Gut August 2017 PMID 28325746

Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation.

Benoit Chassaing, Tom Van de Wiele, Jana De Bodt, Massimo Marzorati, Andrew T Gewirtz

Mentions

88
Peak: 3 in Aug 2024
across 5 sources since Jan 2019

Extended reach

26,418
potential audience

Total likes

114

Video views

4,584

Mentions per month

Jan 2019 – Oct 2025

Where it's discussed

  • News40 articles
  • Facebook32 posts
  • X / Twitter8 posts
  • Blogs6 articles
  • YouTube2 videos

AI synopsis

What people are saying

The overall tone reflects strong agreement with the study's findings, with posts highlighting issues like inflammation and microbiota disruption, using words such as 'detrimental,' 'disrupt,' and 'dangerous.' The discussion demonstrates high interest through mentions of further research and health implications, contributing to a perception of the research's importance and potential influence on dietary guidelines.

AgreementStrong agreement

Most discussions support the findings, with many acknowledging that emulsifiers have negative effects on gut health.

InterestHigh interest

The posts actively engage with the topic, citing research and potential health implications, indicating high interest.

EngagementModerate engagement

Discussions include references to scientific studies, future research, and health concerns, showing a moderate level of deep engagement.

ImpactHigh impact

Participants emphasize the significance of the research for public health and food safety, indicating a high perceived impact.

Abstract in brief

  • The study finds that dietary emulsifiers, specifically polysorbate 80 (P80) and carboxymethylcellulose (CMC), directly alter gut microbiota composition and gene expression, leading to increased intestinal inflammation.
  • Using an ex vivo model (MSHIME), researchers observed that CMC quickly increased proinflammatory markers like flagellin through microbiota gene expression changes, while P80 caused a slower increase linked to shifts in microbial species.
  • Transferring microbiota from emulsifier-treated models to germ-free mice reproduced many inflammation-related changes, showing that these food additives directly impact microbiota in ways that promote gut inflammation, independent of host factors.

Top posts

Most liked on X and Bluesky
Rina Saltman
@rinatie_ceo · X

Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation | ⁦@GUTJournal_BMJ⁩ https://t.co/p1QjCzPS4b

Jan 22, 2019 · 1 like · 3,567 followers View post →
Mikki Williden PhD
@MikkiWilliden · X

Dietary Emulsifiers Directly Alter Human Microbiota Composition and Gene Expression Ex Vivo Potentiating Intestinal… https://t.co/m9xCxx1Q9A

May 31, 2020 · 1 like · 2,241 followers View post →
Chassaing Laboratory
@BenoitChassaing · X

@zinocker @ggkuhnle Here also, in addition to highlight these limits in our study, we are working on follow study to investigate these important point. And in both mice and in vitro, we have found similar effects for doses 10 times lower ;-) https://t.co/kwK0TvhMjj https://t.co/Ms4Ji2zTyh

Oct 14, 2020 · 1 like · 1,786 followers View post →
jacob peters
@J__Cub · X

why are people saying emulsifiers are dangerous? research suggests they can disrupt the gut microbiome, leading to a host of problems: • weight gain • inflammation • digestive issues • autoimmune diseases and allergies https://t.co/Wrofw5bhxc

Apr 20, 2023 · 10,964 followers View post →
Chassaing Laboratory
@BenoitChassaing · X

Such detrimental effect of emulsifiers are mediated through their direct effects on the intestinal #microbiota, as reported in both pre-clinical models https://t.co/Ms4Ji2zTyh as well as in humans https://t.co/cAQg8YVmwZ, while the exact impact on human health remained unclear 3/

Apr 24, 2024 · 1,786 followers View post →
Sean Hurley
@Age_Wisely · X

@ZKForTre Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation Benoit Chassaing, Jana De Bodt, [...], and Andrew T. Gewirtz

Nov 28, 2019 · 1,153 followers View post →

All mentions

Spider
@IntuitiveSpider · X

@rf121rf Viennois et al. (2017). Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation. Gut, 66(8), 1414–1427. P80 exposure in human microbiota model upregulated inflammation genes and altered composition.

Oct 29, 2025 · 338 followers View post →
Emazing Earth
@EmazingEarth · X

#health #wellness #foodadditives #guthealth #healthalert #digestivehealth #cleaneating #digestivesystem #foodeducation #fda https://t.co/wfTUq3AQjm https://t.co/V2feyS0a3C https://t.co/BSPGhLUoCc https://t.co/Al2Xjd2OZp https://t.co/rd0OM6nE3a

Aug 31, 2024 View post →
Chassaing Laboratory
@BenoitChassaing · X

Such detrimental effect of emulsifiers are mediated through their direct effects on the intestinal #microbiota, as reported in both pre-clinical models https://t.co/Ms4Ji2zTyh as well as in humans https://t.co/cAQg8YVmwZ, while the exact impact on human health remained unclear 3/

Apr 24, 2024 · 1,786 followers View post →
jacob peters
@J__Cub · X

why are people saying emulsifiers are dangerous? research suggests they can disrupt the gut microbiome, leading to a host of problems: • weight gain • inflammation • digestive issues • autoimmune diseases and allergies https://t.co/Wrofw5bhxc

Apr 20, 2023 · 10,964 followers View post →
Chassaing Laboratory
@BenoitChassaing · X

@zinocker @ggkuhnle Here also, in addition to highlight these limits in our study, we are working on follow study to investigate these important point. And in both mice and in vitro, we have found similar effects for doses 10 times lower ;-) https://t.co/kwK0TvhMjj https://t.co/Ms4Ji2zTyh

Oct 14, 2020 · 1 like · 1,786 followers View post →
Mikki Williden PhD
@MikkiWilliden · X

Dietary Emulsifiers Directly Alter Human Microbiota Composition and Gene Expression Ex Vivo Potentiating Intestinal… https://t.co/m9xCxx1Q9A

May 31, 2020 · 1 like · 2,241 followers View post →
Sean Hurley
@Age_Wisely · X

@ZKForTre Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation Benoit Chassaing, Jana De Bodt, [...], and Andrew T. Gewirtz

Nov 28, 2019 · 1,153 followers View post →
Rina Saltman
@rinatie_ceo · X

Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation | ⁦@GUTJournal_BMJ⁩ https://t.co/p1QjCzPS4b

Jan 22, 2019 · 1 like · 3,567 followers View post →