Front Syst Neurosci April 2017 PMID 28496402

Cortico-Striatal-Thalamic Loop Circuits of the Orbitofrontal Cortex: Promising Therapeutic Targets in Psychiatric Illness.

Peter Fettes, Laura Schulze, Jonathan Downar

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Mentions

13
Peak: 4 in Jan 2021
across 5 sources since Nov 2019

Extended reach

40,831
potential audience

Total likes

93

Video views

3,863

Mentions per month

Nov 2019 – Oct 2024

Where it's discussed

  • X / Twitter4 posts
  • News4 articles
  • YouTube2 videos
  • Facebook2 posts
  • Reddit1 posts

AI synopsis

What people are saying

The overall insights reveal a positive and interested perspective, with posts referencing the biological basis of OCD and related treatments, such as neurostimulation techniques, which demonstrate an understanding of the article’s implications. The tone suggests excitement about future therapeutic possibilities, although the conversation remains relatively surface-level with brief mentions rather than deep debates.

AgreementModerate agreement

Most discussions acknowledge the importance of the research, especially highlighting the potential for targeted treatments, indicating general agreement about the article's value.

InterestHigh interest

The discussion shows high interest, with comments referencing the biological mechanisms and potential therapies, engaging curiosity about psychiatric treatment innovations.

EngagementModerate engagement

Engagement is moderate; posts mention understanding OCD and treatment options, suggesting some depth but limited active discussion or critical analysis.

ImpactModerate impact

The discussions hint at a moderate impact, emphasizing potential for new therapies and the significance of neural circuit understanding in psychiatric illnesses.

Abstract in brief

  • This article explores how the corticostriatal circuits in the orbitofrontal cortex (OFC), involving the medial and lateral parts, are crucial for human behaviors like decision-making, emotion regulation, and reward processing, and how dysfunctions in these circuits are linked to psychiatric disorders such as depression, OCD, and substance use disorders.
  • It emphasizes that different connectivity profiles of the medial and lateral OFC circuits influence various goal-directed behaviors and that disruptions here can lead to psychiatric symptoms, which can potentially be treated using neurostimulation techniques like DBS, ECT, rTMS, and tDCS.
  • The review discusses how these therapies may work by restoring normal activity in the OFC corticostriatal circuits and considers future prospects for treatments targeting these pathways to improve mental health conditions.]

Top posts

Most liked on X and Bluesky
Ava Mason
@Ava_Mason_1 · X

Hi all! This video looks on what is OCD and how can we treat it. I speak about the biology and psychological theories behind the disorder and how it relates to treatment. Hope you enjoy https://t.co/FWlj1O6OMq

Jan 28, 2021 · 4 likes · 1 share · 498 followers View post →
Dr. John Mark Froiland
@DrJohnFroiland · X

RT @Ava_Mason_1: Hi all! This video looks on what is OCD and how can we treat it. I speak about the biology and psychological theories behi…

Jan 28, 2021 · 1 share · 35,942 followers View post →
Charles Thomas Wild
@CharlesThomasW7 · X

Cortico-Striatal-Thalamic Loop Circuits of the Orbitofrontal ... Frontiers ... Cortico-Striatal-Thalamic Loop Circuits of the Orbitofrontal Cortex: Promising Therapeutic Targets in Psychiatric Illness ... Corticostriatal circuits through

Oct 23, 2024 · 359 followers View post →
Peter Fettes
@peter_fettes · X

@hubermanlab https://t.co/npDucnLeAM

May 27, 2022 · 96 followers View post →

All mentions

Charles Thomas Wild
@CharlesThomasW7 · X

Cortico-Striatal-Thalamic Loop Circuits of the Orbitofrontal ... Frontiers ... Cortico-Striatal-Thalamic Loop Circuits of the Orbitofrontal Cortex: Promising Therapeutic Targets in Psychiatric Illness ... Corticostriatal circuits through

Oct 23, 2024 · 359 followers View post →
Peter Fettes
@peter_fettes · X

@hubermanlab https://t.co/npDucnLeAM

May 27, 2022 · 96 followers View post →
Dr. John Mark Froiland
@DrJohnFroiland · X

RT @Ava_Mason_1: Hi all! This video looks on what is OCD and how can we treat it. I speak about the biology and psychological theories behi…

Jan 28, 2021 · 1 share · 35,942 followers View post →
Ava Mason
@Ava_Mason_1 · X

Hi all! This video looks on what is OCD and how can we treat it. I speak about the biology and psychological theories behind the disorder and how it relates to treatment. Hope you enjoy https://t.co/FWlj1O6OMq

Jan 28, 2021 · 4 likes · 1 share · 498 followers View post →
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