J Evid Based Med May 2017 PMID 28452193

Effects of placebos without deception compared with no treatment: A systematic review and meta-analysis.

James E G Charlesworth, Grace Petkovic, John M Kelley, Monika Hunter, Igho Onakpoya, Nia Roberts, Franklin G Miller, Jeremy Howick

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Mentions

56
Peak: 6 in Aug 2021
across 5 sources since May 2017

Extended reach

286,231
potential audience

Total likes

238

Video views

881

Mentions per month

May 2017 – Aug 2023

Where it's discussed

  • X / Twitter49 posts
  • YouTube2 videos
  • News2 articles
  • Blogs2 articles
  • Facebook1 posts

AI synopsis

What people are saying

The discussions reflect a consensus that open-label placebos can have beneficial effects, as evidenced by posts referencing various studies and emphasizing ethical advantages, with phrases like 'positive effect' and 'ethical approach.' The tone and context show curiosity about scientific validity and ethical implications, reinforcing a moderate but meaningful impact of the article's findings.

AgreementModerate agreement

Most discussions acknowledge the findings that open-label placebos have some positive effects, indicating general agreement with the article's conclusions.

InterestHigh interest

There is high curiosity and active engagement, with posts referencing multiple studies and ethical considerations, showing sustained interest.

EngagementModerate engagement

Posts delve into scientific details, ethical debates, and references to research, indicating a moderate level of deep involvement.

ImpactModerate impact

While some posts suggest the findings could influence medical practices and ethical standards, the overall perceived impact is moderate, acknowledging the need for further research.

Abstract in brief

  • The study reviewed existing research and found that open-label placebos (placebos given honestly without deception) can have positive effects on conditions like irritable bowel syndrome, depression, allergies, back pain, and ADHD, compared to no treatment.
  • The analysis included five clinical trials with 260 participants, but the researchers noted limitations such as a small number of studies, moderate bias risk, and the lack of blinding, which could affect the results.
  • The findings suggest that open-label placebos could be beneficial, but more large-scale, well-designed studies are needed to confirm their effectiveness and understand how positive messages and ethics play a role.

Top posts

Most liked on X and Bluesky
WEBPMAFIA
@criskingdom · X

@Thomas_Banacek @BadMedicalTakes Believe it or not, no: https://t.co/VGTmyaMMKD. (tl;dr - the evidence isn't *perfect*, but open-label placebos have a small positive effect, better than no treatment, esp. because it's usually paired with a positive message like "this is a placebo but you may feel better anyway")

Dec 27, 2022 · 71 likes · 177 followers View post →
Fizz-DI@比較と使い分け-KOJIMA Yushi
@Fizz_DI · X

@pharmacist753 オープンラベルでプラセボを使っても臨床的には有益かもしれない…みたいなSR&MAはあったりしますφ(..) https://t.co/gon1btqGi3

Sep 10, 2020 · 15 likes · 2 shares · 34,635 followers View post →
kuriedits
@kuriedits · X

@santoph ②プラセボ効果。生薬少し入っただけで、劇的に変わるものなのか。「プラセボと認めたら効果なくなるじゃないか」と思われるかもしれませんが、ご安心ください。近年のプラセボ研究では幾つかの疾患で「プラセボとわかってて使っても薬効は得られる」ことが知られています。 https://t.co/cvDRPnRVsx

Apr 12, 2022 · 7 likes · 1 share · 5,040 followers View post →
Abdülaziz AlEnazi عبدالعزيز سعود العنزي
@Abdulaziz_Enazy · X

لا تعرف معنى #بلاسيبو ؟ #الأدوية_الوهمية https://t.co/QQb1HCoCeT #هنا شرحًا قصيرًا https://t.co/VL4r8dBUvn

Aug 20, 2021 · 7 likes · 4 shares · 4,864 followers View post →
Dominik Andree
@andree_dominik · X

@Mami_mit_Herz @FrankBettina Auch offene Placebogabe kann zu Effekten führen. Eine verdeckte Gabe - und damit das Belügen des Patienten - wäre unethisch. https://t.co/bIYL8jAwnQ https://t.co/DUwocy7WLc https://t.co/IZ5qaygJ2l

Jan 15, 2021 · 7 likes · 3,227 followers View post →
Dominik Andree
@andree_dominik · X

@Kachelmann @Dinsteru @skt_johann @Susannchen01 Jupp. Placeboeffekte können auch auftreten, wenn man aufgeklärt wurde: https://t.co/bIYL8jAwnQ https://t.co/DUwocy7WLc https://t.co/IZ5qaygJ2l https://t.co/WGdGhGl2NT

May 25, 2021 · 7 likes · 3,227 followers View post →

All mentions

Ian Derrington
@ian_derrington · X

@jonatanpallesen What does that mean for all the studies that suggest the opposite where they compare treatment and no treatment in 3 arm trials? https://t.co/gSd6m3MfIw and here (and many more places) https://t.co/ddyyrgMRLJ Are you cherry-picking your analysis studies?

Aug 27, 2023 · 122 followers View post →
Anatoly Lubarsky
@anatoly · X

@jonatanpallesen The review study from 2004 has 2 authors (basically that means 1 author). Here is a study from 2017 where they found positive effect of open-label placebo for certain conditions. Seems to be more reliable. https://t.co/88RlgGqi2w https://t.co/Gex242r8f2

Aug 21, 2023 · 1 like · 5,649 followers View post →
Anatoly Lubarsky
@anatoly · X

@ScottAdamsSays >>Well, how about this?<< The review study from 2004 linked by the OP has 2 authors (basically that means 1 author). Here is a study from 2017 where they found positive effect of open-label placebo for certain conditions. Seems to be more reliable. https://t.co/88RlgGqi2w https://t.co/8IlWOxdHiC

Aug 21, 2023 · 3 likes · 5,649 followers View post →
Shane Littrell, PhD
@MetacogniShane · X

@PhilippMarkolin I'd urge caution before believing a post from a guy who's a non-expert in the research he's pontificating about and is relying on a 20 year old paper to support his questionable position. Especially when more modern research conflicts w/ his claims: https://t.co/ZNIILiuh3U

Aug 21, 2023 · 1 like · 878 followers View post →
На остров чуть-чуть обосранных одеял
@codemancer · X

@shipilev Для тех, кому интересно https://t.co/haJhEZWY5j

Aug 19, 2023 · 1 like · 826 followers View post →
麻丸
@uPMjpeOzmJ8ylh1 · X

RT @yakusoutaima: 同じようにアレルギー、腰痛、ADHDやうつの症状改善にもこれらの手法が役立つようです。これらの疾患は大麻が効くと言われているものと似ており、大部分が思い込み効果である可能性があります。 医療として語るならこうした不都合からも目を逸らしてはな…

Jul 12, 2023 · 2 shares · 305 followers View post →
薬草大麻ラボ
@yakusoutaima · X

同じようにアレルギー、腰痛、ADHDやうつの症状改善にもこれらの手法が役立つようです。これらの疾患は大麻が効くと言われているものと似ており、大部分が思い込み効果である可能性があります。 医療として語るならこうした不都合からも目を逸らしてはならないのです。 https://t.co/HyYITRB4pK

Jul 12, 2023 · 7 likes · 2 shares · 502 followers View post →
Non sono in grado
@xGaBollo · X

Jun 18, 2023 · 199 followers View post →
Unai Aso | Psicólogo Sanitario
@unaiaso · X

Charlesworth, J. E., Petkovic, G., Kelley, J. M., Hunter, M., Onakpoya, I., Roberts, N., ... & Howick, J. (2017). Effects of placebos without deception compared with no treatment: a systematic review and meta‐analysis. Journal of Evidence‐Based Medicine, 10(2), 97-107.

Feb 27, 2023 · 2,256 followers View post →
WEBPMAFIA
@criskingdom · X

@Thomas_Banacek @BadMedicalTakes Believe it or not, no: https://t.co/VGTmyaMMKD. (tl;dr - the evidence isn't *perfect*, but open-label placebos have a small positive effect, better than no treatment, esp. because it's usually paired with a positive message like "this is a placebo but you may feel better anyway")

Dec 27, 2022 · 71 likes · 177 followers View post →
Dominik Andree
@andree_dominik · X

@StroganovMarc1 @Asei_sano @zeitonline @mycountrytalks Hier nur eine Auswahl der Evidenz dazu. Sie erzählen – wie die ganze Zeit schon – ahnungslosen Unsinn. https://t.co/bIYL8jAwnQ https://t.co/TZ06rsTkgp https://t.co/IZ5qaygJ2l https://t.co/pw3XVSBoH9.

Jul 25, 2022 · 1 like · 3,227 followers View post →
A Rooted Life
@TheRootCauseCo · X

Do your own research: https://t.co/G12rk8cnpY https://t.co/xvuGRS8L8f https://t.co/X3UMDk66OU https://t.co/ZuOKA9r8NI https://t.co/cznSCc4Wet

Jul 21, 2022 · 4 likes · 41,693 followers View post →
結
@happy_heiakanet · X

RT @kuriedits: @santoph ②プラセボ効果。生薬少し入っただけで、劇的に変わるものなのか。「プラセボと認めたら効果なくなるじゃないか」と思われるかもしれませんが、ご安心ください。近年のプラセボ研究では幾つかの疾患で「プラセボとわかってて使っても薬効は得られる…

Apr 12, 2022 · 1 share · 206 followers View post →
kuriedits
@kuriedits · X

@santoph ②プラセボ効果。生薬少し入っただけで、劇的に変わるものなのか。「プラセボと認めたら効果なくなるじゃないか」と思われるかもしれませんが、ご安心ください。近年のプラセボ研究では幾つかの疾患で「プラセボとわかってて使っても薬効は得られる」ことが知られています。 https://t.co/cvDRPnRVsx

Apr 12, 2022 · 7 likes · 1 share · 5,040 followers View post →
Dominik Andree
@andree_dominik · X

@Die_Apitz @erik_fluegge Ja, das suggeriert zumindest einige Evidenz. Wäre auf jeden Fall ethisch vertretbarer. https://t.co/bIYL8jAwnQ https://t.co/DUwocy7WLc https://t.co/IZ5qaygJ2l https://t.co/pw3XVSBoH9.

Mar 29, 2022 · 3,227 followers View post →
Dominik Andree
@andree_dominik · X

@666WAYNTRAIN999 @DerWebschreiner Unter anderem: https://t.co/bIYL8jAwnQ https://t.co/DUwocy7WLc https://t.co/IZ5qaygJ2l https://t.co/pw3XVSBoH9

Feb 19, 2022 · 1 like · 3,227 followers View post →
Dominik Andree
@andree_dominik · X

@tief_kultur @franke_karsten @Lam3th @tomdabassman @Peter55263714 Hier ein paar, die Evidenzlage ist dazu aber noch relativ dünn, da auch relativ neu. https://t.co/bIYL8jAwnQ https://t.co/DUwocy7WLc https://t.co/IZ5qaygJ2l https://t.co/aq5KA1Q9yT

Jan 4, 2022 · 3 likes · 3,227 followers View post →
Dominik Andree
@andree_dominik · X

@Jan73090646 @TomFragt @TheBigBadMax @MinorPolitical @kattascha Nein, es gibt mehrere Studien dazu. Hier sogar ein sys. Review dazu: https://t.co/bIYL8jAwnQ Und die Formulierung „am Rad drehen” ist Mal völlig daneben...

Dec 6, 2021 · 2 likes · 3,227 followers View post →
Dominik Andree
@andree_dominik · X

@freeheinz @xxSkyeHighxx @FrauHaensch @NatalieGrams @katjaberlin Nein, Placeboeffekte können auch dann auftreten, wenn man bescheid weiß.

Nov 22, 2021 · 3 likes · 3,227 followers View post →
Dominik Andree
@andree_dominik · X

@BlaueSeelentore @schnudelmann @tlnue Das stimmt so nicht. Placeboeffekte können auch dann auftreten, wenn der Patient bescheid weiß:https://t.co/bIYL8jAwnQ https://t.co/DUwocy7WLc https://t.co/IZ5qaygJ2l Interessant dazu auch: https://t.co/CWz1To16NO

Sep 12, 2021 · 3 likes · 3,227 followers View post →
Dominik Andree
@andree_dominik · X

@Norabelle124 @KopfYvonne 1/2 Es gibt einige Evidenz, die zeigt, dass Placeboeffekte auch dann noch auftreten können, wenn man aufgeklärt darüber ist:https://t.co/bIYL8jAwnQ https://t.co/DUwocy7WLc https://t.co/IZ5qaygJ2l

Sep 12, 2021 · 5 likes · 3,227 followers View post →
Abdulraheem MSc, PhD, MBA, PMP® عبدالرحيم الشريف
@alshareefam · X

RT @DrAbdulaziiiz: لا تعرف معنى #بلاسيبو ؟ #الأدوية_الوهمية https://t.co/QQb1HCoCeT #هنا شرحًا قصيرًا https://t.co/VL4r8dBUvn

Aug 21, 2021 · 4 shares · 2,555 followers View post →
Dr. Zeinab Klaab, P.hD
@Nooraloyoun · X

RT @DrAbdulaziiiz: لا تعرف معنى #بلاسيبو ؟ #الأدوية_الوهمية https://t.co/QQb1HCoCeT #هنا شرحًا قصيرًا https://t.co/VL4r8dBUvn

Aug 21, 2021 · 4 shares · 10,611 followers View post →
العنود ‏القويضي
@NudFaisal · X

RT @DrAbdulaziiiz: لا تعرف معنى #بلاسيبو ؟ #الأدوية_الوهمية https://t.co/QQb1HCoCeT #هنا شرحًا قصيرًا https://t.co/VL4r8dBUvn

Aug 20, 2021 · 4 shares · 19,213 followers View post →
تجمع أطباء العالم | Doctors world
@DoctorsWorld_ · X

RT @DrAbdulaziiiz: لا تعرف معنى #بلاسيبو ؟ #الأدوية_الوهمية https://t.co/QQb1HCoCeT #هنا شرحًا قصيرًا https://t.co/VL4r8dBUvn

Aug 20, 2021 · 4 shares · 44,082 followers View post →
Abdülaziz AlEnazi عبدالعزيز سعود العنزي
@Abdulaziz_Enazy · X

لا تعرف معنى #بلاسيبو ؟ #الأدوية_الوهمية https://t.co/QQb1HCoCeT #هنا شرحًا قصيرًا https://t.co/VL4r8dBUvn

Aug 20, 2021 · 7 likes · 4 shares · 4,864 followers View post →
Dominik Andree
@andree_dominik · X

@SvenKoe @kaschewi Placeboeffekte können auch dann funktionieren, wenn man darüber bescheid weiß:https://t.co/bIYL8jAwnQ https://t.co/DUwocy7WLc https://t.co/IZ5qaygJ2l

Aug 10, 2021 · 2 likes · 3,227 followers View post →
Dominik Andree
@andree_dominik · X

@28Jahre2020 @NicErzer @instanthero Das ist falsch. Placeboeffekte können auch dann auftreten, wenn man bescheid weiß:https://t.co/bIYL8jAwnQ https://t.co/DUwocy7WLc https://t.co/IZ5qaygJ2l Und Homöopathie wirkt nicht über Kontexteffekte hinaus. Das ist Fakt.

Jul 14, 2021 · 3,227 followers View post →
Dominik Andree
@andree_dominik · X

@munichlion @LissysFrauchen @Naturschuetzen @ApothekerDer @wolke_sieben Das ist nicht richtig. Placeboeffekte können auch auftreten, wenn ethisch gehandelt und aufgeklärt wird: https://t.co/IZ5qaygJ2l https://t.co/DUwocy7WLc https://t.co/bIYL8jAwnQ

Jul 12, 2021 · 1 like · 3,227 followers View post →
青島周一
@syuichiao89 · X

RT @syuichiao89: Effects of placebos without deception compared with no treatment: A systematic review and meta-analysis https://t.co/6kvGt…

May 31, 2021 · 2 shares · 8,600 followers View post →
SystematicReviewBot
@EvidenceRobot · X

RT @syuichiao89: Effects of placebos without deception compared with no treatment: A systematic review and meta-analysis https://t.co/6kvGt…

May 30, 2021 · 2 shares · 6,687 followers View post →
青島周一
@syuichiao89 · X

Effects of placebos without deception compared with no treatment: A systematic review and meta-analysis https://t.co/6kvGtADh9l

May 30, 2021 · 4 likes · 2 shares · 8,600 followers View post →
Dominik Andree
@andree_dominik · X

@Kachelmann @Dinsteru @skt_johann @Susannchen01 Jupp. Placeboeffekte können auch auftreten, wenn man aufgeklärt wurde: https://t.co/bIYL8jAwnQ https://t.co/DUwocy7WLc https://t.co/IZ5qaygJ2l https://t.co/WGdGhGl2NT

May 25, 2021 · 7 likes · 3,227 followers View post →
Dominik Andree
@andree_dominik · X

@Dbroecker44 @dscharpfMD @drluebbers Wieso erzählen Sie das, wo Sie offensichtlich keinerlei Ahnung davon haben? Auch offen verabreichte Placebos können durchaus Effekte erzielen und wären wenigstens ethisch vertretbar:https://t.co/bIYL8jAwnQ https://t.co/IZ5qaygJ2l

Apr 30, 2021 · 3,227 followers View post →
Dominik Andree
@andree_dominik · X

@Mami_mit_Herz @FrankBettina Auch offene Placebogabe kann zu Effekten führen. Eine verdeckte Gabe - und damit das Belügen des Patienten - wäre unethisch. https://t.co/bIYL8jAwnQ https://t.co/DUwocy7WLc https://t.co/IZ5qaygJ2l

Jan 15, 2021 · 7 likes · 3,227 followers View post →
Dominik Andree
@andree_dominik · X

@chriss3138 @homeopathy_inh https://t.co/bIYL8jAwnQ https://t.co/DUwocy7WLc https://t.co/IZ5qaygJ2l Placeboeffekte sind aber trotzdem keine Rechtfertigung für Homöopathie. Die Behandlung müsste dann auch wirklich offen, ohne Dogmen etc. erfolgen. Und dafür gibt's auch P-Tabletten.

Jan 4, 2021 · 2 likes · 3,227 followers View post →
Dominik Andree
@andree_dominik · X

@Herming1Stephan @DailyKaffee @AndreasMaierHom Falsch. Sie kennen sich Mal so gar nicht aus, ne? Auch offene Placebogabe „wirkt”... Wäre auch als einziges ethisch vertretbar.

Dec 7, 2020 · 3 likes · 3,227 followers View post →
Jed Rosenfeld
@JedIsOverParty · X

@beartoolansnr @PinkieCLC @IncredibleCulk Not so: https://t.co/O8zc9gKHp0

Oct 8, 2020 · 1 like · 118 followers View post →
もぐみ@手洗いうがい
@5DGdrCkeq787SBD · X

RT @Fizz_DI: @pharmacist753 オープンラベルでプラセボを使っても臨床的には有益かもしれない…みたいなSR&MAはあったりしますφ(..) https://t.co/gon1btqGi3

Sep 10, 2020 · 2 shares · 1,525 followers View post →
Fizz-DI@比較と使い分け-KOJIMA Yushi
@Fizz_DI · X

@pharmacist753 オープンラベルでプラセボを使っても臨床的には有益かもしれない…みたいなSR&MAはあったりしますφ(..) https://t.co/gon1btqGi3

Sep 10, 2020 · 15 likes · 2 shares · 34,635 followers View post →
Dominik Andree
@andree_dominik · X

@Eduardo61962868 @Alma75614899 Ja, gibt es. Gucken Sie Mal hier: https://t.co/bIYL8jiUZg https://t.co/DUwocxQlmC https://t.co/IZ5qayyjTT https://t.co/4enJxVP6TD

Sep 5, 2020 · 3 likes · 3,227 followers View post →
Dominik Andree
@andree_dominik · X

@fractality @tailor281 @drluebbers Das geht tatsächlich: https://t.co/IZ5qaygJ2l https://t.co/DUwocy7WLc https://t.co/bIYL8jAwnQ https://t.co/2LmxTg7Dwu

Sep 5, 2020 · 3 likes · 3,227 followers View post →
Dominik Andree
@andree_dominik · X

@luise_michaelis @CS070798 @HNR_shook0 @slidecurry @fabiandoehla Wieso denn nicht? Placeboantworten hängen nicht unbedingt vom Glauben daran ab. Studien zeigen, dass es auch ohne Lügen geht: https://t.co/IZ5qaygJ2l https://t.co/DUwocy7WLc https://t.co/bIYL8jAwnQ https://t.co/CWz1To16NO

Sep 2, 2020 · 3,227 followers View post →
Citron Archialcalin
@CitronAlcalin · X

@BrunoSWAC @le_science4all M'enfin même sur des interrogations liées, comme sur l'effet des placebo déclarés, on va dans le même sens puisqu'on trouve que les effets contextuels vont surtout venir du rationnel donné. https://t.co/n6iV3mDQfR https://t.co/yNISCsdb6d https://t.co/R2922cuWx7

Jun 24, 2019 · 1 like · 3,154 followers View post →
Citron Archialcalin
@CitronAlcalin · X

@Samwell57375890 @ThelordOTGeek @VieDeCarabin Non les effets contextuels sont bel et bien encore là même quand on sait que l'intervention (type cachet) est un placebo. Entre autres car il y a beaucoup plus que celle-ci qui entre en considération. https://t.co/R2922cuWx7

May 12, 2019 · 3,154 followers View post →
Citron Archialcalin
@CitronAlcalin · X

@CecileDuflot @corsedurable @LaurentLantieri Le fait qu'il existe aussi un effet placebo dans une certaine mesure et surtout selon la présentation qui en est faite avec des placebos non-masqués est une toute autre question que l'intérêt clinique de cet effet. https://t.co/R2922cuWx7

Apr 27, 2019 · 3,154 followers View post →
Citron Archialcalin
@CitronAlcalin · X

@Khamsin_ @Phartonium Les effets contextuels ne sont pas limités à l'intervention placebo (faux-médicament ou autre), donc déjà oui pour ces autres effets. Et pour l'intervention aussi probablement bien qu'ils soient en général limités (mensonge ou pas). https://t.co/dQSGhz83Kp

Apr 8, 2019 · 3,154 followers View post →
Citron Archialcalin
@CitronAlcalin · X

@Ptitpigeonvert @Larmonicateur1 @Morebeny @franceinfo Pas vraiment d'abord parce que les effets contextuels ne sont pas limités à l'intervention placebo elle-même (pseudo-traitement quelconque) et existent sans elle, ensuite parce que même en sachant que c'est placebo, il y a un effet. https://t.co/yNISCsdb6d https://t.co/R2922cuWx7

Apr 4, 2019 · 3,154 followers View post →
Citron Archialcalin
@CitronAlcalin · X

@skinnytop @GeorgePecheur @TroncheBiais Il semble pourtant bien que oui, d'autant plus que les effets contextuels ne se limitent pas à l'intervention placebo elle-même (genre prendre une pillule). https://t.co/R2922cuWx7

Apr 3, 2019 · 1 like · 3,154 followers View post →
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