PubHawk
Mol Autism October 2017 PMID 27957319

Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders.

Maria Fiorentino, Anna Sapone, Stefania Senger, Stephanie S Camhi, Sarah M Kadzielski, Timothy M Buie, Deanna L Kelly, Nicola Cascella, Alessio Fasano

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Mentions

96
Peak: 3 in Jan 2019
across 6 sources since Jan 2019

Extended reach

41,534
potential audience

Total likes

35

Video views

705

Mentions per month

Jan 2019 – May 2025

Where it's discussed

  • Facebook63 posts
  • X / Twitter13 posts
  • News8 articles
  • Blogs8 articles
  • YouTube2 videos
  • Reddit2 posts

AI synopsis

What people are saying

Posts reflect a general interest in the link between the gut and brain barriers in autism, with some comments highlighting its potential significance, such as noting shared genes and barriers. The tone varies from curiosity to skepticism, demonstrating a nuanced engagement with the research's implications and limitations.

AgreementNeither agree nor disagree

The discussions show mixed reactions; some support the findings while others express skepticism, such as the comment questioning the vaccine link, indicating a neutral stance overall.

InterestModerate interest

The posts reveal curiosity about the connection between gut and brain barriers and autism, suggesting moderate interest without deep exploration.

EngagementModerate engagement

Several discussions mention genetic links and implications, like referencing shared genes, indicating active engagement with the topic.

ImpactModerate impact

The influence of the research appears acknowledged, with some seeing it as a significant insight, but there’s also skepticism about broader implications, making the overall perceived impact moderate.

Abstract in brief

  • The study suggests that individuals with autism spectrum disorder (ASD) may have changes in both the blood-brain barrier (BBB) and gut lining, which could allow harmful substances or immune complexes to pass into the brain and contribute to neuroinflammation.
  • In ASD brains, certain proteins (Claudin 5 and 12) related to the integrity of barriers are increased, indicating altered BBB function, while in the intestines of ASD patients, many show weakened barrier components compared to healthy controls.
  • These findings imply that disrupted barrier functions in the brain and gut, along with increased neuroinflammation, might play a role in the development of ASD, although more research is needed to understand differences with other disorders like schizophrenia.]
Read the full abstract

Top posts

Most liked on X and Bluesky
UltimApe
@ultimape · X

Solve autism, they said. I'm sure you won't undermine 85% of the medical system's models of disease, they said. https://t.co/AHm77s0FlH

Jun 17, 2021 · 5 likes · 6,713 followers View post →
UltimApe
@ultimape · X

@TCM_tweets @ReimanSaara @phoebeg234 The blood-brain-barrier and Gut barrier seem to be playing a role in this space for both as well. https://t.co/UCSwGkwaHi

Jul 17, 2022 · 2 likes · 1 share · 6,713 followers View post →
Matthew J.
@infinitywaltz · X

@StefanieParty @horny_antifa @EricTopol Damn, @StefanieParty, good eye! I think this is the paper being referenced: https://t.co/s6K7EDaRMx

Feb 2, 2022 · 1 like · 711 followers View post →
Evolutamente
@evolutaMente · X

AUTISMO E PERMEABILITA' DI BARRIERA Un soggetto su 32 in USA, secondo recenti analisi (pochi anni fa erano 68!), soffre di disturbi dello spettro autistico. Incredibile lavoro del team di ricerca,... https://t.co/fm8zsPC0a1

Jan 22, 2019 · 1 like · 253 followers View post →
katie wright
@katiewr31413491 · X

RT @CFitzenreiter: Altered bbb and gut@permeability in ASD https://t.co/KzXFNHixLL

Jan 8, 2019 · 2 shares · 13,208 followers View post →
UltimApe
@ultimape · X

@30ASeawitch @Robin_P_Patriot @NDthriving I don't think it's the vaccines, personally. I think its neat that the gut and brain barrier share a lot of genes. Cuz it it directly suggests how people with autism and gut barrier issues can also have BBB issues. https://t.co/UCSwGkwIwQ

Jan 22, 2023 · 6,713 followers View post →

All mentions

Nico
@NicolasBorga · X

@NeuroscienceNew @Anjunadeep @elonmusk @heniek_htw @SmartBiology3D @BioavailableNd @NTFabiano @ChrisStringer65 Blood-brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders https://t.co/ZzlYbYTeh1 https://t.co/FCYxH4zzCZ

Nov 7, 2024 · 443 followers View post →
Nico
@NicolasBorga · X

@NeuroscienceNew @Anjunadeep @elonmusk @heniek_htw @SmartBiology3D @BioavailableNd Blood–brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders https://t.co/TEA9o1XuUj

Aug 17, 2024 · 443 followers View post →
UltimApe
@ultimape · X

@30ASeawitch @Robin_P_Patriot @NDthriving I don't think it's the vaccines, personally. I think its neat that the gut and brain barrier share a lot of genes. Cuz it it directly suggests how people with autism and gut barrier issues can also have BBB issues. https://t.co/UCSwGkwIwQ

Jan 22, 2023 · 6,713 followers View post →
Devin Nunes' Cabrito Fella - NOT a nazi
@tallulahhulabel · X

RT @ultimape: @TCM_tweets @ReimanSaara @phoebeg234 The blood-brain-barrier and Gut barrier seem to be playing a role in this space for both…

Jul 17, 2022 · 1 share · 1,292 followers View post →
UltimApe
@ultimape · X

@TCM_tweets @ReimanSaara @phoebeg234 The blood-brain-barrier and Gut barrier seem to be playing a role in this space for both as well. https://t.co/UCSwGkwaHi

Jul 17, 2022 · 2 likes · 1 share · 6,713 followers View post →
Carolyn
@CFitzenreiter · X

Blood–brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders | Molecular Autism | Full Text https://t.co/KzXFNHixLL

Jun 16, 2022 · 103 followers View post →
Matthew J.
@infinitywaltz · X

@StefanieParty @horny_antifa @EricTopol Damn, @StefanieParty, good eye! I think this is the paper being referenced: https://t.co/s6K7EDaRMx

Feb 2, 2022 · 1 like · 711 followers View post →
Carolyn
@CFitzenreiter · X

https://t.co/fH3CZozjw9

Dec 30, 2021 · 103 followers View post →
UltimApe
@ultimape · X

Solve autism, they said. I'm sure you won't undermine 85% of the medical system's models of disease, they said. https://t.co/AHm77s0FlH

Jun 17, 2021 · 5 likes · 6,713 followers View post →
Carolyn
@CFitzenreiter · X

Blood–brain barrier and intestinal epithelial barrier alterations in autism spectrum disorders | Molecular Autism | Full Text https://t.co/KzXFNHixLL

Dec 30, 2019 · 103 followers View post →
Evolutamente
@evolutaMente · X

AUTISMO E PERMEABILITA' DI BARRIERA Un soggetto su 32 in USA, secondo recenti analisi (pochi anni fa erano 68!), soffre di disturbi dello spettro autistico. Incredibile lavoro del team di ricerca,... https://t.co/fm8zsPC0a1

Jan 22, 2019 · 1 like · 253 followers View post →
Plum Remson
@PlumRemson · X

RT @CFitzenreiter: Altered bbb and gut@permeability in ASD https://t.co/KzXFNHixLL

Jan 8, 2019 · 2 shares · 4,019 followers View post →
katie wright
@katiewr31413491 · X

RT @CFitzenreiter: Altered bbb and gut@permeability in ASD https://t.co/KzXFNHixLL

Jan 8, 2019 · 2 shares · 13,208 followers View post →