J Am Chem Soc January 2017 PMID 27936329

Chemomechanical Coupling in Hexameric Protein-Protein Interfaces Harnesses Energy within V-Type ATPases.

Abhishek Singharoy, Christophe Chipot, Mahmoud Moradi, Klaus Schulten

Mentions

12
Peak: 5 in Jun 2022
across 3 sources since Jun 2017

Extended reach

6,815
potential audience

Total likes

19

Video views

3,893

Mentions per month

Jun 2017 – Jun 2022

Where it's discussed

  • X / Twitter5 posts
  • News5 articles
  • YouTube2 videos

AI synopsis

What people are saying

The discussions primarily focus on the technical achievements, such as modeling ATP hydrolysis and the simulation of the rotatory cycle, with words like 'universal step', 'complete cycle', and exclamation marks emphasizing excitement and perceived importance. This indicates a high level of interest and appreciation for the research's contribution to the field.

AgreementModerate agreement

The overall tone indicates strong support and recognition of the significance of the research, especially with phrases like 'simulated the complete ROTATORY CATALYSIS cycle !!'.

InterestHigh interest

Many discussions highlight fascination with the detailed modeling of ATP hydrolysis, showing high curiosity about the mechanistic aspects.

EngagementModerate engagement

Posts delve into specifics such as the simulation of the entire rotational cycle, demonstrating a moderate level of engagement beyond superficial interest.

ImpactModerate impact

The language suggests that the findings are viewed as meaningful advancements in understanding enzyme mechanics, which could influence further research.

Abstract in brief

  • The study investigates how ATP hydrolysis energy is converted into mechanical work in V-type ATPases through conformational changes at protein-protein interfaces, particularly focusing on the Vring structure.
  • Using advanced simulation techniques, researchers found that ATP hydrolysis primarily drives the rotation of the central stalk, with the rate of this process influenced by the mechanical properties of the stalk itself.
  • The research outlines a detailed sequence of events—ADP and Pi release, ATP binding, and torque generation—highlighting intermediate states that have been confirmed through crystallography, deepening understanding of the enzyme's molecular mechanism.

Top posts

Most liked on X and Bluesky
Abhishek Singharoy
@abhisekhsingha1 · X

Modeled an universal step of ATP hydrolysis by proteins. Out in @ACSCentSci the kinetics of 'inward vs outward product release' path in V1-ATPase. With https://t.co/femFZuATWZ + https://t.co/oQD3PfMVSY, now we have now simulated the complete ROTATORY CATALYSIS cycle !! (1/2) https://t.co/eQ010UsZBw https://t.co/O6W8Hs7kHZ

Jun 15, 2022 · 19 likes · 4 shares · 995 followers View post →
ASU School of Molecular Sciences
@ASU_SMS · X

RT @abhisekhsingha1: Modeled an universal step of ATP hydrolysis by proteins. Out in @ACSCentSci the kinetics of 'inward vs outward product…

Jun 15, 2022 · 4 shares · 970 followers View post →
トミー
@AunderbTommy888 · X

RT @abhisekhsingha1: Modeled an universal step of ATP hydrolysis by proteins. Out in @ACSCentSci the kinetics of 'inward vs outward product…

Jun 15, 2022 · 4 shares · 628 followers View post →
Mrinal Shekhar
@mrinal1989 · X

RT @abhisekhsingha1: Modeled an universal step of ATP hydrolysis by proteins. Out in @ACSCentSci the kinetics of 'inward vs outward product…

Jun 15, 2022 · 4 shares · 259 followers View post →

All mentions

ASU School of Molecular Sciences
@ASU_SMS · X

RT @abhisekhsingha1: Modeled an universal step of ATP hydrolysis by proteins. Out in @ACSCentSci the kinetics of 'inward vs outward product…

Jun 15, 2022 · 4 shares · 970 followers View post →
sukanya konar
@sukanyakonar1 · X

RT @abhisekhsingha1: Modeled an universal step of ATP hydrolysis by proteins. Out in @ACSCentSci the kinetics of 'inward vs outward product…

Jun 15, 2022 · 4 shares · 31 followers View post →
Mrinal Shekhar
@mrinal1989 · X

RT @abhisekhsingha1: Modeled an universal step of ATP hydrolysis by proteins. Out in @ACSCentSci the kinetics of 'inward vs outward product…

Jun 15, 2022 · 4 shares · 259 followers View post →
トミー
@AunderbTommy888 · X

RT @abhisekhsingha1: Modeled an universal step of ATP hydrolysis by proteins. Out in @ACSCentSci the kinetics of 'inward vs outward product…

Jun 15, 2022 · 4 shares · 628 followers View post →
Abhishek Singharoy
@abhisekhsingha1 · X

Modeled an universal step of ATP hydrolysis by proteins. Out in @ACSCentSci the kinetics of 'inward vs outward product release' path in V1-ATPase. With https://t.co/femFZuATWZ + https://t.co/oQD3PfMVSY, now we have now simulated the complete ROTATORY CATALYSIS cycle !! (1/2) https://t.co/eQ010UsZBw https://t.co/O6W8Hs7kHZ

Jun 15, 2022 · 19 likes · 4 shares · 995 followers View post →