Cell Metab December 2016 PMID 28068222

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice.

Kathryn F Mills, Shohei Yoshida, Liana R Stein, Alessia Grozio, Shunsuke Kubota, Yo Sasaki, Philip Redpath, Marie E Migaud, Rajendra S Apte, Koji Uchida, Jun Yoshino, Shin-Ichiro Imai

Mentions

121
Peak: 6 in Feb 2025
across 6 sources since Jun 2019

Extended reach

361,776
potential audience

Total likes

6,058

Video views

293,436

Mentions per month

Jun 2019 – Jul 2025

Where it's discussed

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AI synopsis

What people are saying

The discussions highlight both appreciation for the scientific work, such as expressions of admiration for Dr. Sinclair’s studies, and a strong interest in the biological mechanisms, exemplified by mentions of NAD+ and mitochondrial function. The tone ranges from supportive to inquisitive, emphasizing the potential of NMN as an anti-aging treatment, though some comments question accessibility or broader applicability, which tempers expectations of immediate impact.

AgreementModerate agreement

Most discussions show support or positive acknowledgment of the research findings, indicating general agreement with the potential benefits of NMN.

InterestHigh interest

The discussions reveal high interest, as many participants actively analyze the scientific details or express curiosity about NMN’s effects.

EngagementModerate engagement

Participants demonstrate moderate engagement by referencing related studies, acknowledging scientists’ work, and discussing implications in detail.

ImpactModerate impact

While some recognize the significance of this research for anti-aging strategies, the discussions suggest a cautious optimism rather than widespread revolutionary impact.

Abstract in brief

  • The study found that long-term oral administration of Nicotinamide Mononucleotide (NMN) in mice helps reduce age-related decline by improving energy metabolism, physical activity, insulin sensitivity, and eye function without causing toxicity.
  • NMN works by boosting NAD biosynthesis in tissues, which in turn supports mitochondrial function, preserves gene expression related to aging, and prevents harmful changes in key metabolic organs during aging.
  • These findings suggest that NAD intermediates like NMN have strong potential as anti-aging treatments for humans, given their ability to prevent and mitigate age-associated physiological declines.]

Top posts

Most liked on X and Bluesky
Transhumanism Australia
@transhumanAU · X

Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice https://t.co/qG2qb8zcng

Nov 4, 2020 · 3 likes · 1 share · 18,566 followers View post →
Mr_Fireside
@Mr_Fireside · X

@boof_ivermectin @morellifit https://t.co/OXic9aSbuX

Mar 7, 2025 · 2 likes · 19,464 followers View post →
ピチュー
@cs5ou18UZO498hl · X

昔、ワシントン大学の今井先生がvivoでのデータは出してたけど、ヒトのエビデンスはあるのかしら。 Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice: Cell Metabolism https://t.co/Cm9VNBP850 https://t.co/iMsgcuknss

May 4, 2025 · 1 like · 1,573 followers View post →
Revel Peters
@urbanlamb · X

In part 2 coming in a few days he actually managed to get hold of Sincliars latest NMN research. This should be fun! (this guy is awesome!) https://t.co/l8YdCdcOSB

Sep 25, 2023 · 1 like · 105 followers View post →
Neal Asher
@nealasher · X

https://t.co/TS2j914fCa

Sep 25, 2023 · 13,035 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/334E7K6wTZ

Jan 27, 2023 · 3,134 followers View post →

All mentions

Brian Ravenscroft
@brian_raven1933 · X

https://t.co/IpAWOYJJAM

May 19, 2025 · 2,236 followers View post →
ピチュー
@cs5ou18UZO498hl · X

昔、ワシントン大学の今井先生がvivoでのデータは出してたけど、ヒトのエビデンスはあるのかしら。 Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice: Cell Metabolism https://t.co/Cm9VNBP850 https://t.co/iMsgcuknss

May 4, 2025 · 1 like · 1,573 followers View post →
Mr_Fireside
@Mr_Fireside · X

@boof_ivermectin @morellifit https://t.co/OXic9aSbuX

Mar 7, 2025 · 2 likes · 19,464 followers View post →
いらクル
@real_trubsolver · X

NMN果然是沒啥用 I read every human NMN study: Is it a Health Scam? https://t.co/JB24B4cIZn @YouTubeより

Feb 26, 2025 · 1,951 followers View post →
Jacob Mckuin
@JacobMckuin · X

@davidasinclair First of all I want to say I really appreciate your work. I am an aspiring physician and I want to believe what you are saying. Promoting it at as a drug though rather than keeping it more readily available to everyone is difficult to understand. https://t.co/yMNeeZrGuw

Nov 30, 2024 · 70 followers View post →
Revel Peters
@urbanlamb · X

In part 2 coming in a few days he actually managed to get hold of Sincliars latest NMN research. This should be fun! (this guy is awesome!) https://t.co/l8YdCdcOSB

Sep 25, 2023 · 1 like · 105 followers View post →
What?
@5152007 · X

I read every human NMN study: Is it a Health Scam? https://t.co/Jaf6oUmCl0 via @YouTube

Sep 25, 2023 · 80 followers View post →
Neal Asher
@nealasher · X

https://t.co/TS2j914fCa

Sep 25, 2023 · 13,035 followers View post →
luis hernan graffe
@hernangraffe · X

https://t.co/334E7K6wTZ

Jan 27, 2023 · 3,134 followers View post →
りかこ| 電子カルテ革命
@dr_rika_beauty · X

参考文献 https://t.co/oeYu1YylNp https://t.co/FlftF6RxL8

Sep 10, 2022 · 351 followers View post →
CalerieLife
@CalerieLife · X

NAD+ is involved in manufacturing ATP energy during the metabolism of food. NMN is a precursor of NAD+. In animal research it effectively diminished age-associated physical decline. NMN enhances energy metabolism & improves mitochondrial metabolism. https://t.co/lHnIpNUYyc

Apr 26, 2022 · 65 followers View post →
bladerunner
@bladerunner3049 · X

https://t.co/u9TOGV3Sr9

Dec 25, 2021 · 710 followers View post →
Xenomorph13x
@Xenomorph13x · X

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice https://t.co/VGw8nSU7sf

Feb 13, 2021 · 17 followers View post →
jordi de Haro
@zazen71 · X

NMN previno los cambios en la expresión génica asociados con la edad en órganos metabólicos clave y mejoró el metabolismo oxidativo mitocondrial y el desequilibrio proteico mitonuclear en el músculo esquelético. https://t.co/xCVAhVOL68

Dec 13, 2020 · 627 followers View post →
Chrysanthemum
@Chrysan51142054 · X

RT @transhumanismAU: Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice https:/…

Nov 5, 2020 · 1 share · 372 followers View post →
Transhumanism Australia
@transhumanAU · X

Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice https://t.co/qG2qb8zcng

Nov 4, 2020 · 3 likes · 1 share · 18,566 followers View post →
Michael Taylor
@writetothepoint · X

Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice https://t.co/XRs40F5TZH

Feb 17, 2020 · 19 followers View post →
Karl Steinkamp
@Karl_Steinkamp · X

Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice (2013) https://t.co/p6uiI031Vt #antiaging #NMN #LONGEVITY

Jan 14, 2020 · 2,896 followers View post →
Dr L Boominathan PhD
@DrLBoominathan · X

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice https://t.co/5KzNimOAHQ Visit the link below to find more ideas related to this area of research: https://t.co/ci6Ff5WcYn

Nov 19, 2019 · 873 followers View post →
David J Laurie
@DavidjLaurie · X

Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice https://t.co/dqxX1n9pYC

Jul 13, 2019 · 124 followers View post →
George KUCHEL
@george_kuchel · X

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. - PubMed - NCBI https://t.co/LuqC4PW46p

Jun 14, 2019 · 2,072 followers View post →