A resource of potential drug targets and strategic decision-making for obstructive sleep apnoea pharmacotherapy.

Abstract in brief

• This review explores the potential for developing pharmacological treatments for obstructive sleep apnea (OSA), emphasizing a logical decision-making process that involves characterizing individual patient factors, identifying strategies to target those factors, and pinpointing drug targets related to upper airway control.
• It concludes that there are two promising pharmacological approaches for OSA, with the most potential benefiting from targeting the upper airway motor circuitry, and highlights existing drug targets that could be further developed to improve treatment options.
• The authors also note that while pharmacotherapy might not fully cure OSA, it could serve as an effective supplement to existing treatments, enhancing overall management and patient adherence.]