Br J Pharmacol July 2017 PMID 28444738

Factors influencing biased agonism in recombinant cells expressing the human α -adrenoceptor.

Edilson Dantas da Silva Junior, Masaaki Sato, Jon Merlin, Natalie Broxton, Dana S Hutchinson, Sabatino Ventura, Bronwyn A Evans, Roger J Summers

Download social card

Mentions

Peak: 3 in Feb 2020

across 3 sources since Feb 2020

Extended reach

4,070

potential audience

Total likes

Video views

1,752

Mentions per month

Feb 2020 – Feb 2023

Where it's discussed

X / Twitter3 posts
YouTube2 videos
Facebook2 posts

AI synopsis

What people are saying

Several discussions highlight the importance of considering endogenous receptor effects, describing how the study reveals potential confounding factors in biased agonism research. Words like 'significant,' 'important,' and 'implications' suggest a recognition of the work's relevance, though the tone remains mainly informative rather than deeply analytical.

AgreementModerate agreement

Most discussions acknowledge the significance of the study in advancing understanding of biased signaling at adrenoceptors, with some emphasizing its relevance to drug discovery.

InterestModerate interest

Participants show moderate interest, mentioning how the findings could influence future research and pharmacology.

EngagementNeutral engagement

The discussions are somewhat superficial, with limited in-depth analysis or technical debate, reflecting a moderate level of engagement.

ImpactModerate impact

There is a general consensus that the research has meaningful implications, especially for designing selective drugs and understanding off-target effects.

Abstract in brief

The study investigates how biased signaling at human adrenoceptors in recombinant cells can be influenced by off-target effects from endogenous receptors, with a focus on ERK12 phosphorylation and calcium mobilization.
Results show that while some agonists like phenylephrine and methoxamine exhibit genuine bias towards specific pathways, others like oxymetazoline appear biased due to off-target effects at serotonin (5HT) receptors present in the cells.
The research emphasizes the importance of considering confounding factors, such as endogenous GPCRs in cell lines, when studying biased agonism for drug discovery purposes.]

Read the full abstract

All mentions

Understanding Factors Affecting Biased Agonism in Human Alpha-Adrenoceptors

This study investigates how biased signaling at human adrenoceptors in recombinant cells can be influenced by off-target effects from endogenous receptors, with a focus on ERK12 phosphorylation and calcium mobilization…

British Pharmacological Society · Feb 25, 2020 1,175 views

Biased Signaling at Human Adrenoceptors and Its Role in Drug Discovery

This study explores how biased signaling at human adrenoceptors in recombinant cells can be affected by off-target effects from endogenous receptors. Results highlight the importance of considering confounding factors…

British Pharmacological Society · Feb 25, 2020 578 views

愛媛大学消化器・内分泌・代謝内科

@aidaisannai · X

明日の抄読会は内分泌・代謝グループの中口先生。BPS Publications https://t.co/wrECDAguQy

Feb 8, 2023 · 2 likes · 701 followers View post →

Charles Whalley

@cwhalleypub · X

https://t.co/RB5HuE7dB4

Mar 2, 2020 · 809 followers View post →