Circulation April 2017 PMID 28289069

Omega-3 Polyunsaturated Fatty Acid (Fish Oil) Supplementation and the Prevention of Clinical Cardiovascular Disease: A Science Advisory From the American Heart Association.

David S Siscovick, Thomas A Barringer, Amanda M Fretts, Jason H Y Wu, Alice H Lichtenstein, Rebecca B Costello, Penny M Kris-Etherton, Terry A Jacobson, Mary B Engler, Heather M Alger, Lawrence J Appel, Dariush Mozaffarian

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Mentions

170
Peak: 8 in Jun 2024
across 5 sources since Nov 2019

Extended reach

542,253
potential audience

Total likes

27,040

Video views

402,522

Mentions per month

Nov 2019 – Nov 2025

Where it's discussed

  • News122 articles
  • Facebook26 posts
  • X / Twitter12 posts
  • YouTube5 videos
  • Blogs5 articles

AI synopsis

What people are saying

Discussions explore the reliability of clinical guidelines based on large RCTs versus mechanistic studies, with posts mentioning the 2002 AHA recommendation and negative trial outcomes, showing a balanced engagement that recognizes both the importance of evidence and existing controversies.

AgreementModerate agreement

Most discussions highlight the importance of rigorous evidence, with some skeptical comments about negative trial results, suggesting general agreement on the cautious interpretation of the research.

InterestModerate interest

The posts focus mainly on clinical guidelines and trial outcomes, indicating moderate interest in the specifics of the publication.

EngagementModerate engagement

Participants reference guidelines, previous studies, and trial results, demonstrating moderate depth of engagement with the content.

ImpactNeutral impact

Comments acknowledge the significance of large RCTs and guidelines but do not suggest transformative change, reflecting a moderate perceived impact.

Top posts

Most liked on X and Bluesky
Gil Carvalho MD PhD
@NutritionMadeS3 · X

"RCTs of major disease end points, when available, should trump studies of intermediate end points and mechanistic studies when clinical decisions are being made" understanding this simple idea dispels 90% of social media wellness confusion https://t.co/EKxuQjy0HQ

Jun 23, 2024 · 46 likes · 7 shares · 27,882 followers View post →
CardioNerds Journal Club
@CardioNerdsJC · X

In 2002, AHA recommended that patients with documented coronary artery disease take ~1 g/d EPA + DHA (after talking to a physician). #CardsJC https://t.co/kwG1N4hYU5

Feb 9, 2021 · 8 likes · 2 shares · 8,215 followers View post →
Eric Secemsky MD MSc
@EricSecemskyMD · X

@GopalKkoduru @Angiologist @DLBHATTMD Plenty of negative fish oil trials for secondary prevention or high risk CV patients, almost all of which were negative. Nicely reviewed here, see Table 3: https://t.co/66T8B1eLh6

Nov 20, 2019 · 2 likes · 4,617 followers View post →
CardioNerds
@CardioNerds · X

RT @CardioNerdsJC: In 2002, AHA recommended that patients with documented coronary artery disease take ~1 g/d EPA + DHA (after talking to a…

Feb 9, 2021 · 2 shares · 40,611 followers View post →
Simon Hill MSc, BSc
@theproof · X

RT @NutritionMadeS3: "RCTs of major disease end points, when available, should trump studies of intermediate end points and mechanistic stu…

Jun 23, 2024 · 7 shares · 34,220 followers View post →
Michael Joseph
@Nutradvance · X

RT @NutritionMadeS3: "RCTs of major disease end points, when available, should trump studies of intermediate end points and mechanistic stu…

Jun 24, 2024 · 7 shares · 11,778 followers View post →

All mentions

Omega-3 Index and Heart Disease Risk Explained

This video explores the Omega-3 Index, a measure of EPA and DHA levels in red blood cells, and its significance as a risk factor for coronary heart disease. Higher levels provide greater protection, making it a valuable…

Physionic · Nov 20, 2025 30,521 views
Revel Peters
@urbanlamb · X

RT @NutritionMadeS3: "RCTs of major disease end points, when available, should trump studies of intermediate end points and mechanistic stu…

Jun 25, 2024 · 7 shares · 109 followers View post →
Sebastian Catana
@sebastiancatana · X

RT @NutritionMadeS3: "RCTs of major disease end points, when available, should trump studies of intermediate end points and mechanistic stu…

Jun 25, 2024 · 7 shares · 65 followers View post →
Kille Tölönen
@Neonomide · X

RT @NutritionMadeS3: "RCTs of major disease end points, when available, should trump studies of intermediate end points and mechanistic stu…

Jun 24, 2024 · 7 shares · 926 followers View post →
Michael Joseph
@Nutradvance · X

RT @NutritionMadeS3: "RCTs of major disease end points, when available, should trump studies of intermediate end points and mechanistic stu…

Jun 24, 2024 · 7 shares · 11,778 followers View post →
Rx Readmore Livemore
@SopitaSirirata1 · X

RT @NutritionMadeS3: "RCTs of major disease end points, when available, should trump studies of intermediate end points and mechanistic stu…

Jun 24, 2024 · 7 shares · 167 followers View post →
Colleen Griffith
@Griffith17431 · X

RT @NutritionMadeS3: "RCTs of major disease end points, when available, should trump studies of intermediate end points and mechanistic stu…

Jun 23, 2024 · 7 shares · 931 followers View post →
Simon Hill MSc, BSc
@theproof · X

RT @NutritionMadeS3: "RCTs of major disease end points, when available, should trump studies of intermediate end points and mechanistic stu…

Jun 23, 2024 · 7 shares · 34,220 followers View post →
Gil Carvalho MD PhD
@NutritionMadeS3 · X

"RCTs of major disease end points, when available, should trump studies of intermediate end points and mechanistic studies when clinical decisions are being made" understanding this simple idea dispels 90% of social media wellness confusion https://t.co/EKxuQjy0HQ

Jun 23, 2024 · 46 likes · 7 shares · 27,882 followers View post →
Daniel Ambinder, MD
@Dr_DanMD · X

RT @CardioNerdsJC: In 2002, AHA recommended that patients with documented coronary artery disease take ~1 g/d EPA + DHA (after talking to a…

Feb 9, 2021 · 2 shares · 10,087 followers View post →
CardioNerds
@CardioNerds · X

RT @CardioNerdsJC: In 2002, AHA recommended that patients with documented coronary artery disease take ~1 g/d EPA + DHA (after talking to a…

Feb 9, 2021 · 2 shares · 40,611 followers View post →
CardioNerds Journal Club
@CardioNerdsJC · X

In 2002, AHA recommended that patients with documented coronary artery disease take ~1 g/d EPA + DHA (after talking to a physician). #CardsJC https://t.co/kwG1N4hYU5

Feb 9, 2021 · 8 likes · 2 shares · 8,215 followers View post →
Eric Secemsky MD MSc
@EricSecemskyMD · X

@GopalKkoduru @Angiologist @DLBHATTMD Plenty of negative fish oil trials for secondary prevention or high risk CV patients, almost all of which were negative. Nicely reviewed here, see Table 3: https://t.co/66T8B1eLh6

Nov 20, 2019 · 2 likes · 4,617 followers View post →