July 2017 PMID 28381470

Evidence Supporting the Existence of a Distinct Obese Phenotype of Heart Failure With Preserved Ejection Fraction.

Masaru Obokata, Yogesh N V Reddy, Sorin V Pislaru, Vojtech Melenovsky, Barry A Borlaug

Mentions

26
Peak: 6 in Dec 2021
across 4 sources since Dec 2019

Extended reach

136,820
potential audience

Total likes

133

Video views

3,405

Mentions per month

Dec 2019 – Aug 2023

Where it's discussed

  • X / Twitter16 posts
  • Facebook5 posts
  • News3 articles
  • YouTube2 videos

AI synopsis

What people are saying

The collection shows a strong consensus supporting the idea of a distinct obese HFpEF phenotype, with discussions emphasizing mechanistic details such as epicardial fat, pericardial restraint, and plasma volume expansion, using technical language indicative of deep engagement. The references to ongoing studies and clinical implications highlight the potential impact of this research on future treatment strategies.

AgreementModerate agreement

Most discussions acknowledge the findings of the publication and support the idea of a distinct obese HFpEF phenotype, indicating a generally positive consensus.

InterestHigh interest

The discussions reflect high interest, with users focusing on clinical implications, mechanisms, and ongoing research, demonstrating engagement with the topic.

EngagementModerate engagement

Posts often refer to specific physiological mechanisms, clinical considerations, and ongoing studies, indicating a moderate level of deep engagement.

ImpactModerate impact

The discussions suggest that the research could influence future treatment approaches and understanding of HFpEF in obese patients, indicating a recognized potential for significant impact.

Abstract in brief

  • Obese HFpEF patients show distinct heart structure and function features, including increased plasma volume, concentric left ventricular remodeling, and right ventricular dilatation, setting them apart from nonobese HFpEF patients and healthy controls.
  • These differences are linked to higher epicardial fat, greater heart volumes, and increased pericardial restraint, despite lower levels of N-terminal proBNP, indicating unique pathophysiology in obese HFpEF.
  • The study suggests that obesity-related traits like plasma volume and body mass are correlated with pulmonary pressure in obese HFpEF, implying that obesity could define a specific, distinct subtype of HFpEF that may require tailored treatment approaches.]

Top posts

Most liked on X and Bluesky
Sarah Hudson
@sarahhudsonuk · X

Remember that in obese pts with HFpEF, there is a low NTproBNP despite a high PCWP Slide shared by @lamcardio at #BSHAM2021 Paper: https://t.co/7TwKESSimU #CardioEd https://t.co/VRcPHCWx3B

Dec 3, 2021 · 18 likes · 5 shares · 8,060 followers View post →
Sanjiv J. Shah, MD
@HFpEF · X

Answer: Obesity HFpEF phenotype with severe pericardial, epicardial fat over the RV causing pericardial constraint (not constrictive pericarditis--pericardium was normal). See: https://t.co/Sy7krJKTyg https://t.co/8rHupPG152

Dec 9, 2020 · 11 likes · 6,014 followers View post →
Sanjiv J. Shah, MD
@HFpEF · X

@Sandeepchennadi Here is the original paper, which describes it in detail: https://t.co/Sy7krJKTyg

Dec 9, 2020 · 5 likes · 6,014 followers View post →
Yogesh Reddy
@yreddyhf · X

@djc795 @naderjo @Steph_Achenbach @Obisht @mmamas1973 @mirvatalasnag @jedicath @SVRaoMD @aspergian1 @kaschenke @KardiologieHH @Hragy @rvprog @willsuh76 @lorenzbott @DavidLBrownMD @DFCapodanno The association with HF and HFpEF is particularly strong and probably causal although we need intervention studies of weight loss to prove causality for sure which are ongoing https://t.co/9ONlPRKo3w

Apr 9, 2022 · 5 likes · 1 share · 1,385 followers View post →
Sergio Caravita
@CaravitaSergio · X

@jeanlucvachiery @ATS_PC @awtpulmdoc @RyanTedfordMD 2/ High likelihood of high PAWP, either due to LV diast dysf or constrictive-like features promoted by excess epicardial and intrathoracic adipose tissue, along with plasma volume expansion. https://t.co/HF4O4Z1cnr

Aug 24, 2021 · 2 likes · 1 share · 560 followers View post →
Yogesh Reddy
@yreddyhf · X

@iamritu @Charles_Kyr @AndreasGevaert @JGrapsa @rudolf_deboer @kevin_damman @GiuseppeGalati_ @AnastasiaSMihai @vass_vassiliou @hvanspall @DrWillWatson And we’ve observed this as well in part due to pseudo constriction physiology. https://t.co/9ONlPRKo3w

Dec 14, 2019 · 1 like · 1,385 followers View post →

All mentions

Linda
@wordfinga · X

RT @yreddyhf: @djc795 @naderjo @Steph_Achenbach @Obisht @mmamas1973 @mirvatalasnag @jedicath @SVRaoMD @aspergian1 @kaschenke @KardiologieHH…

Apr 10, 2022 · 1 share · 4,583 followers View post →
Yogesh Reddy
@yreddyhf · X

@djc795 @naderjo @Steph_Achenbach @Obisht @mmamas1973 @mirvatalasnag @jedicath @SVRaoMD @aspergian1 @kaschenke @KardiologieHH @Hragy @rvprog @willsuh76 @lorenzbott @DavidLBrownMD @DFCapodanno The association with HF and HFpEF is particularly strong and probably causal although we need intervention studies of weight loss to prove causality for sure which are ongoing https://t.co/9ONlPRKo3w

Apr 9, 2022 · 5 likes · 1 share · 1,385 followers View post →
水野篤@心臓の医者✨✨
@atmizu · X

RT @uni_pharmacist: MS13 HFpEFの診断と治療2022 小保方 優先生 「肥満HFpEF症例ではNP濃度が低い!」 NEPによるNP分解亢進も関与? ARNI良いかも

Mar 12, 2022 · 2 shares · 9,927 followers View post →
ときヲ
@toki_wo_koe · X

RT @uni_pharmacist: MS13 HFpEFの診断と治療2022 小保方 優先生 「肥満HFpEF症例ではNP濃度が低い!」 NEPによるNP分解亢進も関与? ARNI良いかも

Mar 12, 2022 · 2 shares · 2,590 followers View post →
The Pulmonary Vascular Research Institute
@PVRI · X

Ref 1 / 3 https://t.co/q6ZSxNufD8

Mar 4, 2022 · 2,436 followers View post →
SHFNF
@ScottishHFNF · X

RT @sarahhudsonuk: Remember that in obese pts with HFpEF, there is a low NTproBNP despite a high PCWP Slide shared by @lamcardio at #BSH…

Dec 4, 2021 · 5 shares · 1,288 followers View post →
Hany Ragy
@Hragy · X

RT @sarahhudsonuk: Remember that in obese pts with HFpEF, there is a low NTproBNP despite a high PCWP Slide shared by @lamcardio at #BSH…

Dec 4, 2021 · 5 shares · 80,675 followers View post →
Jan Verwerft
@VerwerftJan · X

RT @sarahhudsonuk: Remember that in obese pts with HFpEF, there is a low NTproBNP despite a high PCWP Slide shared by @lamcardio at #BSH…

Dec 3, 2021 · 5 shares · 4,264 followers View post →
Maria
@paton_maria · X

RT @sarahhudsonuk: Remember that in obese pts with HFpEF, there is a low NTproBNP despite a high PCWP Slide shared by @lamcardio at #BSH…

Dec 3, 2021 · 5 shares · 1,553 followers View post →
CardioEd Bot
@CardioBot · X

RT @sarahhudsonuk: Remember that in obese pts with HFpEF, there is a low NTproBNP despite a high PCWP Slide shared by @lamcardio at #BSH…

Dec 3, 2021 · 5 shares · 1,207 followers View post →
Sarah Hudson
@sarahhudsonuk · X

Remember that in obese pts with HFpEF, there is a low NTproBNP despite a high PCWP Slide shared by @lamcardio at #BSHAM2021 Paper: https://t.co/7TwKESSimU #CardioEd https://t.co/VRcPHCWx3B

Dec 3, 2021 · 18 likes · 5 shares · 8,060 followers View post →
ATS PC Assembly
@ATS_PC · X

RT @CaravitaSergio: @jeanlucvachiery @ATS_PC @awtpulmdoc @RyanTedfordMD 2/ High likelihood of high PAWP, either due to LV diast dysf or con…

Aug 24, 2021 · 1 share · 1,398 followers View post →
Sergio Caravita
@CaravitaSergio · X

@jeanlucvachiery @ATS_PC @awtpulmdoc @RyanTedfordMD 2/ High likelihood of high PAWP, either due to LV diast dysf or constrictive-like features promoted by excess epicardial and intrathoracic adipose tissue, along with plasma volume expansion. https://t.co/HF4O4Z1cnr

Aug 24, 2021 · 2 likes · 1 share · 560 followers View post →
Sanjiv J. Shah, MD
@HFpEF · X

@Sandeepchennadi Here is the original paper, which describes it in detail: https://t.co/Sy7krJKTyg

Dec 9, 2020 · 5 likes · 6,014 followers View post →
Sanjiv J. Shah, MD
@HFpEF · X

Answer: Obesity HFpEF phenotype with severe pericardial, epicardial fat over the RV causing pericardial constraint (not constrictive pericarditis--pericardium was normal). See: https://t.co/Sy7krJKTyg https://t.co/8rHupPG152

Dec 9, 2020 · 11 likes · 6,014 followers View post →
Yogesh Reddy
@yreddyhf · X

@iamritu @Charles_Kyr @AndreasGevaert @JGrapsa @rudolf_deboer @kevin_damman @GiuseppeGalati_ @AnastasiaSMihai @vass_vassiliou @hvanspall @DrWillWatson And we’ve observed this as well in part due to pseudo constriction physiology. https://t.co/9ONlPRKo3w

Dec 14, 2019 · 1 like · 1,385 followers View post →