Inverted U-Shaped Dose-Response Curve of the Anxiolytic Effect of Cannabidiol during Public Speaking in Real Life.

Abstract in brief

• This study explored whether the anxiety-reducing (anxiolytic) effects of cannabidiol (CBD) follow an inverted U-shaped dose-response curve, similar to patterns seen in animal research, with different doses (100, 300, and 900 mg) tested during public speaking in real life.
• Results showed that CBD at 300 mg significantly reduced feelings of anxiety during the speech, confirming a dose-dependent effect, while lower (100 mg) and higher (900 mg) doses were less effective, supporting the inverted U-shape pattern.
• Additionally, clonazepam proved to be more sedative and caused fewer blood pressure increases compared to CBD, but both clonazepam and CBD 300 mg improved anxiety without excessive sedation, highlighting CBD's potential as an anxiolytic agent with a specific optimal dosage.]