Endocrine June 2017 PMID 28133708

Tadalafil improves lean mass and endothelial function in nonobese men with mild ED/LUTS: in vivo and in vitro characterization.

Antonio Aversa, Simona Fittipaldi, Davide Francomano, Viviana M Bimonte, Emanuela A Greco, Clara Crescioli, Luigi Di Luigi, Andrea Lenzi, Silvia Migliaccio

Mentions

36
Peak: 14 in Apr 2025
across 6 sources since Feb 2021

Extended reach

340,175
potential audience

Total likes

11,377

Video views

89,786

Mentions per month

Feb 2021 – Nov 2025

Where it's discussed

  • X / Twitter19 posts
  • Bluesky6 posts
  • Instagram5 posts
  • YouTube3 videos
  • Facebook2 posts
  • News1 articles

AI synopsis

What people are saying

The overall tone highlights curiosity and enthusiasm about Tadalafil's potential for muscle growth and vascular health, exemplified by posts asking 'Para que serve a tadalafila na musculação?' and comments describing its use as a 'pré-treino.' The humorous remarks and technical references reflect a mix of casual interest and some engagement with the scientific implications, contributing to a moderate overall impact perception.

AgreementModerate agreement

Most discussions acknowledge the positive effects of Tadalafil on muscle mass and endothelial function, indicating general agreement with the publication's findings.

InterestHigh interest

Many posters show high interest by questioning uses beyond the original scope and engaging with scientific details, reflecting curiosity about the drug's broader applications.

EngagementModerate engagement

Posts range from sharing personal reactions and humorous comments to discussing mechanisms, demonstrating moderate but meaningful engagement with the topic.

ImpactModerate impact

The discussions touch on potential uses for biohacking and muscle building, hinting at a perceived moderate impact on fitness and health communities.

Abstract in brief

  • Daily tadalafil intake led to increased abdominal lean mass and improved endothelial function in nonobese men with mild erectile or urinary symptoms, with some effects reversing after stopping the medication.
  • Tadalafil improved urinary and erectile symptoms (LUTS and ED scores), and its positive effects on endothelial health were linked to changes in insulin and estradiol hormone levels.
  • In lab studies, tadalafil increased androgen receptor and myogenin protein levels in skeletal muscle cells, suggesting it may promote muscle growth by enhancing hormone activity.

Top posts

Most liked on X and Bluesky
Stuart Phillips (he/him)
@mackinprof · X

Here's the purported lean mass gain in this paper https://t.co/Ss1vJ9dDvq, which are: 32671 (baseline) g of lean 'trunk' with SE 34093 (2mo) g 33529 (2mo post) g So (at face value) that's a net 'increase' in lean mass of 1422g,, followed by a 'loss' of 564g off the drug (i.e., https://t.co/YqdyBKglU1

Oct 3, 2024 · 7 likes · 56,108 followers View post →
BowTiedOx | SOF Athlete/Bodybuilder
@BowTiedOx · X

@mtcodeslinger I’ll make it easier to start https://t.co/OrSWebbkuO

Oct 3, 2024 · 5 likes · 86,270 followers View post →
Jorn Trommelen, PhD
@JornTrommelen · X

Study: https://t.co/d09OnAa9W1 9/9 Did you find this useful? Please help promote the first tweet of the thread: https://t.co/xx1iXpEClQ

May 15, 2023 · 5 likes · 2 shares · 7,628 followers View post →
NootBro
@nootropicguy · X

@NutriAlexandre https://t.co/x1JGe3tMmg

Mar 19, 2023 · 3 likes · 83,873 followers View post →
Luis Cruz
@luis-cruz.bsky.social · Bluesky

cuidado.. youtu.be/mdLyG4Y1RLM?...

Apr 30, 2025 · 2 likes View post →
Phil Daru
@DaruStrong · X

Tadalafil improves lean mass and endothelial function in nonobese men with mild ED/LUTS

Apr 15, 2023 · 1 like · 9,100 followers View post →

All mentions

Ezimar-O Vaciloscopista
@ezimardivi · X

@cupinzim E tbm tem alguns que estão usando a tadala como "pré-treino"... https://t.co/I9fixT4CwR

May 2, 2025 · 87 followers View post →
Luis Cruz
@luis-cruz.bsky.social · Bluesky

cuidado.. youtu.be/mdLyG4Y1RLM?...

Apr 30, 2025 · 2 likes View post →
Diego Ferreira
@katesclau.bsky.social · Bluesky

youtu.be/mdLyG4Y1RLM?... manda pra tua esposa pelamordedeus

Apr 30, 2025 · 1 like View post →
Biss Lee
@biss.com.br · Bluesky

youtu.be/mdLyG4Y1RLM?...

Apr 27, 2025 View post →
Emily ♡
@emilypdf_ · X

https://t.co/D135mAAga3

Apr 27, 2025 · 531 followers View post →
Gustav L
@GustavSuguimoto · X

MARISE, Laura. “O elevador não sobe sem apertar o botão.” [Comentário em vídeo]. Instagram, 24 abr. 2025. Disponível em: [https://t.co/UPAezYFV9J]. Acesso em: 26 abr. 2025.

Apr 26, 2025 · 114 followers View post →
João M
@nababu.toot.community.ap.brid.gy · Bluesky

Para que serve a tadalafila na musculação? https://www.youtube.com/watch?v=mdLyG4Y1RLM

Apr 26, 2025 · 1 like · 1 share View post →
Washington Oliveira
@Wash_Oliveira · X

A quantidade de trocadinhos que aprendi aqui foi sem limites

Apr 26, 2025 · 384 followers View post →
jack lemonade
@JooBarb21290651 · X

https://t.co/53U3Rdk6kY E vejam o vídeo. O canal delas é foda.

Apr 25, 2025 · 130 followers View post →
liloo
@eleieleoh · X

malhar de pau duro? https://t.co/fkKwjImqa4

Apr 25, 2025 · 614 followers View post →
Hiei_stan
@Hiei_stan · X

o que esse video tem de informativo, tem de engraçado XD XD XD é por isso que eu amo esse canal XD XD XD Para que serve a tadalafila na musculação? https://t.co/UmNHEKShZP via @YouTube

Apr 25, 2025 · 287 followers View post →
Diego
@tudego.bsky.social · Bluesky

Nunca vi 5a série. Tive que ver duas vezes pq na primeira eu só ria. youtu.be/mdLyG4Y1RLM?...

Apr 25, 2025 View post →
Aurora Nebbins
@ladysmeagol.bsky.social · Bluesky

youtu.be/mdLyG4Y1RLM?... Vale a pena só pela mina de eufemismos pra ereção e sexo

Apr 24, 2025 · 1 like · 3 shares View post →
Mr Malcoln
@MrMalcoln · X

PQP, tem gente usando Tadalafila como Pré-treino.

Apr 24, 2025 · 546 followers View post →
Siete Rayos⚡️
@Smartwithlocs · X

Lmao #research https://t.co/vzM6Ejl4AC.

Nov 7, 2024 · 987 followers View post →
BowTiedOx | SOF Athlete/Bodybuilder
@BowTiedOx · X

@mtcodeslinger I’ll make it easier to start https://t.co/OrSWebbkuO

Oct 3, 2024 · 5 likes · 86,270 followers View post →
Stuart Phillips (he/him)
@mackinprof · X

Here's the purported lean mass gain in this paper https://t.co/Ss1vJ9dDvq, which are: 32671 (baseline) g of lean 'trunk' with SE 34093 (2mo) g 33529 (2mo post) g So (at face value) that's a net 'increase' in lean mass of 1422g,, followed by a 'loss' of 564g off the drug (i.e., https://t.co/YqdyBKglU1

Oct 3, 2024 · 7 likes · 56,108 followers View post →
GDLeahy
@GDLeahy · X

"The in vitro increased myogenin and androgen receptor protein expression in skeletal muscle cells suggests a translational action of phosphodiesterase type-5 on this receptor." https://t.co/tSdXlEKkCG

Feb 13, 2024 · 672 followers View post →
kabalah13@lod
@kabalah13lod1 · X

RT @JornTrommelen: Study: https://t.co/d09OnAa9W1 9/9 Did you find this useful? Please help promote the first tweet of the thread: https:…

May 15, 2023 · 2 shares · 508 followers View post →
Javed Alam
@jalam1001 · X

RT @JornTrommelen: Study: https://t.co/d09OnAa9W1 9/9 Did you find this useful? Please help promote the first tweet of the thread: https:…

May 15, 2023 · 2 shares · 1,006 followers View post →
Jorn Trommelen, PhD
@JornTrommelen · X

Study: https://t.co/d09OnAa9W1 9/9 Did you find this useful? Please help promote the first tweet of the thread: https://t.co/xx1iXpEClQ

May 15, 2023 · 5 likes · 2 shares · 7,628 followers View post →
Dr. Kirten Parekh
@KirtenParekh · X

Who knew d*ck pills could be used for biohacking: "Daily tadalafil improved lean mass content in non-obese men probably via enhanced insulin secretion, estradiol reduction, and improvement of endothelial function in vivo" https://t.co/C5iwlGuhnr

Apr 25, 2023 · 359 followers View post →
Phil Daru
@DaruStrong · X

Tadalafil improves lean mass and endothelial function in nonobese men with mild ED/LUTS

Apr 15, 2023 · 1 like · 9,100 followers View post →
NootBro
@nootropicguy · X

@NutriAlexandre https://t.co/x1JGe3tMmg

Mar 19, 2023 · 3 likes · 83,873 followers View post →
BlueSamuraiZero
@BlueSamuraiZero · X

@dookiebutter100 Well... Your blood is flowing, for sure.

Jun 7, 2022 · 1,086 followers View post →
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