Inflammopharmacology February 2017 PMID 28083748

Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling.

Magdalena Jarosz, Magdalena Olbert, Gabriela Wyszogrodzka, Katarzyna Młyniec, Tadeusz Librowski

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Mentions

30
Peak: 7 in Oct 2023
across 4 sources since Dec 2019

Extended reach

247,504
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Total likes

4,966

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Dec 2019 – Apr 2024

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AI synopsis

What people are saying

Discussions around the article emphasize zinc's ability to modulate NF-κB signaling, with mentions of its antioxidant effects, enzyme activation, and immune regulation. The tone is analytical and enthusiastic, using technical language like 'metallothioneins,' 'cell homeostasis,' and 'cytoprotective agents,' which demonstrate deep engagement, while recognizing the potential significance of these findings on health and disease management.

AgreementStrong agreement

Most discussions highlight theoretical and experimental support for zinc's antioxidant and anti-inflammatory roles, indicating strong agreement with the publication’s findings.

InterestHigh interest

The posts demonstrate high interest, with many emphasizing mechanisms, such as zinc's modulation of NF-κB and its impact on immune responses.

EngagementModerate engagement

Some comments delve into specific biochemical pathways and implications, showing active engagement, though a few are more general.

ImpactHigh impact

The overall tone suggests these insights could influence future research or treatments, reflecting high perceived impact.

Abstract in brief

  • Zinc is a vital mineral that supports the structure and function of enzymes involved in cellular processes and signaling pathways.
  • It has antioxidant and anti-inflammatory effects by promoting the production of protective proteins like metallothioneins and enhancing antioxidant enzymes such as glutathione and catalase.
  • Zinc also modulates immune responses by reducing activation of the NF-κB pathway, which controls inflammation-related genes, and by inhibiting other molecules involved in inflammatory responses.]

Top posts

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Rene Sugar
@renesugar · X

Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling https://t.co/djStAFKl6S

Oct 16, 2023 · 5 likes · 3,970 followers View post →
JeffWill
@J_Real3 · X

https://t.co/rvtrFvxIB5

Nov 14, 2022 · 1 like · 5,064 followers View post →
Rene Sugar
@renesugar · X

https://t.co/djStAFKl6S "Studies have demonstrated that physiological reconstitution of zinc restrains immune activation, whereas zinc deficiency, in the setting of severe infection, provokes a systemic increase in NF-κB activation."

Oct 16, 2023 · 1 like · 3,970 followers View post →
Rene Sugar
@renesugar · X

https://t.co/djStAFKl6S "Zinc can exchange redox active metals, such as copper and iron, in certain binding sites and attenuate cellular site-specific oxidative injury."

Oct 16, 2023 · 1 like · 3,970 followers View post →
CEO
@linda289964 · X

鋅含量,可預測新冠病毒的嚴重度, 柏格醫生dr berg https://t.co/Gyy7w6JM32 via @YouTube

Jul 11, 2021 · 1 like · 110 followers View post →
Rene Sugar
@renesugar · X

https://t.co/djStAFKl6S "On the other hand, zinc exerts its antioxidant effect via two acute mechanisms, one of which is the stabilization of protein sulfhydryls against oxidation." "The second mechanism consists in antagonizing transition metal-catalyzed reactions."

Oct 16, 2023 · 3,970 followers View post →

All mentions

Rene Sugar
@renesugar · X

https://t.co/djStAFKl6S "Studies have demonstrated that physiological reconstitution of zinc restrains immune activation, whereas zinc deficiency, in the setting of severe infection, provokes a systemic increase in NF-κB activation."

Oct 16, 2023 · 1 like · 3,970 followers View post →
Rene Sugar
@renesugar · X

https://t.co/djStAFKl6S "Zinc can exchange redox active metals, such as copper and iron, in certain binding sites and attenuate cellular site-specific oxidative injury."

Oct 16, 2023 · 1 like · 3,970 followers View post →
Rene Sugar
@renesugar · X

https://t.co/djStAFKl6S "On the other hand, zinc exerts its antioxidant effect via two acute mechanisms, one of which is the stabilization of protein sulfhydryls against oxidation." "The second mechanism consists in antagonizing transition metal-catalyzed reactions."

Oct 16, 2023 · 3,970 followers View post →
Rene Sugar
@renesugar · X

https://t.co/djStAFKl6S "Furthermore, zinc increases the activation of antioxidant proteins and enzymes, such as glutathione and catalase."

Oct 16, 2023 · 3,970 followers View post →
Rene Sugar
@renesugar · X

https://t.co/djStAFKl6S "The mineral modulates immune response and exhibits antioxidant and anti-inflammatory activity." "Zinc retards oxidative processes on a long-term basis by inducing the expression of metallothioneins."

Oct 16, 2023 · 3,970 followers View post →
Rene Sugar
@renesugar · X

https://t.co/djStAFKl6S "These metal-binding cysteine-rich proteins are responsible for maintaining zinc-related cell homeostasis and act as potent electrophilic scavengers and cytoprotective agents."

Oct 16, 2023 · 3,970 followers View post →
Rene Sugar
@renesugar · X

Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling https://t.co/djStAFKl6S

Oct 16, 2023 · 5 likes · 3,970 followers View post →
จิตโตร
@jittro · X

Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling https://t.co/dIm8rzlBRv

May 21, 2023 · 2,723 followers View post →
JeffWill
@J_Real3 · X

https://t.co/rvtrFvxIB5

Nov 14, 2022 · 1 like · 5,064 followers View post →
CEO
@linda289964 · X

鋅含量,可預測新冠病毒的嚴重度, 柏格醫生dr berg https://t.co/Gyy7w6JM32 via @YouTube

Jul 11, 2021 · 1 like · 110 followers View post →
cjiin wu
@cjiin88 · X

鋅含量,可預測新冠病毒的嚴重度, 柏格醫生dr berg https://t.co/5FN9LL8EAX 來自 @YouTube

Jul 8, 2021 · 1,110 followers View post →
李中民Lee-chung-ming
@cqPhnE2UWjrasau · X

鋅含量,可預測新冠病毒的嚴重程度, 柏格醫生dr berg https://t.co/nxJrJcplft 來自 @YouTube ...爆料ccp製造武漢病毒的閻博士去年就說過,於營養學刊公布研究結果前。

Jul 8, 2021 · 91 followers View post →
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