YLYi-Chang Liu
@YCnLiu · X
A very elegant way to tell alpha2,3-/2,6-linked sialic acid apart by MS https://t.co/5hKikD3xMF
May 10, 2021 · 68 followers
View post →
February 2017 PMID 28194959
Differentiation of Sialyl Linkage Isomers by One-Pot Sialic Acid Derivatization for Mass Spectrometry-Based Glycan Profiling.
Mentions
3
Peak: 1 in May 2021
across 2 sources since May 2021
Extended reach
6,925
potential audience
Total likes
51
Video views
6,858
Mentions per month
May 2021 – Nov 2021Where it's discussed
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YouTube2 videos
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X / Twitter1 posts
AI synopsis
What people are saying
The discussions emphasize the technical achievement, such as describing the method as 'very elegant,' which underscores appreciation for its precision and simplicity, while the brevity indicates a moderate level of engagement without deep dives into its broader significance.
AgreementModerate agreement
The posts reflect a general appreciation for the method, with one calling it 'very elegant,' indicating positive recognition of the research's innovation.
InterestModerate interest
The mentions reveal a moderate level of curiosity, focusing on the technical aspect of distinguishing linkage types by mass spectrometry.
EngagementModerate engagement
Posts show some engagement by discussing the technique's beauty and utility, but they lack extensive detail or critical analysis.
ImpactNeutral impact
The discussion implies some interest in the method's usefulness but does not suggest it has widely transformative implications yet.
Abstract in brief
- The article introduces a new method called SALSA for analyzing glycans with sialic acids using mass spectrometry, which allows for the differentiation of linkage isomers (specifically 2,3- and 2,6-linked sialic acids) by selectively amidating them with different alkyl chains.
- SALSA stabilizes sialic acids, making them more reliable for analysis, and can be combined with existing glycan purification techniques like hydrazide bead purification, simplifying the process of studying complex biological samples such as human plasma.
- The method has been tested with standards and applied to real samples, demonstrating its effectiveness for accurate profiling of sialyl linkage isomers in glycan analysis.
Top posts
Most liked on X and BlueskyAll mentions
Differentiating Sialic Acid Linkages in Glycosphingolipids Using Ring-Opening Aminolysis
This video explains the new aminolysis SALSA method for identifying specific sialic acid linkages in glycosphingolipids, simplifying glycan isomer analysis and enhancing mass spectrometry applications in glycan research.
株式会社島津製作所 / Shimadzu Corporation · Aug 5, 2021
4,883 views
Advancements in Mass Spectrometry for Disease Detection and Glycan Analysis
The Koichi Tanaka Mass Spectrometry Research Laboratory specializes in early disease detection and molecular analysis using MALDI-IMS. This 4-minute overview highlights recent research breakthroughs, including…
株式会社島津製作所 / Shimadzu Corporation · Nov 29, 2021
1,976 views
Yi-Chang Liu
@YCnLiu · X
A very elegant way to tell alpha2,3-/2,6-linked sialic acid apart by MS https://t.co/5hKikD3xMF
May 10, 2021 · 68 followers
View post →
No mentions from this source yet.