June 2017 PMID 28472278

Dihydrotestosterone: Biochemistry, Physiology, and Clinical Implications of Elevated Blood Levels.

Ronald S Swerdloff, Robert E Dudley, Stephanie T Page, Christina Wang, Wael A Salameh

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Mentions

29
Peak: 3 in Jan 2022
across 4 sources since Jul 2021

Extended reach

70,823
potential audience

Total likes

1,731

Video views

69,689

Mentions per month

Jul 2021 – Jul 2025

Where it's discussed

  • Reddit18 posts
  • News7 articles
  • X / Twitter2 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions demonstrate a positive reception of the article’s findings, such as comments on DHT's effects on lipid metabolism in rodents and editorial insights on related research, illustrating curiosity about biochemical mechanisms and clinical implications. The tone mixes scientific curiosity with cautious optimism, which supports the overall moderate interest and engagement levels.

AgreementModerate agreement

Most discussions reflect agreement with the publication, especially regarding the safety of elevated blood DHT levels and their limited systemic effects.

InterestHigh interest

Posts show high interest, with some mentioning specific biochemical effects like lipid generation suppression and editorial insights on related studies.

EngagementModerate engagement

The engagement is moderate, as commenters refer to detailed observations and related research, but there are no deep debates or extensive analysis.

ImpactModerate impact

The discussions indicate that the article influences opinions about androgen therapy safety and opens considerations for further research, making its impact notable but not transformative.

Abstract in brief

  • The text explains that circulating levels of Dihydrotestosterone (DHT) are not strongly linked to its activity within tissues, meaning that blood DHT levels are not necessarily an indicator of androgenic effects like prostate growth or function.
  • It highlights that modest increases in blood DHT due to testosterone therapy do not appear to raise risks for prostate diseases, cardiovascular issues, or cause other systemic problems based on current clinical data, although there is a lack of large, long-term studies.
  • The overall conclusion is that elevated blood DHT levels, especially those resulting from androgen therapies, are generally not a cause for concern in clinical practice, and their safety profile seems comparable to that of testosterone itself.]

Top posts

Most liked on X and Bluesky
Finasteride Watch
@FinasterideInfo · X

Editorial comments on Swerdloff et al, 2017 https://t.co/Ejkg4gjSOd

Jul 2, 2021 · 817 followers View post →
JJames94
@jjames94X · X

DHT (and DHEA) seem to shut down lipid generation (in rodents anyways) in case anyone is worried about de novo creation of fats from carbohydrate. https://t.co/EKplOHsZvv

Jul 23, 2025 · 68 followers View post →

All mentions

JJames94
@jjames94X · X

DHT (and DHEA) seem to shut down lipid generation (in rodents anyways) in case anyone is worried about de novo creation of fats from carbohydrate. https://t.co/EKplOHsZvv

Jul 23, 2025 · 68 followers View post →
Finasteride Watch
@FinasterideInfo · X

Editorial comments on Swerdloff et al, 2017 https://t.co/Ejkg4gjSOd

Jul 2, 2021 · 817 followers View post →
tdickgrowthresearch
Reddit

Endocrine reviews, 38(3), 220–254. https://doi.org/10.1210/er.2016-1067. Rosenberg, E. A., Bůžková, P., Fink, H. A., Robbins, J. A., Shores, M. M., Matsumoto ...

Dec 13, 2025 View →
The TOT Bible V1 | PDF | Testosterone | Estrogen
News

doi: 10.1210/er.2016-1067. Swerdloff RS1, Dudley RE2, Page ST3, Wang C1,4, (DHT). Salameh WA1 ...

Dec 13, 2025 View →
Aging and Sex Hormones in Males | PDF | Luteinizing Hormone ...
News

Endocrine Reviews, 38(3), 220–254. https://doi.org/10.1210/er.2016-1067. Swerdloff, R. S., Wang, C., White, W. B., Kaminetsky, ...

Dec 13, 2025 View →
Equine Anabolic Steroids Review | PDF | Luteinizing Hormone ...
News

https://doi.org/10.1210/er.2016-1067 of Endocrinology, 180, R201–R 212. https://doi.org/10.1530/ Tang, P. W., Ip, W. C., Law, W. C., Wan, T. S. M., & Crone ...

Dec 13, 2025 View →
女性倾向跨性别者的激素治疗简介
News

[DOI:10.1210/er.2016-1067] T'Sjoen, G. G., Beguin, Y., Feyen, E., Rubens, R., Kaufman, J., & Gooren, L. (2005). Influence of exogenous oestrogen or (anti ...

Dec 13, 2025 View →
Testosterone Optimization Therapy Bible - Jay Campbell & Jim ...
News

... 10.1210/edrv-8-1-1. PMID 3549275. 104 http://www.webmd.com/men/guide ... er.2015-1010. 108. Are oestrogens involved in falling sperm counts and ...

Dec 13, 2025 View →
Testosterone Boosting Guide | PDF | Fat | Milk
News

doi: 10.1210/er.2016-1067. PMID: 28472278; PMCID: PMC6459338. Shimizu Y, Ntege EH, Sunami H, Inoue Y. Regenerative medicine strategies for hair growth and ...

Dec 13, 2025 View →
I'm sick of this hair loss... I'm about to try something crazy. Wish me ...
Reddit

https://sci-hub.se/10.1210/er.2016-1067 · https://sci-hub.se/10.1007/978-1-59745-453-7_12. tl;dr you don't want removal of the adrenals, as ...

Mar 17, 2025 View →
La dutasterida tarda de 1 a 3 meses en hacer efecto en el cuero ...
Reddit

https://sci-hub.scrongyao.com/10.1210/er.2016-1067. La DHT en suero está mayormente unida a la globulina fijadora de hormonas sexuales (SHBG) ...

Aug 21, 2024 View →
Dutasteridi vie 1-3 kuukautta vaikuttaakseen päänahassa. Ei ...
Reddit

... 10.1210/er.2016-1067. Seerumin DHT on enimmäkseen sitoutunut sukupuolihormoneja sitovaan globuliiniin (SHBG) verenkierrossa. SHBG auttaa ...

Aug 21, 2024 View →
Dutasteride takes 1-3 months to work in the scalp. Not weeks. Be ...
Reddit

https://sci-hub.scrongyao.com/10.1210/er.2016-1067. Serum DHT is mostly bound to sex hormone-binding globulin (SHBG) when in the bloodstream ...

Aug 21, 2024 View →
Androtase MT Mai22 | PDF
News

Endocrine Reviews; Copyright (2017) DOI: 10.1210/er.2016-1067 18. USTUNER ET. Cause of androgenic alopecia: crux of the matter. Plast ...

May 22, 2024 View →
我所知道的关于DHT 的一切: r/transgenderau
Reddit

org/10.1210/er.2016-1067. Rosenberg, E. A., Bůžková, P., Fink, H. A., Robbins, J. A., Shores, M. M., Matsumoto, A. M., & Mukamal, K. J. (2021) ...

Apr 6, 2024 View →
Everything I know about DHT : r/transgenderau
Reddit

https://doi.org/10.1210/er.2016-1067. Rosenberg, E. A., Bůžková, P., Fink, H. A., Robbins, J. A., Shores, M. M., Matsumoto, A. M., & Mukamal ...

Apr 6, 2024 View →
Creatine and dht : r/DrWillPowers
Reddit

you probably just aren't finding the right studies. https://sci-hub.se/10.1210/er.2016-1067. Furthermore, it is well documented that DHT can ...

Oct 20, 2023 View →
Is Dutasteride even needed anymore with Low T level?? : r ...
Reddit

... id=10.1371/journal.pbio.3000198 · https://sci-hub.se/10.1210/er.2016-1067 · https://academic.oup.com/endo/article/158/4/1015/2939508.

Mar 6, 2023 View →
Finasteride and allopregnanolone : r/DrWillPowers
Reddit

https://sci-hub.se/10.1210/er.2016-1067. Does finasteride actually inhibit 5AR 1 aswell? https://en.wikipedia.org/wiki/Finasteride.

Aug 9, 2022 View →
“Dr. Powers is an idiot” : r/DrWillPowers
Reddit

... Progesterone to DHT: https://sci-hub.se/10.1210/er.2016-1067. Estrone sulfate: https://pubmed.ncbi.nlm.nih.gov/8478138/ · More replies.

May 3, 2022 View →
“Powers 医生是个傻子” : r/DrWillPowers
Reddit

:) DeannaWilliams222. • 4年前. 孕酮到DHT: https://sci-hub.se/10.1210/er.2016-1067. 硫酸雌酮: https://pubmed.ncbi.nlm.nih.gov/8478138/ · 更多回复.

May 3, 2022 View →
Can a cis woman really have 200 pg/ml of DHT? : r/DrWillPowers
Reddit

... 10.1210/er.2016-1067. This study revealed mean serum DHT concentrations in healthy pre- and postmenopausal women of about 9 ng/dL (0.3 nmol/L) ...

Apr 9, 2022 View →
Hair loss and bad hair regrowth on HRT despite the low levels of T ...
Reddit

... 10.1210/er.2016-1067. in my opinion, if you have active 5AR activity, then the solution is dutasteride which directly inhibits the 5AR ...

Feb 7, 2022 View →
DHT cream on genitals in FTM? : r/DrWillPowers
Reddit

... 10.1210/er.2016-1067. section II, paragraph A on page 3 (conversion of T into DHT in peripheral tissues). section II, paragraph B on page 3 ...

Jan 7, 2022 View →
DHT-kräm på genitalier i FTM? : r/DrWillPowers
Reddit

... 10.1210/er.2016-1067. Avsnitt II, stycke A på sida 3 (omvandling av T till DHT i perifera vävnader). Avsnitt II, stycke B på sida 3 (potens).

Jan 7, 2022 View →
Крем с ДГТ на гениталии у FTM? : r/DrWillPowers
Reddit

... 10.1210/er.2016-1067. раздел II, пункт A на странице 3 (преобразование Т в ДГТ в периферических тканях). раздел II, пункт B на странице 3 ...

Jan 7, 2022 View →
Bica post-orchi to block androgens from progesterone? : r ...
Reddit

https://sci-hub.se/10.1210/er.2016-1067. Dihydrotestosterone is one of four principle androgens in humans and is synthesized primarily via ...

Dec 19, 2021 View →