. https://t.co/n2JKHLifnx It shows huge variation of stroke risk in untreated AF pts across CHADSVASC categories. The notion that a CHADVASC of X corresponds to Y stroke risk is utter fantasy.

Apr 1, 2019 · 18 likes · 4 shares · 69,013 followers View post →
John Mandrola, MD
@drjohnm · X

@DrLindaDykes @venkmurthy @pash22 @mancunianmedic @DrAoifeMolloy @MarshallProf @drtimwilson @AndrewFoy82 @AFPJournal Check out these 2 important papers This from @hoomankamel et al https://t.co/cAmpSAUMjg This from Quinn et al https://t.co/n2JKHLifnx What we DO NOT know in the AF-stroke space is incredible. Future generations will laugh at our worship of the CHADSVASC

Jun 30, 2019 · 12 likes · 5 shares · 69,013 followers View post →
John Mandrola, MD
@drjohnm · X

@bogdienache @SZDiederichsen @EJSMD One of the most under cited papers. IMO — shows we really don’t know un-treated stroke risk. (Link) That + such early termination makes we wonder about a potential pro-coagulant effect from XI cc @kaulcsmc https://t.co/kwnVfJCRkz

Nov 21, 2023 · 8 likes · 69,013 followers View post →
Jordan Strom, MD, MSc, FACC, FASE
@DocStrom · X

@adnanalkhouli @drpaulfriedman @DrTomEP @DJ_Lakkireddy @djc795 @ba_steinberg @davidrholmes2 @cardiacpolymath @SurajKapa @abhishek_mbbs @melchami99 @guroledip Agree with @djc795 re high competing risk of mortality and variable stroke rates among different cohorts. https://t.co/tITcoVUwQN

Dec 25, 2019 · 4 likes · 2 shares · 7,354 followers View post →

All mentions

JI Sáez de Ibarra S
@jisaezdeibarra · X

RT @drjohnm: Please look at Gene Quinn et al paper. The problem and this is warning. You can’t unsee the massive variance in stroke risk at…

Nov 13, 2025 · 11 shares · 1,376 followers View post →
Jinn-Yuh Guh
@guhjy · X

RT @drjohnm: Please look at Gene Quinn et al paper. The problem and this is warning. You can’t unsee the massive variance in stroke risk at…

Nov 13, 2025 · 11 shares · 139 followers View post →
Mohammad Elidy
@elidyynwa · X

RT @drjohnm: Please look at Gene Quinn et al paper. The problem and this is warning. You can’t unsee the massive variance in stroke risk at…

Nov 12, 2025 · 11 shares · 721 followers View post →
Raphael Bass MD
@RaphaelBass03 · X

RT @drjohnm: Please look at Gene Quinn et al paper. The problem and this is warning. You can’t unsee the massive variance in stroke risk at…

Nov 12, 2025 · 11 shares · 2,249 followers View post →
HAIDER AL TAII
@HaiderTaii · X

RT @drjohnm: Please look at Gene Quinn et al paper. The problem and this is warning. You can’t unsee the massive variance in stroke risk at…

Nov 12, 2025 · 11 shares · 486 followers View post →
Richard Schaaf
@RichardSchaaf7 · X

RT @drjohnm: Please look at Gene Quinn et al paper. The problem and this is warning. You can’t unsee the massive variance in stroke risk at…

Nov 12, 2025 · 11 shares · 158 followers View post →
Carlos Rubén
@caruben89 · X

RT @drjohnm: Please look at Gene Quinn et al paper. The problem and this is warning. You can’t unsee the massive variance in stroke risk at…

Nov 12, 2025 · 11 shares · 993 followers View post →
Nashwa Abdulsalam
@Nashwa_Salem_ · X

RT @drjohnm: Please look at Gene Quinn et al paper. The problem and this is warning. You can’t unsee the massive variance in stroke risk at…

Nov 12, 2025 · 11 shares · 1,159 followers View post →
Sahar Samimi, MD
@SaharSamimii · X

RT @drjohnm: Please look at Gene Quinn et al paper. The problem and this is warning. You can’t unsee the massive variance in stroke risk at…

Nov 11, 2025 · 11 shares · 1,250 followers View post →
Anish Koka, MD
@anish_koka · X

RT @drjohnm: Please look at Gene Quinn et al paper. The problem and this is warning. You can’t unsee the massive variance in stroke risk at…

Nov 11, 2025 · 11 shares · 27,781 followers View post →
John Mandrola, MD
@drjohnm · X

Please look at Gene Quinn et al paper. The problem and this is warning. You can’t unsee the massive variance in stroke risk at a set CHADSVASC score. https://t.co/n2JKHLifnx Read paper. Save it. CHADSVASC calculator = folly https://t.co/WWpxS39KXk

Nov 11, 2025 · 65 likes · 11 shares · 69,013 followers View post →
Joseph N Macaluso MD FACS
@MacalusoJoseph · X

https://t.co/xJATxxuzpz Conclusions: majority of cohorts did not observe #stroke rates that would indicate a clear expected net #clinical benefit for #anticoagulating #AF patients with CHA2DS2-VASc scores of 1 or 2. @ACCinTouch @AmerMedicalAssn @American_Heart @CardiologyToday

Feb 16, 2025 · 1,875 followers View post →
John Mandrola, MD
@drjohnm · X

@bogdienache @SZDiederichsen @EJSMD One of the most under cited papers. IMO — shows we really don’t know un-treated stroke risk. (Link) That + such early termination makes we wonder about a potential pro-coagulant effect from XI cc @kaulcsmc https://t.co/kwnVfJCRkz

Nov 21, 2023 · 8 likes · 69,013 followers View post →
Ash Paul
@pash22 · X

RT @drjohnm: @DrLindaDykes @venkmurthy @pash22 @mancunianmedic @DrAoifeMolloy @MarshallProf @drtimwilson @AndrewFoy82 @AFPJournal Check out…

Apr 18, 2023 · 5 shares · 32,306 followers View post →
Sonya
@sonyaheatherb · X

RT @drjohnm: @DrLindaDykes @venkmurthy @pash22 @mancunianmedic @DrAoifeMolloy @MarshallProf @drtimwilson @AndrewFoy82 @AFPJournal Check out…

Apr 18, 2023 · 5 shares · 552 followers View post →
Dr Anastasia Mihailidou FAHA FCSANZ FESC
@AnastasiaSMihai · X

RT @drjohnm: This paper crushes the notion of using CHADSVASC score. https://t.co/cBpug3K7rE We hardly know the untreated risk! https://…

Mar 9, 2021 · 3 shares · 19,396 followers View post →
JP Sand
@JPSand5 · X

RT @drjohnm: This paper crushes the notion of using CHADSVASC score. https://t.co/cBpug3K7rE We hardly know the untreated risk! https://…

Mar 9, 2021 · 3 shares · 202 followers View post →
Dr Kit Byatt
@Laconic_doc · X

RT @drjohnm: This paper crushes the notion of using CHADSVASC score. https://t.co/cBpug3K7rE We hardly know the untreated risk!

Mar 9, 2021 · 3 shares · 4,602 followers View post →
John Mandrola, MD
@drjohnm · X

This paper crushes the notion of using CHADSVASC score. https://t.co/cBpug3K7rE We hardly know the untreated risk! https://t.co/pfysDYJARg

Mar 9, 2021 · 31 likes · 3 shares · 69,013 followers View post →
John Mandrola, MD
@drjohnm · X

@DrJasonAndrade 1) Would you have expected lower? 2) I wanna push back on your projected stroke rate. I think we kid ourselves thinking we know the annual untreated stroke rate. See one of my faves: Quinn et al https://t.co/6G3U9HG1Gv

Sep 21, 2020 · 2 likes · 69,013 followers View post →
Atrial Fibrillation
@AFib_Disease · X

RT @DocStrom: @adnanalkhouli @drpaulfriedman @DrTomEP @DJ_Lakkireddy @djc795 @ba_steinberg @davidrholmes2 @cardiacpolymath @SurajKapa @abhi…

Dec 25, 2019 · 2 shares · 1,347 followers View post →
NeuroCardiology
@norocardiology · X

RT @DocStrom: @adnanalkhouli @drpaulfriedman @DrTomEP @DJ_Lakkireddy @djc795 @ba_steinberg @davidrholmes2 @cardiacpolymath @SurajKapa @abhi…

Dec 25, 2019 · 2 shares · 1,074 followers View post →
Jordan Strom, MD, MSc, FACC, FASE
@DocStrom · X

@adnanalkhouli @drpaulfriedman @DrTomEP @DJ_Lakkireddy @djc795 @ba_steinberg @davidrholmes2 @cardiacpolymath @SurajKapa @abhishek_mbbs @melchami99 @guroledip Agree with @djc795 re high competing risk of mortality and variable stroke rates among different cohorts. https://t.co/tITcoVUwQN

Dec 25, 2019 · 4 likes · 2 shares · 7,354 followers View post →
Madhusree⚕️ Singh, MD
@thinkalot · X

RT @drjohnm: @DrLindaDykes @venkmurthy @pash22 @mancunianmedic @DrAoifeMolloy @MarshallProf @drtimwilson @AndrewFoy82 @AFPJournal Check out…

Jun 30, 2019 · 5 shares · 3,360 followers View post →
Edward Schenck MD
@edschenck · X

RT @drjohnm: @DrLindaDykes @venkmurthy @pash22 @mancunianmedic @DrAoifeMolloy @MarshallProf @drtimwilson @AndrewFoy82 @AFPJournal Check out…

Jun 30, 2019 · 5 shares · 1,028 followers View post →
Dr Linda Dykes has moved to Bluesky
@DrLindaDykes · X

RT @drjohnm: @DrLindaDykes @venkmurthy @pash22 @mancunianmedic @DrAoifeMolloy @MarshallProf @drtimwilson @AndrewFoy82 @AFPJournal Check out…

Jun 30, 2019 · 5 shares · 31,886 followers View post →
John Mandrola, MD
@drjohnm · X

@DrLindaDykes @venkmurthy @pash22 @mancunianmedic @DrAoifeMolloy @MarshallProf @drtimwilson @AndrewFoy82 @AFPJournal Check out these 2 important papers This from @hoomankamel et al https://t.co/cAmpSAUMjg This from Quinn et al https://t.co/n2JKHLifnx What we DO NOT know in the AF-stroke space is incredible. Future generations will laugh at our worship of the CHADSVASC

Jun 30, 2019 · 12 likes · 5 shares · 69,013 followers View post →
Camilla Alderighi
@camialderighi · X

RT @drjohnm: @venkmurthy @sonodoc99 @VPrasadMDMPH @AndrewFoy82 This is a super important paper. Quinn et al. https://t.co/n2JKHLifnx It sh…

Apr 2, 2019 · 4 shares · 508 followers View post →
Ritu Thamman MD
@iamritu · X

RT @drjohnm: @venkmurthy @sonodoc99 @VPrasadMDMPH @AndrewFoy82 This is a super important paper. Quinn et al. https://t.co/n2JKHLifnx It sh…

Apr 2, 2019 · 4 shares · 31,840 followers View post →
Siyab Panhwar, MD
@DrSiyabMD · X

RT @drjohnm: @venkmurthy @sonodoc99 @VPrasadMDMPH @AndrewFoy82 This is a super important paper. Quinn et al. https://t.co/n2JKHLifnx It sh…

Apr 1, 2019 · 4 shares · 11,376 followers View post →
Vasu Palli
@vpalli · X

RT @drjohnm: @venkmurthy @sonodoc99 @VPrasadMDMPH @AndrewFoy82 This is a super important paper. Quinn et al. https://t.co/n2JKHLifnx It sh…

Apr 1, 2019 · 4 shares · 61 followers View post →
John Mandrola, MD
@drjohnm · X

@venkmurthy @sonodoc99 @VPrasadMDMPH @AndrewFoy82 This is a super important paper. Quinn et al. https://t.co/n2JKHLifnx It shows huge variation of stroke risk in untreated AF pts across CHADSVASC categories. The notion that a CHADVASC of X corresponds to Y stroke risk is utter fantasy.

Apr 1, 2019 · 18 likes · 4 shares · 69,013 followers View post →