PubHawk
Neurotherapeutics April 2017 PMID 27928708

Withania somnifera Reverses Transactive Response DNA Binding Protein 43 Proteinopathy in a Mouse Model of Amyotrophic Lateral Sclerosis/Frontotemporal Lobar Degeneration.

Kallol Dutta, Priyanka Patel, Reza Rahimian, Daniel Phaneuf, Jean-Pierre Julien

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Mentions

8
Peak: 4 in Jan 2020
across 3 sources since Jan 2020

Extended reach

101,974
potential audience

Total likes

2,212

Video views

93,041

Mentions per month

Jan 2020 – Aug 2025

Where it's discussed

  • X / Twitter4 posts
  • YouTube2 videos
  • News2 articles

AI synopsis

What people are saying

Comments such as 'Let's party' and mentions of making supplement stacks suggest a casual attitude and mild curiosity, while references to specific extracts like Ashwagandha’s potential benefits indicate some recognition of the research's relevance, but the tone remains mostly superficial without in-depth analysis or strong opinions.

AgreementNeither agree nor disagree

The discussions are mixed; some posts show curiosity or mild support, but none strongly affirm or oppose the research findings.

InterestModerate interest

There is slight interest expressed, especially through posts suggesting practical applications like supplement stacks.

EngagementNeutral engagement

The comments are mostly casual and do not deeply explore the scientific details, indicating limited engagement.

ImpactNeutral impact

Overall, the discussions hint at some awareness but do not demonstrate significant influence or consensus on the research's importance.

Abstract in brief

  • Abnormal TDP-43 mislocalization is linked to ALS and FTLD-U, and targeting NF-κB may help treat these conditions.
  • Oral administration of Ashwagandha extract in transgenic mice improved motor and cognitive functions, reduced neuroinflammation, and enhanced neuromuscular junctions.
  • The treatment reversed TDP-43 mislocalization and aggregation in neurons, indicating that Ashwagandha could be a potential therapy for TDP-43-related diseases.
Read the full abstract

Top posts

Most liked on X and Bluesky
EndALS
@FinishALS · X

If you’re looking into making your own supplement stack to try and fight ALS, consider making ashwagandha one of your choices: https://t.co/PrSCWo2tka

Jan 16, 2020 · 7 likes · 2,470 followers View post →
EndALS
@FinishALS · X

@aliciadubinski https://t.co/PrSCWo2tka and https://t.co/WgFLrRBLzc And https://t.co/1TPiqQY1cU

Jan 20, 2020 · 4 likes · 2,470 followers View post →
No More Excuses ALS Watchdogs!
@als_now · X

Let's party. https://t.co/utWOdtGcAa

Jan 22, 2020 · 1 like · 3,789 followers View post →
Rich
@Richard52950257 · X

Ashwaganda Report https://t.co/l7el58rCol

Jan 21, 2020 · 205 followers View post →

All mentions

No More Excuses ALS Watchdogs!
@als_now · X

Let's party. https://t.co/utWOdtGcAa

Jan 22, 2020 · 1 like · 3,789 followers View post →
Rich
@Richard52950257 · X

Ashwaganda Report https://t.co/l7el58rCol

Jan 21, 2020 · 205 followers View post →
EndALS
@FinishALS · X

@aliciadubinski https://t.co/PrSCWo2tka and https://t.co/WgFLrRBLzc And https://t.co/1TPiqQY1cU

Jan 20, 2020 · 4 likes · 2,470 followers View post →
EndALS
@FinishALS · X

If you’re looking into making your own supplement stack to try and fight ALS, consider making ashwagandha one of your choices: https://t.co/PrSCWo2tka

Jan 16, 2020 · 7 likes · 2,470 followers View post →