PubHawk
Am J Psychiatry September 2017 PMID 28494655

Significant Locus and Metabolic Genetic Correlations Revealed in Genome-Wide Association Study of Anorexia Nervosa.

Laramie Duncan, Zeynep Yilmaz, Helena Gaspar, Raymond Walters, Jackie Goldstein, Verneri Anttila, Brendan Bulik-Sullivan, Stephan Ripke, Laura Thornton, Anke Hinney, Mark Daly, Patrick F Sullivan, Eleftheria Zeggini, Gerome Breen

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Mentions

102
Peak: 1 in Aug 2019
across 6 sources since Aug 2019

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AI synopsis

What people are saying

Several posts emphasize the importance of the genetic links uncovered, with references to related conditions like schizophrenia and autism, illustrating how these findings could influence perceptions of anorexia nervosa as both a psychiatric and metabolic disorder. The tone is analytical and conclusive, reflecting active interest and recognition of the study's potential impact.

AgreementModerate agreement

Most discussions recognize the significance of the genetic findings and agree that anorexia nervosa involves both psychiatric and metabolic factors.

InterestHigh interest

Posts show high interest by referencing specific studies, genetic links, and related mental health conditions, indicating active engagement with the research.

EngagementHigh engagement

Discussion participants cite multiple studies, explain the connections between disorders, and emphasize the importance of the findings, demonstrating deep engagement with the topic.

ImpactHigh impact

The posts highlight the potential to reshape understanding and treatment approaches for anorexia nervosa, suggesting the research could influence future studies and clinical practices.

Abstract in brief

  • The study conducted a comprehensive genome-wide association analysis on anorexia nervosa, identifying a significant genetic locus on chromosome 12 linked to autoimmune disease, and found that common genetic variations contribute to about 20% of the hereditary risk.
  • Researchers discovered meaningful genetic correlations between anorexia nervosa and other psychiatric traits like schizophrenia and neuroticism, as well as metabolic traits such as cholesterol levels and body mass index, highlighting the complex genetic architecture of the disorder.
  • The findings suggest that anorexia nervosa is influenced by both psychiatric and metabolic genetic factors, prompting a need to rethink how we understand and treat this often deadly condition.]
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Top posts

Most liked on X and Bluesky
RichardCy
@RichardCye · X

Pour rappel, l'Anorexie n'est pas un problème strictement psy! Elle est associée également à des facteurs métaboliques et immunitaires Je vous renvoie sur l'étude de Duncan et al. parue en 2017 https://t.co/5nI0AzdlFT

Oct 27, 2022 · 2 likes · 1,209 followers View post →
Dionysus
@AstroYoungLoL · X

@Kel_MHB AN + Schizophrenics have a poor connection to their emotions, body and reality. Final secret: AN, AUtism and schizophrenia all related in GWAS studies e.g., (AN + Autism) Koch et al., 2015 https://t.co/zSbQEv1O3o , (AN + Schizo) Duncan et al., 2017 https://t.co/qFYiRPkYHp

Dec 8, 2022 · 1 like · 15 followers View post →

All mentions

Dionysus
@AstroYoungLoL · X

@Kel_MHB AN + Schizophrenics have a poor connection to their emotions, body and reality. Final secret: AN, AUtism and schizophrenia all related in GWAS studies e.g., (AN + Autism) Koch et al., 2015 https://t.co/zSbQEv1O3o , (AN + Schizo) Duncan et al., 2017 https://t.co/qFYiRPkYHp

Dec 8, 2022 · 1 like · 15 followers View post →
RichardCy
@RichardCye · X

Pour rappel, l'Anorexie n'est pas un problème strictement psy! Elle est associée également à des facteurs métaboliques et immunitaires Je vous renvoie sur l'étude de Duncan et al. parue en 2017 https://t.co/5nI0AzdlFT

Oct 27, 2022 · 2 likes · 1,209 followers View post →
Academy for Eating Disorders
@aedweb · X

RT @ANZAED1: The first GWAS or genetic study of #anorexianervosa... more data has found that although some genetic loci were initially iden…

Aug 24, 2019 · 1 share · 12,742 followers View post →