Do carb-restricting diets do better than fat-restricting ones? No – says this meta-analysis of 32 controlled feeding studies. https://t.co/qEC0dMFs04 https://t.co/292gE2H4Wl
Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition.
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Jun 2019 – Oct 2025Where it's discussed
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AI synopsis
What people are saying
The collective discourse underscores the importance of controlled studies and meta-analyses, such as Kevin Hall’s work, which consistently show negligible differences in fat loss between diets when calories and protein are equal. Phrases like 'meta-analysis of 32 controlled studies' and 'no meaningful difference when calories and protein are matched' highlight rigorous scientific backing, while tone is analytical and occasionally dismissive of less evidence-based claims, reflecting high interest and deep engagement.
Most posts support the idea that calorie balance primarily governs weight regulation, referencing meta-analyses and controlled studies that show no significant difference between diets when calories and protein are matched.
The discussions demonstrate high curiosity, with many references to detailed scientific studies, data, and meta-analyses, indicating a strong interest in the scientific evidence behind diet effects.
Posts actively analyze research results, critique theories, and cite multiple controlled studies, showing deep engagement with the scientific content and debate around diet composition and energy balance.
The discussions emphasize that the meta-analyses and controlled experiments are foundational, challenging popular misconceptions and potentially influencing perspectives on dietary recommendations and obesity understanding.
Abstract in brief
- Body weight changes are driven by imbalances between calorie intake and expenditure, but weight loss is often resisted by physiological processes that regulate energy balance.
- A meta-analysis of controlled studies found that diets lower in fat slightly increase energy expenditure and promote fat loss compared to high-fat diets.
- The review discusses different models of body weight regulation, particularly emphasizing the setpoint model, which suggests the body actively maintains a certain weight through complex biological mechanisms.
Top posts
Most liked on X and BlueskyAnother thing that stands out to me about this graph is its concordance with modeled predictions about human body weight regulation. For example, scenarios B and C from this @KevinH_PhD paper. https://t.co/xomGEdxePs https://t.co/Hh3fNQng3p
@zachcaceres Sure, here's a meta-analysis of diets that restricted either carbs or fat. https://t.co/qEC0dMFs04 In general I recommend Stephan Guyenet's work on this. But I'm not claiming he is a good basis for govt policy either, just that the sugar=bad thesis isn't well-supported. https://t.co/qQBvoyadBg
@Guiller05303935 No, I've not seen any evidence supporting that. A meta-analaysis of 80 controlled trials found that differences between low-carb and low-fat diets were negligable when protein and calorie intake are controlled. https://t.co/jLq2CUbDLY
@SiponenMatti @TheBhupiThakur @davidludwigmd @AlbiteArencibia @BioLayne @The_Nutrivore @TheAlanAragon @JoseAntonioPhD @BradSchoenfeld @mackinprof When protein and calories are equated between groups, there isn't a meaningful difference in body fat or energy expenditure. Meta-analysis of 32 such studies. If anything, slightly favors low-fat diets. https://t.co/jLq2CUsGNY
https://t.co/nnUzEPikYZ
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@BillOccham0 @ZeroCarbHealth @wilsonhlthcoach You can read Hall’s response to the critique of the 2015 study here: https://t.co/uRkR92bUJn And the 2017 study here: https://t.co/ULMCG0kC0i
@KingManninen @gregmushen He most likely refers to https://t.co/hTlcIwEc8D which was probably a response to https://t.co/yZ8hrH6tHJ
https://t.co/jCkrFx1N7n
https://t.co/jCkrFx1fhP
@Guiller05303935 No, I've not seen any evidence supporting that. A meta-analaysis of 80 controlled trials found that differences between low-carb and low-fat diets were negligable when protein and calorie intake are controlled. https://t.co/jLq2CUbDLY
https://t.co/jCkrFx1fhP
@Jeff_T @lowcarbGP @DrEenfeldt @rcgp @DrDuaneRD @BrownAdey @KenDBerryMD @SBakerMD @drjasonfung @LoreofRunning1 @lowcarb_aus You're hopped up on bullshit. Excess energy doesn't vanish. No one has too little insulin to store it all. High carb diets perform better for fat loss and preservation of fat-free mass. https://t.co/PGibdLVihA https://t.co/Jmj7w4X2A8
3) “Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition” (2017) www.sciencedirect.com/science/arti...
https://t.co/Fr9FqZtW7p
1) https://t.co/z6qOgWG9yG https://t.co/7Zbqqi34NG
@ElijahSchaffer https://t.co/kpc5ciTVGm
@notsoErudite https://t.co/kpc5ciTVGm
@Joey38822317240 @ted_ryce In iso caloric iso protein setup, low carbs works slightly worse than low fat https://t.co/cBaFbZxNhP
Why we lose and regain weight, over and over again... [Science Explained] https://t.co/f6yYms5ut2
@Chaddadbod @PetrosVon @DoctorTro https://t.co/GJUCjH6KbR
@PramilaMundra Here is a meta analysis:“our meta-analysis of 32 controlled feeding studies with isocaloric substitution of carbohydrate for fat found that both energy expenditure (26 kcal/d; P <.0001) and fat loss (16 g/d; P <.0001) were greater with lower fat diets.” https://t.co/cBaFbZyl7n
@thalesnemo @bigfatsurprise @HarvardChanSPH If you want long term data, here it is: With keto, you’re telling stories, not science. Science needs evidence not stories. https://t.co/cBaFbZyl7n
@FrontKick4Life @AlaskanAsshole @MarkBski then why is it that metabolic ward studies show equal weight loss and health outcomes when calories and protein are matched.. despite differing levels of carbs? https://t.co/GJUCjH6KbR
@Lone_Star_Keto @5MinuteBody If hormones mattered more, then a metabolic ward study with hyper-insulemic treatment arm should gain weight.. or at least not lose as much as the calorie/protein matche low carb group. This did not happen. https://t.co/GJUCjH6KbR
@MarkBski @SamaHoole This would mean something if you've actually published studies on nutritional biochemistry. Explain the metabolic ward studies (32.of them) showing weight to be directly related to calorie intake. https://t.co/GJUCjH6KbR
adding muscle mass. - The Daily Pump @Schwarzenegger @BornFitness @ketch https://t.co/0Yya0J4622 https://t.co/jSGKp2V7Ng
@David_5150 example studies: Low fat better results than low carb (marginally): https://t.co/B2Y4g4UiUH Meta analysis comparing low carb / low fat: https://t.co/TddekU93k8 Keto vs. high carb - https://t.co/lrKIJbCrqf
@aCarnivoreDiet @REGISMOREAU It's a meta analysis. https://t.co/GJUCjH6KbR
@aCarnivoreDiet @RiskManager1983 @ThomasDeLauer @BioLayne you must be a parody account. If that theory were true, an insulinogenic diet would cause fat gsin in an isocaloric situation. It doesn't. Your theory is incorrect. https://t.co/GJUCjH6KbR
@pnsclips @ScepticalDoctor @WayneSimbo When you can show metabolic ward studies that show a diatinct and repeated advantage when calories and protein are matched then we have a conversation. https://t.co/GJUCjH6KbR
@RealMarcFoxx @SmilerTurner @ElieJarrougeMD https://t.co/GJUCjH6KbR
@robertlufkinmd do you have a metabolic ward study that definitively shows this? Here's one that shows it doesn't.. https://t.co/GJUCjH6cmj
@mattkoshko @MohammedAlo @annemariegunn @TuckerGoodrich The problem is in these ridiculous false dilemma scenarios. When protein is matched, carb/fat levels don't make a difference. Here's the evidence. https://t.co/GJUCjH6KbR
When calories & protein are equated between diets that vary in carbs & fats, we don’t see differences in fat loss. https://t.co/5K2EyP1dsT
@MajorPriapus @robertlufkinmd if this were the case a metabolic ward study would show an isocaloric diet with protein matched would produce weight gain in the high carb, insulinogenic diet. it doesn't. https://t.co/GJUCjH6KbR
@Aristotle_Code @FenixAmmunition @MelonieMac I’m saying there are no randomized human control trials or meta-analyses that verify your claims. But the laws of thermodynamics work against you. Keto and insulin regulation aren’t magic. https://t.co/jU4yDAo0jH https://t.co/p15njRSVl9 https://t.co/lEX5Tl6t93
Finally! A meta-analysis (study of studies) of 32 different controlled studies by Kevin Hall Key point: Fat loss was greater in the low fat diets by 16 grams per day https://t.co/oaS8vgt2k1 https://t.co/9WKDDyId61
摂ったら代謝があがったと報告しているのは20件。そのうち14件に有意差があった 糖質制限にくらべて高糖質のほうが平均で1日16gほど体脂肪が減る傾向があった 糖質を増やそうが減らそうがどっちでもいい https://t.co/CRnB3oxstq #自分用メモ
@frost_mats När jag gav ut min bok så hade Kevin Hall inte gjort någon interventionsstudie på kost. I första upplagan fanns där inga referenser till något som Kevin Hall gjort. I andra hade jag en, https://t.co/yf7bL3xEnu Så min bok är verkligen inte tungt influerad av honom
@SaintCrawford @eeb54862610 fun fact.. taubes' organization PAID for this study.. annnnd it disproved his insulin model
@SaintCrawford @eeb54862610 let's start with the fact that just about all of them deny the impact of calorie balance when it comes to weight regulation. https://t.co/GJUCjH6KbR
@KennyDeMetter @L_Zen @jordanbpeterson @robkhenderson https://t.co/GJUCjH6KbR
@ZsoltNagy7 https://t.co/GJUCjH6KbR
https://t.co/wcsdzZiQPS
@AWojnarowski1 @thalesnemo @SentientBlobBob @DereckChildres @KenDBerryMD you were the one wanking about the res of studies showing keto/carnivore were superior. You haven't posted a single paper. Here's a metabolic ward meta showing that when protein is matched, there's no difference in carb/fat levels. https://t.co/GJUCjH6KbR
@ERF0207 @funmidniterider @ElieJarrougeMD @kpvsmom https://t.co/GJUCjH6KbR
@hormonedietdoc Nope. thank goodness for voices like Spencer Nadolsky, Layne Norton etc. https://t.co/jcu5mwbFb9
https://t.co/Sy1zk4Uigy https://t.co/EAaPvohHz4 https://t.co/WmspHwOcKC
@pjungar @MarkBski @ScepticalDoctor Funny that.. when under controlled environments people lose/gain predictably according to their calorie intake.. which isnt to say there arent biological/hormonal influences.. just not the fu*kity-fu*k you've been fed by taubes and his ilk. https://t.co/GJUCjHnNdR
RT @gregorythomp: @drantbradley @nicknorwitz @KenDBerryMD @tednaiman @drtonyhampton Then you'll appreciate this much higher quality study w…
@faisanzheikh A highly insulinogenic diet should then (according to your theory) should prevent weight loss or cause weight gain conoared to a vlc diet. It doesnt. https://t.co/GJUCjHnNdR
@KhalidalKanadee @Losing200Pounds When calories and protein are matched, carb and fat levels make precious f*ck all of a difference. This is a metabolic ward meta. if you have citations with equal or greater methodological power Im all ears. https://t.co/GJUCjHnNdR
Another thing that stands out to me about this graph is its concordance with modeled predictions about human body weight regulation. For example, scenarios B and C from this @KevinH_PhD paper. https://t.co/xomGEdxePs https://t.co/Hh3fNQng3p
@ZsoltNagy7 @MSOElevator @bengreenfield https://t.co/GJUCjHnNdR
@thalesnemo @maheklokhandwa2 @saaiyer https://t.co/GJUCjHnNdR
https://t.co/nnUzEPikYZ
Fat loss is not different between low carb or low fat diets during controlled feeding studies when calories/protein are matched: https://t.co/SUyfFzdjO2 But again there are outliers so see what works for you!! #obesity #nutrition #health #fitness #sarasota #lakewoodranch
@drantbradley @nicknorwitz @KenDBerryMD @tednaiman @drtonyhampton Then you'll appreciate this much higher quality study which shows essentially no difference between high carb and low carb (I say essentially b/c it favored high carb, but it was such an insignificant amount). https://t.co/CO2KiGi6U7
Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition @aga_pallavi https://t.co/EYwFSHELqh
@thalesnemo @shameermulji @AndrewOilGas @Dmozaffarian No https://t.co/2MCpbeFtl9
@paulmelzer1 @rethinkingMD However, diets with equal calories of fat and carbohydrate will have very similar effects on body fat changes. That's pretty well established. https://t.co/2MCpbeFtl9
https://t.co/sukVhD4FSv https://t.co/cc2bNaAokz
@garytaubes @BioLayne @TheAlanAragon https://t.co/1Gyd5VzKlF Hope this helps
@DrPaulMason @Nutrillermo 3. https://t.co/xIoewINNb4 https://t.co/3ih1eTjIDe https://t.co/KLzu3KSq4Z https://t.co/h287zk5uWC https://t.co/uYLUoDUCn7
@John_G_Willis @hburki89 @JoshuaRainier3 @BioLayne If protein and calories are equated, no matter how much carbs or fat for fat loss!! https://t.co/dmilUYkimJ
Como adelanto un metaanálisis muy chulo sobre el tema https://t.co/34KnPf7eJW
@chelseakwt @Travis_Statham @kamleshkhunti @parthaskar @ERobertson02 @AbdTahrani @AmarPut @DiabetesUK @ABCDiab @LDC_tweets @drpatrickholmes @ADA_DiabetesPro @NHSDiabetesProg Wrong! Doesn’t matter when calories and protein are equal! HALL, Kevin D.; GUO, Juen. Obesity energetics: body weight regulation and the effects of diet composition. Gastroenterology, v. 152, n. 7, p. 1718-1727. e3, 2017. What is your evidence?
@shivadas29 @Anurag817 @BioLayne @shivadas29 - or we could look at body comp outcomes in multiple studies equating prot & kcal, and see that you're missing the forest for the trees while incorrectly presuming the direction of causality: https://t.co/2Eszyho8AY More discussion here: https://t.co/wOi7uWqIk8
@rebelhealth1 Kevin Hall be like "hold my beer" https://t.co/2MCpbeFtl9
@SiponenMatti @TheBhupiThakur @davidludwigmd @AlbiteArencibia @BioLayne @The_Nutrivore @TheAlanAragon @JoseAntonioPhD @BradSchoenfeld @mackinprof When protein and calories are equated between groups, there isn't a meaningful difference in body fat or energy expenditure. Meta-analysis of 32 such studies. If anything, slightly favors low-fat diets. https://t.co/jLq2CUsGNY
RT @s8mb: @zachcaceres Sure, here's a meta-analysis of diets that restricted either carbs or fat. https://t.co/qEC0dMFs04 In general I re…
RT @s8mb: Do carb-restricting diets do better than fat-restricting ones? No – says this meta-analysis of 32 controlled feeding studies. ht…
RT @s8mb: Do carb-restricting diets do better than fat-restricting ones? No – says this meta-analysis of 32 controlled feeding studies. ht…
RT @s8mb: Do carb-restricting diets do better than fat-restricting ones? No – says this meta-analysis of 32 controlled feeding studies. ht…
RT @s8mb: Do carb-restricting diets do better than fat-restricting ones? No – says this meta-analysis of 32 controlled feeding studies. ht…
RT @s8mb: Do carb-restricting diets do better than fat-restricting ones? No – says this meta-analysis of 32 controlled feeding studies. ht…
Do carb-restricting diets do better than fat-restricting ones? No – says this meta-analysis of 32 controlled feeding studies. https://t.co/qEC0dMFs04 https://t.co/292gE2H4Wl
@zachcaceres Sure, here's a meta-analysis of diets that restricted either carbs or fat. https://t.co/qEC0dMFs04 In general I recommend Stephan Guyenet's work on this. But I'm not claiming he is a good basis for govt policy either, just that the sugar=bad thesis isn't well-supported. https://t.co/qQBvoyadBg
@PeterFaberSP “Calories don’t matter, it’s all insulin”. For your reading pleasure. https://t.co/UyYUei5oyw https://t.co/xNU1Av5jlW https://t.co/ZCp2Iqwaw7 https://t.co/EL2kEOLmKZ https://t.co/woijUoBmc5 https://t.co/oUM2nYCGll https://t.co/HZVzJw659z
@DNSWilson @bschermd @DaveKeto @fancypirate8 @DoctorTro What do you think about: “Our meta-analysis of 32 controlled feeding studies with isocaloric substitution of carbohydrate for fat found that both energy expenditure (26 kcal/d; P <.0001) and fat loss (16 g/d; P <.0001) were greater with lower fat diets.” https://t.co/dmilUYkimJ
@Jordan_theCoach @BioLayne @antoniotherose @allthewaywell As did @KevinH_PhD's meta of iso-caloric/iso-protein controlled feeding studies (which Layne has mentioned numerous times before). Metas on observational and controlled studies converging - would think that strengthens the case even more. Thing of beauty. https://t.co/gXzsVeKZDZ
@Jordan_theCoach Since there's no response I'll continue on my own. The CHO-insulin model does not claim that ketogenic diets necessarily increase energy expenditure as you seemed to imply by referencing the study "Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition".
RT @sjoshimd: @janvyjidak @kevinnbass @TheSohoForum @DrDavidKatz A serious answer - we're already aware. It should be fixed for the print i…
@janvyjidak @kevinnbass @TheSohoForum @DrDavidKatz A serious answer - we're already aware. It should be fixed for the print issue. Reference 2 should be this study: Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition https://t.co/GIBXPlRuc5
RT @faraz9994: Here's the evidence, biggest meta-analysis (analysis of multiple studies) on this area https://t.co/OhvmDpz1oK "Obesity Ene…
Here's the evidence, biggest meta-analysis (analysis of multiple studies) on this area https://t.co/OhvmDpz1oK "Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition" Kevin Hall and Juen Guo, National Institute of Diabetes & Digestive & Kidney Diseases https://t.co/z4Y7aXaxzJ
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