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BMC Genomics February 2017 PMID 28178941

Implications of human evolution and admixture for mitochondrial replacement therapy.

Lavanya Rishishwar, I King Jordan

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Mentions

7
Peak: 4 in Apr 2023
across 3 sources since Nov 2019

Extended reach

55,033
potential audience

Total likes

1,172

Video views

49,728

Mentions per month

Nov 2019 – Sep 2024

Where it's discussed

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  • News1 articles

AI synopsis

What people are saying

Discussions highlight examples like the natural occurrence of mismatched mitochondrial and nuclear genomes, referencing studies on haplogroup distributions and evolutionary implications. The tone suggests a cautious but analytical attitude, with some opinions stressing the importance of considering natural diversity before applying mitochondrial replacement therapies.

AgreementModerate agreement

Most discussions appear to acknowledge the scientific findings, with some supporting the need for caution in mitochondrial replacement therapy based on natural genome diversity.

InterestNeutral interest

The posts show moderate interest, referencing technical details like haplogroups and natural genome mismatches, but not deep engagement with the broader ethical or practical implications.

EngagementModerate engagement

Several contributions analyze the data and implications, such as discussing the natural occurrence of mismatched genomes, indicating a decent level of engagement.

ImpactModerate impact

Users seem to recognize the research's significance for future medical applications, suggesting it could influence how mitochondrial therapies are approached.

Abstract in brief

  • Mitochondrial replacement therapy (MR) is a technique to prevent mitochondrial disorders, but concerns arise from the natural coevolution of nuclear and mitochondrial genomes, which might lead to incompatibility issues.
  • Researchers tested the nuclearmitochondrial mismatch hypothesis in humans using data from the 1000 Genomes Project and the Human Genome Diversity Project, finding that while nuclear and mitochondrial genomes generally coevolve, mismatched combinations do occur naturally within individuals.
  • These findings suggest that, although nuclear and mitochondrial genomes tend to correlate within populations, mismatched mitochondrial and nuclear genome combinations can still be present in humans, raising questions about the safety of MR therapy based on natural genome diversity.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Chigeorge
@Chigeorge72 · X

@StopYourBsSerb @TheRisingFinix @kolonjar @Darnakas3 @dsgsdfg51647791 @IoannisKapo1 @PallasGlaux @Konstan16204029 @bigjohn53979259 @tricomtech @G7uQ40F6VP1Rv2U @_Makedonuts_ @eftimia60 @andros_sk_mari @TreloKomio5 @Tutunarot1 @DirectorMKD @lolita194636511 @JordanTviterka @theoperi @vladegv @No_Grik_Style @helleniccanuck1 @aleviyemem @haha_bou @Samet22326848 @APsilos @makedonien_mk @GrecoStrategos @THE_GREEK_007 @MAKEDONMMA @max_zek_x @Aretitheta @Ar_MA_ge_don @SrebreniKopja @OKOTOnaSE @panbog2 @YiosDia @Alexand45539671 @mmamakedonia @BasilesNikolaou @MakedonPaeon @AITWLOS @dokurcev @PegoEmpresa @basedfootball_ @dondon90820793 @xKilluminatix_ @orguel1984 @Okurcan3 Africans Greeks and Japanese haplogroups don't look similar to me

Apr 25, 2023 · 5 likes · 2 shares · 549 followers View post →
30inSword
@30inchsword · X

Human mtDNA haplogroup distribution, based on analysis of 2,054 individuals from 26 populations. - Rishishwar L, Jordan IK (2017). "Implications of human evolution and admixture for mitochondrial replacement therapy" https://t.co/oNOK8nBVkw

Apr 22, 2023 · 2 likes · 1,024 followers View post →
Pallas Athena
@PallasGlaux · X

RT @Chigeorge72: @StopYourBsSerb @TheRisingFinix @kolonjar @Darnakas3 @dsgsdfg51647791 @IoannisKapo1 @PallasGlaux @Konstan16204029 @bigjohn…

Apr 25, 2023 · 2 shares · 3,502 followers View post →
Ζαντος Γιάννης
@G7uQ40F6VP1Rv2U · X

RT @Chigeorge72: @StopYourBsSerb @TheRisingFinix @kolonjar @Darnakas3 @dsgsdfg51647791 @IoannisKapo1 @PallasGlaux @Konstan16204029 @bigjohn…

Apr 25, 2023 · 2 shares · 208 followers View post →

All mentions

Pallas Athena
@PallasGlaux · X

RT @Chigeorge72: @StopYourBsSerb @TheRisingFinix @kolonjar @Darnakas3 @dsgsdfg51647791 @IoannisKapo1 @PallasGlaux @Konstan16204029 @bigjohn…

Apr 25, 2023 · 2 shares · 3,502 followers View post →
Ζαντος Γιάννης
@G7uQ40F6VP1Rv2U · X

RT @Chigeorge72: @StopYourBsSerb @TheRisingFinix @kolonjar @Darnakas3 @dsgsdfg51647791 @IoannisKapo1 @PallasGlaux @Konstan16204029 @bigjohn…

Apr 25, 2023 · 2 shares · 208 followers View post →
Chigeorge
@Chigeorge72 · X

@StopYourBsSerb @TheRisingFinix @kolonjar @Darnakas3 @dsgsdfg51647791 @IoannisKapo1 @PallasGlaux @Konstan16204029 @bigjohn53979259 @tricomtech @G7uQ40F6VP1Rv2U @_Makedonuts_ @eftimia60 @andros_sk_mari @TreloKomio5 @Tutunarot1 @DirectorMKD @lolita194636511 @JordanTviterka @theoperi @vladegv @No_Grik_Style @helleniccanuck1 @aleviyemem @haha_bou @Samet22326848 @APsilos @makedonien_mk @GrecoStrategos @THE_GREEK_007 @MAKEDONMMA @max_zek_x @Aretitheta @Ar_MA_ge_don @SrebreniKopja @OKOTOnaSE @panbog2 @YiosDia @Alexand45539671 @mmamakedonia @BasilesNikolaou @MakedonPaeon @AITWLOS @dokurcev @PegoEmpresa @basedfootball_ @dondon90820793 @xKilluminatix_ @orguel1984 @Okurcan3 Africans Greeks and Japanese haplogroups don't look similar to me

Apr 25, 2023 · 5 likes · 2 shares · 549 followers View post →
30inSword
@30inchsword · X

Human mtDNA haplogroup distribution, based on analysis of 2,054 individuals from 26 populations. - Rishishwar L, Jordan IK (2017). "Implications of human evolution and admixture for mitochondrial replacement therapy" https://t.co/oNOK8nBVkw

Apr 22, 2023 · 2 likes · 1,024 followers View post →
Aay6826 Antonio SM | PDF | Genealogy | Population Genetics
News

doi:10.1186/s12864- 017-3539-3 Medline 69. G. D. Poznik, Identifying Y-chromosome haplogroups in arbitrarily large samples of sequenced or ...

Nov 8, 2019 View →