Neuron April 2017 PMID 28318784

Kinetics of Endogenous CaMKII Required for Synaptic Plasticity Revealed by Optogenetic Kinase Inhibitor.

Hideji Murakoshi, Myung Eun Shin, Paula Parra-Bueno, Erzsebet M Szatmari, Akihiro C E Shibata, Ryohei Yasuda

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Peak: 2 in Mar 2017

across 5 sources since Mar 2017

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6,135

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2,784

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Mar 2017 – Oct 2022

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AI synopsis

What people are saying

Many discussions highlight the significance of the timing of CaMKII activity in synaptic plasticity, with examples like references to Murakoshi et al.'s work and mentions of optogenetic tools. The tone incorporates scientific terms and references that indicate a motivated yet cautious interest in the study's implications.

AgreementModerate agreement

The discussions generally acknowledge the importance of the study, with some referencing prior work, indicating overall support for the research findings.

InterestModerate interest

Participants show moderate curiosity, mentioning specific mechanisms like CaMKII signaling and methods such as optogenetics, but without deep enthusiasm.

EngagementModerate engagement

Comments include references to related literature and attempts to connect the findings to broader questions in neuroscience, reflecting thoughtful engagement.

ImpactModerate impact

The discussions recognize potential implications for understanding memory and learning, suggesting the research could influence future investigations.

Abstract in brief

The study focuses on understanding the timing of CaMKII signaling necessary for synaptic and behavioral plasticity.
A genetically engineered inhibitor, paAIP2, was used to temporarily block CaMKII activity, revealing that the first 1-2 minutes of activation is critical for long-term potentiation (LTP) and memory formation.
Findings suggest that manipulating CaMKII activity at specific times can help clarify its role in learning and memory processes.

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All mentions

Understanding CaMKII's Role in Synaptic Plasticity and Memory

Hideji Murakoshi Myung Eun Shin Paula ParraBueno Erzsebet Szatmari Akihiro C E Shibata and Ryohei Yasuda 2017 Neuron DOI 101016jneuron201702036. The study explores the timing of CaMKII signaling in synaptic and…

MPFNeuro · Mar 16, 2017 2,547 views

Analyzing CaMKII Kinetics in Synaptic Plasticity Using Optogenetics

This video explores how the timing of CaMKII activation influences synaptic and behavioral plasticity, highlighting the critical first 1-2 minutes for long-term potentiation and memory formation using optogenetic kinase…

AJE Video Bytes · Mar 17, 2017 237 views

luca Leli.

@adamoprogresso · X

Kinetics of Endogenous CaMKII Required for Synaptic Plasticity Revealed by Optogenetic Kinase Inhibitor https://t.co/T0cn6dMXVe

Oct 6, 2022 · 3,277 followers View post →

Frank

@FranzG89 · X

@KennethHayworth I'd like to put forward Murakoshi et al. 2017 10.1016/j.neuron.2017.02.036

Sep 15, 2019 · 74 followers View post →